• 2933 Citations
  • 30 h-Index
19962019
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Research Output 1996 2019

  • 2933 Citations
  • 30 h-Index
  • 80 Article
  • 1 Chapter
  • 1 Letter
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Article
2019
4 Citations (Scopus)
Open Access
Cell-Penetrating Peptides
Tight Junctions
Permeability
Cell Membrane
Claudin-4

Multilevel structure–activity profiling reveals multiple green tea compound families that each modulate ubiquitin-activating enzyme and ubiquitination by a distinct mechanism

Fenteany, G., Gaur, P., Hegedűs, L., Dudás, K., Kiss, E., Wéber, E., Hackler, L., Martinek, T., Puskás, L. & Haracska, L., dec. 1 2019, In : Scientific reports. 9, 1, 12801.

Research output: Article

Open Access
Ubiquitin-Activating Enzymes
Ubiquitination
Tea
Pharmacologic Actions
Proliferating Cell Nuclear Antigen

Rapid evolution of reduced susceptibility against a balanced dual-targeting antibiotic through stepping-stone mutations

Szili, P., Draskovits, G., Révész, T., Bogár, F., Balogh, D., Martinek, T., Daruka, L., Spohn, R., Vásárhelyi, B. M., Czikkely, M., Kintses, B., Grézal, G., Ferenc, G., Pál, C. & Nyerges, Á., jan. 1 2019, In : Antimicrobial Agents and Chemotherapy. 63, 9, e00207-19.

Research output: Article

Anti-Bacterial Agents
Mutation
Klebsiella pneumoniae
DNA Topoisomerase IV
DNA Gyrase
2018
48 Citations (Scopus)

Antibiotic-resistant bacteria show widespread collateral sensitivity to antimicrobial peptides

Lázár, V., Martins, A., Spohn, R., Daruka, L., Grézal, G., Fekete, G., Számel, M., Jangir, P. K., Kintses, B., Csörgo, B., Nyerges, Á., Györkei, Á., Kincses, A., Dér, A., Walter, F. R., Deli, M. A., Urbán, E., Hegedus, Z., Olajos, G., Méhi, O. & 5 others, Bálint, B., Nagy, I., Martinek, T., Papp, B. & Pál, C., jún. 1 2018, In : Nature Microbiology. 3, 6, p. 718-731 14 p.

Research output: Article

Anti-Bacterial Agents
Bacteria
Peptides
Multiple Drug Resistance
Microbial Drug Resistance

Peripheral cyclic β-amino acids balance the stability and edge-protection of β-sandwiches

Olajos, G., Hetényi, A., Wéber, E., Szögi, T., Fülöp, L. & Martinek, T., jan. 1 2018, In : Organic and Biomolecular Chemistry. 16, 30, p. 5492-5499 8 p.

Research output: Article

Cyclic Amino Acids
strands
amino acids
sandwich structures
Temperature
2 Citations (Scopus)

Structural optimization of foldamer-dendrimer conjugates as multivalent agents against the toxic effects of amyloid beta oligomers

Bartus, É., Olajos, G., Schuster, I., Bozsó, Z., Deli, M. A., Veszelka, S., Walter, F. R., Datki, Z., Szakonyi, Z., Martinek, T. & Fülöp, L., okt. 2 2018, In : Molecules. 23, 10, 2523.

Research output: Article

Dendrimers
Structural optimization
Poisons
dendrimers
oligomers
2017
4 Citations (Scopus)
Calmodulin
Proteins
Bearings (structural)
Sulfhydryl Compounds
Scaffolds
2016
3 Citations (Scopus)

Foldameric probes for membrane interactions by induced β-sheet folding

Hegedüs, Z., Makra, I., Imre, N., Hetényi, A., Mándity, I., Monostori, E. & Martinek, T., jan. 31 2016, In : Chemical Communications. 52, 9, p. 1891-1894 4 p.

Research output: Article

Peptides
Conformations
Membranes

Target-specific NMR detection of protein–ligand interactions with antibody-relayed 15N-group selective STD

Hetényi, A., Hegedűs, Z., Fajka-Boja, R., Monostori, É., Kövér, K. & Martinek, T., dec. 1 2016, In : Journal of Biomolecular NMR. 66, 4, p. 227-232 6 p.

Research output: Article

Nuclear magnetic resonance
Antibodies
Monoclonal Antibodies
Proteins
Drug Design
2015
9 Citations (Scopus)

Induced Folding of Protein-Sized Foldameric β-Sandwich Models with Core β-Amino Acid Residues

Olajos, G., Hetényi, A., Wéber, E., Németh, L. J., Szakonyi, Z., Fülöp, F. & Martinek, T., ápr. 13 2015, In : Chemistry - A European Journal. 21, 16, p. 6173-6180 8 p.

Research output: Article

Amino acids
Cycloleucine
Circular dichroism spectroscopy
Proteins
Heptanes

Two-stage interaction of the tumor nursing galectin-1 with the antiangiogenic peptide anginex

Hegedüs, Z., Wéber, E., Végh, L., Váczi, B., Tubak, V., Kriston-Pál, É., Kele, Z., Monostori, E. & Martinek, T., márc. 30 2015, In : Journal of Thermal Analysis and Calorimetry. 120, 1, p. 449-456 8 p.

Research output: Article

Galectin 1
Nursing
peptides
affinity
Tumors
2014
101 Citations (Scopus)

Peptides containing β-amino acid patterns: Challenges and successes in medicinal chemistry

Cabrele, C., Martinek, T., Reiser, O. & Berlicki, Ł., dec. 11 2014, In : Journal of Medicinal Chemistry. 57, 23, p. 9718-9739 22 p.

Research output: Article

Pharmaceutical Chemistry
Amino Acids
Peptides
Amino Acid Sequence
Proteins
8 Citations (Scopus)

Predicting order and disorder for β-peptide foldamers in water

Németh, L. J., Hegedüs, Z. & Martinek, T., okt. 27 2014, In : Journal of Chemical Information and Modeling. 54, 10, p. 2776-2783 8 p.

Research output: Article

Peptides
water
simulation
Water
Molecular Dynamics Simulation
2013
26 Citations (Scopus)

Foldameric α/β-peptide analogs of the β-sheet-forming antiangiogenic anginex: Structure and bioactivity

Hegedüs, Z., Wéber, E., Kriston-Pál, É., Makra, I., Czibula, A., Monostori, E. & Martinek, T., nov. 6 2013, In : Journal of the American Chemical Society. 135, 44, p. 16578-16584 7 p.

Research output: Article

Bioactivity
Peptides
Substitution reactions
Amino acids
Nuclear magnetic resonance
11 Citations (Scopus)
helices
Peptides
Self assembly
peptides
Proteins
2012
31 Citations (Scopus)

A foldamer-dendrimer conjugate neutralizes synaptotoxic β-amyloid oligomers

Fülöp, L., Mándity, I., Juhász, G., Szegedi, V., Hetényi, A., Wéber, E., Bozsó, Z., Simon, D., Benko, M., Király, Z. & Martinek, T., júl. 30 2012, In : PLoS One. 7, 7, e39485.

Research output: Article

Dendrimers
amyloid
Oligomers
Amyloid
biomimetics
322 Citations (Scopus)

Peptidic foldamers: Ramping up diversity

Martinek, T. & Fülöp, F., jan. 21 2012, In : Chemical Society Reviews. 41, 2, p. 687-702 16 p.

Research output: Article

Nanostructured materials
Nanostructures
Polymers
Molecules
18 Citations (Scopus)
Heptanes
Carboxylic Acids
helices
Nuclear magnetic resonance
Molecular modeling
19 Citations (Scopus)
alkylation
hydrochlorides
formaldehyde
closures
Derivatives
59 Citations (Scopus)

Unique α,β- and α,α,β,β-peptide foldamers based on cis-β-aminocyclopentanecarboxylic acid

Berlicki, Ł., Pilsl, L., Wéber, E., Mándity, I., Cabrele, C., Martinek, T., Fülöp, F. & Reiser, O., febr. 27 2012, In : Angewandte Chemie - International Edition. 51, 9, p. 2208-2212 5 p.

Research output: Article

NSC 153174
Cycloleucine
Peptides
Methanol
Acids
2011
15 Citations (Scopus)
Loratadine
Cyclodextrins
Solubility
Biological Availability
Dissolution
2010
7 Citations (Scopus)
Epitopes
Screening
Nuclear magnetic resonance
Galectin 1
Ligands
51 Citations (Scopus)
Carboxylic Acids
Polymorphism
helices
Self assembly
folding
97 Citations (Scopus)
Peptide Fragments
cysteine
Amyloid
Gold
Nanoparticles
6 Citations (Scopus)

Galectin-1-asialofetuin interaction is inhibited by peptides containing the Tyr-Xxx-Tyr motif acting on the glycoprotein

Wéber, E., Hetényi, A., Váczi, B., Szolnoki, É., Fajka-Boja, R., Tubak, V., Monostori, E. & Martinek, T., jan. 25 2010, In : ChemBioChem. 11, 2, p. 228-234 7 p.

Research output: Article

Galectin 1
Glycoproteins
Peptides
Galactosides
Glycoconjugates
22 Citations (Scopus)
nitromethane
Lithium
Amides
amides
amino acids
2009
16 Citations (Scopus)

A simple, efficient, and selective deuteration via a flow chemistry approach

Mándity, I., Martinek, T., Darvas, F. & Fülöp, F., júl. 29 2009, In : Tetrahedron Letters. 50, 30, p. 4372-4374 3 p.

Research output: Article

Deuterium
Hydrogenation
Substrates
7 Citations (Scopus)
Histidine
Metal ions
Zinc
Copper
Ions
80 Citations (Scopus)
Biometrics
13 Citations (Scopus)

Efficient synthesis of 3,4- and 4,5-dihydroxy-2-amino-cyclohexanecarboxylic acid enantiomers

Benedek, G., Palkó, M., Wéber, E., Martinek, T., Forró, E. & Fülöp, F., okt. 6 2009, In : Tetrahedron Asymmetry. 20, 19, p. 2220-2225 6 p.

Research output: Article

Enantiomers
enantiomers
amino acids
Amino acids
acids
35 Citations (Scopus)
Heptanes
Heptane
Carboxylic Acids
Carboxylic acids
Oligomers
25 Citations (Scopus)
Peptides
Stabilization
Water
Rigidity
Hydrogen bonds
2008
2 Citations (Scopus)
Stachys
Iridoids
X-Ray Emission Spectrometry
Rectum
Inflorescence
30 Citations (Scopus)

Cytotoxic activities of Stachys species

Háznagy-Radnai, E., Réthy, B., Czigle, S., Zupkó, I., Wéber, E., Martinek, T., Falkay, G. & Máthé, I., dec. 2008, In : Fitoterapia. 79, 7-8, p. 595-597 3 p.

Research output: Article

Stachys
Adenocarcinoma
Cervix Uteri
Doxorubicin
Cisplatin
30 Citations (Scopus)

Efficient synthesis of hydroxy-substituted cispentacin derivatives

Benedek, G., Palkó, M., Wéber, E., Martinek, T., Forró, E. & Fülöp, F., júl. 2008, In : European Journal of Organic Chemistry. 21, p. 3724-3730 7 p.

Research output: Article

Derivatives
acids
Acids
synthesis
Stereochemistry
5 Citations (Scopus)
Flocculation
Crosslinking
Ligands
Nuclear magnetic resonance
Peptidomimetics
35 Citations (Scopus)

Stereoselective synthesis of hydroxylated β-aminocyclohexanecarboxylic acids

Kiss, L., Forró, E., Martinek, T., Bernáth, G., De Kimpe, N. & Fülöp, F., máj. 26 2008, In : Tetrahedron. 64, 22, p. 5036-5043 8 p.

Research output: Article

Lactams
Stereoisomerism
Epoxy Compounds
Amino Acids
Acids
2007
15 Citations (Scopus)
Cinchona
Platinum
Ketones
ketones
Hydrogenation
65 Citations (Scopus)
Vitex
Diterpenes
Fruits
Flavonoids
Inhibitory Concentration 50
32 Citations (Scopus)
Cinchona Alkaloids
alkaloids
Ketones
ketones
Nuclear magnetic resonance spectroscopy
94 Citations (Scopus)
Amber
Force Field
Ensemble
Membrane
Lipids
15 Citations (Scopus)
Monoterpenes
Lactams
Enantiomers
enantiomers
amino acids
1 Citation (Scopus)

Synthesis and steric structure of pyrrolidine- and piperidine-fused 1,3,4,2-oxadiazaphosphinanes

Martinek, T., Szolnoki, É., Zalán, Z. & Fülöp, F., 2007, In : Arkivoc. 2007, 5, p. 202-209 8 p.

Research output: Article

Oxides
Conformations
Cyclization
Phosphorus
Nitrogen
13 Citations (Scopus)

β-methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent δ opioid antagonists

Tóth, G., Ioja, E., Tömböly, C., Ballet, S., Tourwé, D., Péter, A., Martinek, T., Chung, N. N., Schiller, P. W., Benyhe, S. & Borsodi, A., jan. 25 2007, In : Journal of Medicinal Chemistry. 50, 2, p. 328-333 6 p.

Research output: Article

Tics
Narcotic Antagonists
Assays
Substitution reactions
Vas Deferens
2006
250 Citations (Scopus)
Cyclic Amino Acids
Amino Acids
Peptides
Biochemistry
Monomers
20 Citations (Scopus)
Chirality
Conformations
flexibility
Opiate Alkaloids
Dinoprost
98 Citations (Scopus)
Cycloleucine
Self assembly
Peptides
NSC 153174
Molecular modeling
69 Citations (Scopus)
Amino alcohols
Amino Alcohols
Aldehydes
aldehydes
alcohols
86 Citations (Scopus)
Self assembly
Peptides
Membranes
Biopolymers