• 5302 Citations
  • 27 h-Index
1981 …2019

Research output per year

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Research Output

  • 5302 Citations
  • 27 h-Index
  • 67 Article
  • 8 Review article
  • 2 Comment/debate
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Article
2019

Modelling the neuropathology of lysosomal storage disorders through disease-specific human induced pluripotent stem cells

Kobolák, J., Molnár, K., Varga, E., Bock, I., Jezsó, B., Téglási, A., Zhou, S., Lo Giudice, M., Hoogeveen-Westerveld, M., Pijnappel, WWM. P., Phanthong, P., Varga, N., Kitiyanant, N., Freude, K., Nakanishi, H., László, L., Hyttel, P. & Dinnyés, A., júl. 15 2019, In : Experimental Cell Research. 380, 2, p. 216-233 18 p.

Research output: Article

Open Access
4 Citations (Scopus)
2018
Open Access
2 Citations (Scopus)

Filamentous Aggregation of Sequestosome-1/p62 in Brain Neurons and Neuroepithelial Cells upon Tyr-Cre-Mediated Deletion of the Autophagy Gene Atg7

Sukseree, S., László, L., Gruber, F., Bergmann, S., Narzt, M. S., Nagelreiter, I. M., Höftberger, R., Molnár, K., Rauter, G., Birngruber, T., Larue, L., Kovacs, G. G., Tschachler, E. & Eckhart, L., nov. 1 2018, In : Molecular Neurobiology. 55, 11, p. 8425-8437 13 p.

Research output: Article

3 Citations (Scopus)

Grapefruit seed extract inhibits the formation of amyloid-like fibrils by trypsin in aqueous ethanol

Kasi, P. B., Borics, A., Varga, M., Endre, G., Molnár, K., László, L. & Kotormán, M., jan. 1 2018, In : Natural Product Communications. 13, 11, p. 1437-1440 4 p.

Research output: Article

2 Citations (Scopus)

Lysosomal response in relation to α-synuclein pathology differs between Parkinson's disease and multiple system atrophy

Puska, G., Lutz, M. I., Molnar, K., Regelsberger, G., Ricken, G., Pirker, W., László, L. & Kovacs, G. G., jún. 1 2018, In : Neurobiology of Disease. 114, p. 140-152 13 p.

Research output: Article

5 Citations (Scopus)

The inhibitory effect of Panax ginseng extract on amyloid-like fibril formation of trypsin in aqueous ethanol

Kasi, P. B., Kotormán, M., Borics, A., Hervay, B. G., Molnár, K. & László, L., jan. 1 2018, In : Protein and Peptide Letters. 25, 3, p. 253-259 7 p.

Research output: Article

3 Citations (Scopus)
2017

Comparison of 2D and 3D neural induction methods for the generation of neural progenitor cells from human induced pluripotent stem cells

Chandrasekaran, A., Avci, H. X., Ochalek, A., Rösingh, L. N., Molnár, K., László, L., Bellák, T., Téglási, A., Pesti, K., Mike, A., Phanthong, P., Bíró, O., Hall, V., Kitiyanant, N., Krause, K. H., Kobolák, J. & Dinnyés, A., dec. 1 2017, In : Stem Cell Research. 25, p. 139-151 13 p.

Research output: Article

20 Citations (Scopus)

Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation

Ochalek, A., Mihalik, B., Avci, H. X., Chandrasekaran, A., Téglási, A., Bock, I., Giudice, M. L., Táncos, Z., Molnár, K., László, L., Nielsen, J. E., Holst, B., Freude, K., Hyttel, P., Kobolák, J. & Dinnyés, A., dec. 1 2017, In : Alzheimer's Research and Therapy. 9, 1, 90.

Research output: Article

45 Citations (Scopus)
2014

Intracellular processing of disease-associated α-synuclein in the human brain suggests prion-like cell-to-cell spread

Kovacs, G. G., Breydo, L., Green, R., Kis, V., Puska, G., Lorincz, P., Perju-Dumbrava, L., Giera, R., Pirker, W., Lutz, M., Lachmann, I., Budka, H., Uversky, V. N., Molnár, K. & László, L., szept. 2014, In : Neurobiology of Disease. 69, p. 76-92 17 p.

Research output: Article

71 Citations (Scopus)
2013

Rapidly progressive dementia with thalamic degeneration and peculiar cortical prion protein immunoreactivity, but absence of proteinase K resistant PrP: a new disease entity?

Kovacs, G. G., Peden, A., Weis, S., Höftberger, R., Berghoff, A. S., Yull, H., Ströbel, T., Koppi, S., Katzenschlager, R., Langenscheidt, D., Assar, H., Zaruba, E., Gröner, A., Voigtländer, T., Puska, G., Hametner, E., Grams, A., Muigg, A., Knoflach, M., László, L. & 3 others, Ironside, J. W., Head, M. W. & Budka, H., 2013, In : Acta neuropathologica communications. 1, 1, p. 72 1 p.

Research output: Article

10 Citations (Scopus)
4 Citations (Scopus)
2012
13 Citations (Scopus)

Novel crystalloid oligodendrogliopathy in hereditary spastic paraplegia

Woehrer, A., Laszlo, L., Finsterer, J., Stöllberger, C., Furtner, J., Rinner, W., Molnar, K., Budka, H. & Kovacs, G. G., okt. 1 2012, In : Acta neuropathologica. 124, 4, p. 583-591 9 p.

Research output: Article

4 Citations (Scopus)
2011

A peculiar constellation of tau pathology defines a subset of dementia in the elderly

Kovacs, G. G., Molnár, K., László, L., Ströbel, T., Botond, G., Hönigschnabl, S., Reiner-Concin, A., Palkovits, M., Fischer, P. & Budka, H., aug. 1 2011, In : Acta neuropathologica. 122, 2, p. 205-222 18 p.

Research output: Article

56 Citations (Scopus)

Genetic Creutzfeldt-Jakob disease associated with the E200K mutation: Characterization of a complex proteinopathy

Kovacs, G. G., Seguin, J., Quadrio, I., Höftberger, R., Kapás, I., Streichenberger, N., Biacabe, A. G., Meyronet, D., Sciot, R., Vandenberghe, R., Majtenyi, K., László, L., Ströbel, T., Budka, H. & Perret-Liaudet, A., jan. 1 2011, In : Acta neuropathologica. 121, 1, p. 39-57 19 p.

Research output: Article

70 Citations (Scopus)
2010

Increased neuronal Rab5 immunoreactive endosomes do not colocalize with TDP-43 in motor neuron disease

Matej, R., Botond, G., László, L., Kopitar-Jerala, N., Rusina, R., Budka, H. & Kovacs, G. G., szept. 1 2010, In : Experimental Neurology. 225, 1, p. 133-139 7 p.

Research output: Article

9 Citations (Scopus)
2008

MAPT S305I mutation: Implications for argyrophilic grain disease

Kovacs, G. G., Pittman, A., Revesz, T., Luk, C., Lees, A., Kiss, E., Tariska, P., Laszlo, L., Molnár, K., Molnar, M. J., Tolnay, M. & de Silva, R., júl. 1 2008, In : Acta neuropathologica. 116, 1, p. 103-118 16 p.

Research output: Article

36 Citations (Scopus)
2007

Emberi prionbetegségek: magyarországi tapasztalatok.

Kovács, G. G., Bakos, A., Mitrova, E., Minárovits, J., László, L. & Majtényi, K., nov. 30 2007, In : Ideggyógyászati szemle. 60, 11-12, p. 447-452 6 p.

Research output: Article

8 Citations (Scopus)
2006

Alterations of NADPH:protochlorophyllide oxidoreductase quantity and lipid composition in etiolated barley seedlings infected by Barley stripe mosaic virus (BSMV)

Harsányi, A., Ryberg, M., Andersson, M. X., Bóka, K., László, L., Botond, G., Böddi, B. & Gáborjányi, R., okt. 26 2006, In : Molecular Plant Pathology. 7, 6, p. 533-541 9 p.

Research output: Article

5 Citations (Scopus)
19 Citations (Scopus)
2005

Increased incidence of genetic human prion disease in Hungary

Kovács, G. G., László, L., Bakos, A., Minárovits, J., Bishop, M. T., Ströbel, T., Vajna, B., Mitrova, E. & Majtényi, K., nov. 2005, In : Neurology. 65, 10, p. 1666-1669 4 p.

Research output: Article

15 Citations (Scopus)

The ubiquitin-proteasome system in Creutzfeldt-Jakob and Alzheimer disease: Intracellular redistribution of components correlates with neuronal vulnerability

Ádori, C., Kovács, G. G., Low, P., Molnár, K., Gorbea, C., Fellinger, E., Budka, H., Mayer, R. J. & László, L., aug. 1 2005, In : Neurobiology of Disease. 19, 3, p. 427-435 9 p.

Research output: Article

18 Citations (Scopus)
2004
25 Citations (Scopus)

Mouse in red: Red fluorescent protein expression in mouse ES cells, embryos, and adult animals

Vintersten, K., Monetti, C., Gertsenstein, M., Zhang, P., Laszlo, L., Biechele, S. & Nagy, A., dec. 1 2004, In : Genesis. 40, 4, p. 241-246 6 p.

Research output: Article

223 Citations (Scopus)

Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies

Kovács, G. G., László, L., Kovács, J., Jensen, P. H., Lindersson, E., Botond, G., Molnár, T., Perczel, A., Hudecz, F., Mezo, G., Erdei, A., Tirián, L., Lehotzky, A., Gelpi, E., Budka, H. & Ovádi, J., nov. 1 2004, In : Neurobiology of Disease. 17, 2, p. 155-162 8 p.

Research output: Article

100 Citations (Scopus)

The prion protein in human neuromuscular diseases

Kovács, G. G., Kalev, O., Gelpi, E., Haberler, C., Wanschitz, J., Strohschneider, M., Molnár, M. J., László, L. & Budka, H., nov. 1 2004, In : Journal of Pathology. 204, 3, p. 241-247 7 p.

Research output: Article

12 Citations (Scopus)
2003

Serum amyloid P component induces neuronal apoptosis and β-amyloid immunoreactivity

Urbányi, Z., László, L., Tomasi, T. B., Tóth, E., Mekes, É., Sass, M. & Pázmány, T., okt. 24 2003, In : Brain research. 988, 1-2, p. 69-77 9 p.

Research output: Article

14 Citations (Scopus)
2002

Immunohistochemistry for the prion protein: Comparison of different monoclonal antibodies in human prion disease subtypes

Kovács, G. G., Head, M. W., Hegyi, I., Bunn, T. J., Flicker, H., Hainfellner, J. A., McCardle, L., László, L., Jarius, C., Ironside, J. W. & Budka, H., 2002, In : Brain Pathology. 12, 1, p. 1-11 11 p.

Research output: Article

91 Citations (Scopus)
30 Citations (Scopus)
2001

Cytotoxic effect of alcohol-withdrawal on primary cultures of cortical neurones

Nagy, J., Müller, F. & László, L., jan. 1 2001, In : Drug and Alcohol Dependence. 61, 2, p. 155-162 8 p.

Research output: Article

26 Citations (Scopus)

Inherited prion disease with A117V mutation of the prion protein gene: A novel Hungarian family

Kovács, G. G., Ertsey, C., Majtényi, C., Jelencsik, I., László, L., Flicker, H., Strain, L., Szirmai, I. & Budka, H., jún. 1 2001, In : Journal of Neurology Neurosurgery and Psychiatry. 70, 6, p. 802-805 4 p.

Research output: Article

16 Citations (Scopus)

Prominent stress response of Purkinje cells in Creutzfeldt-Jakob disease

Kovács, G. G., Kurucz, I., Budka, H., Ádori, C., Müller, F., Ács, P., Klöppel, S., Schätzl, H. M., Mayer, R. J. & László, L., jan. 1 2001, In : Neurobiology of Disease. 8, 5, p. 881-889 9 p.

Research output: Article

23 Citations (Scopus)

Receptor-like properties of the 26 kDa transmembrane form of TNF

Domonkos, Á., Udvardy, A., László, L., Nagy, T. & Duda, E., 2001, In : European Cytokine Network. 12, 3, p. 411-419 9 p.

Research output: Article

41 Citations (Scopus)
2000

Clinicopathological phenotype of codon 129 valine homozygote sporadic Creutzfeldt-Jakob disease

Kovacs, G. G., Head, M. W., Bunn, T., Laszlo, L., Will, R. G. & Ironside, J. W., okt. 30 2000, In : Neuropathology and Applied Neurobiology. 26, 5, p. 463-472 10 p.

Research output: Article

35 Citations (Scopus)
1999

Ultrastructural localization of Hsp-72 examined with a new polyclonal antibody raised against the truncated variable domain of the heat shock protein

Kurucz, I., Tombor, B., Prechl, J., Erdö, F., Hegedüs, E., Nagy, Z., Vitai, M., Korányi, L. & László, L., jún. 1999, In : Cell Stress and Chaperones. 4, 2, p. 139-152 14 p.

Research output: Article

41 Citations (Scopus)
1997

A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis

Schätzl, H. M., Laszlo, L., Holtzman, D. M., Tatzelt, J., Dearmond, S. J., Weiner, R. I., Mobley, W. C. & Prusiner, S. B., nov. 1 1997, In : Journal of Virology. 71, 11, p. 8821-8831 11 p.

Research output: Article

228 Citations (Scopus)

Ubiquitinated extracellular matrix proteins in insect cuticle

Löw, P., Borhegyi, N. H., Sass, M., László, L. & Reynolds, S. E., okt. 13 1997, In : Biochemical Society Transactions. 25, 3, p. 379S

Research output: Article

1996

Endosome-lysosomes, ubiquitin and neurodegeneration

Mayer, R. J., Tipler, C., Arnold, J., Laszlo, L., Al-Khedhairy, A., Lowe, J. & Landon, M., dec. 1 1996, In : Advances in experimental medicine and biology. 389, p. 261-269 9 p.

Research output: Article

35 Citations (Scopus)
25 Citations (Scopus)
1995

Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform

Taraboulos, A., Scott, M., Semenov, A., Avraham, D., Laszlo, L. & Prusiner, S. B., ápr. 1995, In : Journal of Cell Biology. 129, 1, p. 121-132 12 p.

Research output: Article

487 Citations (Scopus)

Related organelles of the endosome-lysosome system contain a different repertoire of ubiquitinated proteins in Sf9 insect cells

Löw, P., Doherty, F. J., Fellinger, E., Sass, M., John Mayer, R. & László, L., júl. 10 1995, In : FEBS letters. 368, 1, p. 125-131 7 p.

Research output: Article

10 Citations (Scopus)

The abnormal isoform of the prion protein accumulates in late‐endosome‐like organelles in scrapie‐infected mouse brain

Arnold, J. E., Tipler, C., Laszlo, L., Hope, J., Landon, M. & Mayer, R. J., aug. 1995, In : The Journal of Pathology. 176, 4, p. 403-411 9 p.

Research output: Article

141 Citations (Scopus)
1994

Endosome-lysosomes and neurodegeneration

Mayer, R. J., Tipler, C., Laszlo, L., Arnold, J., Lowe, J. & Landon, M., 1994, In : Biomedicine and Pharmacotherapy. 48, 7, p. 282-286 5 p.

Research output: Article

9 Citations (Scopus)

Is there a common intracellular bioreactor in which amyloid formation is initiated in neurodegenerative diseases?

Mayer, R. J., Landon, M., Lowe, J., Tipler, C., Arnold, J. & Laszlo, L., jan. 1 1994, In : Biochemical Society transactions. 22, 1, p. 151-155 5 p.

Research output: Article

1993
12 Citations (Scopus)
1992

A role for lysosomes in scrapie pathogenesis

Kenward, N., Laszlo, L., Landon, M., Fergusson, J., Lowe, J., McDermott, H., Hope, J., Brown, J. & Mayer, R. J., jan. 1 1992, In : Biochemical Society transactions. 20, 3, p. 265S

Research output: Article

4 Citations (Scopus)

Immunoreactivity to ubiquitin—protein conjugates is present early in the disease process in the brains of scrapie‐infected mice

Lowe, J., Fergusson, J., Kenward, N., Laszlo, L., Landon, M., Farquhar, C., Brown, J., Hope, J. & Mayer, R. J., okt. 1992, In : The Journal of Pathology. 168, 2, p. 169-177 9 p.

Research output: Article

35 Citations (Scopus)

Lysosomes as key organelles in the pathogenesis of prion encephalopathies

Laszlo, L., Lowe, J., Self, T., Kenward, N., Landon, M., McBride, T., Farquhar, C., McConnell, I., Brown, J., Hope, J. & Mayer, R. J., ápr. 1992, In : The Journal of Pathology. 166, 4, p. 333-341 9 p.

Research output: Article

144 Citations (Scopus)

Protein processing in lysosomes: the new therapeutic target in neurodegenerative disease

Mayer, R. J., Landon, M., Laszlo, L., Lowe, J. & Lennox, G., júl. 18 1992, In : The Lancet. 340, 8812, p. 156-159 4 p.

Research output: Article

42 Citations (Scopus)

Ubiquitin, Lysosomes, and Neurodegenerative Diseases

MAYER, R. JOHN., LASZLO, LAJOS., LANDON, MICHAEL., HOPE, JAMES. & LOWE, JAMES., dec. 1992, In : Annals of the New York Academy of Sciences. 674, 1, p. 149-160 12 p.

Research output: Article

10 Citations (Scopus)