(1) The isolated frog's heart, repeatedly washed with Ca-free Ringer's solution, stops and, after discontinuing washing, begins to move again in spite of Ca lack. The heart adapts in the same way to the common lack of Ca and K, furthermore to Ringer's solution containing 10-20 times more K than normal. (2) Adaptation was not observed on isolated ventricle driven with electrical current. (3) It is concluded that the isolated frog's heart adapts to the ion composition of the surrounding fluid as a whole, and that the auricle plays an essential role in this process.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)