A possible association of periodontal infectious diseases in pregnant women with isolated orofacial clefts in their children: A population-based case-control study

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Abstract

BACKGROUND: The aim of the study was to check the association of maternal periodontal infectious disease (MPID) during pregnancy and the possible risk for birth outcomes, mainly structural birth defects: congenital abnormalities (CAs) in their children. METHODS: The population-based data set of the Hungarian Case-Control Surveillance System of Congenital Abnormalities, 1980-1996, was evaluated. The occurrence of medically recorded MPID in the prenatal maternity logbook was compared in 22,843 cases with different CAs and 38,151 matched controls without defects. RESULTS: Twenty-one case mothers who had offspring with a CA (case group) and 17 pregnant women who delivered newborn infants without a CA (control group) had an MPID. However, of 21 cases, 6 had isolated cleft lip ± palate (OR with 95% CI: 10.7, 4.2-27.3), and 2 were affected with isolated cleft palate (7.9, 1.8-34.2). Of these 8 cases, 6 had mothers with the exposure of MPID in the critical period of these orofacial clefts, 7 mothers were visited at home, and 6 were smokers during pregnancy. CONCLUSIONS: The unexpected findings of the study showed a strong association of MPID during pregnancy with a higher risk of isolated orofacial clefts in their children.

Original languageEnglish
Pages (from-to)466-473
Number of pages8
JournalBirth Defects Research Part A - Clinical and Molecular Teratology
Volume88
Issue number6
DOIs
Publication statusPublished - jún. 2010

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Embryology
  • Developmental Biology

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