• 2488 Citations
  • 22 h-Index
19962020

Research output per year

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Research Output

  • 2488 Citations
  • 22 h-Index
  • 38 Article
  • 3 Chapter
  • 3 Review article
  • 1 Comment/debate
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Article
2020

Discovering the chloride pathway in the CFTR channel

Farkas, B., Tordai, H., Padányi, R., Tordai, A., Gera, J., Paragi, G. & Hegedűs, T., febr. 1 2020, In : Cellular and Molecular Life Sciences. 77, 4, p. 765-778 14 p.

Research output: Article

Open Access
2019

Chemically modified derivatives of the activator compound cloxyquin exert inhibitory effect on TRESK (K2P18.1) background potassium channel

Lengyel, M., Erdélyi, F., Pergel, E., Bálint-Polonka, Á., Dobolyi, A., Bozsaki, P., Dux, M., Király, K., Hegedüs, T., Czirják, G., Mátyus, P. & Enyedi, P., 2019, In : Molecular pharmacology. 95, 6, p. 652-660 9 p.

Research output: Article

1 Citation (Scopus)
2018

Clinically relevant mutations in the ABCG2 transporter uncovered by genetic analysis linked to erythrocyte membrane protein expression

Zámbó, B., Bartos, Z., Mózner, O., Szabó, E., Várady, G., Poór, G., Pálinkás, M., Andrikovics, H., Hegedus, T., Homolya, L. & Sarkadi, B., dec. 1 2018, In : Scientific reports. 8, 1, 7487.

Research output: Article

4 Citations (Scopus)
2 Citations (Scopus)
2017

ABCMdb reloaded: Updates on mutations in ATP binding cassette proteins

Tordai, H., Jakab, K., Gyimesi, G., András, K., Brózik, A., Sarkadi, B. & Hegedus, T., jan. 1 2017, In : Database. 2017, 1, bax023.

Research output: Article

2 Citations (Scopus)

GLUT10—lacking in arterial tortuosity syndrome—is localized to the endoplasmic reticulum of human fibroblasts

Gamberucci, A., Marcolongo, P., Németh, C. E., Zoppi, N., Szarka, A., Chiarelli, N., Hegedűs, T., Ritelli, M., Carini, G., Willaert, A., Callewaert, B. L., Coucke, P. J., Benedetti, A., Margittai, É., Fulceri, R., Bánhegyi, G. & Colombi, M., aug. 22 2017, In : International journal of molecular sciences. 18, 8, 1820.

Research output: Article

6 Citations (Scopus)

Molecular dynamics of the cryo-EM CFTR structure

Tordai, H., Leveles, I. & Hegedűs, T., szept. 30 2017, In : Biochemical and biophysical research communications. 491, 4, p. 986-993 8 p.

Research output: Article

10 Citations (Scopus)

Transcriptome analysis of inflammation-related gene expression in endothelial cells activated by complement MASP-1

Schwaner, E., Németh, Z., Jani, P. K., Kajdácsi, E., Debreczeni, M. L., Doleschall, Z., Dobó, J., Gál, P., Rigó, J., András, K., Hegedus, T. & Cervenak, L., dec. 1 2017, In : Scientific reports. 7, 1, 10462.

Research output: Article

2 Citations (Scopus)
2016

Access path to the ligand binding pocket may play a role in xenobiotics selection by AhR

Szöllösi, D., Erdei, Á., Gyimesi, G., Magyar, C. & Hegedüs, T., jan. 4 2016, In : PloS one. 11, 1, e0146066.

Research output: Article

6 Citations (Scopus)

A systematic study of protein labeling by fluorogenic probes using cysteine targeting vinyl sulfone-cyclooctyne tags

Söveges, B., Imre, T., Szende, T., Póti, L., Cserép, G. B., Hegedus, T., Kele, P. & Németh, K., jan. 1 2016, In : Organic and Biomolecular Chemistry. 14, 25, p. 6071-6078 8 p.

Research output: Article

4 Citations (Scopus)

Jump into a new fold-A homology based model for the ABCG2/BCRP multidrug transporter

Lászloá, L., Sarkadi, B. & Hegedüs, T., okt. 2016, In : PloS one. 11, 10, e0164426.

Research output: Article

25 Citations (Scopus)
2015
2 Citations (Scopus)

Inconsistencies in the red blood cell membrane proteome analysis: Generation of a database for research and diagnostic applications

Hegedus, T., Chaubey, P. M., Várady, G., Szabó, E., Sarankó, H., Hofstetter, L., Roschitzki, B., Stieger, B. & Sarkadi, B., 2015, In : Database. 2015, bav056.

Research output: Article

15 Citations (Scopus)

The linker region of breast cancer resistance protein ABCG2 is critical for coupling of ATP-dependent drug transport

Macalou, S., Robey, R. W., Jabor Gozzi, G., Shukla, S., Grosjean, I., Hegedűs, T., Ambudkar, S. V., Bates, S. E. & Di Pietro, A., dec. 26 2015, (Accepted/In press) In : Cellular and Molecular Life Sciences. p. 1-11 11 p.

Research output: Article

5 Citations (Scopus)
2014

Cystic fibrosis: Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression

Veit, G., Avramescu, R. G., Perdomo, D., Phuan, P. W., Bagdany, M., Apaja, P. M., Borot, F., Szollosi, D., Wu, Y. S., Finkbeiner, W. E., Hegedus, T., Verkman, A. S. & Lukacs, G. L., júl. 23 2014, In : Science Translational Medicine. 6, 246, 246ra97.

Research output: Article

194 Citations (Scopus)

Discrete molecular dynamics can predict helical prestructured motifs in disordered proteins

Szöllosi, D., Horváth, T., Han, K. H., Dokholyan, N. V., Tompa, P., Kalmár, L. & Hegedus, T., ápr. 24 2014, In : PloS one. 9, 4, e95795.

Research output: Article

17 Citations (Scopus)
2013
20 Citations (Scopus)
28 Citations (Scopus)

Mechanism-based corrector combination restores ΔF508-CFTR folding and function

Okiyoneda, T., Veit, G., Dekkers, J. F., Bagdany, M., Soya, N., Xu, H., Roldan, A., Verkman, A. S., Kurth, M., Simon, A., Hegedus, T., Beekman, J. M. & Lukacs, G. L., júl. 1 2013, In : Nature Chemical Biology. 9, 7, p. 444-454 11 p.

Research output: Article

219 Citations (Scopus)
7 Citations (Scopus)
2011

ATP hydrolysis at one of the two sites in ABC transporters initiates transport related conformational transitions

Gyimesi, G., Ramachandran, S., Kota, P., Dokholyan, N. V., Sarkadi, B. & Hegedus, T., dec. 1 2011, In : Biochimica et Biophysica Acta - Biomembranes. 1808, 12, p. 2954-2964 11 p.

Research output: Article

37 Citations (Scopus)
2009

Influence of DF508 on CFTR assembly and function

Riordan, J. R., Dokholyan, N., Serohijos, A., Cui, L., Hegedus, T., Aleksandrov, L., He, L. & Aleksandrov, A. A., okt. 14 2009, In : Pediatric pulmonology. 44, SUPPL. 32, p. 122-123 2 p.

Research output: Article

Role of individual R domain phosphorylation sites in CFTR regulation by protein kinase A

Hegedus, T., Aleksandrov, A., Mengos, A., Cui, L., Jensen, T. J. & Riordan, J. R., jún. 1 2009, In : Biochimica et Biophysica Acta - Biomembranes. 1788, 6, p. 1341-1349 9 p.

Research output: Article

32 Citations (Scopus)
2008

Computational Studies Reveal Phosphorylation-dependent Changes in the Unstructured R Domain of CFTR

Hegedus, T., Serohijos, A. W. R., Dokholyan, N. V., He, L. & Riordan, J. R., máj. 16 2008, In : Journal of molecular biology. 378, 5, p. 1052-1063 12 p.

Research output: Article

46 Citations (Scopus)

Diminished self-chaperoning activity of the ΔF508 mutant of CFTR results in protein misfolding

Serohijos, A. W. R., Hegedus, T., Riordan, J. R. & Dokholyan, N. V., febr. 2008, In : PLoS computational biology. 4, 2

Research output: Article

33 Citations (Scopus)

Interaction with the 5D3 monoclonal antibody is regulated by intramolecular rearrangements but not by covalent dimer formation of the human ABCG2 multidrug transporter

Özvegy-Laczka, C., Laczko, R., Hegedus, C., Litman, T., Várady, G., Goda, K., Hegedus, T., Dokholyan, N. V., Sorrentino, B. P., Váradi, A. & Sarkadi, B., szept. 19 2008, In : Journal of Biological Chemistry. 283, 38, p. 26059-26070 12 p.

Research output: Article

30 Citations (Scopus)

Multiple membrane-cytoplasmic domain contacts in the cystic fibrosis transmembrane conductance regulator (CFTR) mediate regulation of channel gating

He, L., Aleksandrov, A. A., Serohijos, A. W. R., Hegedus, T., Aleksandrov, L. A., Cui, L., Dokholyan, N. V. & Riordan, J. R., szept. 26 2008, In : Journal of Biological Chemistry. 283, 39, p. 26383-26390 8 p.

Research output: Article

93 Citations (Scopus)

Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function

Serohijos, A. W. R., Hegedus, T., Aleksandrov, A. A., He, L., Cui, L., Dokholyan, N. V. & Riordan, J. R., márc. 4 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 9, p. 3256-3261 6 p.

Research output: Article

282 Citations (Scopus)
2007

Domain Interdependence in the Biosynthetic Assembly of CFTR

Cui, L., Aleksandrov, L., Chang, X. B., Hou, Y. X., He, L., Hegedus, T., Gentzsch, M., Aleksandrov, A., Balch, W. E. & Riordan, J. R., jan. 26 2007, In : Journal of molecular biology. 365, 4, p. 981-994 14 p.

Research output: Article

154 Citations (Scopus)
2006

F508del CFTR with two altered RXR motifs escapes from ER quality control but its channel activity is thermally sensitive

Hegedus, T., Aleksandrov, A., Cui, L., Gentzsch, M., Chang, X. B. & Riordan, J. R., máj. 1 2006, In : Biochimica et Biophysica Acta - Biomembranes. 1758, 5, p. 565-572 8 p.

Research output: Article

47 Citations (Scopus)
1 Citation (Scopus)
2004
279 Citations (Scopus)
2003

C-terminal phosphorylation of MRP2 modulates its interaction with PDZ proteins

Hegedüs, T., Sessler, T., Scott, R., Thelin, W., Bakos, É., Váradi, A., Szabó, K., Homolya, L., Milgram, S. L. & Sarkadi, B., márc. 14 2003, In : Biochemical and biophysical research communications. 302, 3, p. 454-461 8 p.

Research output: Article

72 Citations (Scopus)
1999
75 Citations (Scopus)
1998
22 Citations (Scopus)
1997
1996

Membrane topology and glycosylation of the human multidrug resistance-associated proteins

Bakos, É., Hegedüs, T., Holló, Z., Welker, E., Tusnády, G. E., Zaman, G. J. R., Flens, M. J., Váradi, A. & Sarkadi, B., jan. 1 1996, In : Journal of Biological Chemistry. 271, 21, p. 12322-12326 5 p.

Research output: Article

Open Access
190 Citations (Scopus)
180 Citations (Scopus)