• 2399 Citations
  • 21 h-Index
19962019
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Research Output 1996 2019

  • 2399 Citations
  • 21 h-Index
  • 42 Article
  • 2 Chapter
2019
1 Citation (Scopus)

Chemically Modified Derivatives of the Activator Compound Cloxyquin Exert Inhibitory Effect on TRESK (K2P18.1) Background Potassium Channel

Lengyel, M., Erdélyi, F., Pergel, E., Bálint-Polonka, Á., Dobolyi, A., Bozsaki, P., Dux, M., Király, K., Hegedűs, T., Czirják, G., Mátyus, P. & Enyedi, P., jún. 1 2019, In : Molecular pharmacology. 95, 6, p. 652-660 9 p.

Research output: Article

Tandem Pore Domain Potassium Channels
Spinal Ganglia
Migraine Disorders
Neurons
Nociception

Discovering the chloride pathway in the CFTR channel

Farkas, B., Tordai, H., Padányi, R., Tordai, A., Gera, J., Paragi, G. & Hegedűs, T., jan. 1 2019, In : Cellular and Molecular Life Sciences.

Research output: Article

Open Access
Chloride Channels
Chlorides
Cystic Fibrosis
Ions
Lipids
2018
4 Citations (Scopus)

Clinically relevant mutations in the ABCG2 transporter uncovered by genetic analysis linked to erythrocyte membrane protein expression

Zámbó, B., Bartos, Z., Mózner, O., Szabó, E., Várady, G., Poór, G., Pálinkás, M., Andrikovics, H., Hegedűs, T., Homolya, L. & Sarkadi, B., dec. 1 2018, In : Scientific Reports. 8, 1, 7487.

Research output: Article

Erythrocyte Membrane
Membrane Proteins
Gout
Mutation
Precision Medicine
1 Citation (Scopus)
Membrane Proteins
Proteins
Membranes
Cryoelectron Microscopy
X ray crystallography
2017
1 Citation (Scopus)

ABCMdb reloaded: Updates on mutations in ATP binding cassette proteins

Tordai, H., Jakab, K., Gyimesi, G., András, K., Brózik, A., Sarkadi, B. & Hegedűs, T., jan. 1 2017, In : Database. 2017, 1, bax023.

Research output: Article

Adenosinetriphosphate
Carrier Proteins
Adenosine Triphosphate
Proteins
mutation
4 Citations (Scopus)

GLUT10—lacking in arterial tortuosity syndrome—is localized to the endoplasmic reticulum of human fibroblasts

Gamberucci, A., Marcolongo, P., Németh, C. E., Zoppi, N., Szarka, A., Chiarelli, N., Hegedűs, T., Ritelli, M., Carini, G., Willaert, A., Callewaert, B. L., Coucke, P. J., Benedetti, A., Margittai, E., Fulceri, R., Bánhegyi, G. & Colombi, M., aug. 22 2017, In : International Journal of Molecular Sciences. 18, 8, 1820.

Research output: Article

endoplasmic reticulum
fibroblasts
Fibroblasts
Endoplasmic Reticulum
transporter
10 Citations (Scopus)

Molecular dynamics of the cryo-EM CFTR structure

Tordai, H., Leveles, I. & Hegedűs, T., szept. 30 2017, In : Biochemical and Biophysical Research Communications. 491, 4, p. 986-993 8 p.

Research output: Article

Molecular Dynamics Simulation
Cystic Fibrosis
Molecular dynamics
Nucleotides
Cystic Fibrosis Transmembrane Conductance Regulator
2 Citations (Scopus)

Transcriptome analysis of inflammation-related gene expression in endothelial cells activated by complement MASP-1

Schwaner, E., Németh, Z., Jani, P. K., Kajdácsi, E., Debreczeni, M. L., Doleschall, Z., Dobó, J., Gál, P., Rigó, J., András, K., Hegedűs, T. & Cervenák, L., dec. 1 2017, In : Scientific Reports. 7, 1, 10462.

Research output: Article

Mannose-Binding Protein-Associated Serine Proteases
Gene Expression Profiling
Endothelial Cells
Inflammation
Gene Expression
2016
5 Citations (Scopus)

Access path to the ligand binding pocket may play a role in xenobiotics selection by AhR

Szöllösi, D., Erdei, Á., Gyimesi, G., Magyar, C. & Hegedűs, T., jan. 4 2016, In : PLoS One. 11, 1, e0146066.

Research output: Article

Aryl Hydrocarbon Receptors
Xenobiotics
xenobiotics
hydrocarbons
Ligands
4 Citations (Scopus)

A systematic study of protein labeling by fluorogenic probes using cysteine targeting vinyl sulfone-cyclooctyne tags

Söveges, B., Imre, T., Szende, T., Póti, L., Cserép, G. B., Hegedűs, T., Kele, P. & Németh, K., 2016, In : Organic and Biomolecular Chemistry. 14, 25, p. 6071-6078 8 p.

Research output: Article

sulfones
cysteine
Labeling
marking
Cysteine
2015
2 Citations (Scopus)
drug toxicity
Xenobiotics
Drug-Related Side Effects and Adverse Reactions
Metabolism
pharmacokinetics
ATP-Binding Cassette Transporters
Databases
Mutation
Hematologic Diseases
Gout
15 Citations (Scopus)

Inconsistencies in the red blood cell membrane proteome analysis: Generation of a database for research and diagnostic applications

Hegedűs, T., Chaubey, P. M., Várady, G., Szabó, E., Sarankó, H., Hofstetter, L., Roschitzki, B., Stieger, B. & Sarkadi, B., 2015, In : Database : the journal of biological databases and curation. 2015, bav056.

Research output: Article

Proteome
Cell membranes
proteome
cell membranes
Blood
18 Citations (Scopus)

Lipid Regulation of the ABCB1 and ABCG2 Multidrug Transporters

Hegedüs, C., Telbisz, Á., Hegedűs, T., Sarkadi, B. & Özvegy-Laczka, C., 2015, In : Advances in Cancer Research. 125, p. 97-137 41 p.

Research output: Article

Lipids
ATP-Binding Cassette Transporters
Cholesterol
ATP Binding Cassette Transporter, Sub-Family G, Member 2
Xenobiotics
3 Citations (Scopus)

The linker region of breast cancer resistance protein ABCG2 is critical for coupling of ATP-dependent drug transport

Macalou, S., Robey, R. W., Jabor Gozzi, G., Shukla, S., Grosjean, I., Hegedűs, T., Ambudkar, S. V., Bates, S. E. & Di Pietro, A., dec. 26 2015, (Accepted/In press) In : Cellular and Molecular Life Sciences. p. 1-11 11 p.

Research output: Article

Adenosine Triphosphate
Breast Neoplasms
Nucleotides
Pharmaceutical Preparations
Mitoxantrone
2014
180 Citations (Scopus)

Cystic fibrosis: Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression

Veit, G., Avramescu, R. G., Perdomo, D., Phuan, P. W., Bagdany, M., Apaja, P. M., Borot, F., Szollosi, D., Wu, Y. S., Finkbeiner, W. E., Hegedűs, T., Verkman, A. S. & Lukacs, G. L., júl. 23 2014, In : Science Translational Medicine. 6, 246, 246ra97.

Research output: Article

Cystic Fibrosis
Mutation
Endoplasmic Reticulum
Genetic Suppression
Respiratory Mucosa
16 Citations (Scopus)

Discrete molecular dynamics can predict helical prestructured motifs in disordered proteins

Szöllosi, D., Horváth, T., Han, K. H., Dokholyan, N. V., Tompa, P., Kalmár, L. & Hegedűs, T., ápr. 24 2014, In : PLoS One. 9, 4, e95795.

Research output: Article

molecular dynamics
Molecular Dynamics Simulation
Molecular dynamics
Intrinsically Disordered Proteins
Proteins
2013
18 Citations (Scopus)
Gout
Polymorphism
Mutation
Cell membranes
Processing
27 Citations (Scopus)
Bile Acids and Salts
Cholesterol
Lipids
Detergents
Adenosine Triphosphatases
209 Citations (Scopus)

Mechanism-based corrector combination restores ΔF508-CFTR folding and function

Okiyoneda, T., Veit, G., Dekkers, J. F., Bagdany, M., Soya, N., Xu, H., Roldan, A., Verkman, A. S., Kurth, M., Simon, A., Hegedűs, T., Beekman, J. M. & Lukacs, G. L., júl. 2013, In : Nature Chemical Biology. 9, 7, p. 444-454 11 p.

Research output: Article

Cystic Fibrosis Transmembrane Conductance Regulator
Nucleotides
Cystic Fibrosis
Cell Membrane
Organoids
7 Citations (Scopus)
ATP-Binding Cassette Transporters
Pharmacology
Carrier Proteins
Adenosine Triphosphate
Proteins
2012
1 Citation (Scopus)
ATP-Binding Cassette Transporters
Hydrolysis
Adenosine Triphosphate
2011
36 Citations (Scopus)

ATP hydrolysis at one of the two sites in ABC transporters initiates transport related conformational transitions

Gyimesi, G., Ramachandran, S., Kota, P., Dokholyan, N. V., Sarkadi, B. & Hegedűs, T., dec. 2011, In : BBA - Biomembranes. 1808, 12, p. 2954-2964 11 p.

Research output: Article

ATP-Binding Cassette Transporters
Hydrolysis
Nucleotides
Adenosine Triphosphate
Conformations

CFTR: Understanding the cause and influencing the outcome of a major genetic disease

Hegedűs, T., Gentzsch, M. & Riordan, J. R., jan. 1 2011, The ABC Transporters of Human Physiology and Disease: Genetics and Biochemistry of ATP Binding Cassette Transporters. World Scientific Publishing Co., p. 269-310 42 p.

Research output: Chapter

Inborn Genetic Diseases
79 Citations (Scopus)
ATP-Binding Cassette Transporters
Multiple Drug Resistance
Protein-Tyrosine Kinases
Modulators
Adenosine Triphosphate
2009

Influence of DF508 on CFTR assembly and function

Riordan, J. R., Dokholyan, N., Serohijos, A., Cui, L., Hegedűs, T., Aleksandrov, L., He, L. & Aleksandrov, A. A., 2009, In : Pediatric Pulmonology. 44, SUPPL. 32, p. 122-123 2 p.

Research output: Article

31 Citations (Scopus)

Role of individual R domain phosphorylation sites in CFTR regulation by protein kinase A

Hegedűs, T., Aleksandrov, A., Mengos, A., Cui, L., Jensen, T. J. & Riordan, J. R., jún. 2009, In : BBA - Biomembranes. 1788, 6, p. 1341-1349 9 p.

Research output: Article

Cystic Fibrosis Transmembrane Conductance Regulator
Phosphorylation
Cyclic AMP-Dependent Protein Kinases
Serine
Transcytosis
2008
44 Citations (Scopus)

Computational Studies Reveal Phosphorylation-dependent Changes in the Unstructured R Domain of CFTR

Hegedűs, T., Serohijos, A. W. R., Dokholyan, N. V., He, L. & Riordan, J. R., máj. 16 2008, In : Journal of Molecular Biology. 378, 5, p. 1052-1063 12 p.

Research output: Article

Cystic Fibrosis Transmembrane Conductance Regulator
Phosphorylation
Chloride Channels
Cyclic AMP-Dependent Protein Kinases
Cystic Fibrosis
32 Citations (Scopus)

Diminished self-chaperoning activity of the ΔF508 mutant of CFTR results in protein misfolding

Serohijos, A. W. R., Hegedűs, T., Riordan, J. R. & Dokholyan, N. V., febr. 2008, In : PLoS Computational Biology. 4, 2

Research output: Article

Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator
cystic fibrosis
ethyl-2-methylthio-4-methyl-5-pyrimidine carboxylate
Conductance
30 Citations (Scopus)

Interaction with the 5D3 monoclonal antibody is regulated by intramolecular rearrangements but not by covalent dimer formation of the human ABCG2 multidrug transporter

Özvegy-Laczka, C., Laczko, R., Hegedus, C., Litman, T., Várady, G., Goda, K., Hegedűs, T., Dokholyan, N. V., Sorrentino, B. P., Váradi, A. & Sarkadi, B., szept. 19 2008, In : Journal of Biological Chemistry. 283, 38, p. 26059-26070 12 p.

Research output: Article

Dimers
Monoclonal Antibodies
Proteins
Dithiothreitol
Membrane Glycoproteins
91 Citations (Scopus)

Multiple membrane-cytoplasmic domain contacts in the cystic fibrosis transmembrane conductance regulator (CFTR) mediate regulation of channel gating

He, L., Aleksandrov, A. A., Serohijos, A. W. R., Hegedűs, T., Aleksandrov, L. A., Cui, L., Dokholyan, N. V. & Riordan, J. R., szept. 26 2008, In : Journal of Biological Chemistry. 283, 39, p. 26383-26390 8 p.

Research output: Article

Cystic Fibrosis Transmembrane Conductance Regulator
Cell Membrane
Membranes
Nucleotides
Adenosine Triphosphate
276 Citations (Scopus)

Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function

Serohijos, A. W. R., Hegedűs, T., Aleksandrov, A. A., He, L., Cui, L., Dokholyan, N. V. & Riordan, J. R., márc. 4 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 9, p. 3256-3261 6 p.

Research output: Article

Cystic Fibrosis Transmembrane Conductance Regulator
Phenylalanine
Cell Membrane
ATP-Binding Cassette Transporters
Endocytosis
2007
151 Citations (Scopus)

Domain Interdependence in the Biosynthetic Assembly of CFTR

Cui, L., Aleksandrov, L., Chang, X. B., Hou, Y. X., He, L., Hegedűs, T., Gentzsch, M., Aleksandrov, A., Balch, W. E. & Riordan, J. R., jan. 26 2007, In : Journal of Molecular Biology. 365, 4, p. 981-994 14 p.

Research output: Article

Endoplasmic Reticulum
Cystic Fibrosis Transmembrane Conductance Regulator
Nucleotides
Quality Control
Mutation
2006
47 Citations (Scopus)

F508del CFTR with two altered RXR motifs escapes from ER quality control but its channel activity is thermally sensitive

Hegedűs, T., Aleksandrov, A., Cui, L., Gentzsch, M., Chang, X. B. & Riordan, J. R., máj. 2006, In : BBA - Biomembranes. 1758, 5, p. 565-572 8 p.

Research output: Article

Cystic Fibrosis
Endoplasmic Reticulum
Quality Control
Quality control
Chloride Channels
2 Citations (Scopus)
Database Management Systems
Cystic Fibrosis Transmembrane Conductance Regulator
Phosphorylation
cystic fibrosis
management systems
2005
73 Citations (Scopus)
Databases
Mutation
Genes
Hereditary Angioedemas
Hereditary Angioedema Types I and II
2004
277 Citations (Scopus)
Protein-Tyrosine Kinases
P-Glycoproteins
P-Glycoprotein
Membrane Transport Proteins
ATP Binding Cassette Transporter, Sub-Family G, Member 2
2003
71 Citations (Scopus)

C-terminal phosphorylation of MRP2 modulates its interaction with PDZ proteins

Hegedűs, T., Sessler, T., Scott, R., Thelin, W., Bakos, E., Váradi, A., Szabó, K., Homolya, L., Milgram, S. L. & Sarkadi, B., márc. 14 2003, In : Biochemical and Biophysical Research Communications. 302, 3, p. 454-461 8 p.

Research output: Article

Phosphorylation
Proteins
PDZ Domains
Carrier Proteins
Adenosine Triphosphate
2002
166 Citations (Scopus)
P-Glycoprotein
Protein-Tyrosine Kinases
Pharmaceutical Preparations
Neoplasms
Molecular Structure
1999
75 Citations (Scopus)
Cystic Fibrosis Transmembrane Conductance Regulator
Nucleotides
Adenosine Triphosphate
Chloride Channels
Vanadates
1998
22 Citations (Scopus)
P-Glycoproteins
P-Glycoprotein
Fluorescent Antibody Technique
Multidrug Resistance-Associated Proteins
Fluorometry
1997
Multidrug Resistance-Associated Proteins
multiple drug resistance
P-Glycoprotein
transporters
glycoproteins
1996
190 Citations (Scopus)
Glycosylation
Multidrug Resistance-Associated Proteins
Topology
Membranes
Proteolysis
178 Citations (Scopus)
Multidrug Resistance-Associated Proteins
Transport properties
Tumors
Cells
Glutathione