Abstract
The teratogenic risk means the probability of the occurrence of congenital abnormalities in fetuses after the exposure of teratogenic agents, mainly drugs during pregnancy. The recent highresolution ultrasound scanning may help us to concretize this teratogenic risk. The Genetic, Teratogenic and Family Planning Counseling Clinic of the authors in Budapest were visited by 10,557 couples or client between 1998 and 2007. Ten pregnant women visited this Clinic due to the isotretinoin (Roaccutan) treatment during pregnancy during the 10 years study period. At present Roaccutan is the most teratogenic drug among the medicinal products in Hungary because its teratogenic risk is 25% for a characteristic pattern of congenital abnormality syndrome including a/microtia, ventriculomegaly and contruncal cardiovascular malformation. These fetal defects are detectable by the high-resolution ultrasound scanning between 18th and 20th gestational week of pregnant women. Thus this examination was recommended for the 10 pregnant women with unintended use of isotretinoin (Roaccutan) in early pregnancy. Six pregnant women followed our advice and the repeated ultrasound scanning was not able to detect the above-mentioned characteristic defects and all the 6 newborns were healthy after birth. In conclusion the recent highresolution ultrasound examination provides a chance for the diagnosis of certain fetal defect between 18th and 20th gestational week of pregnant women. The Hungarian law allows these pregnant women to decide the termination of pregnancy until 20th (24th) gestational week after the diagnosis of severe fetal defects. However, this approach can protect the life of the major part of fetuses in pregnant women at high risk.
| Original language | Hungarian |
|---|---|
| Pages (from-to) | 513-517 |
| Number of pages | 5 |
| Journal | Lege Artis Medicinae |
| Volume | 20 |
| Issue number | 8 |
| Publication status | Published - aug. 2010 |
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Keywords
- Characteristic pattern of defects in isotretinoin syndrome
- High-resolution ultrasound scanning
- Isotretinoin (Roaccutan)
- Prevention of unaffected fetuses
- Teratogenic drugs
ASJC Scopus subject areas
- Medicine(all)
Cite this
Lehetoség a magzati teratogén kockázat konkretizálására : Hat terhes isotretinoinkezelé sének értékelése. / Gábor, Timmermann; Béla, Kondér; János, Gidai; Czeizel, E.
In: Lege Artis Medicinae, Vol. 20, No. 8, 08.2010, p. 513-517.Research output: Article
}
TY - JOUR
T1 - Lehetoség a magzati teratogén kockázat konkretizálására
T2 - Hat terhes isotretinoinkezelé sének értékelése
AU - Gábor, Timmermann
AU - Béla, Kondér
AU - János, Gidai
AU - Czeizel, E.
PY - 2010/8
Y1 - 2010/8
N2 - The teratogenic risk means the probability of the occurrence of congenital abnormalities in fetuses after the exposure of teratogenic agents, mainly drugs during pregnancy. The recent highresolution ultrasound scanning may help us to concretize this teratogenic risk. The Genetic, Teratogenic and Family Planning Counseling Clinic of the authors in Budapest were visited by 10,557 couples or client between 1998 and 2007. Ten pregnant women visited this Clinic due to the isotretinoin (Roaccutan) treatment during pregnancy during the 10 years study period. At present Roaccutan is the most teratogenic drug among the medicinal products in Hungary because its teratogenic risk is 25% for a characteristic pattern of congenital abnormality syndrome including a/microtia, ventriculomegaly and contruncal cardiovascular malformation. These fetal defects are detectable by the high-resolution ultrasound scanning between 18th and 20th gestational week of pregnant women. Thus this examination was recommended for the 10 pregnant women with unintended use of isotretinoin (Roaccutan) in early pregnancy. Six pregnant women followed our advice and the repeated ultrasound scanning was not able to detect the above-mentioned characteristic defects and all the 6 newborns were healthy after birth. In conclusion the recent highresolution ultrasound examination provides a chance for the diagnosis of certain fetal defect between 18th and 20th gestational week of pregnant women. The Hungarian law allows these pregnant women to decide the termination of pregnancy until 20th (24th) gestational week after the diagnosis of severe fetal defects. However, this approach can protect the life of the major part of fetuses in pregnant women at high risk.
AB - The teratogenic risk means the probability of the occurrence of congenital abnormalities in fetuses after the exposure of teratogenic agents, mainly drugs during pregnancy. The recent highresolution ultrasound scanning may help us to concretize this teratogenic risk. The Genetic, Teratogenic and Family Planning Counseling Clinic of the authors in Budapest were visited by 10,557 couples or client between 1998 and 2007. Ten pregnant women visited this Clinic due to the isotretinoin (Roaccutan) treatment during pregnancy during the 10 years study period. At present Roaccutan is the most teratogenic drug among the medicinal products in Hungary because its teratogenic risk is 25% for a characteristic pattern of congenital abnormality syndrome including a/microtia, ventriculomegaly and contruncal cardiovascular malformation. These fetal defects are detectable by the high-resolution ultrasound scanning between 18th and 20th gestational week of pregnant women. Thus this examination was recommended for the 10 pregnant women with unintended use of isotretinoin (Roaccutan) in early pregnancy. Six pregnant women followed our advice and the repeated ultrasound scanning was not able to detect the above-mentioned characteristic defects and all the 6 newborns were healthy after birth. In conclusion the recent highresolution ultrasound examination provides a chance for the diagnosis of certain fetal defect between 18th and 20th gestational week of pregnant women. The Hungarian law allows these pregnant women to decide the termination of pregnancy until 20th (24th) gestational week after the diagnosis of severe fetal defects. However, this approach can protect the life of the major part of fetuses in pregnant women at high risk.
KW - Characteristic pattern of defects in isotretinoin syndrome
KW - High-resolution ultrasound scanning
KW - Isotretinoin (Roaccutan)
KW - Prevention of unaffected fetuses
KW - Teratogenic drugs
UR - http://www.scopus.com/inward/record.url?scp=77956725204&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956725204&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:77956725204
VL - 20
SP - 513
EP - 517
JO - Lege Artis Medicinae
JF - Lege Artis Medicinae
SN - 0866-4811
IS - 8
ER -