A large European, multicenter, multinational validation study of the Brief Negative Symptom Scale

Armida Mucci, Annarita Vignapiano, István Bitter, Stephen F. Austin, Camille Delouche, Sonia Dollfus, Andreas Erfurth, W. Wolfgang Fleischhacker, Giulia M. Giordano, Igor Gladyshev, Birte Glenthøj, Karoline Gütter, Alex Hofer, Jan Hubeňák, Stefan Kaiser, Jan Libiger, Ingrid Melle, Mette Nielsen, Oleg Papsuev, Janusz K. RybakowskiGabriele Sachs, Alp Üçok, Pawel Wojciak, Silvana Galderisi

Research output: Article

7 Citations (Scopus)

Abstract

Negative symptoms represent an unmet need of treatment in schizophrenia. Although a consensus exists on negative symptom construct, and second generation assessment instruments reflecting the consensus are available, studies still rely upon old assessment instruments, that do not reflect recent conceptualizations and might limit progress in the search for effective treatments. This is often the case in the European context, where one of the challenges encountered in designing large studies is the availability of validated instruments in the many languages of the continent. To address this challenge and promote sound research on negative symptoms in Europe, the ECNP Schizophrenia Network coordinated a large multicenter, multinational validation study of the Brief Negative Symptom Scale (BNSS). Clinically-stable subjects with schizophrenia (SCZ, N = 249) were recruited from 10 European Countries. Apart from BNSS, subjects were administered the Positive and Negative Syndrome Scale (PANSS) and standardized instruments for depression, extrapyramidal symptoms and psychosocial functioning. Results showed an excellent internal consistency, convergent and discriminant validity of BNSS and replicated a 5 factor-model. A larger number of subjects with predominant negative symptoms, i.e. the target population for clinical trials, was identified by using the BNSS compared to the PANSS. Regression analysis showed that BNSS-avolition, a key negative symptom poorly assessed by PANSS, explained 23.9% of psychosocial functioning, while no combination of the PANSS core negative symptoms showed the same impact on functioning. The study demonstrated that BNSS has substantial advantages with respect to PANSS for the identification of the avolition domain and subjects with predominant negative symptoms.

Original languageEnglish
Pages (from-to)947-959
Number of pages13
JournalEuropean Neuropsychopharmacology
Volume29
Issue number8
DOIs
Publication statusPublished - aug. 2019

ASJC Scopus subject areas

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Pharmacology (medical)

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    Mucci, A., Vignapiano, A., Bitter, I., Austin, S. F., Delouche, C., Dollfus, S., Erfurth, A., Fleischhacker, W. W., Giordano, G. M., Gladyshev, I., Glenthøj, B., Gütter, K., Hofer, A., Hubeňák, J., Kaiser, S., Libiger, J., Melle, I., Nielsen, M., Papsuev, O., ... Galderisi, S. (2019). A large European, multicenter, multinational validation study of the Brief Negative Symptom Scale. European Neuropsychopharmacology, 29(8), 947-959. https://doi.org/10.1016/j.euroneuro.2019.05.006