A homozygous genetic variant of mitochondrial uncoupling protein 4 affects the occurrence of leukoaraiosis

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9 Citations (Scopus)

Abstract

Objectives: We hypothesized that an appropriate balance of the mitochondrial energy production is essential in the maintenance of the glia cells in the brain. The aim of this study was to examine the roles of the rs10807344 and rs2270450 genetic variants of mitochondrial uncoupling protein 4 in the development of vascular demyelinization of the white matter of the brain, referred to as leukoaraiosis (LA). The mUCPs are presumed to be of great importance in the regulation of the mitochondrial membrane potential (MMP) and the cellular energy metabolism. Materials and Methods: An analysis was performed on the clinical and genetic data on 401 LA patients without infarction and on 451 neuroimaging alteration-free subjects. After univariate statistical approaches, logistic regression models were also used to adjust differences in significant clinical factors between the patients and controls. Results: The rs10807344 CC genotype proved to exert a protective effect on the occurrence of LA (neuroimaging alteration-free controls: 57.7%, LA group: 44.9%, P

Original languageEnglish
Pages (from-to)352-357
Number of pages6
JournalActa Neurologica Scandinavica
Volume123
Issue number5
DOIs
Publication statusPublished - máj. 2011

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Leukoaraiosis
Neuroimaging
Logistic Models
Mitochondrial Membrane Potential
Brain
Neuroglia
Infarction
Energy Metabolism
Blood Vessels
Genotype
Maintenance
Uncoupling Protein 1

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

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title = "A homozygous genetic variant of mitochondrial uncoupling protein 4 affects the occurrence of leukoaraiosis",
abstract = "Objectives: We hypothesized that an appropriate balance of the mitochondrial energy production is essential in the maintenance of the glia cells in the brain. The aim of this study was to examine the roles of the rs10807344 and rs2270450 genetic variants of mitochondrial uncoupling protein 4 in the development of vascular demyelinization of the white matter of the brain, referred to as leukoaraiosis (LA). The mUCPs are presumed to be of great importance in the regulation of the mitochondrial membrane potential (MMP) and the cellular energy metabolism. Materials and Methods: An analysis was performed on the clinical and genetic data on 401 LA patients without infarction and on 451 neuroimaging alteration-free subjects. After univariate statistical approaches, logistic regression models were also used to adjust differences in significant clinical factors between the patients and controls. Results: The rs10807344 CC genotype proved to exert a protective effect on the occurrence of LA (neuroimaging alteration-free controls: 57.7{\%}, LA group: 44.9{\%}, P",
keywords = "Genetics, Leukoaraiosis, Mitochondria, UCP variants",
author = "Z. Szolnoki and A. Kondacs and Y. M{\'a}ndi and A. Bodor and F. Somogyv{\'a}ri",
year = "2011",
month = "5",
doi = "10.1111/j.1600-0404.2010.01391.x",
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pages = "352--357",
journal = "Acta Neurologica Scandinavica",
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TY - JOUR

T1 - A homozygous genetic variant of mitochondrial uncoupling protein 4 affects the occurrence of leukoaraiosis

AU - Szolnoki, Z.

AU - Kondacs, A.

AU - Mándi, Y.

AU - Bodor, A.

AU - Somogyvári, F.

PY - 2011/5

Y1 - 2011/5

N2 - Objectives: We hypothesized that an appropriate balance of the mitochondrial energy production is essential in the maintenance of the glia cells in the brain. The aim of this study was to examine the roles of the rs10807344 and rs2270450 genetic variants of mitochondrial uncoupling protein 4 in the development of vascular demyelinization of the white matter of the brain, referred to as leukoaraiosis (LA). The mUCPs are presumed to be of great importance in the regulation of the mitochondrial membrane potential (MMP) and the cellular energy metabolism. Materials and Methods: An analysis was performed on the clinical and genetic data on 401 LA patients without infarction and on 451 neuroimaging alteration-free subjects. After univariate statistical approaches, logistic regression models were also used to adjust differences in significant clinical factors between the patients and controls. Results: The rs10807344 CC genotype proved to exert a protective effect on the occurrence of LA (neuroimaging alteration-free controls: 57.7%, LA group: 44.9%, P

AB - Objectives: We hypothesized that an appropriate balance of the mitochondrial energy production is essential in the maintenance of the glia cells in the brain. The aim of this study was to examine the roles of the rs10807344 and rs2270450 genetic variants of mitochondrial uncoupling protein 4 in the development of vascular demyelinization of the white matter of the brain, referred to as leukoaraiosis (LA). The mUCPs are presumed to be of great importance in the regulation of the mitochondrial membrane potential (MMP) and the cellular energy metabolism. Materials and Methods: An analysis was performed on the clinical and genetic data on 401 LA patients without infarction and on 451 neuroimaging alteration-free subjects. After univariate statistical approaches, logistic regression models were also used to adjust differences in significant clinical factors between the patients and controls. Results: The rs10807344 CC genotype proved to exert a protective effect on the occurrence of LA (neuroimaging alteration-free controls: 57.7%, LA group: 44.9%, P

KW - Genetics

KW - Leukoaraiosis

KW - Mitochondria

KW - UCP variants

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