A practical process for the preparation of bis(2,2,2-trifluoroethyl) 2-oxoalkylphosphonates by acylation with carboxylic esters

Katalin Molnár, László Takács, Mihály Kádár, Ferenc Faigl, Zsuzsanna Kardos

Research output: Article

7 Citations (Scopus)

Abstract

The preparation of bis(2,2,2-trifluoroethyl) 2-oxoalkylphosphonates by the acylation of bis(2,2,2-trifluoroethyl) methylphosphonate was re-investigated using esters rather than the sensitive acyl chlorides. Based on our optimization, the best results were achieved when the base (LiHMDS) was added to a solution of the phosphonate and the acylating agent at -90°C.

Original languageEnglish
Pages (from-to)4877-4879
Number of pages3
JournalTetrahedron Letters
Volume56
Issue number34
DOIs
Publication statusPublished - júl. 20 2015

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'A practical process for the preparation of bis(2,2,2-trifluoroethyl) 2-oxoalkylphosphonates by acylation with carboxylic esters'. Together they form a unique fingerprint.

  • Cite this