A highly collateralized thalamic cell type with arousal-predicting activity serves as a key hub for graded state transitions in the forebrain

Ferenc Mátyás, Gergely Komlósi, Ákos Babiczky, Kinga Kocsis, P. Barthó, Boglárka Barsy, Csaba Dávid, Vivien Kanti, Cesar Porrero, Aletta Magyar, Iván Szűcs, Francisco Clasca, L. Acsády

Research output: Article

7 Citations (Scopus)

Abstract

Sleep cycles consist of rapid alterations between arousal states, including transient perturbation of sleep rhythms, microarousals, and full-blown awake states. Here we demonstrate that the calretinin (CR)-containing neurons in the dorsal medial thalamus (DMT) constitute a key diencephalic node that mediates distinct levels of forebrain arousal. Cell-type-specific activation of DMT/CR+ cells elicited active locomotion lasting for minutes, stereotyped microarousals, or transient disruption of sleep rhythms, depending on the parameters of the stimulation. State transitions could be induced in both slow-wave and rapid eye-movement sleep. The DMT/CR+ cells displayed elevated activity before arousal, received selective subcortical inputs, and innervated several forebrain sites via highly branched axons. Together, these features enable DMT/CR+ cells to summate subcortical arousal information and effectively transfer it as a rapid, synchronous signal to several forebrain regions to modulate the level of arousal.

Original languageEnglish
Pages (from-to)1551-1562
Number of pages12
JournalNature Neuroscience
Volume21
Issue number11
DOIs
Publication statusPublished - nov. 1 2018

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Calbindin 2
Prosencephalon
Arousal
Thalamus
Sleep
REM Sleep
Locomotion
Axons
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

A highly collateralized thalamic cell type with arousal-predicting activity serves as a key hub for graded state transitions in the forebrain. / Mátyás, Ferenc; Komlósi, Gergely; Babiczky, Ákos; Kocsis, Kinga; Barthó, P.; Barsy, Boglárka; Dávid, Csaba; Kanti, Vivien; Porrero, Cesar; Magyar, Aletta; Szűcs, Iván; Clasca, Francisco; Acsády, L.

In: Nature Neuroscience, Vol. 21, No. 11, 01.11.2018, p. 1551-1562.

Research output: Article

Mátyás, F, Komlósi, G, Babiczky, Á, Kocsis, K, Barthó, P, Barsy, B, Dávid, C, Kanti, V, Porrero, C, Magyar, A, Szűcs, I, Clasca, F & Acsády, L 2018, 'A highly collateralized thalamic cell type with arousal-predicting activity serves as a key hub for graded state transitions in the forebrain', Nature Neuroscience, vol. 21, no. 11, pp. 1551-1562. https://doi.org/10.1038/s41593-018-0251-9
Mátyás, Ferenc ; Komlósi, Gergely ; Babiczky, Ákos ; Kocsis, Kinga ; Barthó, P. ; Barsy, Boglárka ; Dávid, Csaba ; Kanti, Vivien ; Porrero, Cesar ; Magyar, Aletta ; Szűcs, Iván ; Clasca, Francisco ; Acsády, L. / A highly collateralized thalamic cell type with arousal-predicting activity serves as a key hub for graded state transitions in the forebrain. In: Nature Neuroscience. 2018 ; Vol. 21, No. 11. pp. 1551-1562.
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