• 1549 Citations
  • 22 h-Index
19982019
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Research Output 1998 2019

  • 1549 Citations
  • 22 h-Index
  • 56 Article
  • 1 Review article
2019
4 Citations (Scopus)
Open Access
Cell-Penetrating Peptides
Tight Junctions
Permeability
Cell Membrane
Claudin-4
Open Access
Neuronal Plasticity
Amyloid beta-Protein Precursor
plastic properties
Transgenic Mice
Plasticity
4 Citations (Scopus)

Key Peptides and Proteins in Alzheimer's Disease

Penke, B., Bogár, F., Paragi, G., Gera, J. & Fülöp, L., jan. 1 2019, In : Current protein & peptide science. 20, 6, p. 577-599 23 p.

Research output: Article

Alzheimer Disease
Peptides
Amyloid beta-Protein Precursor
Poisons
Proteins
4 Citations (Scopus)

Mechanisms Associated with Type 2 Diabetes as a Risk Factor for Alzheimer-Related Pathology

Su, M., Naderi, K., Samson, N., Youssef, I., Fülöp, L., Bozsó, Z., Laroche, S., Delatour, B. & Davis, S., jan. 1 2019, (Accepted/In press) In : Molecular Neurobiology.

Research output: Article

Type 2 Diabetes Mellitus
Memory Disorders
Pathology
Alzheimer Disease
Phosphatidylinositol 3-Kinases
2018
3 Citations (Scopus)

Exceptional in vivo catabolism of neurodegeneration-related aggregates

Datki, Z., Olah, Z., Hortobágyi, T., Macsai, L., Zsuga, K., Fülöp, L., Bozsó, Z., Galik, B., Ács, E., Foldi, A., Szarvas, A. & Kálmán, J., jan. 1 2018, In : Zoological Letters. 4, 1, 6.

Research output: Article

protein aggregates
Rotifera
metabolism
neurodegenerative diseases
prions
2 Citations (Scopus)

GABAA receptor subunit deregulation in the hippocampus of human foetuses with Down syndrome

Milenkovic, I., Stojanovic, T., Aronica, E., Fülöp, L., Bozsó, Z., Máté, Z., Yanagawa, Y., Adle-Biassette, H., Lubec, G., Szabó, G., Harkany, T., Kovács, G. G. & Keimpema, E., ápr. 1 2018, In : Brain Structure and Function. 223, 3, p. 1501-1518 18 p.

Research output: Article

GABA-A Receptors
Down Syndrome
Hippocampus
Fetus
Amyloid
7 Citations (Scopus)

Niosomes decorated with dual ligands targeting brain endothelial transporters increase cargo penetration across the blood-brain barrier

Mészáros, M., Porkoláb, G., Kiss, L., Pilbat, A. M., Kóta, Z., Kupihár, Z., Kéri, A., Galbács, G., Siklós, L., Tóth, A., Fülöp, L., Csete, M., Sipos, Á., Hülper, P., Sipos, P., Páli, T., Rákhely, G., Szabó-Révész, P., Deli, M. A. & Veszelka, S., okt. 15 2018, In : European Journal of Pharmaceutical Sciences. 123, p. 228-240 13 p.

Research output: Article

Blood-Brain Barrier
Liposomes
Ligands
Brain
Endothelial Cells

Peripheral cyclic β-amino acids balance the stability and edge-protection of β-sandwiches

Olajos, G., Hetényi, A., Wéber, E., Szögi, T., Fülöp, L. & Martinek, T., jan. 1 2018, In : Organic and Biomolecular Chemistry. 16, 30, p. 5492-5499 8 p.

Research output: Article

Cyclic Amino Acids
strands
amino acids
sandwich structures
Temperature
2 Citations (Scopus)

Searching for improved mimetic peptides inhibitors preventing conformational transition of amyloid-β42 monomer

Gera, J., Szögi, T., Bozsó, Z., Fülöp, L., Barrera, E. E., Rodriguez, A. M., Méndez, L., Delpiccolo, C. M. L., Mata, E. G., Cioffi, F., Broersen, K., Paragi, G. & Enriz, R. D., dec. 1 2018, In : Bioorganic Chemistry. 81, p. 211-221 11 p.

Research output: Article

Molecular Dynamics Simulation
Amyloid
Alzheimer Disease
Agglomeration
Monomers
2 Citations (Scopus)

Structural optimization of foldamer-dendrimer conjugates as multivalent agents against the toxic effects of amyloid beta oligomers

Bartus, É., Olajos, G., Schuster, I., Bozsó, Z., Deli, M. A., Veszelka, S., Walter, F. R., Datki, Z., Szakonyi, Z., Martinek, T. & Fülöp, L., okt. 2 2018, In : Molecules. 23, 10, 2523.

Research output: Article

Dendrimers
Structural optimization
Poisons
dendrimers
oligomers
20 Citations (Scopus)
Neurodegenerative Diseases
Endoplasmic Reticulum
Unfolded Protein Response
Mitochondria
Proteins
2017
3 Citations (Scopus)

Biotin and glutathione targeting of solid nanoparticles to cross human brain endothelial cells

Veszelka, S., Mészáros, M., Kiss, L., Kóta, Z., Páli, T., Hoyk, Z., Bozsó, Z., Fülöp, L., Tóth, A., Rákhely, G. & Deli, M. A., aug. 1 2017, In : Current Pharmaceutical Design. 23, 28, p. 4198-4205 8 p.

Research output: Article

Biotin
Nanoparticles
Glutathione
Endothelial Cells
Brain
15 Citations (Scopus)

Studies for improving a rat model of Alzheimer's disease: ICV administration of well-characterized β-amyloid 1-42 oligomers induce dysfunction in spatial memory

Kasza, Á., Penke, B., Frank, Z., Bozsó, Z., Szegedi, V., Hunya, Á., Németh, K., Kozma, G. & Fülöp, L., nov. 1 2017, In : Molecules. 22, 11, 2007.

Research output: Article

oligomers
Oligomers
Amyloid
rats
Rats
2016
9 Citations (Scopus)

New small-size peptides modulators of the exosite of BACE1 obtained from a structure-based design

Gutierrez, L. J., Angelina, E., Gyebrovszki, A., Fülöp, L., Peruchena, N., Baldoni, H. A., Penke, B. & Enriz, R. D., febr. 24 2016, (Accepted/In press) In : Journal of Biomolecular Structure and Dynamics. p. 1-14 14 p.

Research output: Article

Peptides
Quantum Theory
Gases
Enzymes
20 Citations (Scopus)
Neurodegenerative diseases
Protein folding
Mitochondria
Endoplasmic Reticulum Stress
Protein Folding
31 Citations (Scopus)

Reversible Opening of Intercellular Junctions of Intestinal Epithelial and Brain Endothelial Cells with Tight Junction Modulator Peptides

Bocsik, A., Walter, F. R., Gyebrovszki, A., Fülöp, L., Blasig, I., Dabrowski, S., Ötvös, F., Tóth, A., Rákhely, G., Veszelka, S., Vastag, M., Szabó-Révész, P. & Deli, M., febr. 1 2016, In : Journal of Pharmaceutical Sciences. 105, 2, p. 754-765 12 p.

Research output: Article

Intercellular Junctions
Tight Junctions
Claudin-5
Endothelial Cells
Occludin
2015
11 Citations (Scopus)
Long-Term Potentiation
Information Storage and Retrieval
Alzheimer Disease
Perforant Pathway
amyloid beta-protein (1-42)
5 Citations (Scopus)

Amyloid-like fibril formation by trypsin in aqueous ethanol. inhibition of fibrillation by PEG

Kotormán, M., Simon, L. M., Borics, A., Szabó, M. R., Szabó, K., Szögi, T. & Fülöp, L., dec. 1 2015, In : Protein and Peptide Letters. 22, 12, p. 1104-1110 7 p.

Research output: Article

Amyloid
Trypsin
Ethanol
Congo Red
Agglomeration
23 Citations (Scopus)
Neuronal Plasticity
Recycling
Amyloid
Synapses
Glutamic Acid
2 Citations (Scopus)

Opposite effect of Ca2+/Mg2+ ions on the aggregation of native and precursor-derived Aβ42

Bogár, F., Simon, D., Bozsó, Z., Janáky, T., Veszelka, S., Tóth, A. E., Deli, M., Borics, A., Násztor, Z., Gyebrovszki, A., Penke, B. & Fülöp, L., szept. 12 2015, In : Structural Chemistry. 26, 5-6, p. 1389-1403 15 p.

Research output: Article

Agglomeration
Ions
peptides
metal ions
preparation
2014
13 Citations (Scopus)
AMPA Receptors
N-Methyl-D-Aspartate Receptors
Neuropharmacology
6-Cyano-7-nitroquinoxaline-2,3-dione
Glutamate Receptors
23 Citations (Scopus)
Oligomers
Peptides
Stabilization
Carboxylic Acids
Transmission Electron Microscopy
19 Citations (Scopus)

IKKβ deficiency in myeloid cells ameliorates Alzheimer's disease-related symptoms and pathology

Liu, Y., Liu, X., Hao, W., Decker, Y., Schomburg, R., Fülöp, L., Pasparakis, M., Menger, M. D. & Fassbender, K., szept. 24 2014, In : Journal of Neuroscience. 34, 39, p. 12982-12999 18 p.

Research output: Article

Myeloid Cells
Alzheimer Disease
Pathology
Microglia
Innate Immunity
12 Citations (Scopus)
Dendritic Spines
Rats
Brain
Spine
Data storage equipment
2013
22 Citations (Scopus)
Complement Receptors
Rheumatoid Arthritis
B-Lymphocytes
Complement 3d Receptors
Tissue Donors
37 Citations (Scopus)

Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer's disease

Zilberter, M., Ivanov, A., Ziyatdinova, S., Mukhtarov, M., Malkov, A., Alpár, A., Tortoriello, G., Botting, C. H., Fülöp, L., Osypov, A. A., Pitkänen, A., Tanila, H., Harkany, T. & Zilberter, Y., ápr. 2013, In : Journal of Neurochemistry. 125, 1, p. 157-171 15 p.

Research output: Article

Alzheimer Disease
Energy Metabolism
Transgenic Mice
Nutrition
Diet
34 Citations (Scopus)

Docosahexaenoic acid reduces amyloid-β induced toxicity in cells of the neurovascular unit

Veszelka, S., Tóth, A. E., Walter, F. R., Datki, Z., Mózes, E., Fülöp, L., Bozsó, Z., Hellinger, É., Vastag, M., Orsolits, B., Környei, Z., Penke, B. & Deli, M., 2013, In : Journal of Alzheimer's Disease. 36, 3, p. 487-501 15 p.

Research output: Article

Docosahexaenoic Acids
Amyloid
Endothelial Cells
Brain
Pericytes
2012
31 Citations (Scopus)

A foldamer-dendrimer conjugate neutralizes synaptotoxic β-amyloid oligomers

Fülöp, L., Mándity, I., Juhász, G., Szegedi, V., Hetényi, A., Wéber, E., Bozsó, Z., Simon, D., Benko, M., Király, Z. & Martinek, T., júl. 30 2012, In : PLoS One. 7, 7, e39485.

Research output: Article

Dendrimers
amyloid
Oligomers
Amyloid
biomimetics
7 Citations (Scopus)

Conformational dynamics of titin PEVK explored with FRET spectroscopy

Huber, T., Grama, L., Hetényi, C., Schay, G., Fülöp, L., Penke, B. & Kellermayer, M., okt. 3 2012, In : Biophysical Journal. 103, 7, p. 1480-1489 10 p.

Research output: Article

Connectin
Fluorescence Resonance Energy Transfer
Spectrum Analysis
Peptides
Polymers
29 Citations (Scopus)
Chelating Agents
Histidine
Peptides
Metals
Amyloid
9 Citations (Scopus)

The formation of amyloid-like fibrils of αchymotrypsin in different aqueous organic solvents

Simon, L. M., Laczkó, I., Demcsák, A., Tóth, D., Kotormán, M. & Fülöp, L., máj. 2012, In : Protein and Peptide Letters. 19, 5, p. 544-550 7 p.

Research output: Article

Chymotrypsin
Amyloid
Organic solvents
Congo Red
Dimethylformamide
2011
19 Citations (Scopus)

Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation

Virók, D., Simon, D., Bozsó, Z., Rajkó, R., Datki, Z., Bálint, É., Szegedi, V., Janáky, T., Penke, B. & Fülöp, L., ápr. 1 2011, In : Journal of Proteome Research. 10, 4, p. 1538-1547 10 p.

Research output: Article

Protein Array Analysis
Protein Biosynthesis
Amyloid
Proteins
Toxicity
2010
51 Citations (Scopus)
Carboxylic Acids
Polymorphism
helices
Self assembly
folding
35 Citations (Scopus)

Controlled in situ preparation of Aβ(1-42) oligomers from the isopeptide "iso-Aβ(1-42)", physicochemical and biological characterization

Bozsó, Z., Penke, B., Simon, D., Laczkó, I., Juhász, G., Szegedi, V., Kasza, Á., Soós, K., Hetényi, A., Wéber, E., Tóháti, H., Csete, M., Zarándi, M. & Fülöp, L., febr. 2010, In : Peptides. 31, 2, p. 248-256 9 p.

Research output: Article

Oligomers
Agglomeration
Peptides
Solubility
Rats
2 Citations (Scopus)

Effect of nanogold particles on coupled plasmon resonance on biomolecule covered prepatterned multilayers

Sipos, Á., Tóháti, H., Mathesz, A., Szalai, A., Budai, J., Deli, M., Fülöp, L., Köházi-Kis, A., Csete, M. & Bor, Z., jún. 2010, In : Sensor Letters. 8, 3, p. 512-520 9 p.

Research output: Article

Biomolecules
Multilayers
Gold
Surface plasmon resonance
Full width at half maximum
13 Citations (Scopus)

Fibrillar Aβ1-42 enhances NMDA receptor sensitivity via the integrin signaling pathway

Uhász, G. J., Barkóczi, B., Vass, G., Datki, Z., Hunya, Á., Fülöp, L., Budai, D., Penke, B. & Szegedi, V., 2010, In : Journal of Alzheimer's Disease. 19, 3, p. 1055-1067 13 p.

Research output: Article

N-Methylaspartate
Integrins
src-Family Kinases
Blocking Antibodies
Electrophysiology
97 Citations (Scopus)
Peptide Fragments
cysteine
Amyloid
Gold
Nanoparticles
22 Citations (Scopus)

Intranasal delivery of human β-amyloid peptide in rats: Effective brain targeting

Sipos, E., Kurunczi, A., Fehér, A., Penke, Z., Fülöp, L., Kasza, Á., Horváth, J., Horvát, S., Veszelka, S., Balogh, G., Kürti, L., Erös, I., Szabó-Révész, P., Párducz, A., Penke, B. & Deli, M., ápr. 2010, In : Cellular and Molecular Neurobiology. 30, 3, p. 405-413 9 p.

Research output: Article

Amyloid
Peptides
Olfactory Bulb
Brain
Nose
15 Citations (Scopus)

Protection of the blood-brain barrier by pentosan against amyloid-β-induced toxicity

Deli, M., Veszelka, S., Csiszár, B., Tóth, A., Kittel, A., Csete, M., Sipos, Á., Szalai, A., Fülöp, L., Penke, B., Ábrahám, C. & Niwa, M., 2010, In : Journal of Alzheimer's Disease. 22, 3, p. 777-794 18 p.

Research output: Article

Blood-Brain Barrier
Amyloid
Endothelial Cells
Brain
Poisons
31 Citations (Scopus)
Chelating Agents
Amyloid
Derivatives
Metal ions
Metals
2009
312 Citations (Scopus)

Amyloid β-induced neuronal hyperexcitability triggers progressive epilepsy

Minkeviciene, R., Rheims, S., Dobszay, M. B., Zilberter, M., Hartikainen, J., Fülöp, L., Penke, B., Zilberter, Y., Harkany, T., Pitkänen, A. & Tanila, H., márc. 18 2009, In : Journal of Neuroscience. 29, 11, p. 3453-3462 10 p.

Research output: Article

Amyloid
Epilepsy
Seizures
Pyramidal Cells
Baths
16 Citations (Scopus)
Alzheimer Disease
Hippocampal CA1 Region
Serum Amyloid A Protein
Iontophoresis
Tritium
2008
15 Citations (Scopus)
Agglomeration
Serum Amyloid A Protein
Peptides
Conformations
Infrared radiation
21 Citations (Scopus)

Characterization of the interaction between Aβ 1-42 and glyceraldehyde phosphodehydrogenase

Verdier, Y., Földi, I., Sergeant, N., Fülöp, L., Penke, Z., Janáky, T., Szücs, M. & Penke, B., jún. 2008, In : Journal of Peptide Science. 14, 6, p. 755-762 8 p.

Research output: Article

Glyceraldehyde
Proteins
Subcellular Fractions
Proteoglycans
Mitochondria
5 Citations (Scopus)
Flocculation
Crosslinking
Ligands
Nuclear magnetic resonance
Peptidomimetics
2007
39 Citations (Scopus)

Synthesis of Aβ(1-42) and its derivatives with improved efficiency

Zarándi, M., Soós, K., Fülöp, L., Bozsó, Z., Datki, Z., Tóth, G. & Penke, B., febr. 2007, In : Journal of Peptide Science. 13, 2, p. 94-99 6 p.

Research output: Article

Derivatives
Synthetic Chemistry Techniques
Dimethylformamide
Peptides
Solid-Phase Synthesis Techniques
2006
98 Citations (Scopus)
Cycloleucine
Self assembly
Peptides
NSC 153174
Molecular modeling
20 Citations (Scopus)

Endomorphin-2, an endogenous tetrapeptide, protects against Abeta1-42 in vitro and in vivo.

Szegedi, V., Juhá, G., Rózsa, É., Juhász-Vedres, G., Datki, Z., Fülöp, L., Bozsó, Z., Lakatos, A., Laczkó, I., Farkas, T., Kis, Z., Tóth, G., Soós, K., Zarándi, M., Budai, D., Toldi, J. & Penke, B., jún. 2006, In : FASEB Journal. 20, 8, p. 1191-1193 3 p.

Research output: Article

mu Opioid Receptor
glycyl-glycyl-glycyl-glycine
Assays
Alzheimer Disease
Ala(2)-MePhe(4)-Gly(5)-enkephalin
61 Citations (Scopus)

Non-fibrillar β-amyloid abates spike-timing-dependent synaptic potentiation at excitatory synapses in layer 2/3 of the neocortex by targeting postsynaptic AMPA receptors

Shemer, I., Holmgren, C., Min, R., Fülöp, L., Zilberter, M., Sousa, K. M., Farkas, T., Härtig, W., Penke, B., Burnashev, N., Tanila, H., Zilberter, Y. & Harkany, T., ápr. 2006, In : European Journal of Neuroscience. 23, 8, p. 2035-2047 13 p.

Research output: Article

AMPA Receptors
Pyramidal Cells
Neocortex
Amyloidogenic Proteins
Amyloid
86 Citations (Scopus)
Self assembly
Peptides
Membranes
Biopolymers