• 3561 Citations
  • 25 h-Index
1991 …2019
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Research Output 1991 2019

  • 3561 Citations
  • 25 h-Index
  • 56 Article
  • 1 Chapter
  • 1 Review article
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Article
2019

Cellular expression and function of naturally occurring variants of the human ABCG2 multidrug transporter

Zámbó, B., Mózner, O., Bartos, Z., Török, G., Várady, G., Telbisz, Á., Homolya, L., Orbán, T. I. & Sarkadi, B., jan. 1 2019, In : Cellular and Molecular Life Sciences.

Research output: Article

Open Access
Hyperuricemia
Gout
Protein Folding
Xenobiotics
Drug-Related Side Effects and Adverse Reactions

En bloc release of MVB-like small extracellular vesicle clusters by colorectal carcinoma cells

Valcz, G., Búzás, E., Kittel, A., Krenács, T., Visnovitz, T., Spisák, S., Török, G., Homolya, L., Zsigrai, S., Kiszler, G., Antalffy, G., Pálóczi, K., Szállási, Z., Szabó, V., Sebestyén, A., Solymosi, N., Kalmár, A., Dede, K., Lőrincz, P., Tulassay, Z. & 2 others, Igaz, P. & Molnár, B., jan. 1 2019, In : Journal of Extracellular Vesicles. 8, 1, 1596668.

Research output: Article

Open Access
Multivesicular Bodies
Colorectal Neoplasms
Cell Membrane
Extracellular Vesicles
Exocytosis
2018
1 Citation (Scopus)

A new fluorescent dye accumulation assay for parallel measurements of the ABCG2, ABCB1 and ABCC1 multidrug transporter functions

Szabó, E., Türk, D., Telbisz, Á., Kucsma, N., Horváth, T., Szakács, G., Homolya, L., Sarkadi, B. & Várady, G., jan. 1 2018, In : PLoS One. 13, 1, e0190629.

Research output: Article

fluorescent dyes
Fluorescent Dyes
transporters
Assays
Fluorescence
2 Citations (Scopus)
Induced Pluripotent Stem Cells
Dentate Gyrus
Calcium
Neurons
Proteins
3 Citations (Scopus)

Clinically relevant mutations in the ABCG2 transporter uncovered by genetic analysis linked to erythrocyte membrane protein expression

Zámbó, B., Bartos, Z., Mózner, O., Szabó, E., Várady, G., Poór, G., Pálinkás, M., Andrikovics, H., Hegedűs, T., Homolya, L. & Sarkadi, B., dec. 1 2018, In : Scientific Reports. 8, 1, 7487.

Research output: Article

Erythrocyte Membrane
Membrane Proteins
Gout
Mutation
Precision Medicine

Enhancement of chicken primordial germ cell in vitro maintenance using an automated cell image analyser

Anand, M., Lázár, B., Tóth, R., Páll, E., Patakiné Várkonyi, E., Liptói, K., Homolya, L., Hegyi, Z., Hidas, A. & Gócza, E., dec. 1 2018, In : Acta Veterinaria Hungarica. 66, 4, p. 518-529 12 p.

Research output: Article

Germ Cells
Chickens
germ cells
Maintenance
chickens
1 Citation (Scopus)

Generation of multidrug resistant human tissues by overexpression of the ABCG2 multidrug transporter in embryonic stem cells

Erdei, Z., Schamberger, A., Török, G., Szebényi, K., Várady, G., Orbán, T. I., Homolya, L., Sarkadi, B. & Apáti, A., ápr. 1 2018, In : PLoS One. 13, 4, e0194925.

Research output: Article

embryonic stem cells
Embryonic Stem Cells
Stem cells
transporters
stem cells
2017
1 Citation (Scopus)

Ezrin interacts with S100A4 via both its N- and C-terminal domains

Biri-Kovács, B., Kiss, B., Vadászi, H., Gógl, G., Pálfy, G., Török, G., Homolya, L., Bodor, A. & Nyitray, L., máj. 1 2017, In : PLoS One. 12, 5, e0177489.

Research output: Article

metastasis
actin
kinetics
family relations
proteins
1 Citation (Scopus)

Functional shift with maintained regenerative potential following portal vein ligation

Kovács, T., Máthé, D., Fülöp, A., Jemnitz, K., Bátai-Konczos, A., Veres, Z., Török, G., Veres, D. S., Horváth, I., Szigeti, K., Homolya, L. & Szijártó, A., dec. 1 2017, In : Scientific Reports. 7, 1, 18065.

Research output: Article

Portal Vein
Ligation
Liver
Bilirubin
Hypertrophy
4 Citations (Scopus)

Histone deacetylase inhibitor treatment increases the expression of the plasma membrane Ca2+ pump PMCA4b and inhibits the migration of melanoma cells independent of ERK

Hegedüs, L., Padányi, R., Molnár, J., Pászty, K., Varga, K., Kenessey, I., Sárközy, E., Wolf, M., Grusch, M., Hegyi, Z., Homolya, L., Aigner, C., Garay, T., Hegedűs, B., Tímár, J., Kállay, E. & Enyedi, A., máj. 24 2017, In : Frontiers in Oncology. 7, MAY, 95.

Research output: Article

Histone Deacetylase Inhibitors
Calcium-Transporting ATPases
Cell Movement
Melanoma
Cell Membrane
1 Citation (Scopus)

Proteasome Subunit Beta Type 1 P11A Polymorphism Is a New Prognostic Marker in Multiple Myeloma

Varga, G., Mikala, G., Kiss, K. P., Kosóczki, É., Szabó, E., Meggyesi, N., Balassa, K., Kövy, P., Tegze, B., Szombath, G., Tordai, A., Andrikovics, H., Homolya, L. & Masszi, T., nov. 1 2017, In : Clinical Lymphoma, Myeloma and Leukemia. 17, 11, p. 734-742 9 p.

Research output: Article

Proteasome Endopeptidase Complex
Multiple Myeloma
Alleles
Disease-Free Survival
Genotype
2016
9 Citations (Scopus)

Application of fluorescent dye substrates for functional characterization of ABC multidrug transporters at a single cell level

Nerada, Z., Hegyi, Z., Szepesi, Á., Tóth, S., Hegedüs, C., Várady, G., Matula, Z., Homolya, L., Sarkadi, B. & Telbisz, Á., szept. 1 2016, In : Cytometry Part A. 89, 9, p. 826-834 9 p.

Research output: Article

ATP-Binding Cassette Transporters
Fluorescent Dyes
Coloring Agents
Poisons
Multiple Drug Resistance
5 Citations (Scopus)

Characterization of NF-κB reporter U937 cells and their application for the detection of inflammatory immune-complexes

Kecse-Nagy, C., Szittner, Z., Papp, K., Hegyi, Z., Rovero, P., Migliorini, P., Lóránd, V., Homolya, L. & Prechl, J., máj. 1 2016, In : PLoS One. 11, 5, e0156328.

Research output: Article

U937 Cells
antigen-antibody complex
Antigen-Antibody Complex
Immunoglobulin G
immunoglobulins
1 Citation (Scopus)
Cytochrome P-450 CYP2B1
Taurocholic Acid
Kupffer Cells
Coculture Techniques
Bilirubin
1 Citation (Scopus)
Drug Hypersensitivity
Pharmaceutical Preparations
Poisons
Prion Proteins
Prions
5 Citations (Scopus)

Functional cooperativity between ABCG4 and ABCG1 isoforms

Hegyi, Z. & Homolya, L., máj. 1 2016, In : PLoS One. 11, 5, e0156516.

Research output: Article

transporters
Protein Isoforms
Apoptosis
ATP-Binding Cassette Transporters
Dimerization
12 Citations (Scopus)
Drug interactions
Bile Acids and Salts
Drug Interactions
Pumps
Mutation
2015
2 Citations (Scopus)
Tight Junctions
Hepatocytes
MARVEL Domain Containing 2 Protein
Claudin-4
Agrin
8 Citations (Scopus)

Generation of a Homozygous Transgenic Rat Strain Stably Expressing a Calcium Sensor Protein for Direct Examination of Calcium Signaling

Szebenyi, K., Füredi, A., Kolacsek, O., Pergel, E., Bösze, Z., Bender, B., Vajdovich, P., Tóvári, J., Homolya, L., Szakács, G., Heja, L., Enyedi, A., Sarkadi, B., Apáti, A. & Orban, T. I., aug. 3 2015, In : Scientific Reports. 5, 12645.

Research output: Article

Transgenic Rats
Calcium Signaling
Calcium
Pharmacology
Proteins
10 Citations (Scopus)
Plasma Membrane Calcium-Transporting ATPases
Vitamins
Colonic Neoplasms
Protein Isoforms
Up-Regulation
2014
22 Citations (Scopus)

LKB1/AMPK and PKA Control ABCB11 trafficking and polarization in hepatocytes

Homolya, L., Fu, D., Sengupta, P., Jarnik, M., Gillet, J. P., Vitale-Cross, L., Gutkind, J. S., Lippincott-Schwartz, J. & Arias, I. M., márc. 18 2014, In : PLoS One. 9, 3, e91921.

Research output: Article

AMP-Activated Protein Kinases
hepatocytes
Hepatocytes
Polarization
Taurocholic Acid
2013
9 Citations (Scopus)

Resveratrol modulates ATPase activity of liposome-reconstituted ABCG1

De Athayde Moncorvo Collado, A., Corbalán, N., Homolya, L., Morero, R. & Minahk, C., aug. 2 2013, In : FEBS Letters. 587, 15, p. 2359-2363 5 p.

Research output: Article

Liposomes
Adenosine Triphosphatases
Peroxisome Proliferator-Activated Receptors
Polyphenols
Homeostasis
2012
23 Citations (Scopus)

Calcium signaling in pluripotent stem cells

Apáti, A., Pászty, K., Erdei, Z., Szebényi, K., Homolya, L. & Sarkadi, B., ápr. 28 2012, In : Molecular and Cellular Endocrinology. 353, 1-2, p. 57-67 11 p.

Research output: Article

Pluripotent Stem Cells
Calcium Signaling
Stem cells
Calcium
Mesenchymal Stromal Cells
2011
19 Citations (Scopus)
Mitoxantrone
Cell membranes
Cell Membrane
Lipid Bilayers
Extrusion
2010
43 Citations (Scopus)
Dendritic Cells
Monocytes
Ligands
Lipids
Gene Expression
23 Citations (Scopus)

Evaluation of ABCG2 expression in human embryonic stem cells: Crossing the same river twice?

Sarkadi, B., Orbán, T. I., Szakács, G., Várady, G., Schamberger, A., Erdei, Z., Szebényi, K., Homolya, L. & Apáti, A., jan. 2010, In : Stem Cells. 28, 1, p. 174-176 3 p.

Research output: Article

Neoplasm Proteins
Pluripotent Stem Cells
ATP-Binding Cassette Transporters
Embryonic Stem Cells
Reverse Transcriptase Polymerase Chain Reaction
2009
50 Citations (Scopus)

Applying a "double-feature" promoter to identify cardiomyocytes differentiated from human embryonic stem cells following transposon-based gene delivery

Orbán, T. I., Apáti, A., Németh, A., Varga, N., Krizsik, V., Schamberger, A., Szebényi, K., Erdei, Z., Várady, G., Karászi, É., Homolya, L., Német, K., Gócza, E., Miskey, C., Mátés, L., Ivics, Z., Izsvák, Z. & Sarkadi, B., máj. 2009, In : Stem Cells. 27, 5, p. 1077-1087 11 p.

Research output: Article

Cardiac Myocytes
Transgenes
Genes
Stem Cells
Phosphoglycerate Kinase
6 Citations (Scopus)

Effects of putative catalytic base mutation E211Q on ABCG2-mediated methotrexate transport

Hou, Y. X., Li, C. Z., Palaniyandi, K., Magtibay, P. M., Homolya, L., Sarkadi, B. & Chang, X. B., 2009, In : Biochemistry. 48, 38, p. 9122-9131 10 p.

Research output: Article

Methotrexate
Adenosine Triphosphate
Mutation
Membranes
Adenosine Triphosphatases
44 Citations (Scopus)

Ins and outs of the ABCG2 multidrug transporter: An update on in vitro functional assays

Hegedus, C., Szakács, G., Homolya, L., Orbán, T. I., Telbisz, Á., Jani, M. & Sarkadi, B., jan. 31 2009, In : Advanced Drug Delivery Reviews. 61, 1, p. 47-56 10 p.

Research output: Article

ATP-Binding Cassette Transporters
Drug Interactions
Proteins
Pharmacology
In Vitro Techniques
8 Citations (Scopus)
Systems Analysis
Cholesterol
ATP Binding Cassette Transporter 1
Cell Membrane
Brefeldin A
2008
14 Citations (Scopus)
Assays
Cells
Cytology
Pharmaceutical Preparations
Dimerization
17 Citations (Scopus)

Functional ABCG1 expression induces apoptosis in macrophages and other cell types

Seres, L., Cserepes, J., Elkind, N., Törőcsik, D., Nagy, L., Sarkadi, B. & Homolya, L., okt. 2008, In : BBA - Biomembranes. 1778, 10, p. 2378-2387 10 p.

Research output: Article

Macrophages
Apoptosis
Cell death
Cell Death
Chemical activation
62 Citations (Scopus)

High level functional expression of the ABCG2 multidrug transporter in undifferentiated human embryonic stem cells

Apáti, A., Orbán, T. I., Varga, N., Németh, A., Schamberger, A., Krizsik, V., Erdélyi-Belle, B., Homolya, L., Várady, G., Padányi, R., Karászi, É., Kemna, E. W. M., Német, K. & Sarkadi, B., dec. 2008, In : BBA - Biomembranes. 1778, 12, p. 2700-2709 10 p.

Research output: Article

Stem cells
ATP-Binding Cassette Transporters
Stem Cells
Mitoxantrone
Cytoprotection
2007
87 Citations (Scopus)
Human Activities
Cholesterol
Membranes
Sf9 Cells
Multiple Drug Resistance
102 Citations (Scopus)
Poisons
Glucuronic Acid
ATP-Binding Cassette Transporters
Leukotrienes
P-Glycoprotein
2006
479 Citations (Scopus)
ATP-Binding Cassette Transporters
Multiple Drug Resistance
Xenobiotics
Drug Resistance
Cell Physiological Phenomena
2005
187 Citations (Scopus)
Epidermal Growth Factor Receptor
Cell Death
Neoplasms
Receptor Protein-Tyrosine Kinases
ATP Binding Cassette Transporter, Sub-Family G, Member 2
21 Citations (Scopus)

The caspase-3 cleavage product of the plasma membrane Ca 2+-ATPase 4b is activated and appropriately targeted

Pászty, K., Antalffy, G., Penheiter, A. R., Homolya, L., Padányi, R., Iliás, A., Filoteo, A. G., Penniston, J. T. & Enyedi, A., nov. 1 2005, In : Biochemical Journal. 391, 3, p. 687-692 6 p.

Research output: Article

Cell membranes
Caspase 3
Adenosine Triphosphatases
Cell Membrane
Clone cells
2004
66 Citations (Scopus)

Functional expression and characterization of the human ABCG1 and ABCG4 proteins: Indications for heterodimerization

Cserepes, J., Szentpétery, Z., Seres, L., Özvegy-Laczka, C., Langmann, T., Schmitz, G., Glavinas, H., Klein, I., Homolya, L., Váradi, A., Sarkadi, B. & Elkind, N., júl. 30 2004, In : Biochemical and Biophysical Research Communications. 320, 3, p. 860-867 8 p.

Research output: Article

Adenosine Triphosphatases
Catalytic Domain
ATP-Binding Cassette Transporters
Dimerization
Sterols
2003
30 Citations (Scopus)

Application of a human multidrug transporter (ABCG2) variant as selectable marker in gene transfer to progenitor cells

Ujhelly, O., Özvegy-Laczka, C., Várady, G., Cervenak, J., Homolya, L., Grez, M., Scheffer, G., Roos, D., Bates, S. E., Váradi, A., Sarkadi, B. & Német, K., márc. 1 2003, In : Human Gene Therapy. 14, 4, p. 403-412 10 p.

Research output: Article

Stem Cells
Genetic Therapy
Mutant Proteins
Genes
Chronic Granulomatous Disease
70 Citations (Scopus)

C-terminal phosphorylation of MRP2 modulates its interaction with PDZ proteins

Hegedűs, T., Sessler, T., Scott, R., Thelin, W., Bakos, E., Váradi, A., Szabó, K., Homolya, L., Milgram, S. L. & Sarkadi, B., márc. 14 2003, In : Biochemical and Biophysical Research Communications. 302, 3, p. 454-461 8 p.

Research output: Article

Phosphorylation
Proteins
PDZ Domains
Carrier Proteins
Adenosine Triphosphate
140 Citations (Scopus)
Multidrug Resistance-Associated Proteins
Glucuronic Acid
Glutathione Disulfide
Sulfates
Glutathione
29 Citations (Scopus)

Subcellular localization and N-glycosylation of human ABCC6, expressed in MDCKII cells

Sinkó, E., Iliás, A., Ujhelly, O., Homolya, L., Scheffer, G. L., Bergen, A. A. B., Sarkadi, B. & Váradi, A., aug. 22 2003, In : Biochemical and Biophysical Research Communications. 308, 2, p. 263-269 7 p.

Research output: Article

Glycosylation
Proteolysis
Proteins
ATP-Binding Cassette Transporters
Rubber
2001
68 Citations (Scopus)

Calcein assay for multidrug resistance reliably predicts therapy response and survival rate in acute myeloid leukaemia

Karászi, É., Jakab, K., Homolya, L., Szakács, G., Holló, Z., Telek, B., Kiss, A., Rejtô, L., Nahajevszky, S., Sarkadi, B. & Kappelmayer, J., 2001, In : British Journal of Haematology. 112, 2, p. 308-314 7 p.

Research output: Article

Multiple Drug Resistance
Acute Myeloid Leukemia
Survival Rate
R Factors
Leukemia
2000
201 Citations (Scopus)

Cell to cell communication in response to mechanical stress via bilateral release of ATP and UTP in polarized epithelia

Homolya, L., Steinberg, T. H. & Boucher, R. C., szept. 18 2000, In : Journal of Cell Biology. 150, 6, p. 1349-1359 11 p.

Research output: Article

Uridine Triphosphate
Mechanical Stress
Cell Communication
Purinergic Receptors
Epithelium
1999
157 Citations (Scopus)

Effect of loss of P2Y2 receptor gene expression on nucleotide regulation of murine epithelial Cl- transport

Cressman, V. L., Lazarowski, E., Homolya, L., Boucher, R. C., Koller, B. H. & Grubb, B. R., szept. 10 1999, In : Journal of Biological Chemistry. 274, 37, p. 26461-26468 8 p.

Research output: Article

Purinergic P2Y2 Receptors
Gene expression
Ion Transport
Nucleotides
Gene Expression
106 Citations (Scopus)

Nucleotide-regulated calcium signaling in lung fibroblasts and epithelial cells from normal and P2Y2 receptor (-/-) mice

Homolya, L., Watt, W. C., Lazarowski, E. R., Koller, B. H. & Boucher, R. C., szept. 10 1999, In : Journal of Biological Chemistry. 274, 37, p. 26454-26460 7 p.

Research output: Article

Purinergic P2Y2 Receptors
Calcium Signaling
Fibroblasts
Nucleotides
Epithelial Cells
1998
22 Citations (Scopus)
P-Glycoproteins
P-Glycoprotein
Fluorescent Antibody Technique
Multidrug Resistance-Associated Proteins
Fluorometry
1997
248 Citations (Scopus)

Direct demonstration of mechanically induced release of cellular UTP and its implication for uridine nucleotide receptor activation

Lazarowski, E. R., Homolya, L., Boucher, R. C. & Harden, T. K., szept. 26 1997, In : Journal of Biological Chemistry. 272, 39, p. 24348-24354 7 p.

Research output: Article

Uridine Triphosphate
Demonstrations
Chemical activation
Nucleotides
Adenosine Triphosphate
101 Citations (Scopus)

Identification of an ecto-nucleoside diphosphokinase and its contribution to interconversion of P2 receptor agonists

Lazarowski, E. R., Homolya, L., Boucher, R. C. & Harden, T. K., aug. 15 1997, In : Journal of Biological Chemistry. 272, 33, p. 20402-20407 6 p.

Research output: Article

Nucleoside-Diphosphate Kinase
Uridine Diphosphate
Uridine Triphosphate
Nucleotides
Adenosine Triphosphate