A 31p NMR study of the reaction of adenosine 3′,5′-cyclic monophosphate with 2,4,6-triisopropylbenzenesulfonyl chloride

J. Tomasz, S. Bottka, I. Pelczer

Research output: Article

2 Citations (Scopus)

Abstract

The reaction of adenosine 3′.5′-cyclic monophosphate (cyclic AMP) with 0.5-2.0 molar equivalents of 2,4,6-triisopropylbenzenesulfonyl (p-toluenesulfonyl or mesitylenesulfonyl; chloride leads to the rapid formation of the three possible phosphorus diastereoisomers [RpRp, Sp, Sp and RpSp and of cyclic AMP symmetrical anhydride. The diastereoisomers were characterized by 31p NMR. The cyclic AMP sulfonic mixed anhydride could not be detected.

Original languageEnglish
Pages (from-to)785-792
Number of pages8
JournalNucleosides and Nucleotides
Volume6
Issue number4
DOIs
Publication statusPublished - szept. 1 1987

ASJC Scopus subject areas

  • Biochemistry
  • Genetics

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