A closer look at the structure of sterically stabilized liposomes: A small-angle x-ray scattering study

Zoltán Varga, Szilvia Berényi, Bálint Szokol, László O'rfi, György Kéri, István Peták, Armin Hoell, Attila Bóta

Research output: Article

26 Citations (Scopus)

Abstract

The evaluation of the radial electron density profile of a drug containing a sterically stabilized liposomal system is described. Using synchrotron small-angle X-ray scattering, we were able to characterize the hydrophilic shell of the polyethylene glycol chains. Using a Gaussian model for describing the electron density profile along the normal of the bilayer, we got an asymmetric distribution of PEGylated lipids in accordance with theoretical considerations. Moreover, we used anomalous X-ray scattering to study the localization of a hydrophobic drug (a kinase inhibitor), which revealed that these molecules are mainly located in the hydrocarbon chain region of the phospholipid bilayer.

Original languageEnglish
Pages (from-to)6850-6854
Number of pages5
JournalJournal of Physical Chemistry B
Volume114
Issue number20
DOIs
Publication statusPublished - máj. 27 2010

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films
  • Materials Chemistry

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