A novel method has been developed for the synthesis of the optical antipodes of trans-2-(3-phenylprop-1-yl)cyclohexylamino-2-oxazoline 1 from racemic cis-octahydrocoumarin 4 instead of cyclohexene oxide 2, because the synthesis of 1 from compound 2 was unsuccessful. Compound 4 was resolved with 1-phenylethylamine enantiomers. Although the preparation of this oxazoline from cyclohexene oxide is known, the resolution and the enantiomeric enrichment step have not been described.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry