• 3291 Citations
  • 28 h-Index
1981 …2019

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Article
2019

Experimental motor neuron disease induced in mice with long-term repeated intraperitoneal injections of serum from ALS patients

Obál, I., Nógrádi, B., Meszlényi, V., Patai, R., Ricken, G., Kovacs, G. G., Tripolszki, K., Széll, M., Siklós, L. & Engelhardt, J. I., máj. 2 2019, In : International journal of molecular sciences. 20, 10, 2573.

Research output: Article

Open Access
2 Citations (Scopus)
2018
5 Citations (Scopus)

Niosomes decorated with dual ligands targeting brain endothelial transporters increase cargo penetration across the blood-brain barrier

Mészáros, M., Porkoláb, G., Kiss, L., Pilbat, A. M., Kóta, Z., Kupihár, Z., Kéri, A., Galbács, G., Siklós, L., Tóth, A., Fülöp, L., Csete, M., Sipos, Á., Hülper, P., Sipos, P., Páli, T., Rákhely, G., Szabó-Révész, P., Deli, M. A. & Veszelka, S., okt. 15 2018, In : European Journal of Pharmaceutical Sciences. 123, p. 228-240 13 p.

Research output: Article

8 Citations (Scopus)
2016

Effect of axotomy and 17β-estradiol on P2X7 receptor expression pattern in the hypoglossal nucleus of ovariectomized mice

Barabási, B., Csondor, A., Martín-Pozas, T., Pulupa Sánchez, A. M., Antalffy, G., Siklós, L., Gómez-Pinedo, U., Párducz & Hoyk, Z., ápr. 5 2016, In : Neuroscience. 319, p. 107-115 9 p.

Research output: Article

2 Citations (Scopus)
2014
8 Citations (Scopus)

Highly immunoreactive IgG antibodies directed against a set of twenty human proteins in the sera of patients with amyotrophic lateral sclerosis identified by protein array

May, C., Nordhoff, E., Casjens, S., Turewicz, M., Eisenacher, M., Gold, R., Brüning, T., Pesch, B., Stephan, C., Woitalla, D., Penke, B., Janáky, T., Virók, D., Siklós, L., Engelhardt, J. I. & Meyer, H. E., febr. 26 2014, In : PloS one. 9, 2, e89596.

Research output: Article

19 Citations (Scopus)
2012

An MND/ALS phenotype associated with C9orf72 repeat expansion: Abundant p62-positive, TDP-43-negative inclusions in cerebral cortex, hippocampus and cerebellum but without associated cognitive decline

Troakes, C., Maekawa, S., Wijesekera, L., Rogelj, B., Siklós, L., Bell, C., Smith, B., Newhouse, S., Vance, C., Johnson, L., Hortobágyi, T., Shatunov, A., Al-Chalabi, A., Leigh, N., Shaw, C. E., King, A. & Al-Sarraj, S., okt. 1 2012, In : Neuropathology. 32, 5, p. 505-514 10 p.

Research output: Article

83 Citations (Scopus)

Intra-axonal calcium changes after axotomy in wild-type and slow Wallerian degeneration axons

Adalbert, R., Morreale, G., Paizs, M., Conforti, L., Walker, S. A., Roderick, H. L., Bootman, M. D., Siklós, L. & Coleman, M. P., dec. 6 2012, In : Neuroscience. 225, p. 44-54 11 p.

Research output: Article

27 Citations (Scopus)

Melanoma cell-derived exosomes alter macrophage and dendritic cell functions in vitro

Marton, A., Vizler, C., Kusz, E., Temesfoi, V., Szathmary, Z., Nagy, K., Szegletes, Z., Varo, G., Siklos, L., Katona, R. L., Tubak, V., Howard, O. M. Z., Duda, E., Minarovits, J., Nagy, K. & Buzas, K., nov. 1 2012, In : Immunology letters. 148, 1, p. 34-38 5 p.

Research output: Article

58 Citations (Scopus)
2011
26 Citations (Scopus)

Transmigration of melanoma cells through the blood-brain barrier: Role of endothelial tight junctions and melanoma-released serine proteases

Fazakas, C., Wilhelm, I., Nagyoszi, P., Farkas, A. E., Haskó, J., Molnár, J., Bauer, H., Bauer, H. C., Ayaydin, F., Dung, N. T. K., Siklós, L. & Krizbai, I. A., jún. 9 2011, In : PloS one. 6, 6, e20758.

Research output: Article

73 Citations (Scopus)
2010

17β-estradiol attenuates injury-induced microglia activation in the oculomotor nucleus

Gyenes, A., Hoyk, Z., Csakvari, E., Siklos, L. & Parducz, A., dec. 15 2010, In : Neuroscience. 171, 3, p. 677-682 6 p.

Research output: Article

12 Citations (Scopus)
10 Citations (Scopus)
2009
14 Citations (Scopus)
2008

Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis

Appel, S. H., Engelhardt, J. I., Henkel, J. S., Siklos, L., Beers, D. R., Yen, A. A., Simpson, E. P., Luo, Y., Carrum, G., Heslop, H. E., Brenner, M. K. & Popat, U., okt. 21 2008, In : Neurology. 71, 17, p. 1326-1334 9 p.

Research output: Article

103 Citations (Scopus)
2006
30 Citations (Scopus)

Capsaicin delays regeneration of the neuromuscular junction of rat extensor digitorum longus muscle after ischemia

Turchányi, B., Hamar, J., Tömböl, T. & Siklós, L., ápr. 1 2006, In : Muscle and Nerve. 33, 4, p. 556-567 12 p.

Research output: Article

The chemokine MCP-1 and the dendritic and myeloid cells it attracts are increased in the mSOD1 mouse model of ALS

Henkel, J. S., Beers, D. R., Siklós, L. & Appel, S. H., márc. 1 2006, In : Molecular and Cellular Neuroscience. 31, 3, p. 427-437 11 p.

Research output: Article

121 Citations (Scopus)

Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis

Beers, D. R., Henkel, J. S., Xiao, Q., Zhao, W., Wang, J., Yen, A. A., Siklos, L., McKercher, S. R. & Appel, S. H., okt. 24 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 43, p. 16021-16026 6 p.

Research output: Article

475 Citations (Scopus)
2005

Subcellular localization of IgG from the sera of ALS patients in the nervous system

Engelhardt, J. I., Soós, J., Obál, I., Vigh, L. & Siklós, L., aug. 1 2005, In : Acta Neurologica Scandinavica. 112, 2, p. 126-133 8 p.

Research output: Article

31 Citations (Scopus)

Sublethal dose of 4-hydroxynonenal reduces intracellular calcium in surviving motor neurons in vivo

Vigh, L., Smith, R. G., Soós, J., Engelhardt, J. I., Appel, S. H. & Siklós, L., jún. 1 2005, In : Acta neuropathologica. 109, 6, p. 567-575 9 p.

Research output: Article

11 Citations (Scopus)
2004
40 Citations (Scopus)

Presence of Dendritic Cells, MCP-1, and Activated Microglia/Macrophages in Amyotrophic Lateral Sclerosis Spinal Cord Tissue

Henkel, J. S., Engelhardt, J. I., Siklós, L., Simpson, E. P., Kim, S. H., Pan, T., Goodman, J. C., Siddique, T., Beers, D. R. & Appel, S. H., febr. 1 2004, In : Annals of Neurology. 55, 2, p. 221-235 15 p.

Research output: Article

358 Citations (Scopus)

The expression of PARP, NF-κB and parvalbumin is increased in Parkinson disease

Soós, J., Engelhardt, J. I., Siklós, L., Havas, L. & Majtényi, K., aug. 6 2004, In : Neuroreport. 15, 11, p. 1715-1718 4 p.

Research output: Article

60 Citations (Scopus)

Widespread increased expression of the DNA repair enzyme PARP in brain in ALS

Kim, S. H., Engelhardt, J. I., Henkel, J. S., Siklós, L., Soós, J., Goodman, C. & Appel, S. H., jan. 27 2004, In : Neurology. 62, 2, p. 319-322 4 p.

Research output: Article

38 Citations (Scopus)
2003

PARP expression is increased in astrocytes but decreased in motor neurons in the spinal cord of sporadic ALS patients

Kim, S. H., Henkel, J. S., Beers, D. R., Sengun, I. S., Simpson, E. P., Goodman, J. C., Engelhardt, J. I., Siklós, L. & Appel, S. H., jan. 1 2003, In : Journal of Neuropathology and Experimental Neurology. 62, 1, p. 88-103 16 p.

Research output: Article

Open Access
44 Citations (Scopus)
2002
8 Citations (Scopus)
29 Citations (Scopus)

Immunoglobulin Fcγ receptor promotes immunoglobulin uptake, immunoglobulin-mediated Calcium increase, and neurotransmitter release in motor neurons

Mohamed, H. A., Mosier, D. R., Zou, L. L., Siklós, L., Alexianu, M. E., Engelhardt, J. I., Beers, D. R., Le, W. D. & Appel, S. H., júl. 1 2002, In : Journal of Neuroscience Research. 69, 1, p. 110-116 7 p.

Research output: Article

71 Citations (Scopus)
2001

Calcium: The Darth Vader of ALS

Appel, S. H., Beers, D., Siklos, L., Engelhardt, J. I. & Mosier, D. R., márc. 2001, In : Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 2, SUPPL. 1, p. 47-54 8 p.

Research output: Article

50 Citations (Scopus)
11 Citations (Scopus)

Parvalbumin overexpression alters immune-mediated increases in intracellular calcium, and delays disease onset in a transgenic model of familial amyotrophic lateral sclerosis

Beers, D. R., Ho, B. K., Siklós, L., Alexianu, M. E., Mosier, D. R., Habib Mohamed, A., Otsuka, Y., Kozovska, M. E., McAlhany, R. E., Glenn Smith, R. & Appel, S. H., nov. 14 2001, In : Journal of neurochemistry. 79, 3, p. 499-509 11 p.

Research output: Article

110 Citations (Scopus)

Recruitment of activated microglia cells in the spinal cord of mice by ALS IgG

Obál, I., Jakab, J. S. K., Siklós, L. & Engelhardt, J. I., aug. 8 2001, In : Neuroreport. 12, 11, p. 2449-2452 4 p.

Research output: Article

33 Citations (Scopus)
2000

Altered calcium homeostasis in spinal motoneurons but not in oculomotor neurons of SOD-1 knockout mice

Siklós, L., Engelhardt, J. I., Reaume, A. G., Scott, R. W., Adalbert, R., Obál, I. & Appel, S. H., máj. 2000, In : Acta neuropathologica. 99, 5, p. 517-524 8 p.

Research output: Article

15 Citations (Scopus)

Resistance of extraocular motoneuron terminals to effects of amyotrophic lateral sclerosis sera

Mosier, D. R., Siklós, L. & Appel, S. H., jan. 11 2000, In : Neurology. 54, 1, p. 252-255 4 p.

Research output: Article

26 Citations (Scopus)
Open Access
16 Citations (Scopus)
1999

Calcium-containing endosomes at oculomotor terminals in animal models of ALS

Siklós, L., Engelhardt, J. I., Adalbert, R. & Appel, S. H., aug. 20 1999, In : Neuroreport. 10, 12, p. 2539-2545 7 p.

Research output: Article

10 Citations (Scopus)
1998

Experimental destruction of substantia nigra initiated by Parkinson disease immunoglobulins

Chen, S., Le, W. D., Xie, W. J., Alexianu, M. E., Engelhardt, J. I., Siklós, L. & Appel, S. H., aug. 1 1998, In : Archives of Neurology. 55, 8, p. 1075-1080 6 p.

Research output: Article

84 Citations (Scopus)

Expression of glutamate receptors on cultured cerebral endothelial cells

Krizbai, I. A., Deli, M. A., Pestenácz, A., Siklós, L., Szabó, C. A., András, I. & Joó, F., dec. 15 1998, In : Journal of Neuroscience Research. 54, 6, p. 814-819 6 p.

Research output: Article

110 Citations (Scopus)

Intracellular calcium parallels motoneuron degeneration in SOD-1 mutant mice

Siklös, L., Engelhardt, J. I., Alexianu, M. E., Gurney, M. E., Siddique, T. & Appel, S. H., jún. 1998, In : Journal of Neuropathology and Experimental Neurology. 57, 6, p. 571-587 17 p.

Research output: Article

Open Access
110 Citations (Scopus)
1997
Open Access
39 Citations (Scopus)
10 Citations (Scopus)
28 Citations (Scopus)
1996
25 Citations (Scopus)

Serum prevents glutamate-induced mitochondrial calcium accumulation in primary neuronal cultures

Dux, E., Oschlies, U., Uto, A., Kusumoto, M., Siklos, L., Joo, F. & Hossmann, K. A., szept. 1 1996, In : Acta neuropathologica. 92, 3, p. 264-272 9 p.

Research output: Article

14 Citations (Scopus)

Ultrastructural evidence for altered calcium in motor nerve terminals in amyotrophic lateral sclerosis

Siklós, L., Engelhardt, J., Harati, Y., Smith, R. G., Joó, F. & Appel, S. H., márc. 13 1996, In : Annals of Neurology. 39, 2, p. 203-216 14 p.

Research output: Article

239 Citations (Scopus)
1995
81 Citations (Scopus)

Chloride is preferentially accumulated in a subpopulation of dendrites and periglomerular cells of the main olfactory bulb in adult rats

Siklós, L., Rickmann, M., Joó, F., Freeman, W. J. & Wolff, J. R., jan. 1995, In : Neuroscience. 64, 1, p. 165-172 8 p.

Research output: Article

26 Citations (Scopus)
1994

A new cytochemical method for the ultrastructural localization of calcium in the central nervous system

Buchs, P. A., Stoppini, L., Párducz, A., Siklós, L. & Muller, D., szept. 1994, In : Journal of Neuroscience Methods. 54, 1, p. 83-93 11 p.

Research output: Article

25 Citations (Scopus)