• 3249 Citations
  • 32 h-Index
1981 …2019

Research output per year

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Research Output

2019
2 Citations (Scopus)

Glucopyranosylidene-spiro-imidazolinones, a New Ring System: Synthesis and Evaluation as Glycogen Phosphorylase Inhibitors by Enzyme Kinetics and X-ray Crystallography

Szabó, K. E., Kyriakis, E., Psarra, A. M. G., Karra, A. G., Sipos, Á., Docsa, T., Stravodimos, G. A., Katsidou, E., Skamnaki, V. T., Liggri, P. G. V., Zographos, S. E., Mándi, A., Király, S. B., Kurtán, T., Leonidas, D. D. & Somsák, L., jún. 18 2019, In : Journal of Medicinal Chemistry. 62, 13, p. 6116-6136 21 p.

Research output: Article

2 Citations (Scopus)

Identification of C-β-D-Glucopyranosyl Azole-Type Inhibitors of Glycogen Phosphorylase That Reduce Glycogenolysis in Hepatocytes: In Silico Design, Synthesis, in Vitro Kinetics, and ex Vivo Studies

Barr, D., Szennyes, E., Bokor, É., Al-Oanzi, Z. H., Moffatt, C., Kun, S., Docsa, T., Sipos, Á., Davies, M. P., Mathomes, R. T., Snape, T. J., Agius, L., Somsák, L. & Hayes, J. M., júl. 19 2019, In : ACS Chemical Biology. 14, 7, p. 1460-1470 11 p.

Research output: Article

4 Citations (Scopus)

New syntheses towards C-glycosyl type glycomimetics

Somsák, L., Bokor, É., Juhász, L., Kun, S., Lázár, L., Juhász-Tóth, É. & Tóth, M., júl. 1 2019, In : Pure and Applied Chemistry. 91, 7, p. 1159-1175 17 p.

Research output: Article

Open Access
1 Citation (Scopus)
3 Citations (Scopus)
6 Citations (Scopus)
2018

A multidisciplinary study of 3-(β-D-glucopyranosyl)-5-substituted-1,2,4-triazole derivatives as glycogen phosphorylase inhibitors: Computation, synthesis, crystallography and kinetics reveal new potent inhibitors

Kun, S., Begum, J., Kyriakis, E., Stamati, E. C. V., Barkas, T. A., Szennyes, E., Bokor, É., Szabó, K. E., Stravodimos, G. A., Sipos, Á., Docsa, T., Gergely, P., Moffatt, C., Patraskaki, M. S., Kokolaki, M. C., Gkerdi, A., Skamnaki, V. T., Leonidas, D. D., Somsák, L. & Hayes, J. M., márc. 10 2018, In : European Journal of Medicinal Chemistry. 147, p. 266-278 13 p.

Research output: Article

10 Citations (Scopus)

Glycogen phosphorylase inhibition improves beta cell function

Nagy, L., Márton, J., Vida, A., Kis, G., Bokor, É., Kun, S., Gönczi, M., Docsa, T., Tóth, A., Antal, M., Gergely, P., Csóka, B., Pacher, P., Somsák, L. & Bai, P., jan. 1 2018, In : British journal of pharmacology. 175, 2, p. 301-319 19 p.

Research output: Article

17 Citations (Scopus)

Pd-catalyzed coupling reactions of anhydro-aldose tosylhydrazones with aryl bromides to produce substituted exo-glycals

Kaszás, T., Ivanov, A., Tóth, M., Ehlers, P., Langer, P. & Somsák, L., aug. 2018, In : Carbohydrate Research. 466, p. 30-38 9 p.

Research output: Article

3 Citations (Scopus)

Probing the β-pocket of the active site of human liver glycogen phosphorylase with 3-(C-β-D-glucopyranosyl)-5-(4-substituted-phenyl)-1, 2, 4-triazole inhibitors

Kyriakis, E., Solovou, T. G. A., Kun, S., Czifrák, K., Szőcs, B., Juhász, L., Bokor, É., Stravodimos, G. A., Kantsadi, A. L., Chatzileontiadou, D. S. M., Skamnaki, V. T., Somsák, L. & Leonidas, D. D., ápr. 2018, In : Bioorganic Chemistry. 77, p. 485-493 9 p.

Research output: Article

7 Citations (Scopus)
7 Citations (Scopus)

Synthesis of thiomaltooligosaccharides by a thio-click approach

Lázár, L., Borbás, A. & Somsák, L., dec. 1 2018, In : Carbohydrate Research. 470, p. 8-12 5 p.

Research output: Article

3 Citations (Scopus)

The first general synthesis of 2-C-(β-d-glycopyranosyl)pyrimidines and their evaluation as inhibitors of some glycoenzymes

Szennyes, E., Bokor, E., Langer, P., Gyémánt, G., Docsa, T., Sipos, Á. & Somsák, L., jan. 1 2018, In : New Journal of Chemistry. 42, 21, p. 17439-17446 8 p.

Research output: Article

4 Citations (Scopus)
2017
4 Citations (Scopus)
6 Citations (Scopus)
3 Citations (Scopus)

Nanomolar Inhibitors of Glycogen Phosphorylase Based on β- D -Glucosaminyl Heterocycles: A Combined Synthetic, Enzyme Kinetic, and Protein Crystallography Study

Bokor, É., Kyriakis, E., Solovou, T. G. A., Koppány, C., Kantsadi, A. L., Szabó, K. E., Szakács, A., Stravodimos, G. A., Docsa, T., Skamnaki, V. T., Zographos, S. E., Gergely, P., Leonidas, D. D. & Somsák, L., nov. 22 2017, In : Journal of Medicinal Chemistry. 60, 22, p. 9251-9262 12 p.

Research output: Article

7 Citations (Scopus)

van der Waals interactions govern C-β-D-glucopyranosyl triazoles’ nM inhibitory potency in human liver glycogen phosphorylase

Kantsadi, A. L., Stravodimos, G. A., Kyriakis, E., Chatzileontiadou, D. S. M., Solovou, T. G. A., Kun, S., Bokor, É., Somsák, L. & Leonidas, D. D., júl. 2017, In : Journal of Structural Biology. 199, 1, p. 57-67 11 p.

Research output: Article

8 Citations (Scopus)
2016

Glucose-derived spiro-isoxazolines are anti-hyperglycemic agents against type 2 diabetes through glycogen phosphorylase inhibition

Goyard, D., Kónya, B., Chajistamatiou, A. S., Chrysina, E. D., Leroy, J., Balzarin, S., Tournier, M., Tousch, D., Petit, P., Duret, C., Maurel, P., Somsák, L., Docsa, T., Gergely, P., Praly, J. P., Azay-Milhau, J. & Vidal, S., jan. 27 2016, In : European Journal of Medicinal Chemistry. 108, p. 444-454 11 p.

Research output: Article

35 Citations (Scopus)
5 Citations (Scopus)

One pot InCl3-catalyzed synthesis of 1-glycosylmethyl-1H-imidazoles

Petrušová, M., Smrtičová, H., Pribulová, B., Vlčková, S., Uhliariková, I., Docsa, T., Somsák, L. & Petruš, L., ápr. 28 2016, In : Tetrahedron. 72, 17, p. 2116-2121 6 p.

Research output: Article

6 Citations (Scopus)

Synthetic, enzyme kinetic, and protein crystallographic studies of C-β-D-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase

Kantsadi, A. L., Bokor, É., Kun, S., Stravodimos, G. A., Chatzileontiadou, D. S. M., Leonidas, D. D., Juhász-Tóth, É., Szakács, A., Batta, G., Docsa, T., Gergely, P. & Somsák, L., jan. 1 2016, In : European Journal of Medicinal Chemistry. 123, p. 737-745 9 p.

Research output: Article

22 Citations (Scopus)
2015
22 Citations (Scopus)
7 Citations (Scopus)
15 Citations (Scopus)
8 Citations (Scopus)

Chemoselective hydration of glycosyl cyanides to C-glycosyl formamides using ruthenium complexes in aqueous media

Misra, A. K., Bokor, É., Kun, S., Bolyog-Nagy, E., Kathó, Á., Joó, F. & Somsák, L., okt. 28 2015, In : Tetrahedron Letters. 56, 44, p. 5995-5998 4 p.

Research output: Article

7 Citations (Scopus)
9 Citations (Scopus)
10 Citations (Scopus)
21 Citations (Scopus)

Photoinitiated hydrothiolation of pyranoid exo-glycals: The d-galacto and d-xylo cases

József, J., Juhász, L., Illyés, T. Z., Csávás, M., Borbás, A. & Somsák, L., jún. 22 2015, In : Carbohydrate Research. 413, p. 63-69 7 p.

Research output: Article

14 Citations (Scopus)

Synthesis of 5-aryl-3-C-glycosyl- and unsymmetrical 3,5-diaryl-1,2,4-triazoles from alkylidene-amidrazones

Szcs, B., Bokor, É., Szabó, K. E., Kiss-Szikszai, A., Tóth, M. & Somsák, L., 2015, In : RSC Advances. 5, 54, p. 43620-43629 10 p.

Research output: Article

11 Citations (Scopus)

Thio-click approach to the synthesis of stable glycomimetics

Lázár, L., Csávás, M., Tóth, M., Somsák, L. & Borbá, A., jún. 1 2015, In : Chemical Papers. 69, 6, p. 889-895 7 p.

Research output: Article

19 Citations (Scopus)
2014

Glucopyranosylidene-spiro-iminothiazolidinone, a new bicyclic ring system: Synthesis, derivatization, and evaluation for inhibition of glycogen phosphorylase by enzyme kinetic and crystallographic methods

Czifrák, K., Páhi, A., Deák, S., Kiss-Szikszai, A., Kövér, K. E., Docsa, T., Gergely, P., Alexacou, K. M., Papakonstantinou, M., Leonidas, D. D., Zographos, S. E., Chrysina, E. D. & Somsák, L., aug. 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 15, p. 4028-4041 14 p.

Research output: Article

6 Citations (Scopus)

New synthesis of 3-(β-D-glucopyranosyl)-5-substituted-1,2,4-triazoles, nanomolar inhibitors of glycogen phosphorylase

Kun, S., Bokor, É., Varga, G., Szocs, B., Páhi, A., Czifrák, K., Tóth, M., Juhász, L., Docsa, T., Gergely, P. & Somsák, L., ápr. 9 2014, In : European Journal of Medicinal Chemistry. 76, p. 567-579 13 p.

Research output: Article

32 Citations (Scopus)

Structure-activity relationships of glycogen phosphorylase inhibitor FR258900 and its analogues: A combined synthetic, enzyme kinetics, and computational study

Juhász, L., Varga, G., Sztankovics, A., Béke, F., Docsa, T., Kiss-Szikszai, A., Gergely, P., Kóňa, J., Tvaroška, I. & Somsák, L., nov. 2014, In : ChemPlusChem. 79, 11, p. 1558-1568 11 p.

Research output: Article

2 Citations (Scopus)

Synthesis of C-xylopyranosyl- and xylopyranosylidene-spiro-heterocycles as potential inhibitors of glycogen phosphorylase

Somsák, L., Bokor, É., Czibere, B., Czifrák, K., Koppány, C., Kulcsár, L., Kun, S., Szilágyi, E., Tóth, M., Docsa, T. & Gergely, P., nov. 18 2014, In : Carbohydrate Research. 399, p. 38-48 11 p.

Research output: Article

14 Citations (Scopus)
2013
18 Citations (Scopus)
32 Citations (Scopus)
35 Citations (Scopus)

Radical-mediated brominations at ring-positions of carbohydrates - 35 years later

Somsák, L. & Czifrák, K., 2013, Carbohydrate Chemistry. Royal Society of Chemistry, p. 1-37 37 p. (Carbohydrate Chemistry; vol. 39).

Research output: Chapter

9 Citations (Scopus)
1 Citation (Scopus)

Synthesis, enzyme kinetics and computational evaluation of N-(β-d-glucopyranosyl) oxadiazolecarboxamides as glycogen phosphorylase inhibitors

Polyák, M., Varga, G., Szilágyi, B., Juhász, L., Docsa, T., Gergely, P., Begum, J., Hayes, J. M. & Somsák, L., szept. 15 2013, In : Bioorganic and Medicinal Chemistry. 21, 18, p. 5738-5747 10 p.

Research output: Article

11 Citations (Scopus)
10 Citations (Scopus)
7 Citations (Scopus)
16 Citations (Scopus)
4 Citations (Scopus)

Systematic study on free radical hydrothiolation of unsaturated monosaccharide derivatives with exo- and endocyclic double bonds

Lázár, L., Csávás, M., Hadházi, Á., Herczeg, M., Tóth, M., Somsák, L., Barna, T., Herczegh, P. & Borbás, A., aug. 28 2013, In : Organic and Biomolecular Chemistry. 11, 32, p. 5339-5350 12 p.

Research output: Article

26 Citations (Scopus)
2012
10 Citations (Scopus)