• 7626 Citations
  • 46 h-Index
1978 …2020

Research output per year

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Research Output

2020

Pharmacological overview of the BGP-15 chemical agent as a new drug candidate for the treatment of symptoms of metabolic syndrome

Pető, Á., Kósa, D., Fehér, P., Ujhelyi, Z., Sinka, D., Vecsernyés, M., Szilvássy, Z., Juhász, B., Csanádi, Z., Vígh, L. & Bácskay, I., jan. 20 2020, In : Molecules. 25, 2, 429.

Research output: Review article

Open Access
2019

Hsp70 interactions with membrane lipids regulate cellular functions in health and disease

Balogi, Z., Multhoff, G., Jensen, T. K., Lloyd-Evans, E., Yamashima, T., Jäättelä, M., Harwood, J. L. & Vígh, L., ápr. 1 2019, In : Progress in Lipid Research. 74, p. 18-30 13 p.

Research output: Review article

10 Citations (Scopus)
2018

Cerebrovascular pathology in hypertriglyceridemic APOB-100 transgenic mice

Hoyk, Z., Tóth, M. E., Lénárt, N., Nagy, D., Dukay, B., Csefová, A., Zvara, Á., Seprényi, G., Kincses, A., Walter, F. R., Veszelka, S., Vígh, J., Barabási, B., Harazin, A., Kittel, Á., Puskás, L. G., Penke, B., Vígh, L., Deli, M. & Sántha, M., okt. 25 2018, In : Frontiers in Cellular Neuroscience. 12, 380.

Research output: Article

3 Citations (Scopus)
1 Citation (Scopus)
18 Citations (Scopus)

Lithocholic acid, a bacterial metabolite reduces breast cancer cell proliferation and aggressiveness

Mikó, E., Vida, A., Kovács, T., Ujlaki, G., Trencsényi, G., Márton, J., Sári, Z., Kovács, P., Boratkó, A., Hujber, Z., Csonka, T., Antal-Szalmás, P., Watanabe, M., Gombos, I., Csoka, B., Kiss, B., Vígh, L., Szabó, J., Méhes, G., Sebestyén, A. & 2 others, Goedert, J. J. & Bai, P., szept. 2018, In : Biochimica et Biophysica Acta - Bioenergetics. 1859, 9, p. 958-974 17 p.

Research output: Article

19 Citations (Scopus)

Poly(ADP-ribose) polymerase-2 is a lipid-modulated modulator of muscular lipid homeostasis

Márton, J., Péter, M., Balogh, G., Bódi, B., Vida, A., Szántó, M., Bojcsuk, D., Jankó, L., Bhattoa, H. P., Gombos, I., Uray, K., Horváth, I., Török, Z., Balint, B. L., Papp, Z., Vígh, L. & Bai, P., nov. 2018, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1863, 11, p. 1399-1412 14 p.

Research output: Article

2 Citations (Scopus)
2017

Chaperone co-inducer BGP-15 inhibits histone deacetylases and enhances the heat shock response through increased chromatin accessibility

Budzyński, M. A., Crul, T., Himanen, S. V., Toth, N., Otvos, F., Sistonen, L. & Vigh, L., szept. 1 2017, In : Cell Stress and Chaperones. 22, 5, p. 717-728 12 p.

Research output: Article

4 Citations (Scopus)

Nanotubes connecting B lymphocytes: High impact of differentiation-dependent lipid composition on their growth and mechanics

Tóth, E. A., Oszvald, Á., Péter, M., Balogh, G., Osteikoetxea-Molnár, A., Bozó, T., Szabó-Meleg, E., Nyitrai, M., Derényi, I., Kellermayer, M., Yamaji, T., Hanada, K., Vígh, L. & Matkó, J., szept. 2017, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1862, 9, p. 991-1000 10 p.

Research output: Article

5 Citations (Scopus)
2016

7DHC-induced changes of Kv1.3 operation contributes to modified T cell function in Smith-Lemli-Opitz syndrome

Balajthy, A., Somodi, S., Pethő, Z., Péter, M., Varga, Z., Szabó, G. P., Paragh, G., Vígh, L., Panyi, G. & Hajdu, P., aug. 1 2016, In : Pflugers Archiv European Journal of Physiology. 468, 8, p. 1403-1418 16 p.

Research output: Article

7 Citations (Scopus)
7 Citations (Scopus)

Dihydropyridine Derivatives Modulate Heat Shock Responses and have a Neuroprotective Effect in a Transgenic Mouse Model of Alzheimer's Disease

Kasza, Á., Hunya, Á., Frank, Z., Fülöp, F., Török, Z., Balogh, G., Sántha, M., Bálind, Á., Bernáth, S., Blundell, K. L. I. M., Prodromou, C., Horváth, I., Zeiler, H. J., Hooper, P. L., Vigh, L., Penke, B. & Abisambra, J., 2016, In : Journal of Alzheimer's Disease. 53, 2, p. 557-571 15 p.

Research output: Article

20 Citations (Scopus)

Involvement of small heat shock proteins, trehalose, and lipids in the thermal stress management in Schizosaccharomyces pombe

Glatz, A., Pilbat, A. M., Németh, G. L., Vince-Kontár, K., Jósvay, K., Hunya, Á., Udvardy, A., Gombos, I., Péter, M., Balogh, G., Horváth, I., Vígh, L. & Török, Z., márc. 1 2016, In : Cell Stress and Chaperones. 21, 2, p. 327-338 12 p.

Research output: Article

18 Citations (Scopus)

Reduced expression of CDP-DAG synthase changes lipid composition and leads to male sterility in Drosophila

Laurinyecz, B., Péter, M., Vedelek, V., Kovács, A. L., Juhász, G., Maróy, P., Vígh, L., Balogh, G. & Sinka, R., jan. 2016, In : Open Biology. 6, 1, 150169.

Research output: Article

10 Citations (Scopus)

The central role of heat shock factor 1 in synaptic fidelity and memory consolidation

Hooper, P. L., Durham, H. D., Török, Z., Hooper, P. L., Crul, T. & Vígh, L., szept. 1 2016, In : Cell Stress and Chaperones. 21, 5, p. 745-753 9 p.

Research output: Article

12 Citations (Scopus)

The chaperone co-inducer BGP-15 alleviates ventilation-induced diaphragm dysfunction

Salah, H., Li, M., Cacciani, N., Gastaldello, S., Ogilvie, H., Akkad, H., Venkat Namuduri, A., Morbidoni, V., Artemenko, K. A., Balogh, G., Martinez-Redondo, V., Jannig, P., Hedström, Y., Dworkin, B., Bergquist, J., Ruas, J., Vigh, L., Salviati, L. & Larsson, L., aug. 3 2016, In : Science Translational Medicine. 8, 350, p. 350ra103

Research output: Article

28 Citations (Scopus)
2015

Cell surface localised Hsp70 is a cancer specific regulator of clathrin-independent endocytosis

Nimmervoll, B., Chtcheglova, L. A., Juhasz, K., Cremades, N., Aprile, F. A., Sonnleitner, A., Hinterdorfer, P., Vigh, L., Preiner, J. & Balogi, Z., szept. 14 2015, In : FEBS letters. 589, 19, p. 2747-2753 7 p.

Research output: Article

21 Citations (Scopus)

Cultured cells of the blood-brain barrier from apolipoprotein B-100 transgenic mice: Effects of oxidized low-density lipoprotein treatment

Lénárt, N., Walter, F. R., Bocsik, A., Sántha, P., Tóth, M. E., Harazin, A., Tóth, A. E., Vizler, C., Török, Z., Pilbat, A. M., Vígh, L., Puskás, L. G., Sántha, M. & Deli, M. A., júl. 17 2015, In : Fluids and Barriers of the CNS. 12, 1, 17.

Research output: Article

15 Citations (Scopus)
12 Citations (Scopus)

Membrane fluidity in the center of fever-enhanced immunity

Gombos, I. & Vígh, L., jan. 1 2015, In : Cell cycle (Georgetown, Tex.). 14, 19, p. 3014-3015 2 p.

Research output: Comment/debate

72 Citations (Scopus)
2014

Alcohol stress, membranes, and chaperones

Tóth, M. E., Vígh, L. & Sántha, M., jan. 1 2014, In : Cell Stress and Chaperones. 19, 3, p. 299-309 11 p.

Research output: Review article

12 Citations (Scopus)

Improvement of insulin sensitivity by a novel drug candidate, BGP-15, in different animal studies

Literáti-Nagy, B., Tory, K., Peitl, B., Bajza, Á., Korányi, L., Literáti-Nagy, Z., Hooper, P. L., Vígh, L. & Szilvássy, Z., márc. 1 2014, In : Metabolic syndrome and related disorders. 12, 2, p. 125-131 7 p.

Research output: Article

16 Citations (Scopus)

Plasma membranes as heat stress sensors: From lipid-controlled molecular switches to therapeutic applications

Vigh, L., Török, Z., Crul, T., Maresca, B., Schütz, G. J., Viana, F., Dindia, L., Piotto, S., Brameshuber, M., Balogh, G., Péter, M., Porta, A., Trapani, A., Gombos, I., Glatz, A., Gungor, B., Peksel, B., Vigh, L., Csoboz, B., Horváth, I. & 3 others, Vijayan, M. M., Hooper, P. L. & Harwood, J. L., jún. 2014, In : Biochimica et Biophysica Acta - Biomembranes. 1838, 6, p. 1594-1618 25 p.

Research output: Review article

52 Citations (Scopus)
14 Citations (Scopus)

The importance of the cellular stress response in the pathogenesis and treatment of type 2 diabetes

Hooper, P. L., Balogh, G., Rivas, E., Kavanagh, K. & Vigh, L., júl. 2014, In : Cell Stress and Chaperones. 19, 4, p. 447-464 18 p.

Research output: Review article

60 Citations (Scopus)
2013

Heat stress management in synechocystis PCC 6803: The interplay between membranes and stress protein molecular chaperones

Glatz, A., Török, Z., Vígh, L. & Horváth, I., jan. 1 2013, Stress Biology of Cyanobacteria: Molecular Mechanisms to Cellular Responses. CRC Press, p. 145-154 10 p.

Research output: Chapter

Hydroximic acid derivatives: Pleiotropic Hsp co-inducers restoring homeostasis and robustness

Crul, T., Toth, N., Piotto, S., Literati-Nagy, P., Tory, K., Haldimann, P., Kalmar, B., Greensmith, L., Torok, Z., Balogh, G., Gombos, I., Campana, F., Concilio, S., Gallyas, F., Nagy, G., Berente, Z., Gungor, B., Peter, M., Glatz, A., Hunya, A. & 20 others, Literati-Nagy, Z., Vigh, L., Hoogstra-Berends, F., Heeres, A., Kuipers, I., Loen, L., Seerden, J. P., Zhang, D., Meijering, R. A. M., Henning, R. H., Brundel, B. J. J. M., Kampinga, H. H., Koranyi, L., Szilvassy, Z., Mandl, J., Sumegi, B., Febbraio, M. A., Horvath, I., Hooper, P. L. & Vigh, L., 2013, In : Current pharmaceutical design. 19, 3, p. 309-346 38 p.

Research output: Review article

41 Citations (Scopus)

Key role of lipids in heat stress management

Balogh, G., Péter, M., Glatz, A., Gombos, I., Török, Z., Horváth, I., Harwood, J. L. & Vígh, L., jún. 27 2013, In : FEBS letters. 587, 13, p. 1970-1980 11 p.

Research output: Review article

71 Citations (Scopus)

Lysosomal rerouting of Hsp70 trafficking as a potential immune activating tool for targeting melanoma

Juhász, K., Thuenauer, R., Spachinger, A., Duda, E., Horváth, I., Vígh, L., Sonnleitner, A. & Balogi, Z., 2013, In : Current pharmaceutical design. 19, 3, p. 430-440 11 p.

Research output: Article

14 Citations (Scopus)

Membrane fluidity matters: Hyperthermia from the aspects of lipids and membranes

Csoboz, B., Balogh, G. E., Kusz, E., Gombos, I., Peter, M., Crul, T., Gungor, B., Haracska, L., Bogdanovics, G., Torok, Z., Horvath, I. & Vigh, L., aug. 2013, In : International Journal of Hyperthermia. 29, 5, p. 491-499 9 p.

Research output: Review article

29 Citations (Scopus)

Synergetic insulin sensitizing effect of rimonabant and BGP-15 in zucker-obes rats

Literati-Nagy, Z., Tory, K., Literáti-Nagy, B., Bajza, Á., Vígh, L., Vígh, L., Mandl, J. & Szilvássy, Z., júl. 1 2013, In : Pathology and Oncology Research. 19, 3, p. 571-575 5 p.

Research output: Article

3 Citations (Scopus)
2012

A novel insulin sensitizer drug candidate-BGP-15-can prevent metabolic side effects of atypical antipsychotics

Literati-Nagy, Z., Tory, K., Literáti-Nagy, B., Kolonics, A., Vígh, L., Vígh, L., Mandl, J. & Szilvássy, Z., okt. 1 2012, In : Pathology and Oncology Research. 18, 4, p. 1071-1076 6 p.

Research output: Article

8 Citations (Scopus)

Glycerophospholipid profile in oncogene-induced senescence

Cadenas, C., Vosbeck, S., Hein, E. M., Hellwig, B., Langer, A., Hayen, H., Franckenstein, D., Büttner, B., Hammad, S., Marchan, R., Hermes, M., Selinski, S., Rahnenführer, J., Peksel, B., Török, Z., Vígh, L. & Hengstler, J. G., szept. 1 2012, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1821, 9, p. 1256-1268 13 p.

Research output: Article

28 Citations (Scopus)

Heat shock response in photosynthetic organisms: Membrane and lipid connections

Horváth, I., Glatz, A., Nakamoto, H., Mishkind, M. L., Munnik, T., Saidi, Y., Goloubinoff, P., Harwood, J. L. & Vigh, L., júl. 1 2012, In : Progress in Lipid Research. 51, 3, p. 208-220 13 p.

Research output: Review article

86 Citations (Scopus)
7 Citations (Scopus)

Nutritional lipid supply can control the heat shock response of B16 melanoma cells in culture

Péter, M., Balogh, G., Gombos, I., Liebisch, G., Horváth, I., Török, Z., Nagy, E., Maslyanko, A., Benk, S., Schmitz, G., Harwood, J. L. & Vígh, L., nov. 2012, In : Molecular Membrane Biology. 29, 7, p. 274-289 16 p.

Research output: Article

12 Citations (Scopus)

The HSP co-inducer BGP-15 can prevent the metabolic side effects of the atypical antipsychotics

Literáti-Nagy, Z., Tory, K., Literáti-Nagy, B., Kolonics, A., Török, Z., Gombos, I., Balogh, G., Vígh, L., Horváth, I., Mandl, J., Sümegi, B., Hooper, P. L. & Vígh, L., júl. 1 2012, In : Cell Stress and Chaperones. 17, 4, p. 517-521 5 p.

Research output: Article

21 Citations (Scopus)
2011

Docosahexaenoic acid reduces amyloid β production via multiple pleiotropic mechanisms

Grimm, M. O. W., Kuchenbecker, J., Grosgen, S., Burg, V. K., Hundsdorfer, B., Rothhaar, T. L., Friess, P., De Wilde, M. C., Broersen, L. M., Penke, B., Peter, M., Vígh, L., Grimm, H. S. & Hartmann, T., ápr. 22 2011, In : Journal of Biological Chemistry. 286, 16, p. 14028-14039 12 p.

Research output: Article

124 Citations (Scopus)

Heat stress causes spatially-distinct membrane re-modelling in K562 leukemia cells

Balogh, G., Maulucci, G., Gombos, I., Horváth, I., Török, Z., Péter, M., Fodor, E., Páli, T., Benko, S., Parasassi, T., de Spirito, M., Harwood, J. L. & Vígh, L., 2011, In : PloS one. 6, 6, e21182.

Research output: Article

44 Citations (Scopus)

Membrane-lipid therapy in operation: The HSP co-inducer BGP-15 activates stress signal transduction pathways by remodeling plasma membrane rafts

Gombos, I., Crul, T., Piotto, S., Güngör, B., Török, Z., Balogh, G., Péter, M., Slotte, J. P., Campana, F., Pilbat, A. M., Hunya, Á., Tóth, N., Literati-Nagy, Z., Vígh, L., Glatz, A., Brameshuber, M., Schütz, G. J., Hevener, A., Febbraio, M. A., Horváth, I. & 1 others, Vígh, L., dec. 14 2011, In : PloS one. 6, 12, e28818.

Research output: Article

51 Citations (Scopus)

Targeting membrane heat-shock protein 70 (Hsp70) on tumors by cmHsp70.1 antibody

Stangl, S., Gehrmann, M., Riegger, J., Kuhs, K., Riederer, I., Sievert, W., Hube, K., Mocikat, R., Dressel, R., Kremmer, E., Pockley, A. G., Friedrich, L., Vigh, L., Skerra, A. & Multhoff, G., jan. 11 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 2, p. 733-738 6 p.

Research output: Article

107 Citations (Scopus)

The novel hydroxylamine derivative NG-094 suppresses polyglutamine protein toxicity in Caenorhabditis elegans

Haldimann, P., Muriset, M., Vígh, L. & Goloubinoff, P., máj. 27 2011, In : Journal of Biological Chemistry. 286, 21, p. 18784-18794 11 p.

Research output: Article

25 Citations (Scopus)
2010

Cell biology: Stability in times of stress

Horváth, I. & Vígh, L., jan. 28 2010, In : Nature. 463, 7280, p. 436-438 3 p.

Research output: Short survey

26 Citations (Scopus)

Changes in membrane fluid state and heat shock response cause attenuation of virulence

Porta, A., Eletto, A., Törö, Z., Franceschelli, S., Glatz, A., Vígh, L. & Maresca, B., ápr. 2010, In : Journal of bacteriology. 192, 7, p. 1999-2005 7 p.

Research output: Article

13 Citations (Scopus)

Estradiol binding prevents ApoB-100 misfolding in electronegative LDL(-)

Brunelli, R., Balogh, G., Costa, G., De Spirito, M., Greco, G., Mei, G., Nicolai, E., Vigh, L., Ursini, F. & Parasassi, T., aug. 31 2010, In : Biochemistry. 49, 34, p. 7297-7302 6 p.

Research output: Article

16 Citations (Scopus)

Genetic modification of the Salmonella membrane physical state alters the pattern of heat shock response

Porta, A., Török, Z., Horvath, I., Franceschelli, S., Vígh, L. & Maresca, B., ápr. 2010, In : Journal of bacteriology. 192, 7, p. 1988-1998 11 p.

Research output: Article

14 Citations (Scopus)

Imaging of mobile long-lived nanoplatforms in the live cell plasma membrane

Brameshuber, M., Weghuber, J., Ruprecht, V., Gombos, I., Horváth, I., Vigh, L., Eckerstorfer, P., Kiss, E., Stockinger, H. & Schütz, G. J., dec. 31 2010, In : Journal of Biological Chemistry. 285, 53, p. 41765-41771 7 p.

Research output: Article

80 Citations (Scopus)
53 Citations (Scopus)

Live cell segmentation in fluorescence microscopy via graph cut

Leskó, M., Kato, Z., Nagy, A., Gombos, I., Török, Z., Vígh, L. & Vígh, L., nov. 18 2010, Proceedings - 2010 20th International Conference on Pattern Recognition, ICPR 2010. p. 1485-1488 4 p. 5597303. (Proceedings - International Conference on Pattern Recognition).

Research output: Conference contribution

12 Citations (Scopus)