Shift‐reagent‐aided 23Na NMR spectroscopy allows differentiation of the intracellular (Nai) and extracellular sodium (Na0) signals. The goal of the present study has been to develop a 23Na NMR spectroscopic method to minimize the intensity of the shift‐reagent‐shifted Na0 signal and thus increase Nai resolution. This is achieved by a selective inversion recovery (SIR) method which enhances the resolution between the Nai and Na0 peaks in shift‐reagent‐aided 23Na NMR spectroscopy. The application of SIR with Dy(TTHA), Tm(DOTP), or with low concentrations of Dy(PPP)2 results in both good spectral resolution and physiologically acceptable contractile function in the isolated, perfused rat heart model.
ASJC Scopus subject areas
- Molecular Medicine
- Radiology Nuclear Medicine and imaging