A corpus luteum is nota prerequisite for the expression of progesterone induced blocking factor by T-lymphocytes a week after implantation

Jerome H. Check, Julia Szekeres-Bartho, Parvin Nazari, Youval Katz, Matthew L. Check

Research output: Article

4 Citations (Scopus)


Purpose: To determine if production of the immunomodulatory protein, progesterone induced blocking factor (pibf), requires merely progesterone or whether other factors made by the corpus luteum are required. Methods: The percentage of peripheral lymphocytes expressing PIBF was determined by obtaining a blood sample from women 9-12 days after embryo transfer. The embryos were either fresh ones following hyperstimulation and oocyte retrieval or were frozen-thawed embryos. Preparation for frozen embryo transfer required corpus luteum suppression with exogenous estrogen. The percentage of lymphocytes expressing PIBF was determined by an immunocytochemistry method. Results: PIBF expression (>1%) was found in 20.5% of COH and 13.3% of frozen embryo transfer cycles. There either was a significant difference or a trend for higher pregnancy rates when PIBF expression was detected. Conclusions: These data corroborate previous conclusions that PIBF is detected in a minority of women in the late luteal phase. A corpus luteum is not required for its expression.

Original languageEnglish
Pages (from-to)603-607
Number of pages5
JournalJournal of Assisted Reproduction and Genetics
Issue number11
Publication statusPublished - dec. 1 2001


ASJC Scopus subject areas

  • Reproductive Medicine
  • Genetics
  • Obstetrics and Gynaecology
  • Developmental Biology
  • Genetics(clinical)

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