A prospective multicenter study of insulin and glucagon infusion therapy in acute alcoholic hepatitis

János Fehér, Ágnes Cornides, Anna Romány, Mihály Kárteszi, László Szalay, Árpád Gógl, José Picazo

Research output: Article

38 Citations (Scopus)

Abstract

A randomized, single-blind controlled multicenter study of insulin and glucagon infusion was carried out in 66 patients with acute alcoholic hepatitis. Thirty-three patients were treated with insulin 10 U and glucagon 1 mg in 500 ml 5% glucose in water via a peripheral vein for 2-6 h three times every day for 3 weeks. Patients in the control group received 5% glucose in an identical fashion. Fourteen control patients and five treated patients died from liver failure during the study (P < 0.02). Clinical features of liver disease on entry into the study were similar in the two groups, but the total serum bilirubin, aspartate aminotransferase, gamma-glutamyltranspeptidase activities and prothrombin time significantly improved in the treated patients (P < 0.05). Insulin and glucagon infusion appears to be a promising treatment of acute alcoholic hepatitis.

Original languageEnglish
Pages (from-to)224-231
Number of pages8
JournalJournal of Hepatology
Volume5
Issue number2
DOIs
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Hepatology

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