M. Al-Khrasani

  • Hungary

  • 642 Citations
  • 16 h-Index
20012019
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Research Output 2001 2019

  • 642 Citations
  • 16 h-Index
  • 47 Article
  • 1 Review article
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Article
2019

Biochemical and pharmacological investigation of novel nociceptin/OFQ analogues and N/OFQ-RYYRIK hybrid peptides

Erdei, A., Borbély, A., Magyar, A., Szűcs, E., Ötvös, F., Gombos, D., Al-Khrasani, M., Stefanucci, A., Dimmito, M. P., Luisi, G., Mollica, A. & Benyhe, S., febr. 1 2019, In : Peptides. 112, p. 106-113 8 p.

Research output: Article

Pharmacology
Peptides
Vas Deferens
Bioassay
Biological Assay
1 Citation (Scopus)

Efficacy-based perspective to overcome reduced opioid analgesia of advanced painful diabetic neuropathy in rats

Balogh, M., Zádor, F., Zádori, Z., Shaqura, M., Király, K., Mohammadzadeh, A., Varga, B., Lázár, B., Mousa, S. A., Hosztafi, S., Riba, P., Benyhe, S., Gyires, K., Schäfer, M., Fürst, S. & Al-Khrasani, M., jan. 1 2019, In : Frontiers in Pharmacology. 10, APR, 347.

Research output: Article

Open Access
Diabetic Neuropathies
Analgesia
Opioid Analgesics
Morphine
Sulfates
diprotin A
Dipeptidyl-Peptidase IV Inhibitors
Pain
Opioid Receptors
Freund's Adjuvant
2018
4 Citations (Scopus)

The Peripheral Versus Central Antinociception of a Novel Opioid Agonist: Acute Inflammatory Pain in Rats

Balogh, M., Zádori, Z., Lázár, B., Karádi, D., László, S., Mousa, S. A., Hosztafi, S., Zádor, F., Riba, P., Schäfer, M., Fürst, S. & Al-Khrasani, M., máj. 3 2018, (Accepted/In press) In : Neurochemical Research. p. 1-8 8 p.

Research output: Article

Acute Pain
Opioid Analgesics
Rats
Morphine
Pain
2017
1 Citation (Scopus)

14-O-Methylmorphine: A Novel Selective Mu-Opioid Receptor Agonist with High Efficacy and Affinity

Zádor, F., Balogh, M., Váradi, A., Zádori, Z., Király, K., Szűcs, E., Varga, B., Lázár, B., Hosztafi, S., Riba, P., Benyhe, S., Fürst, S. & Al-Khrasani, M., nov. 5 2017, In : European Journal of Pharmacology. 814, p. 264-273 10 p.

Research output: Article

Vas Deferens
mu Opioid Receptor
Morphine
Opioid Receptors
Opioid Analgesics
10 Citations (Scopus)
Carticaine
Streptozocin
Lidocaine
Spinal Cord
Norepinephrine
2 Citations (Scopus)

New opioid receptor antagonist: Naltrexone-14-O-sulfate synthesis and pharmacology

Zádor, F., Király, K., Váradi, A., Balogh, M., Fehér, Á., Kocsis, D., Erdei, A., Lackó, E., Zádori, Z., Hosztafi, S., Noszál, B., Riba, P., Benyhe, S., Fürst, S. & Al-Khrasani, M., jan. 1 2017, In : European Journal of Pharmacology. 809, p. 111-121 11 p.

Research output: Article

Naltrexone
Narcotic Antagonists
Sulfates
Pharmacology
Naloxone
2016

Dual Alpha2C/5HT1A Receptor Agonist Allyphenyline Induces Gastroprotection and Inhibits Fundic and Colonic Contractility

Zádori, Z., Fehér, Á., Tóth, V. E., Al-Khrasani, M., Köles, L., Sipos, S., Del Bello, F., Pigini, M. & Gyires, K., febr. 10 2016, (Accepted/In press) In : Digestive Diseases and Sciences. p. 1-12 12 p.

Research output: Article

Adrenergic Receptors
Catalase
Electric Stimulation
Superoxide Dismutase
Stomach
2 Citations (Scopus)

Inhibition of α2A-Adrenoceptors Ameliorates Dextran Sulfate Sodium-Induced Acute Intestinal Inflammation in Mice

Zádori, Z., Tóth, V. E., Fehér, Á., Al-Khrasani, M., Puskár, Z., Kozsurek, M., Timár, J., Tábi, T., Helyes, Z., Hein, L., Holzer, P. & Gyires, K., szept. 1 2016, In : Journal of Pharmacology and Experimental Therapeutics. 358, 3, p. 483-491 9 p.

Research output: Article

Dextran Sulfate
Colitis
Adrenergic Receptors
Inflammation
Clonidine
16 Citations (Scopus)

Membrane-bound glucocorticoid receptors on distinct nociceptive neurons as potential targets for pain control through rapid non-genomic effects

Shaqura, M., Li, X., Al-Khrasani, M., Shakibaei, M., Tafelski, S., Fürst, S., Beyer, A., Kawata, M., Schäfer, M. & Mousa, S. A., dec. 1 2016, In : Neuropharmacology. 111, p. 1-13 13 p.

Research output: Article

Nociceptors
Glucocorticoid Receptors
Pain
Membranes
GTP-Binding Proteins
21 Citations (Scopus)
Synaptic Transmission
Neuroglia
Central Nervous System
N-Methyl-D-Aspartate Receptors
Neurotransmitter Agents
5 Citations (Scopus)

New morphine analogs produce peripheral antinociception within a certain dose range of their systemic administration

Lackó, E., Riba, P., Giricz, Z., Váradi, A., Cornic, L., Balogh, M., Király, K., Cseko, K., Mousa, S. A., Hosztafi, S., Schäfer, M., Zádori, Z., Helyes, Z., Ferdinandy, P., Fürst, S. & Al-Khrasani, M., okt. 1 2016, In : Journal of Pharmacology and Experimental Therapeutics. 359, 1, p. 171-181 11 p.

Research output: Article

Morphine
Pain
Opioid Analgesics
Visceral Pain
Gastrointestinal Transit
2015
10 Citations (Scopus)

A new potent analgesic agent with reduced liability to produce morphine tolerance

Kiraly, K., Caputi, F. F., Hanuska, A., Kató, E., Balogh, M., Köles, L., Palmisano, M., Riba, P., Hosztafi, S., Romualdi, P., Candeletti, S., Ferdinándy, P., Fürst, S. & Al-Khrasani, M., aug. 1 2015, In : Brain Research Bulletin. 117, p. 32-38 7 p.

Research output: Article

Morphine
Analgesics
Opioid Analgesics
Pyramidal Cells
Excitatory Postsynaptic Potentials
2014
11 Citations (Scopus)

New insights into mechanisms of opioid inhibitory effects on capsaicin-induced TRPV1 activity during painful diabetic neuropathy

Shaqura, M., Khalefa, B. I., Shakibaei, M., Zöllner, C., Al-Khrasani, M., Fürst, S., Schäfer, M. & Mousa, S. A., 2014, In : Neuropharmacology. 85, p. 142-150 9 p.

Research output: Article

Diabetic Neuropathies
Capsaicin
Opioid Analgesics
Sensory Receptor Cells
Morphine
2013
5 Citations (Scopus)
Epigenomics
Central Nervous System Diseases
Substance-Related Disorders
Learning
Therapeutics
5 Citations (Scopus)
Morphinans
Opioid Analgesics
Oxymorphone
Oxycodone
Ligands
8 Citations (Scopus)

Imidazoline versus alpha2-adrenoceptors in the control of gastric motility in mice

Zádori, Z., Fehér, Á., Al-Khrasani, M., Lackó, E., Tóth, V. E., Brancati, S. B., Hein, L., Mátyus, P. & Gyires, K., ápr. 5 2013, In : European Journal of Pharmacology. 705, 1-3, p. 61-67 7 p.

Research output: Article

Imidazolines
Adrenergic Receptors
Stomach
Imidazoline Receptors
Knockout Mice
9 Citations (Scopus)
Opioid Analgesics
Fentanyl
Morphine
Pain
Analgesics
20 Citations (Scopus)

Reduced number, G protein coupling, and antinociceptive efficacy of spinal mu-opioid receptors in diabetic rats are reversed by nerve growth factor

Shaqura, M., Khalefa, B. I., Shakibaei, M., Winkler, J., Al-Khrasani, M., Fürst, S., Mousa, S. A. & Schäfer, M., júl. 2013, In : Journal of Pain. 14, 7, p. 720-730 11 p.

Research output: Article

mu Opioid Receptor
Nerve Growth Factor
GTP-Binding Proteins
Opioid Analgesics
Experimental Diabetes Mellitus
9 Citations (Scopus)

Spinal interaction between the highly selective μ agonist DAMGO and several δ opioid receptor ligands in naive and morphine-tolerant mice

Szentirmay, A. K., Király, K. P., Lenkey, N., Lackó, E., Al-Khrasani, M., Friedmann, T., Timár, J., Gyarmati, S., Tóth, G., Fürst, S. & Riba, P., jan. 2013, In : Brain Research Bulletin. 90, 1, p. 66-71 6 p.

Research output: Article

Ala(2)-MePhe(4)-Gly(5)-enkephalin
Opioid Receptors
Morphine
Ligands
D-Penicillamine (2,5)-Enkephalin
2 Citations (Scopus)

Viselkedési vizsgálatok a gesztációs-laktációs ido{double acute}szakban morfn-kezelt patkányon

Melinda, S., Júlia, T., Riba, P., Király, K. P., Al-Khrasani, M., Zsuzsanna, G. & Zsuzsanna, F., dec. 2013, In : Neuropsychopharmacologia Hungarica. 15, 4, p. 239-251 13 p.

Research output: Article

Lactation
Morphine
Maternal Behavior
Naloxone
Opioid Analgesics
2012
11 Citations (Scopus)

A novel μ-opioid receptor ligand with high in vitro and in vivo agonist efficacy

Lackó, E., Váradi, A., Rapavi, R., Zádor, F., Riba, P., Benyhe, S., Borsodi, A., Hosztafi, S., Timár, J., Noszál, B., Fürst, S. & Al-Khrasani, M., 2012, In : Current Medicinal Chemistry. 19, 27, p. 4699-4707 9 p.

Research output: Article

Opioid Receptors
Enkephalins
Morphine
Ligands
Rats
8 Citations (Scopus)
Crassulaceae
Glycosides
High Pressure Liquid Chromatography
Electrospray ionization
Hydroxy Acids
17 Citations (Scopus)

The central versus peripheral antinociceptive effects of μ-opioid receptor agonists in the new model of rat visceral pain

Al-Khrasani, M., Lackó, E., Riba, P., Király, K., Sobor, M., Timár, J., Mousa, S., Schäfer, M. & Fürst, S., febr. 10 2012, In : Brain Research Bulletin. 87, 2-3, p. 238-243 6 p.

Research output: Article

Ala(2)-MePhe(4)-Gly(5)-enkephalin
Visceral Pain
Opioid Receptors
Morphine
glycyl-glycyl-glycyl-glycine
2011
5 Citations (Scopus)

Effects of opioid agonist and antagonist in dams exposed to morphine during the perinatal period

Sobor, M., Timar, J., Riba, P., Friedmann, T., Király, K. P., Gyarmati, S., Al-Khrasani, M. & Fürst, S., jan. 15 2011, In : Brain Research Bulletin. 84, 1, p. 53-60 8 p.

Research output: Article

Narcotic Antagonists
Morphine
Naloxone
Maternal Behavior
Weaning
8 Citations (Scopus)

Synthesis and pharmacological activities of 6-glycine substituted 14-phenylpropoxymorphinans, a novel class of opioids with high opioid receptor affinities and antinociceptive potencies

Spetea, M., Windisch, P., Guo, Y., Bileviciute-Ljungar, I., Schütz, J., Asim, M. F., Berzetei-Gurske, I. P., Riba, P., Kiraly, K., Fürst, S., Al-Khrasani, M. & Schmidhammer, H., febr. 24 2011, In : Journal of Medicinal Chemistry. 54, 4, p. 980-988 9 p.

Research output: Article

Opioid Receptors
Glycine
Opioid Analgesics
Analgesics
Pharmacology
7 Citations (Scopus)
Adrenergic Receptors
Stomach
Motor Activity
Clonidine
Oxymetazoline
2010
7 Citations (Scopus)
Maternal Behavior
Lactation
Morphine
Dams
Pregnancy
25 Citations (Scopus)
Opioid Peptides
Sympathetic Nervous System
Peripheral Nervous System
Opioid Analgesics
Blood Vessels
12 Citations (Scopus)

Novel approach to demonstrate high efficacy of μ opioids in the rat vas deferens: A simple model of predictive value

Riba, P., Friedmann, T., Király, K. P., Al-Khrasani, M., Sobor, M., Asim, M. F., Spetea, M., Schmidhammer, H. & Fürst, S., jan. 15 2010, In : Brain Research Bulletin. 81, 1, p. 178-184 7 p.

Research output: Article

Vas Deferens
Opioid Analgesics
Oxymorphone
Ala(2)-MePhe(4)-Gly(5)-enkephalin
Opioid Receptors
11 Citations (Scopus)
Sex Characteristics
Morphine
Morphine Dependence
Maternal Exposure
Locomotion
2009
16 Citations (Scopus)

Increase of intracellular Ca2+ by adenine and uracil nucleotides in human midbrain-derived neuronal progenitor cells

Rubini, P., Milosevic, J., Engelhardt, J., Al-Khrasani, M., Franke, H., Heinrich, A., Sperlágh, B., Schwarz, S. C., Schwarz, J., Nörenberg, W. & Illes, P., máj. 2009, In : Cell Calcium. 45, 5, p. 485-498 14 p.

Research output: Article

Uracil Nucleotides
Adenine Nucleotides
Mesencephalon
Uridine Triphosphate
Stem Cells
10 Citations (Scopus)
Non-Steroidal Anti-Inflammatory Agents
Adrenergic Receptors
Pharmacology
rilmenidine
Clonidine
2008
33 Citations (Scopus)

Endomorphin-2 with a β-turn backbone constraint retains the potent μ-opioid receptor agonist properties

Tömböly, C., Ballet, S., Feytens, D., Kövér, K., Borics, A., Lovas, S., Al-Khrasani, M., Fürst, Z., Tóth, G., Benyhe, S. & Tourwé, D., jan. 10 2008, In : Journal of Medicinal Chemistry. 51, 1, p. 173-177 5 p.

Research output: Article

glycylphenylalanine
Molecular modeling
Opioid Receptors
Scaffolds
Opioid Analgesics
2007
28 Citations (Scopus)
Visceral Pain
Vas Deferens
Enkephalins
Glycine
Morphine
2006
17 Citations (Scopus)
tyrosyl-proline
Rats
Brain
Radioactivity
Opioid Receptors
17 Citations (Scopus)

Partial and full agonism in endomorphin derivatives: Comparison by null and operational model

Rónai, A., Al-Khrasani, M., Benyhe, S., Lengyel, I., Kocsis, L., Orosz, G., Tóth, G., Kató, E. & Tóthfalusi, L., jún. 2006, In : Peptides. 27, 6, p. 1507-1513 7 p.

Research output: Article

Derivatives
Enkephalins
Amides
Morphine
Ala(2)-MePhe(4)-Gly(5)-enkephalin
3 Citations (Scopus)

Synthesis of enzymatically resistant nociceptin-related peptides containing a carbamic acid residue

Ligeti, M., Bősze, S., Csámpai, A., Gündüz, Ö., Al-Khrasani, M., Rónai, A., Medzihradszky-Schweiger, H., Benyhe, S., Borsodi, A., Hudecz, F. & Magyar, A., júl. 2006, In : Journal of Peptide Science. 12, 7, p. 481-490 10 p.

Research output: Article

Peptides
Carbon Monoxide
Aminopeptidases
Ligands
Rats
2005
55 Citations (Scopus)

Peripheral versus central antinociceptive actions of 6-amino acid-substituted derivatives of 14-O-methyloxymorphone in acute and inflammatory pain in the rat

Fürst, S., Riba, P., Friedmann, T., Tímar, J., Al-Khrasani, M., Obara, I., Makuch, W., Spetea, M., Schütz, J., Przewlocki, R., Przewlocka, B. & Schmidhammer, H., febr. 2005, In : Journal of Pharmacology and Experimental Therapeutics. 312, 2, p. 609-618 10 p.

Research output: Article

Acute Pain
Opioid Analgesics
Morphine
Amino Acids
Fentanyl
2004
1 Citation (Scopus)
Sodium Glutamate
Solitary Nucleus
Baclofen
Rats
Norepinephrine
28 Citations (Scopus)
Dopamine Receptors
N-Methylaspartate
Prefrontal Cortex
Adrenergic Receptors
Dopamine
18 Citations (Scopus)

Nociceptin antagonism: Probing the receptor by N-acetyl oligopeptides

Kocsis, L., Orosz, G., Magyar, A., Al-Khrasani, M., Kató, E., Rónai, A., Bes, B., Meunier, J. C., Gündüz, Ö., Tóth, G., Borsodi, A. & Benyhe, S., nov. 15 2004, In : Regulatory Peptides. 122, 3, p. 199-207 9 p.

Research output: Article

Oligopeptides
Assays
Vas Deferens
Opioid Receptors
Brain
48 Citations (Scopus)
Peptides
Stereoisomerism
Opioid Receptors
Biological Assay
Opioid Analgesics
2003
9 Citations (Scopus)

Subsensitivity of P2X but not vanilloid 1 receptors in dorsal root ganglia of rats caused by cyclophosphamide cystitis

Borvendeg, S. J., Al-Khrasani, M., Rubini, P., Fischer, W., Allgaier, C., Wirkner, K., Himmel, H. M., Gillen, C. & Illes, P., aug. 1 2003, In : European Journal of Pharmacology. 474, 1, p. 71-75 5 p.

Research output: Article

Cystitis
Spinal Ganglia
Cyclophosphamide
Capsaicin
Pain
12 Citations (Scopus)
diprotin A
Solitary Nucleus
Enkephalins
Rats
Norepinephrine
2002
38 Citations (Scopus)

Side chain modifications change the binding and agonist properties of endomorphin 2

Lengyel, I., Orosz, G., Tömböly, C., Kocsis, L., Borsodi, A., Orosz, G., Tömböly, C., Al-Khrasani, M., Rónai, A. & Borsodi, A., 2002, In : Biochemical and Biophysical Research Communications. 290, 1, p. 153-161 9 p.

Research output: Article

Amides
Methylation
Enkephalins
mu Opioid Receptor
Naloxone
2001
30 Citations (Scopus)
Enkephalins
Vas Deferens
Opioid Receptors
Ileum
Peptides