A detailed investigation of the preparation of 2,7-diaminosuberic acid and 2,5-diaminoadipic acid derivatives using Kolbe electrolysis

Johann Hiebl, Michael Blanka, A. Guttman, Hermann Kollmann, Kornelia Leitner, Günter Mayrhofer, Franz Rovenszky, Karin Winkler

Research output: Article

33 Citations (Scopus)

Abstract

The yield of protected 2,7-diaminosuberic acid (DAS) prepared by Kolbe reaction of N-protected α-glutamic acid esters is dependent on solvent, temperature, concentration of carboxylate onion, and protecting groups. The highest yield of protected L,L-2,7-diaminosuberic acid is obtained with Boc-Glu-OMe as starting material using MeOH/pyridine/NaOMe as electrolyte.

Original languageEnglish
Pages (from-to)2059-2074
Number of pages16
JournalTetrahedron
Volume54
Issue number10
DOIs
Publication statusPublished - márc. 5 1998

Fingerprint

Electrolysis
Derivatives
Acids
Onions
Electrolytes
Glutamic Acid
Esters
Temperature
2,7-diaminosuberic acid
pyridine

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

A detailed investigation of the preparation of 2,7-diaminosuberic acid and 2,5-diaminoadipic acid derivatives using Kolbe electrolysis. / Hiebl, Johann; Blanka, Michael; Guttman, A.; Kollmann, Hermann; Leitner, Kornelia; Mayrhofer, Günter; Rovenszky, Franz; Winkler, Karin.

In: Tetrahedron, Vol. 54, No. 10, 05.03.1998, p. 2059-2074.

Research output: Article

Hiebl, Johann ; Blanka, Michael ; Guttman, A. ; Kollmann, Hermann ; Leitner, Kornelia ; Mayrhofer, Günter ; Rovenszky, Franz ; Winkler, Karin. / A detailed investigation of the preparation of 2,7-diaminosuberic acid and 2,5-diaminoadipic acid derivatives using Kolbe electrolysis. In: Tetrahedron. 1998 ; Vol. 54, No. 10. pp. 2059-2074.
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AU - Rovenszky, Franz

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