The aim of this study was to estimate the changes in left ventricular diastolic function during dobutamine stress echocardiography. In 39 patients, systolic (left ventricular dimensions, global and regional function) and diastolic parameters (peak velocity and velocity-time integral of E and A waves, E/A ratio, E and A velocity-time integral ratio, deceleration time, atrial and left ventricular filling fractions and isovolumic relaxation time) were measured at rest and at the end of the pharmacological stress test. Twenty patients had a normal resting systo-diastolic left ventricular function (Group 1) while 19 patients exhibited a relaxation-type diastolic dysfunction and a normal systolic function at rest (Group 2). Dobutamine induced new regional wall motion disturbances in 5 patients of both groups (groups 1 and 2 positive), while the stress test was negative in 15 and 14 patients in groups 1 and 2, respectively. During dobutamine stress test, the E/A ratio increased significantly in groups 1 and 2 negative, decreased in Group 1 positive and was unchanged in Group 2 positive. Significant differences were found between Groups 1 negative and 1 positive in the following parameters: peak E velocity, E/A ratio, deceleration time, E velocity-time integral, E and A velocity-time integral ratio, atrial and left ventricular filling fractions and maximal heart rate. Significant differences were found between Groups 2 negative and 2 positive in E/A ratio, deceleration time and maximal heart rate. In conclusion, the changes in diastolic parameters during the pharmacological stress test give additional information for the diagnosis of ischemic heart disease.
|Number of pages||5|
|Publication status||Published - jan. 1 1999|
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Cardiology and Cardiovascular Medicine