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1978 …2019
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Research Output 1978 2019

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Article
Article
232 Citations (Scopus)

Activation of complement by therapeutic liposomes and other lipid excipient-based therapeutic products: Prediction and prevention

Szebeni, J., Muggia, F., Gabizon, A. & Barenholz, Y., szept. 16 2011, In : Advanced Drug Delivery Reviews. 63, 12, p. 1020-1030 11 p.

Research output: Article

Complement Activation
Excipients
Liposomes
Lipids
Nanomedicine
40 Citations (Scopus)

Activation of the human complement system by cholesterol-rich and PEGylated liposomes - Modulation of cholesterol-rich liposome-mediated complement activation by elevated serum LDL and HDL levels

Moghimi, S. M., Hamad, I., Bünger, R., Andresen, T. L., Jørgensen, K., Hunter, A. C., Baranji, L., Rosivall, L. & Szebeni, J., szept. 1 2006, In : Journal of Liposome Research. 16, 3, p. 167-174 8 p.

Research output: Article

Complement Activation
Liposomes
Cholesterol
Serum
Ethylene Glycol
4 Citations (Scopus)

Acute physiological changes caused by complement activators and amphotericin b-containing liposomes in mice

Őrfi, E., Mészáros, T., Hennies, M., Fülöp, T., Dézsi, L., Nardocci, A., Rosivall, L., Hamar, P., Neun, B. W., Dobrovolskaia, M. A., Szebeni, J. & Szénási, G., jan. 1 2019, In : International journal of nanomedicine. 14, p. 1563-1573 11 p.

Research output: Article

Open Access
Liposomes
Amphotericin B
Chemical activation
Cholesterol
Phospholipids
4 Citations (Scopus)
ammonium sulfates
Liposomes
Ammonium Sulfate
Agglomeration
glycols
6 Citations (Scopus)

Animal models for analysis of immunological responses to nanomaterials: Challenges and considerations

Zamboni, W. C., Szebeni, J., Kozlov, S. V., Lucas, A. T., Piscitelli, J. A. & Dobrovolskaia, M. A., jan. 1 2018, (Accepted/In press) In : Advanced Drug Delivery Reviews.

Research output: Article

Nanotechnology
Nanostructures
Animal Models
Nanoparticles
Immune System
124 Citations (Scopus)

Animal models of complement-mediated hypersensitivity reactions to liposomes and other lipid-based nanoparticles

Szebeni, J., Alving, C. R., Rosivall, L., Bünger, R., Baranyi, L., Bedöcs, P., Tóth, M. & Barenholz, Y., ápr. 2007, In : Journal of Liposome Research. 17, 2, p. 107-117 11 p.

Research output: Article

Liposomes
Nanoparticles
Hypersensitivity
Swine
Animal Models
4 Citations (Scopus)

Anticoagulants influence the performance of in vitro assays intended for characterization of nanotechnology-based formulations

Cedrone, E., Neun, B. W., Rodriguez, J., Vermilya, A., Clogston, J. D., McNeil, S. E., Barenholz, Y., Szebeni, J. & Dobrovolskaia, M. A., jan. 1 2018, In : Molecules. 23, 1, 12.

Research output: Article

anticoagulants
Nanotechnology
nanotechnology
Anticoagulants
Assays
69 Citations (Scopus)

A porcine model of complement-mediated infusion reactions to drug carrier nanosystems and other medicines

Szebeni, J., Bedocs, P., Csukás, D., Rosivall, L., Bünger, R. & Urbanics, R., dec. 2012, In : Advanced Drug Delivery Reviews. 64, 15, p. 1706-1716 11 p.

Research output: Article

Drug Carriers
Swine
Pharmaceutical Preparations
Hypersensitivity
Anaphylatoxins
5 Citations (Scopus)

Blood cell changes in complement activation-related pseudoallergy

Patkó, Z. & Szebeni, J., jún. 1 2015, In : European Journal of Nanomedicine. 7, 3, p. 233-244 12 p.

Research output: Article

Anaphylatoxins
blood cells
Complement Activation
Leukocytosis
Platelet Activation
61 Citations (Scopus)

Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes

Wibroe, P. P., Anselmo, A. C., Nilsson, P. H., Sarode, A., Gupta, V., Urbanics, R., Szebeni, J., Hunter, A. C., Mitragotri, S., Mollnes, T. E. & Moghimi, S. M., jún. 6 2017, In : Nature Nanotechnology. 12, 6, p. 589-594 6 p.

Research output: Article

macrophages
Macrophages
erythrocytes
attachment
swine
Interleukin-2
B-Lymphocytes
T-Lymphocytes
Gene Expression
Messenger RNA
85 Citations (Scopus)
Poloxamer
Complement Activation
Lipoproteins
Serum
Complement C3-C5 Convertases
9 Citations (Scopus)

Cerebrovascular involvement in liposome-induced cardiopulmonary distress in pigs

Bodo, M., Szebeni, J., Baranyi, L., Savay, S., Pearce, F. J., Alving, C. R. & Bünger, R., 2005, In : Journal of Liposome Research. 15, 1-2, p. 3-14 12 p.

Research output: Article

Liposomes
Swine
Complement Activation
Bradycardia
Electric Impedance
8 Citations (Scopus)

Comparative in vitro properties and clinical pharmacokinetics of paclitaxel following the administration of taxol® and paxene®

Scripture, C. D., Szebeni, J., Loos, W. J., Figg, W. D. & Sparreboom, A., máj. 2005, In : Cancer Biology and Therapy. 4, 5, p. 555-560 6 p.

Research output: Article

Paclitaxel
Pharmacokinetics
Micelles
In Vitro Techniques
Surface Tension
27 Citations (Scopus)
Sus scrofa
Complement Activation
Toxicity
Chemical activation
Swine
11 Citations (Scopus)

Comparison of the effects of a 50% exchange-transfusion with albumin, hetastarch, and modified hemoglobin solutions

Lieberthal, W., Fuhro, R., Alam, H., Rhee, P., Szebeni, J., Hechtman, H. B., Favuzza, J., Veech, R. L. & Valeri, C. R., jan. 2002, In : Shock. 17, 1, p. 61-69 9 p.

Research output: Article

Hydroxyethyl Starch Derivatives
Albumins
Hemoglobins
Raffinose
Serum Albumin
9 Citations (Scopus)
Mitobronitol
Busulfan
B-Lymphocytes
Homologous Transplantation
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
14 Citations (Scopus)
Complement Receptors
Liposomes
Complement Activation
Thromboxanes
Hemoglobin
42 Citations (Scopus)
Therapeutic Equivalency
Complement Activation
Liposomes
Chemical activation
Pharmaceutical Preparations
271 Citations (Scopus)
Complement Activation
Paclitaxel
Hypersensitivity
Ethanol
Complement Receptors
17 Citations (Scopus)
Liposomes
Complement Activation
Hemoglobin
Endotoxins
Hemoglobins
36 Citations (Scopus)

Complement activation by PEGylated liposomes containing prednisolone

Van Den Hoven, J. M., Nemes, R., Metselaar, J. M., Nuijen, B., Beijnen, J. H., Storm, G. & Szebeni, J., máj. 13 2013, In : European Journal of Pharmaceutical Sciences. 49, 2, p. 265-271 7 p.

Research output: Article

Complement Activation
Prednisolone
Liposomes
Hypersensitivity
Cholesterol
115 Citations (Scopus)

Complement activation by polyethoxylated pharmaceutical surfactants: Cremophor-EL, tween-80 and tween-20

Weiszhár, Z., Czúcz, J., Révész, C., Rosivall, L., Szebeni, J. & Rozsnyay, Z., márc. 12 2012, In : European Journal of Pharmaceutical Sciences. 45, 4, p. 492-498 7 p.

Research output: Article

Polysorbates
Complement Activation
Surface-Active Agents
docetaxel
Pharmaceutical Preparations
132 Citations (Scopus)

Complement activation cascade triggered by PEG-PL engineered nanomedicines and carbon nanotubes: The challenges ahead

Moghimi, S. M., Andersen, A. J., Hashemi, S. H., Lettiero, B., Ahmadvand, D., Hunter, A. C., Andresen, T. L., Hamad, I. & Szebeni, J., szept. 2010, In : Journal of Controlled Release. 146, 2, p. 175-181 7 p.

Research output: Article

Nanomedicine
Carbon Nanotubes
Ethylene Glycol
Complement Activation
Phospholipids
46 Citations (Scopus)

Complement activation during hemorrhagic shock and resuscitation in swine.

Szebeni, J., Baranyi, L., Savay, S., Götze, O., Alving, C. R., Bünger, R. & Mongan, P. D., okt. 2003, In : Shock. 20, 4, p. 347-355 9 p.

Research output: Article

Hemorrhagic Shock
Complement Activation
Resuscitation
Swine
Lactic Acidosis
272 Citations (Scopus)

Complement activation following first exposure to pegylated liposomal doxorubicin (Doxil®): Possible role in hypersensitivity reactions

Chanan-Khan, A., Szebeni, J., Savay, S., Liebes, L., Rafique, N. M., Alving, C. R. & Muggia, F. M., szept. 1 2003, In : Annals of Oncology. 14, 9, p. 1430-1437 8 p.

Research output: Article

Complement Activation
Hypersensitivity
Immediate Hypersensitivity
Immunoglobulin E
liposomal doxorubicin
34 Citations (Scopus)

Complement activation in human serum by liposome-encapsulated hemoglobin: The role of natural anti-phospholipid antibodies

Szebeni, J., Wassef, N. M., Rudolph, A. S. & Alving, C. R., dec. 4 1996, In : BBA - Biomembranes. 1285, 2, p. 127-130 4 p.

Research output: Article

Complement Activation
Liposomes
Anti-Idiotypic Antibodies
Phospholipids
Hemoglobins
53 Citations (Scopus)
Complement Activation
Liposomes
Rats
Anti-Idiotypic Antibodies
Hemoglobins
9 Citations (Scopus)
Complement Activation
Nanoparticles
Swine
Molecular Weight
ferumoxides
40 Citations (Scopus)

Complement activation in vitro by the red cell substitute, liposome- encapsulated hemoglobin: Mechanism of activation and inhibition by soluble complement receptor type 1

Szebeni, J., Wassef, N. M., Hartman, K. R., Rudolph, A. S. & Alving, C. R., febr. 1997, In : Transfusion. 37, 2, p. 150-159 10 p.

Research output: Article

Blood Substitutes
Complement Receptors
Complement Activation
Liposomes
Hemoglobins
74 Citations (Scopus)
Anaphylatoxins
Complement Activation
Anaphylaxis
Liposomes
Adenosine
Open Access
Complement Activation
Liposomes
complement
rats
Rats
382 Citations (Scopus)
Complement Activation
Toxicity
Chemical activation
Hypersensitivity
Pharmaceutical Preparations
Nanomedicine
Medical nanotechnology
Complement Activation
complement
blood
110 Citations (Scopus)
Nanomedicine
Complement Activation
Hypersensitivity
Anaphylatoxins
Mast Cells
Nanomedicine
Medical nanotechnology
Complement Activation
viruses
Viruses
24 Citations (Scopus)
Drug Carriers
Complement Activation
Lipoproteins
Poloxamer
Micelles
96 Citations (Scopus)
Drug Carriers
Complement Activation
Liposomes
Contrast Media
Anaphylatoxins

Complement consumption, hemolysis and thromboxane secretion following injection of hemoglobin-containing liposomes in rats

Szebeni, J., Wassef, N., Spielberg, H. H., Matyas, G., Cliff, R. O., Rudolph, A. S. & Alving, C. R., nov. 1994, In : Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 22, 5

Research output: Article

Liposomes
Thromboxanes
Hemoglobin
Hemolysis
Rats
11 Citations (Scopus)

Complement-Dependent Shock and Tissue Damage Induced by Intravenous Injection of Cholesterol-Enriched Liposomes in Rats

Baranyi, L., Szebeni, J., Sávay, S., Bodo, M., Basta, M., Bentley, T. B., Bunger, R. & Alving, C. R., jún. 2003, In : Journal of Applied Research. 3, 3, p. 221-231 11 p.

Research output: Article

Liposomes
Intravenous Injections
Shock
Cholesterol Embolism
Cholesterol
21 Citations (Scopus)
Liposomes
Hemoglobin
Hemoglobins
Blood substitutes
Blood Substitutes
15 Citations (Scopus)

Dextran-coated superparamagnetic iron oxide nanoparticles for magnetic resonance imaging: Evaluation of size-dependent imaging properties, storage stability and safety

Unterweger, H., Dézsi, L., Matuszak, J., Janko, C., Poettler, M., Jordan, J., Bäuerle, T., Szebeni, J., Fey, T., Boccaccini, A. R., Alexiou, C. & Cicha, I., márc. 28 2018, In : International Journal of Nanomedicine. 13, p. 1899-1915 17 p.

Research output: Article

Dextran
Magnetic resonance
Iron oxides
Nanoparticles
Contrast Media
8 Citations (Scopus)
Zalcitabine
Deoxycytidine
HIV-2
Dipyridamole
Zidovudine
8 Citations (Scopus)
Plasma (human)
Tissue culture
Dipyridamole
Culture Media
Carrier Proteins
2 Citations (Scopus)

Dipyridamole potentiates the activity of zidovudine and other dideoxynucleosides against HIV-1 in cultured cells

Szebeni, J., Wahl, S. M., Schinazi, R. F., Popovic, M., Gartner, S., Wahl, L. M., Weislow, O. S., Betageri, G., Fine, R. L., Dahlberg, J. E., Hunter, E. & Weinstein, J. N., 1990, In : Annals of the New York Academy of Sciences. 616, p. 613-616 4 p.

Research output: Article

Dideoxynucleosides
Dipyridamole
Zidovudine
Cells
41 Citations (Scopus)

Dipyridamole potentiates the inhibition by 3'-azido-3'-deoxythymidine and other dideoxynucleosides of human immunodeficiency virus replication in monocyte-macrophages

Szebeni, J., Wahl, S. M., Popovic, M., Wahl, L. M., Gartner, S., Fine, R. L., Skaleric, U., Friedmann, R. M. & Weinstein, J. N., 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 10, p. 3842-3846 5 p.

Research output: Article

Dideoxynucleosides
Dipyridamole
Zidovudine
Virus Replication
Monocytes
1 Citation (Scopus)

Doxebo (doxorubicin-free Doxil-like liposomes) is safe to use as a pre-treatment to prevent infusion reactions to PEGylated nanodrugs

Bavli, Y., Winkler, I., Chen, B. M., Roffler, S., Cohen, R., Szebeni, J. & Barenholz, Y., júl. 28 2019, In : Journal of Controlled Release. 306, p. 138-148 11 p.

Research output: Article

Liposomes
Doxorubicin
Therapeutics
liposomal doxorubicin
Hypersensitivity
12 Citations (Scopus)

Effect of dipyridamole on transport and phosphorylation of thymidine and 3′-azido-3′-deoxythymidine in human monocyte/macrophages

Betageri, G. V., Szebeni, J., Hung, K., Patel, S. S., Wahl, L. M., Corcoran, M. & Weinstein, J. N., aug. 15 1990, In : Biochemical Pharmacology. 40, 4, p. 867-870 4 p.

Research output: Article

Phosphorylation
Dipyridamole
Zidovudine
Macrophages
Thymidine
11 Citations (Scopus)

Effect of dipyridamole on zidovudine pharmacokinetics and short-term tolerance in asymptomatic human immunodeficiency virus-infected subjects

Hendrix, C. W., Flexner, C., Szebeni, J., Kuwahara, S., Pennypacker, S., Weinstein, J. N. & Lietman, P. S., 1994, In : Antimicrobial Agents and Chemotherapy. 38, 5, p. 1036-1040 5 p.

Research output: Article

Dipyridamole
Zidovudine
Pharmacokinetics
HIV
Nausea
12 Citations (Scopus)

Effects of thymidine and uridine on the phosphorylation of 3'-azido-3'-deoxythymidine (zidovudine) in human mononuclear cells

Szebeni, J., Patel, S. S., Hung, K., Wahl, L. M. & Weinstein, J. N., 1991, In : Antimicrobial Agents and Chemotherapy. 35, 1, p. 198-200 3 p.

Research output: Article

Zidovudine
Uridine
Thymidine
Phosphorylation
Nucleosides