1,6-Dimethyl-4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrido 1,2-a pyrimidine-3-carboxamide (Ch-127) significantly inhibited the intestinal ulceration induced by a single dose of indomethacin (15 mg/kg p.o.). Moreover, indomethacin produced 75% lethality in the dose of 3.5 mg/kg p.o. administered daily for 2 weeks. The concurrent daily administration of Ch-127 (50 mg/kg p.o. + 25 mg/kg s.c.) with indomethacin prevented the gastrointestinal mucosa from histologically detectable changes, and none of the animals died. The 80% lethality following the daily administration of naproxen (60 mg/kg p.o.) for 2 weeks was also significantly decreased by combining it with Ch-127 (50 mg/kg p.o.).
|Number of pages||6|
|Journal||Drugs under Experimental and Clinical Research|
|Publication status||Published - jan. 1 1987|
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery
- Pharmacology (medical)