A kimerizmus immunpatológiai és klinikai jelentősége csontvelő-transzplantációban és szervátültetésekben

Barta Anikó, Lengyel Lilla, Sipos Andrea, Torbágyi Éva, Földi János, Páldi Haris Piroska, Tamáska Júlia, Gyódi Éva, Rajczy Katalin, Hoffer Izabella, Jakab Judit, Kormos Luca, Petrányi Gyózó, Pálóczi Katalin

Research output: Article

Abstract

Chimerism is an exceptional immunogenetic state, characterized by the survival and collaboration of cell populations originated from two different individuals. The prerequisites to induce chimerism are immunosuppression, myeloablation or severe immunodeficiency of the recipients on one side and donor originated immuno-hematopoietic cells in the graft on the other. Special immunogenetic conditions to establish chimerism are combined with bone marrow transplantation, transfusion and various kinds of solid organ grafting. There are various methods to detect the type of chimera state depending on the immunogenetic differences between the donor and recipient. The chimera state seems to be one of the leading factors to influence the course of the post-transplant period, the frequency and severity of graft-versus-host disease (GVHD), and the rate of relapse. However, the most important contribution of the chimeric state is the development of graft versus leukemia (GVL) effect. A new conditioning protocol (DBM/Ara-C/Cy) for allogeneic BMT in CML patients and its consequence on chimera state and GVL effect is demonstrated.

Original languageHungarian
Pages (from-to)15-21
Number of pages7
JournalMagyar onkologia
Volume45
Issue number1
Publication statusPublished - jan. 1 2001

ASJC Scopus subject areas

  • Medicine(all)

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