12.1.2. Pathological findings in cystic craniopharyngiomas after stereotactic intracavitary irradiation with yttrium-90 isotope

G. Szeifert, K. Bálint, L. Sipos, M. Sarker, S. Czirják, J. Julow

Research output: Chapter

12 Citations (Scopus)

Abstract

Histopathological, ultrastructural and polyacrylamide gel electrophoretic examinations were carried out on biopsy, cyst fluid, surgical pathology and autopsy specimens obtained from 7 cystic craniopharyngioma cases before and after yttrium-90 silicate colloid (90Y) irradiation. Light microscopy revealed that the lining epithelial tumor cell layer of the cyst wall was destroyed, and scar tissue containing large amount of hyaline degenerated collagen bundles replaced it. Proliferative postirradiation vasculopathy was also demonstrated in the cyst wall following 90Y installation. Electrophoretic property of cyst fluid was similar to the normal human serum. Considering that scar tissue has a certain propensity to shrink, the fibrosis in the cyst wall together with destruction of neoplastic epithelium and vascular changes might explain diminished fluid production and cyst volume reduction after 90Y treatment.

Original languageEnglish
Title of host publicationRadiosurgery and Pathological Fundamentals
EditorsGyorgy Szeifert, Marc Levivier, Douglas Kondziolka, Dade Lunsford
Pages297-302
Number of pages6
DOIs
Publication statusPublished - dec. 1 2007

Publication series

NameProgress in Neurological Surgery
Volume20
ISSN (Print)0079-6492
ISSN (Electronic)1662-3924

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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    Szeifert, G., Bálint, K., Sipos, L., Sarker, M., Czirják, S., & Julow, J. (2007). 12.1.2. Pathological findings in cystic craniopharyngiomas after stereotactic intracavitary irradiation with yttrium-90 isotope. In G. Szeifert, M. Levivier, D. Kondziolka, & D. Lunsford (Eds.), Radiosurgery and Pathological Fundamentals (pp. 297-302). (Progress in Neurological Surgery; Vol. 20). https://doi.org/10.1159/000100173