• 3521 Citations
  • 32 h-Index
1994 …2020

Research output per year

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Research Output

  • 3521 Citations
  • 32 h-Index
  • 141 Article
  • 1 Comment/debate
2020

Syntheses and reactions of pyrroline, piperidine nitroxide phosphonates

Isbera, M., Bognár, B., Jekő, J., Sár, C., Hideg, K. & Kálai, T., máj. 2020, In : Molecules. 25, 10, 2430.

Research output: Article

Open Access
2019

Antiproliferative Effect of a Novel 4,4’-Disulfonyldiarylidenyl Piperidone in Human Colon Cancer Cells

Prabhat, A. M., Kuppusamy, M. L., Bognár, B., Kálai, T., Hideg, K. & Kuppusamy, P., márc. 15 2019, In : Cell Biochemistry and Biophysics. 77, 1, p. 61-67 7 p.

Research output: Article

4 Citations (Scopus)

Diarylidenylpiperidones, H-4073 and HO-3867, Induce G2/M Cell-Cycle Arrest, Apoptosis and Inhibit STAT3 Phosphorylation in Human Pancreatic Cancer Cells

Mast, J. M., Tse, D., Shee, K., Lakshmi Kuppusamy, M., Kmiec, M. M., Kalai, T. & Kuppusamy, P., jún. 15 2019, In : Cell Biochemistry and Biophysics. 77, 2, p. 109-119 11 p.

Research output: Article

2 Citations (Scopus)

Interaction Kinetics of Sulfadiazine and N-Acetyl-sulfadiazine with Soil Humic Acid: ESR Investigations with Nitroxide Spin Label

Ricke, A., Bondarenko, E., Úr, G., Kálai, T., Hideg, K., Steinhoff, H. J. & Matthies, M., márc. 1 2019, In : Applied Magnetic Resonance. 50, 1-3, p. 171-185 15 p.

Research output: Article

2 Citations (Scopus)

Specific Features of the Intramolecular Spin Exchange in a Novel Nitroxide Triradical

Kokorin, A. I., Gromov, O. I., Kalai, T., Hideg, K. & Putnikov, A. E., szept. 1 2019, In : Russian Journal of Physical Chemistry B. 13, 5, p. 739-743 5 p.

Research output: Article

Synthesis and application of stable nitroxide free radicals fused with carbocycles and heterocycles

Bognár, B., Úr, G., Sár, C., Hankovszky, O. H., Hideg, K. & Kálai, T., jan. 1 2019, In : Current Organic Chemistry. 23, 4, p. 480-501 22 p.

Research output: Article

1 Citation (Scopus)

Synthesis and evaluation of paramagnetic caffeic acid phenethyl ester (CAPE) analogs

Nagane, M., Yamashita, T., Vörös, P., Kálai, T., Hideg, K. & Bognár, B., aug. 1 2019, In : Monatshefte fur Chemie. 150, 8, p. 1513-1522 10 p.

Research output: Article

Open Access
2 Citations (Scopus)

The Structure and Internal Dynamics of R6-p-C6H4-R6 Biradical: EPR, X-ray Crystallography and DFT Calculations

Kokorin, A. I., Gromov, O. I., Dorovatovskii, P. V., Lazarenko, V. A., Khrustalev, V. N., Hideg, K. & Kálai, T., márc. 1 2019, In : Applied Magnetic Resonance. 50, 1-3, p. 425-439 15 p.

Research output: Article

1 Citation (Scopus)
2018

A bifunctional anti-amyloid blocks oxidative stress and the accumulation of intraneuronal amyloid-beta

Hilt, S., Altman, R., Kálai, T., Maezawa, I., Gong, Q., Wachsmann-Hogiu, S., Jin, L. W. & Voss, J. C., aug. 12 2018, In : Molecules. 23, 8, 2010.

Research output: Article

6 Citations (Scopus)

N-vinylation of imidazole and benzimidazole with a paramagnetic vinyl bromide

Úr, G., Fekete, G. G., Hideg, K. & Kalai, T., márc. 1 2018, In : MolBank. 2018, 1, M980.

Research output: Article

1 Citation (Scopus)

Tailored Nitroxide Radicals and Biradical Containing 13C Enriched Acetylene Groups: ENDOR and DFT Investigation

Kokorin, A. I., Zaripov, R. B., Gromov, O. I., Hideg, K. & Kálai, T., febr. 1 2018, In : Applied Magnetic Resonance. 49, 2, p. 137-149 13 p.

Research output: Article

4 Citations (Scopus)
2017

A Metal-Free Method for Producing MRI Contrast at Amyloid-β

Hilt, S., Tang, T., Walton, J. H., Budamagunta, M., Maezawa, I., Kálai, T., Hideg, K., Singh, V., Wulff, H., Gong, Q., Jin, L. W., Louie, A. & Voss, J. C., 2017, In : Journal of Alzheimer's Disease. 55, 4, p. 1667-1681 15 p.

Research output: Article

6 Citations (Scopus)

Chronic PARP-1 inhibition reduces carotid vessel remodeling and oxidative damage of the dorsal hippocampus in spontaneously hypertensive rats

Eros, K., Magyar, K., Deres, L., Skazel, A., Riba, A., Vamos, Z., Kalai, T., Gallyas, F., Sumegi, B., Toth, K. & Halmosi, R., márc. 2017, In : PloS one. 12, 3, e0174401.

Research output: Article

3 Citations (Scopus)

Oligomerization Alters Binding Affinity between Amyloid Beta and a Modulator of Peptide Aggregation

Hilt, S., Rojalin, T., Viitala, T., Koivuniemi, A., Bunker, A., Wachsmann-Hogiu, S., Kalai, T., Hideg, K., Yliperttula, M. & Voss, J. C., nov. 2 2017, In : Journal of Physical Chemistry C. 121, 43, p. 23974-23987 14 p.

Research output: Article

2 Citations (Scopus)

Palladium- and/or Copper-Catalyzed Cross-Coupling Reactions of Paramagnetic Vinyl Bromides and Iodides

Úr, G., Fekete, G. G., Jekå, J., Hideg, K. & Kálai, T., aug. 16 2017, In : Synthesis (Germany). 49, 16, p. 3740-3748 9 p.

Research output: Article

5 Citations (Scopus)

Reaction of β-Bromo-β,γ-unsaturated Pyrroline Nitroxide Aldehydes and Nitriles with Aromatic N,S-Binucleophiles

Bognár, B., Varga, B., Kálai, T., Csokona, V., Gulyás Fekete, G., Sár, C. & Hideg, K., jan. 1 2017, In : Journal of Heterocyclic Chemistry. 54, 4, p. 2556-2562 7 p.

Research output: Article

1 Citation (Scopus)

Synthesis and biological evaluation of curcumin-nitroxide-based molecular hybrids as antioxidant and anti-proliferative agents

Bognár, B., Kuppusamy, M. L., Madan, E., Kalai, T., Balog, M., Jekó́, J., Kuppusamy, P. & Hideg, K., dec. 1 2017, In : Medicinal Chemistry. 13, 8, p. 761-772 12 p.

Research output: Article

7 Citations (Scopus)
2016
7 Citations (Scopus)
5 Citations (Scopus)

Spin Density Distribution in a Nitroxide Biradical Containing 13C-Enriched Acetylene Groups in the Bridge: DFT Calculations and EPR Investigation

Kokorin, A. I., Zaripov, R. B., Gromov, O. I., Sukhanov, A. A., Kálai, T., Lamperth & Hideg, K., szept. 1 2016, In : Applied Magnetic Resonance. 47, 9, p. 1057-1067 11 p.

Research output: Article

9 Citations (Scopus)
2015

Protective spin-labeled fluorenes maintain amyloid beta peptide in small oligomers and limit transitions in secondary structure

Altman, R., Ly, S., Hilt, S., Petrlova, J., Maezawa, I., Kálai, T., Hideg, K., Jin, L. W., Laurence, T. A. & Voss, J. C., dec. 1 2015, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1854, 12, p. 1860-1870 11 p.

Research output: Article

5 Citations (Scopus)

Synthesis of Azoles Condensed with, or Linked to, Nitroxides

Bognár, B., Kálai, T., Gulyás-Fekete, G., Lazsányi, N. & Hideg, K., 2015, In : Synthesis (Germany). 47, 7, p. 985-991 7 p.

Research output: Article

4 Citations (Scopus)

Synthesis of New Pyrroline Nitroxides with Ethynyl Functional Group

Ur, G., Kalai, T., Balog, M., Bognar, B., Gulyas-Fekete, G. & Hideg, K., szept. 17 2015, In : Synthetic Communications. 45, 18, p. 2122-2129 8 p.

Research output: Article

7 Citations (Scopus)
2014
6 Citations (Scopus)

EPR, the X-ray Structure and DFT Calculations of the Nitroxide Biradical with One Acetylene Group in the Bridge

Gromov, O. I., Golubeva, E. N., Khrustalev, V. N., Kálai, T., Hideg, K. & Kokorin, A. I., okt. 18 2014, In : Applied Magnetic Resonance. 45, 10, p. 981-992 12 p.

Research output: Article

13 Citations (Scopus)
1 Citation (Scopus)
18 Citations (Scopus)

Synthesis and functional survey of new Tacrine analogs modified with nitroxides or their precursors

Kálai, T., Altman, R., Maezawa, I., Balog, M., Morisseau, C., Petrlova, J., Hammock, B. D., Jin, L. W., Trudell, J. R., Voss, J. C. & Hideg, K., ápr. 22 2014, In : European Journal of Medicinal Chemistry. 77, p. 343-350 8 p.

Research output: Article

11 Citations (Scopus)

Synthesis of new paramagnetic retinal analogues

Kálai, T., Lazsányi, N., Gulyás-Fekete, G. & Hideg, K., ápr. 2014, In : Monatshefte fur Chemie. 145, 4, p. 651-656 6 p.

Research output: Article

2013

Behavior of Nitroxide Biradicals with Acetylene Bridges in Organic Solvents and Ionic Liquids

Kokorin, A. I., Golubeva, E. N., Mladenova, B. Y., Tran, V. A., Kálai, T., Hideg, K. & Grampp, G., szept. 1 2013, In : Applied Magnetic Resonance. 44, 9, p. 1041-1051 11 p.

Research output: Article

15 Citations (Scopus)

Pulmonary hypertension secondary to left-heart failure involves peroxynitrite-induced downregulation of PTEN in the lung

Ravi, Y., Selvendiran, K., Naidu, S. K., Meduru, S., Citro, L. A., Bognár, B., Khan, M., Kálai, T., Hideg, K., Kuppusamy, P. & Sai-Sudhakar, C. B., márc. 2013, In : Hypertension. 61, 3, p. 593-601 9 p.

Research output: Article

17 Citations (Scopus)
7 Citations (Scopus)
2012
Open Access
2 Citations (Scopus)

Synthesis of nitroxide-annulated carbocycles and heterocycles

Kálai, T., Bognár, B., Zsolnai, D., Berente, Z. & Hideg, K., okt. 31 2012, In : Synthesis (Germany). 44, 23, p. 3655-3660 6 p., SS-2012-N0671-OP.

Research output: Article

12 Citations (Scopus)

The influence of spin-labeled fluorene compounds on the assembly and toxicity of the aβ peptide

Petrlova, J., Kálai, T., Maezawa, I., Altman, R., Harishchandra, G., Hong, H. S., Bricarello, D. A., Parikh, A. N., Lorigan, G. A., Jin, L. W., Hideg, K. & Voss, J. C., ápr. 30 2012, In : PloS one. 7, 4, e35443.

Research output: Article

13 Citations (Scopus)
2011

Amelioration of doxorubicin-induced cardiotoxicity by an anticancer-antioxidant dual-function compound, HO-3867

Dayton, A., Selvendiran, K., Meduru, S., Khan, M., Kuppusamy, M. L., Naidu, S., Kálai, T., Hideg, K. & Kuppusamy, P., nov. 1 2011, In : Journal of Pharmacology and Experimental Therapeutics. 339, 2, p. 350-357 8 p.

Research output: Article

32 Citations (Scopus)

A rigid disulfide-linked nitroxide side chain simplifies the quantitative analysis of PRE data

Fawzi, N. L., Fleissner, M. R., Anthis, N. J., Kálai, T., Hideg, K., Hubbell, W. L. & Clore, G. M., szept. 1 2011, In : Journal of Biomolecular NMR. 51, 1-2, p. 105-114 10 p.

Research output: Article

44 Citations (Scopus)
12 Citations (Scopus)

Dynamics of tropomyosin in muscle fibers as monitored by saturation transfer EPR of bi-functional probe

Rayes, R. F., Kálai, T., Hideg, K., Geeves, M. A. & Fajer, P. G., 2011, In : PloS one. 6, 6, e21277.

Research output: Article

13 Citations (Scopus)

HO-3867, a curcumin analog, sensitizes cisplatin-resistant ovarian carcinoma, leading to therapeutic synergy through STAT3 inhibition

Selvendiran, K., Ahmed, S., Dayton, A., Kuppusamy, M. L., Rivera, B. K., Kálai, T., Hideg, K. & Kuppusamy, P., nov. 1 2011, In : Cancer Biology and Therapy. 12, 9, p. 837-845 9 p.

Research output: Article

43 Citations (Scopus)

Induction of mitochondrial destabilization and necrotic cell death by apolar mitochondria-directed SOD mimetics

Szabo, A., Balog, M., Mark, L., Montsko, G., Turi, Z., Gallyas, F., Sumegi, B., Kalai, T., Hideg, K. & Kovacs, K., máj. 1 2011, In : Mitochondrion. 11, 3, p. 476-487 12 p.

Research output: Article

6 Citations (Scopus)
19 Citations (Scopus)

Structure and dynamics of a conformationally constrained nitroxide side chain and applications in EPR spectroscopy

Fleissner, M. R., Bridges, M. D., Brooks, E. K., Cascio, D., Kálai, T., Hideg, K. & Hubbell, W. L., szept. 27 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 39, p. 16241-16246 6 p.

Research output: Article

100 Citations (Scopus)

Synthesis and metal ion complexation of spin labeled 18-crown-6 ethers containing an acridone or an acridine fluorophore unit

Kertész, J., Bognár, B., Kormos, A., Móczár, I., Baranyai, P., Kubinyi, M., Kálai, T., Hideg, K. & Huszthy, P., nov. 18 2011, In : Tetrahedron. 67, 46, p. 8860-8864 5 p.

Research output: Article

16 Citations (Scopus)
12 Citations (Scopus)

Synthesis and study of new paramagnetic resveratrol analogues

Kálai, T., Borza, E., Antus, C., Radnai, B., Gulyás-Fekete, G., Fehér, A., Sümegi, B. & Hideg, K., dec. 15 2011, In : Bioorganic and Medicinal Chemistry. 19, 24, p. 7311-7317 7 p.

Research output: Article

16 Citations (Scopus)

Synthesis of new spin labels for Cu-free click conjugation

Kálai, T., Fleissner, M. R., Jek, J., Hubbell, W. L. & Hideg, K., máj. 25 2011, In : Tetrahedron Letters. 52, 21, p. 2747-2749 3 p.

Research output: Article

22 Citations (Scopus)

Synthesis of N-substituted 3,5-bis(arylidene)-4-piperidones with high antitumor and antioxidant activity

Kálai, T., Kuppusamy, M. L., Balog, M., Selvendiran, K., Rivera, B. K., Kuppusamy, P. & Hideg, K., aug. 11 2011, In : Journal of Medicinal Chemistry. 54, 15, p. 5414-5421 8 p.

Research output: Article

70 Citations (Scopus)
2010

Anticancer efficacy of a difluorodiarylidenyl piperidone (HO-3867) in human ovarian cancer cells and tumor xenografts

Selvendiran, K., Tong, L., Bratasz, A., Lakshmi Kuppusamy, M., Ahmed, S., Ravi, Y., Trigg, N. J., Rivera, B. K., Kálai, T., Hideg, K. & Kuppusamy, P., máj. 2010, In : Molecular Cancer Therapeutics. 9, 5, p. 1169-1179 11 p.

Research output: Article

49 Citations (Scopus)

Cellular uptake, retention and bioabsorption of HO-3867, a fluorinated curcumin analog with potential antitumor properties

Dayton, A., Selvendiran, K., Kuppusamy, M. L., Rivera, B. K., Meduru, S., Kálai, T., Hideg, K. & Kuppusamy, P., nov. 15 2010, In : Cancer Biology and Therapy. 10, 10, p. 1027-1032 6 p.

Research output: Article

31 Citations (Scopus)