A multimodal microtool for spatially controlled infrared neural stimulation in the deep brain tissue

C. Horváth, C. Boros, S. Beleznai, Sepsi, P. Koppa, Z. Fekete

Research output: Article

2 Citations (Scopus)

Abstract

Infrared neural stimulation (INS) uses pulsed mid-infrared light to generate highly controlled temperature transients in neurons, leading them to fire action potentials. Stimulation of the superficial layer of the intact brain has been demonstrated, however, intervention in the deep neural tissue has larger potential in view of therapeutic use. To reveal the underlying mechanism of deep tissue stimulation properly, we present the design, the fabrication scheme and functional testing of a novel, multimodal optrode for future INS experiments in vivo. Three modalities – electrophysiological recording, thermal measurement and delivery of infrared light – were integrated using silicon MEMS technology. The average overall efficiency of the microoptical system delivering the infrared light at chip-scale is measured as 32.04 ± 4.10%, while the max. efficiency in packaged form is 41.5 ± 3.29%. The average beam spot size at the probe tip is 0.024 ± 0.006 mm2. The temperature coefficient of resistance of the integrated thermal sensor monitoring the change in background temperature is 2636 ± 75 ppm/°C. The average impedance of the electrophysiological recording sites is 1031 ± 95 kΩ. Based on beam profile measurements and multiphysical modeling, the spatial extent of the thermally excited region and its temporal dynamics are estimated in case of both low (30 mW) and high (3 W) power excitation. Due to the monolithically integrated functionalities, a single probe is sufficient to determine safe stimulation parameters in vivo. As far as we know, this is the first planar, multimodal optrode designed for INS studies in the deep tissue.

Original languageEnglish
Pages (from-to)77-86
Number of pages10
JournalSensors and Actuators, B: Chemical
Volume263
DOIs
Publication statusPublished - jún. 15 2018

Fingerprint

stimulation
brain
Brain
Tissue
Infrared radiation
recording
probes
Silicon
neurons
Temperature
Neurons
microelectromechanical systems
MEMS
temperature
delivery
Fires
chips
impedance
Fabrication
fabrication

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

Cite this

A multimodal microtool for spatially controlled infrared neural stimulation in the deep brain tissue. / Horváth, C.; Boros, C.; Beleznai, S.; Sepsi, ; Koppa, P.; Fekete, Z.

In: Sensors and Actuators, B: Chemical, Vol. 263, 15.06.2018, p. 77-86.

Research output: Article

Horváth, C. ; Boros, C. ; Beleznai, S. ; Sepsi, ; Koppa, P. ; Fekete, Z. / A multimodal microtool for spatially controlled infrared neural stimulation in the deep brain tissue. In: Sensors and Actuators, B: Chemical. 2018 ; Vol. 263. pp. 77-86.
@article{b7a403c353164755b588f2d6b4c18ab9,
title = "A multimodal microtool for spatially controlled infrared neural stimulation in the deep brain tissue",
abstract = "Infrared neural stimulation (INS) uses pulsed mid-infrared light to generate highly controlled temperature transients in neurons, leading them to fire action potentials. Stimulation of the superficial layer of the intact brain has been demonstrated, however, intervention in the deep neural tissue has larger potential in view of therapeutic use. To reveal the underlying mechanism of deep tissue stimulation properly, we present the design, the fabrication scheme and functional testing of a novel, multimodal optrode for future INS experiments in vivo. Three modalities – electrophysiological recording, thermal measurement and delivery of infrared light – were integrated using silicon MEMS technology. The average overall efficiency of the microoptical system delivering the infrared light at chip-scale is measured as 32.04 ± 4.10{\%}, while the max. efficiency in packaged form is 41.5 ± 3.29{\%}. The average beam spot size at the probe tip is 0.024 ± 0.006 mm2. The temperature coefficient of resistance of the integrated thermal sensor monitoring the change in background temperature is 2636 ± 75 ppm/°C. The average impedance of the electrophysiological recording sites is 1031 ± 95 kΩ. Based on beam profile measurements and multiphysical modeling, the spatial extent of the thermally excited region and its temporal dynamics are estimated in case of both low (30 mW) and high (3 W) power excitation. Due to the monolithically integrated functionalities, a single probe is sufficient to determine safe stimulation parameters in vivo. As far as we know, this is the first planar, multimodal optrode designed for INS studies in the deep tissue.",
keywords = "Infrared waveguide, Neural stimulation, Optical stimulation, Optrode, Silicon microelectrode",
author = "C. Horv{\'a}th and C. Boros and S. Beleznai and Sepsi and P. Koppa and Z. Fekete",
year = "2018",
month = "6",
day = "15",
doi = "10.1016/j.snb.2018.02.034",
language = "English",
volume = "263",
pages = "77--86",
journal = "Sensors and Actuators, B: Chemical",
issn = "0925-4005",
publisher = "Elsevier",

}

TY - JOUR

T1 - A multimodal microtool for spatially controlled infrared neural stimulation in the deep brain tissue

AU - Horváth, C.

AU - Boros, C.

AU - Beleznai, S.

AU - Sepsi,

AU - Koppa, P.

AU - Fekete, Z.

PY - 2018/6/15

Y1 - 2018/6/15

N2 - Infrared neural stimulation (INS) uses pulsed mid-infrared light to generate highly controlled temperature transients in neurons, leading them to fire action potentials. Stimulation of the superficial layer of the intact brain has been demonstrated, however, intervention in the deep neural tissue has larger potential in view of therapeutic use. To reveal the underlying mechanism of deep tissue stimulation properly, we present the design, the fabrication scheme and functional testing of a novel, multimodal optrode for future INS experiments in vivo. Three modalities – electrophysiological recording, thermal measurement and delivery of infrared light – were integrated using silicon MEMS technology. The average overall efficiency of the microoptical system delivering the infrared light at chip-scale is measured as 32.04 ± 4.10%, while the max. efficiency in packaged form is 41.5 ± 3.29%. The average beam spot size at the probe tip is 0.024 ± 0.006 mm2. The temperature coefficient of resistance of the integrated thermal sensor monitoring the change in background temperature is 2636 ± 75 ppm/°C. The average impedance of the electrophysiological recording sites is 1031 ± 95 kΩ. Based on beam profile measurements and multiphysical modeling, the spatial extent of the thermally excited region and its temporal dynamics are estimated in case of both low (30 mW) and high (3 W) power excitation. Due to the monolithically integrated functionalities, a single probe is sufficient to determine safe stimulation parameters in vivo. As far as we know, this is the first planar, multimodal optrode designed for INS studies in the deep tissue.

AB - Infrared neural stimulation (INS) uses pulsed mid-infrared light to generate highly controlled temperature transients in neurons, leading them to fire action potentials. Stimulation of the superficial layer of the intact brain has been demonstrated, however, intervention in the deep neural tissue has larger potential in view of therapeutic use. To reveal the underlying mechanism of deep tissue stimulation properly, we present the design, the fabrication scheme and functional testing of a novel, multimodal optrode for future INS experiments in vivo. Three modalities – electrophysiological recording, thermal measurement and delivery of infrared light – were integrated using silicon MEMS technology. The average overall efficiency of the microoptical system delivering the infrared light at chip-scale is measured as 32.04 ± 4.10%, while the max. efficiency in packaged form is 41.5 ± 3.29%. The average beam spot size at the probe tip is 0.024 ± 0.006 mm2. The temperature coefficient of resistance of the integrated thermal sensor monitoring the change in background temperature is 2636 ± 75 ppm/°C. The average impedance of the electrophysiological recording sites is 1031 ± 95 kΩ. Based on beam profile measurements and multiphysical modeling, the spatial extent of the thermally excited region and its temporal dynamics are estimated in case of both low (30 mW) and high (3 W) power excitation. Due to the monolithically integrated functionalities, a single probe is sufficient to determine safe stimulation parameters in vivo. As far as we know, this is the first planar, multimodal optrode designed for INS studies in the deep tissue.

KW - Infrared waveguide

KW - Neural stimulation

KW - Optical stimulation

KW - Optrode

KW - Silicon microelectrode

UR - http://www.scopus.com/inward/record.url?scp=85042172727&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042172727&partnerID=8YFLogxK

U2 - 10.1016/j.snb.2018.02.034

DO - 10.1016/j.snb.2018.02.034

M3 - Article

AN - SCOPUS:85042172727

VL - 263

SP - 77

EP - 86

JO - Sensors and Actuators, B: Chemical

JF - Sensors and Actuators, B: Chemical

SN - 0925-4005

ER -