• 3061 Citations
  • 27 h-Index
1990 …2020

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Article
2020

Electrical Restitution and Its Modifications by Antiarrhythmic Drugs in Undiseased Human Ventricular Muscle

Árpádffy-Lovas, T., Baczkó, I., Baláti, B., Bitay, M., Jost, N., Lengyel, C., Nagy, N., Takács, J., Varró, A. & Virág, L., ápr. 30 2020, In : Frontiers in Pharmacology. 11, 479.

Research output: Article

Open Access

Late sodium current in human, canine and guinea pig ventricular myocardium

Horváth, B., Hézső, T., Szentandrássy, N., Kistamás, K., Árpádffy-Lovas, T., Varga, R., Gazdag, P., Veress, R., Dienes, C., Baranyai, D., Almássy, J., Virág, L., Nagy, N., Baczkó, I., Magyar, J., Bányász, T., Varró, A. & Nánási, P. P., febr. 2020, In : Journal of Molecular and Cellular Cardiology. 139, p. 14-23 10 p.

Research output: Article

1 Citation (Scopus)

Poly(ADP-ribose) polymerase-1 depletion enhances the severity of inflammation in an imiquimod-induced model of psoriasis

Kiss, B., Szántó, M., Hegedűs, C., Antal, D., Szödényi, A., Márton, J., Méhes, G., Virág, L., Szegedi, A. & Bai, P., jan. 1 2020, In : Experimental Dermatology. 29, 1, p. 79-85 7 p.

Research output: Article

Open Access
1 Citation (Scopus)

The proteasome activator PA200 regulates expression of genes involved in cell survival upon selective mitochondrial inhibition in neuroblastoma cells

Douida, A., Batista, F., Robaszkiewicz, A., Boto, P., Aladdin, A., Szenykiv, M., Czinege, R., Virág, L. & Tar, K., jún. 1 2020, In : Journal of Cellular and Molecular Medicine. 24, 12, p. 6716-6730 15 p.

Research output: Article

Open Access
2019

Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block

Tomek, J., Bueno-Orovio, A., Passini, E., Zhou, X., Minchole, A., Britton, O., Bartolucci, C., Severi, S., Shrier, A., Virag, L., Varro, A. & Rodriguez, B., dec. 2019, In : eLife. 8, e48890.

Research output: Article

Open Access
4 Citations (Scopus)

Evaluation of Possible Proarrhythmic Potency: Comparison of the Effect of Dofetilide, Cisapride, Sotalol, Terfenadine, and Verapamil on hERG and Native i Kr Currents and on Cardiac Action Potential

Orvos, P., Kohajda, Z., Szlovák, J., Gazdag, P., Árpádffy-Lovas, T., Tóth, D., Geramipour, A., Tálosi, L., Jost, N., Varró, A. & Virág, L., ápr. 1 2019, In : Toxicological Sciences. 168, 2, p. 365-380 16 p.

Research output: Article

6 Citations (Scopus)

Lithocholic acid, a metabolite of the microbiome, increases oxidative stress in breast cancer

Kovács, P., Csonka, T., Kovács, T., Sári, Z., Ujlaki, G., Sipos, A., Karányi, Z., Szeőcs, D., Hegedűs, C., Uray, K., Jankó, L., Kiss, M., Kiss, B., Laoui, D., Virág, L., Méhes, G., Bai, P. & Mikó, E., szept. 2019, In : Cancers. 11, 9, 1255.

Research output: Article

Open Access
6 Citations (Scopus)
5 Citations (Scopus)

Spilanthol inhibits inflammatory transcription factors and iNOS expression in macrophages and exerts anti-inflammatory effects in dermatitis and pancreatitis

Bakondi, E., Singh, S. B., Hajnády, Z., Nagy-Pénzes, M., Regdon, Z., Kovács, K., Hegedűs, C., Madácsy, T., Maléth, J., Hegyi, P., Demény, M., Nagy, T., Kéki, S., Szabó, É. & Virág, L., szept. 1 2019, In : International journal of molecular sciences. 20, 17, 4308.

Research output: Article

Open Access
5 Citations (Scopus)
2018
1 Citation (Scopus)

Diverse effect of BMP-2 homodimer on mesenchymal progenitors of different origin

Hrubi, E., Imre, L., Robaszkiewicz, A., Virág, L., Kerényi, F., Nagy, K., Varga, G., Jenei, A. & Hegedüs, C., ápr. 1 2018, In : Human Cell. 31, 2, p. 139-148 10 p.

Research output: Article

3 Citations (Scopus)

Downregulation of PARP1 transcription by CDK4/6 inhibitors sensitizes human lung cancer cells to anticancer drug-induced death by impairing OGG1-dependent base excision repair

Tempka, D., Tokarz, P., Chmielewska, K., Kluska, M., Pietrzak, J., Rygielska, Ż., Virág, L. & Robaszkiewicz, A., máj. 1 2018, In : Redox Biology. 15, p. 316-326 11 p.

Research output: Article

20 Citations (Scopus)

PARP1 facilitates EP300 recruitment to the promoters of the subset of RBL2-dependent genes

Robaszkiewicz, A., Wiśnik, E., Regdon, Z., Chmielewska, K. & Virág, L., jan. 1 2018, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1861, 1, p. 41-53 13 p.

Research output: Article

4 Citations (Scopus)

Redox Profiling Reveals Clear Differences between Molecular Patterns of Wound Fluids from Acute and Chronic Wounds

Bodnár, E., Bakondi, E., Kovács, K., Hegedűs, C., Lakatos, P., Robaszkiewicz, A., Regdon, Z., Virág, L. & Szabó, É., jan. 1 2018, In : Oxidative Medicine and Cellular Longevity. 2018, 1 p.

Research output: Article

5 Citations (Scopus)
2017

A2A adenosine receptors control pancreatic dysfunction in high-fat-diet-induced obesity

Csóka, B., Töro, G., Vindeirinho, J., Varga, Z. V., Koscsó, B., Németh, Z. H., Kókai, E., Antonioli, L., Suleiman, M., Marchetti, P., Cseri, K., Deák, Á., Virág, L., Pacher, P., Bai, P. & Haskó, G., jan. 1 2017, In : FASEB Journal. 31, 11, p. 4985-4997 13 p.

Research output: Article

12 Citations (Scopus)
15 Citations (Scopus)
2016

A novel transgenic rabbit model with reduced repolarization reserve: Long QT syndrome caused by a dominant-negative mutation of the KCNE1 gene

Major, P., Baczkó, I., Hiripi, L., Odening, K. E., Juhász, V., Kohajda, Z., Horváth, A., Seprényi, G., Kovács, M., Virág, L., Jost, N., Prorok, J., Ördög, B., Doleschall, Z., Nattel, S., Varró, A. & Bõsze, Z., jún. 1 2016, In : British journal of pharmacology. 173, 12, p. 2046-2061 16 p.

Research output: Article

15 Citations (Scopus)

Experimentally-based computational investigation into beat-to-beat variability in ventricular repolarization and its response to ionic current inhibition

Pueyo, E., Dangerfield, C. E., Britton, O. J., Virág, L., Kistamás, K., Szentandrássy, N., Jost, N., Varró, A., Nánási, P. P., Burrage, K. & Rodríguez, B., márc. 2016, In : PloS one. 11, 3, e0151461.

Research output: Article

16 Citations (Scopus)
2 Citations (Scopus)
2015

Effects of Chelidonium majus extracts and major alkaloids on hERG potassium channels and on dog cardiac action potential - A safety approach

Orvos, P., Virág, L., Tálosi, L., Hajdú, Z., Csupor, D., Jedlinszki, N., Szél, T., Varró, A. & Hohmann, J., jan. 2015, In : Fitoterapia. 100, p. 156-165 10 p.

Research output: Article

20 Citations (Scopus)
2014

Selective Na +/ Ca 2+ exchanger inhibition prevents Ca 2+ overload-induced triggered arrhythmias

Nagy, N., Kormos, A., Kohajda, Z., Szebeni, Á., Szepesi, J., Pollesello, P., Levijoki, J., Acsai, K., Virág, L., Nánási, P. P., Papp, J. G., Varrõ, A. & Tõth, A., dec. 2014, In : British journal of pharmacology. 171, 24, p. 5665-5681 17 p.

Research output: Article

25 Citations (Scopus)
2013

Altered expression of genes for kir ion channels in dilated cardiomyopathy

Szuts, V., Ménesi, D., Varga-Orvos, Z., Zvara, Á., Houshmand, N., Bitay, M., Bogáts, G., Virág, L., Baczkó, I., Szalontai, B., Geramipoor, A., Cotella, D., Wettwer, E., Ravens, U., Deák, F., Puskás, L. G., Papp, J. G., Kiss, I., Varró, A. & Jost, N., aug. 1 2013, In : Canadian journal of physiology and pharmacology. 91, 8, p. 648-656 9 p.

Research output: Article

17 Citations (Scopus)

Human electrophysiological and pharmacological properties of XEN-D0101: A novel atrial-selective Kv1.5/IKur inhibitor

Ford, J., Milnes, J., Wettwer, E., Christ, T., Rogers, M., Sutton, K., Madge, D., Virag, L., Jost, N., Horvath, Z., Matschke, K., Varro, A. & Ravens, U., máj. 1 2013, In : Journal of cardiovascular pharmacology. 61, 5, p. 408-415 8 p.

Research output: Article

38 Citations (Scopus)

Ionic mechanisms limiting cardiac repolarization reserve in humans compared to dogs

Jost, N., Virág, L., Comtois, P., Ördög, B., Szuts, V., Seprényi, G., Bitay, M., Kohajda, Z., Koncz, I., Nagy, N., Szél, T., Magyar, J., Kovács, M., Puskás, L. G., Lengyel, C., Wettwer, E., Ravens, U., Nánási, P. P., Papp, J. G., Varró, A. & 1 others, Nattel, S., szept. 1 2013, In : Journal of Physiology. 591, 17, p. 4189-4206 18 p.

Research output: Article

75 Citations (Scopus)

L-364,373 (R-L3) enantiomers have opposite modulating effects on Iks in mammalian ventricular myocytes

Corici, C., Kohajda, Z., Kristóf, A., Horváth, A., Virág, L., Szél, T., Nagy, N., Szakonyi, Z., Fülöp, F., Muntean, D. M., Varró, A. & Jost, N., aug. 1 2013, In : Canadian journal of physiology and pharmacology. 91, 8, p. 586-592 7 p.

Research output: Article

2 Citations (Scopus)

Na+/Ca2+ exchangers regulate the migration and proliferation of human gastric myofibroblasts

Kemény, L. V., Schnúr, A., Czepán, M., Rakonczay, Z., Gál, E., Lonovics, J., Lázár, G., Simonka, Z., Venglovecz, V., Maléth, J., Judák, L., Németh, I. B., Szabó, K., Almássy, J., Virág, L., Geisz, A., Tiszlavicz, L., Yule, D. I., Wittmann, T., Varró, A. & 1 others, Hegyi, P., okt. 15 2013, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 305, 8, p. G552-G563

Research output: Article

14 Citations (Scopus)
2012

Diclofenac Prolongs Repolarization in Ventricular Muscle with Impaired Repolarization Reserve

Kristóf, A., Husti, Z., Koncz, I., Kohajda, Z., Szél, T., Juhász, V., Biliczki, P., Jost, N., Baczkó, I., Papp, J. G., Varró, A. & Virág, L., dec. 31 2012, In : PloS one. 7, 12, e53255.

Research output: Article

8 Citations (Scopus)
2011

A multiscale investigation of repolarization variability and its role in cardiac arrhythmogenesis

Pueyo, E., Corrias, A., Virág, L., Jost, N., Szél, T., Varró, A., Szentandrássy, N., Nánási, P. P., Burrage, K. & Rodríguez, B., dec. 21 2011, In : Biophysical journal. 101, 12, p. 2892-2902 11 p.

Research output: Article

75 Citations (Scopus)

Analysis of the contribution of I to to repolarization in canine ventricular myocardium

Virág, L., Jost, N., Papp, R., Koncz, I., Kristóf, A., Kohajda, Z., Harmati, G., Carbonell-Pascual, B., Ferrero, J. M., Papp, J. G., Nánási, P. P. & Varró, A., szept. 1 2011, In : British journal of pharmacology. 164, 1, p. 93-105 13 p.

Research output: Article

15 Citations (Scopus)

Atrial remodeling and novel pharmacological strategies for antiarrhythmic therapy in atrial fibrillation

Jost, N., Kohajda, Z., Kristóf, A., Kovács, P. P., Husti, Z., Juhász, V., Kiss, L., Varró, A., Virág, L. & Baczkó, I., aug. 1 2011, In : Current medicinal chemistry. 18, 24, p. 3675-3694 20 p.

Research output: Article

11 Citations (Scopus)

Class I/B antiarrhythmic property of ranolazine, a novel antianginal agent, in dog and human cardiac preparations

Szél, T., Koncz, I., Jost, N., Baczkó, I., Husti, Z., Virág, L., Bussek, A., Wettwer, E., Ravens, U., Papp, J. G. & Varró, A., júl. 15 2011, In : European Journal of Pharmacology. 662, 1-3, p. 31-39 9 p.

Research output: Article

26 Citations (Scopus)

Electrophysiological effects of ivabradine in dog and human cardiac preparations: Potential antiarrhythmic actions

Koncz, I., Szél, T., Bitay, M., Cerbai, E., Jaeger, K., Fülöp, F., Jost, N., Virág, L., Orvos, P., Tálosi, L., Kristóf, A., Baczkó, I., Papp, J. G. & Varró, A., okt. 15 2011, In : European Journal of Pharmacology. 668, 3, p. 419-426 8 p.

Research output: Article

31 Citations (Scopus)

Mechanism of reverse rate-dependent action of cardioactive agents

Bányász, T., Bárándi, L., Harmati, G., Virág, L., Szentandrássy, N., Márton, I., Zaza, A., Varró, A. & Nánási, P. P., aug. 1 2011, In : Current medicinal chemistry. 18, 24, p. 3597-3606 10 p.

Research output: Article

8 Citations (Scopus)
553 Citations (Scopus)
2010

Reverse rate-dependent changes are determined by baseline action potential duration in mammalian and human ventricular preparations

Nánási, P. P., Bárándi, L., Virág, L., Jost, N., Horváth, Z., Koncz, I., Papp, R., Harmati, G., Horváth, B., Szentandrássy, N., Bányász, T., Magyar, J., Zaza, A. & Varró, A., máj. 1 2010, In : Basic research in cardiology. 105, 3, p. 315-323 9 p.

Research output: Article

39 Citations (Scopus)
2009

5,7,8-trimethyl-benzopyran and 5,7,8-trimethyl-1,4-benzoxazine aminoamide derivatives as novel antiarrhythmics against ischemia-reperfusion injury

Koini, E. N., Papazafiri, P., Vassilopoulos, A., Koufaki, M., Horváth, Z., Koncz, I., Virág, L., Papp, G. J., Varró, A. & Calogeropoulou, T., ápr. 23 2009, In : Journal of Medicinal Chemistry. 52, 8, p. 2328-2340 13 p.

Research output: Article

39 Citations (Scopus)

Herpesvirus-mediated delivery of a genetically encoded fluorescent ca 2+ sensor to canine cardiomyocytes

Prorok, J., Kovács, P. P., Kristf, A. A., Nagy, N., Tombácz, D., Tth, J. S., Ördg, B., Jost, N., Virág, L., Papp, J. G., Varr, A., Tth, A. & Boldogki, Z., aug. 24 2009, In : Journal of Biomedicine and Biotechnology. 2009, 361795.

Research output: Article

12 Citations (Scopus)

Reverse rate dependency is an intrinsic property of canine cardiac preparations

Bányász, T., Horváth, B., Virág, L., Bárándi, L., Szentandrássy, N., Harmati, G., Magyar, J., Marangoni, S., Zaza, A., Varró, A. & Nánási, P. P., nov. 1 2009, In : Cardiovascular research. 84, 2, p. 237-244 8 p.

Research output: Article

38 Citations (Scopus)
23 Citations (Scopus)
2008

Role of slow delayed rectifier K+-current in QT prolongation in the alloxan-induced diabetic rabbit heart

Lengyel, C., Virág, L., Kovács, P. P., Kristóf, A., Pacher, P., Kocsis, E., Koltay, Z. M., Nánási, P. P., Tóth, M., Kecskeméti, V., Papp, J. G., Varró, A. & Jost, N., márc. 1 2008, In : Acta Physiologica. 192, 3, p. 359-368 10 p.

Research output: Article

27 Citations (Scopus)
2007
59 Citations (Scopus)
2005

Cellular electrophysiological effect of terikalant in the dog heart

Biliczki, P., Acsai, K., Virág, L., Tálosi, L., Jost, N., Biliczki, A., Papp, J. G. & Varró, A., márc. 14 2005, In : European Journal of Pharmacology. 510, 3, p. 161-166 6 p.

Research output: Article

3 Citations (Scopus)
89 Citations (Scopus)

Peroxynitrite-induced α-actinin nitration and contractile alterations in isolated human myocardial cells

Borbély, A., Tóth, A., Édes, I., Virág, L., Papp, J. G., Varró, A., Paulus, W. J., Van Der Velden, J., Stienen, G. J. M. & Papp, Z., aug. 1 2005, In : Cardiovascular research. 67, 2, p. 225-233 9 p.

Research output: Article

68 Citations (Scopus)

Restricting excessive cardiac action potential and QT prolongation: A vital role for IKs in human ventricular muscle

Jost, N., Virág, L., Bitay, M., Takács, J., Lengyel, C., Biliczki, P., Nagy, Z., Bogáts, G., Lathrop, D. A., Papp, J. G. & Varró, A., szept. 6 2005, In : Circulation. 112, 10, p. 1392-1399 8 p.

Research output: Article

254 Citations (Scopus)
2004
12 Citations (Scopus)
17 Citations (Scopus)
73 Citations (Scopus)