Új, hazai lehetoség a tartós orális antikoaguláns terápiában

Research output: Review article


Coumarins have been widely used for the prevention of arterial and venous thromboembolism. The importance of oral anticoagulants has steadily increased in internal medicine and cardiology in the past 20 years. Coumarins are vitamin K antagonists by inhibiting the synthesis of vitamin K-dependent coagulation factors in liver cells. Since the average half-life of hydroxy-coumarin is longer than that of aceno-coumarin, the INR of patients treated with hydroxy-coumarin is more stable, thus making it especially suitable for long-term anticoagulant treatment. The main indications of coumarin therapy include secondary prophylaxis of venous thromboembolism, and primary and secondary prevention of arterial thromboembolism, particularly embolic stoke, in patients with cardiovascular disorders. This review summarizes the most important clinical issues of long-term oral anticoagulant therapy including indications, contraindications, dosing, therapeutic range, and laboratory monitoring. Special emphasis is placed on the role of hydroxy-coumarin in long-term oral anticoagulant therapy.

Translated title of the contributionA new way of long-term oral anticoagulant therapy in Hungary
Original languageHungarian
Pages (from-to)203-210
Number of pages8
JournalLege Artis Medicinae
Issue number3
Publication statusPublished - márc. 1 2006


  • Contraindications
  • Coumarins
  • Hydroxy-coumarin
  • Indications
  • Laboratory monitoring
  • Long-term oral anticoagulant therapy
  • Side effects

ASJC Scopus subject areas

  • Medicine(all)

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