• 6499 Citations
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1978 …2019

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Article
2019

Acute physiological changes caused by complement activators and amphotericin b-containing liposomes in mice

Őrfi, E., Mészáros, T., Hennies, M., Fülöp, T., Dézsi, L., Nardocci, A., Rosivall, L., Hamar, P., Neun, B. W., Dobrovolskaia, M. A., Szebeni, J. & Szénási, G., jan. 1 2019, In : International journal of nanomedicine. 14, p. 1563-1573 11 p.

Research output: Article

Open Access
4 Citations (Scopus)
Open Access

Doxebo (doxorubicin-free Doxil-like liposomes) is safe to use as a pre-treatment to prevent infusion reactions to PEGylated nanodrugs

Bavli, Y., Winkler, I., Chen, B. M., Roffler, S., Cohen, R., Szebeni, J. & Barenholz, Y., júl. 28 2019, In : Journal of Controlled Release. 306, p. 138-148 11 p.

Research output: Article

2 Citations (Scopus)

Liposome-induced hypersensitivity reactions: Risk reduction by design of safe infusion protocols in pigs

Fülöp, T., Kozma, G. T., Vashegyi, I., Mészáros, T., Rosivall, L., Urbanics, R., Storm, G., Metselaar, J. M. & Szebeni, J., szept. 10 2019, In : Journal of Controlled Release. 309, p. 333-338 6 p.

Research output: Article

Open Access
1 Citation (Scopus)

Pseudo-anaphylaxis to Polyethylene Glycol (PEG)-Coated Liposomes: Roles of Anti-PEG IgM and Complement Activation in a Porcine Model of Human Infusion Reactions

Kozma, G. T., Mészáros, T., Vashegyi, I., Fülöp, T., Örfi, E., Dézsi, L., Rosivall, L., Bavli, Y., Urbanics, R., Mollnes, T. E., Barenholz, Y. & Szebeni, J., aug. 27 2019, In : ACS Nano. 13, 8, p. 9315-9324 10 p.

Research output: Article

3 Citations (Scopus)
2018

Anticoagulants influence the performance of in vitro assays intended for characterization of nanotechnology-based formulations

Cedrone, E., Neun, B. W., Rodriguez, J., Vermilya, A., Clogston, J. D., McNeil, S. E., Barenholz, Y., Szebeni, J. & Dobrovolskaia, M. A., jan. 1 2018, In : Molecules. 23, 1, 12.

Research output: Article

4 Citations (Scopus)
10 Citations (Scopus)

Dextran-coated superparamagnetic iron oxide nanoparticles for magnetic resonance imaging: Evaluation of size-dependent imaging properties, storage stability and safety

Unterweger, H., Dézsi, L., Matuszak, J., Janko, C., Poettler, M., Jordan, J., Bäuerle, T., Szebeni, J., Fey, T., Boccaccini, A. R., Alexiou, C. & Cicha, I., márc. 28 2018, In : International journal of nanomedicine. 13, p. 1899-1915 17 p.

Research output: Article

18 Citations (Scopus)
5 Citations (Scopus)

Theranostic Imaging May Vaccinate against the Therapeutic Benefit of Long Circulating PEGylated Liposomes and Change Cargo Pharmacokinetics

Børresen, B., Henriksen, J. R., Clergeaud, G., Jørgensen, J. S., Melander, F., Elema, D. R., Szebeni, J., Engelholm, S. A., Kristensen, A. T., Kjær, A., Andresen, T. L. & Hansen, A. E., nov. 27 2018, In : ACS Nano. 12, 11, p. 11386-11398 13 p.

Research output: Article

9 Citations (Scopus)

Understanding the role of anti-PEG antibodies in the complement activation by Doxil in vitro

Neun, B. W., Barenholz, Y., Szebeni, J. & Dobrovolskaia, M. A., jan. 1 2018, In : Molecules. 23, 7, 1700.

Research output: Article

9 Citations (Scopus)
2017

Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes

Wibroe, P. P., Anselmo, A. C., Nilsson, P. H., Sarode, A., Gupta, V., Urbanics, R., Szebeni, J., Hunter, A. C., Mitragotri, S., Mollnes, T. E. & Moghimi, S. M., jún. 6 2017, In : Nature Nanotechnology. 12, 6, p. 589-594 6 p.

Research output: Article

61 Citations (Scopus)

Immunological response to nitroglycerin-loaded shear-responsive liposomes in vitro and in vivo

Buscema, M., Matviykiv, S., Mészáros, T., Gerganova, G., Weinberger, A., Mettal, U., Mueller, D., Neuhaus, F., Stalder, E., Ishikawa, T., Urbanics, R., Saxer, T., Pfohl, T., Szebeni, J., Zumbuehl, A. & Müller, B., okt. 28 2017, In : Journal of Controlled Release. 264, p. 14-23 10 p.

Research output: Article

6 Citations (Scopus)

Non-immunogenic dextran-coated superparamagnetic iron oxide nanoparticles: A biocompatible, size-tunable contrast agent for magnetic resonance imaging

Unterweger, H., Janko, C., Schwarz, M., Dézsi, L., Urbanics, R., Matuszak, J., Őrfi, E., Fülöp, T., Bäuerle, T., Szebeni, J., Journé, C., Boccaccini, A. R., Alexiou, C., Lyer, S. & Cicha, I., júl. 24 2017, In : International journal of nanomedicine. 12, p. 5223-5238 16 p.

Research output: Article

27 Citations (Scopus)
2016
4 Citations (Scopus)
27 Citations (Scopus)

Factor H inhibits complement activation induced by liposomal and micellar drugs and the therapeutic antibody rituximab in vitro

Mészáros, T., Csincsi, Á. I., Uzonyi, B., Hebecker, M., Fülöp, T. G., Erdei, A., Szebeni, J. & Józsi, M., máj. 1 2016, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 12, 4, p. 1023-1031 9 p.

Research output: Article

13 Citations (Scopus)

Liposomal doxorubicin: the good, the bad and the not-so-ugly

Szebeni, J., Fülöp, T., Dézsi, L., Metselaar, B. & Storm, G., ápr. 26 2016, (Accepted/In press) In : Journal of Drug Targeting. p. 1-3 3 p.

Research output: Article

7 Citations (Scopus)

Nanoparticles for intravascular applications: Pcharacterization and cytotoxicity testing

Matuszak, J., Baumgartner, J., Zaloga, J., Juenet, M., Da Silva, A. E., Franke, D., Almer, G., Texier, I., Faivre, D., Metselaar, J. M., Navarro, F. P., Chauvierre, C., Prassl, R., Dézsi, L., Urbanics, R., Alexiou, C., Mangge, H., Szebeni, J., Letourneur, D. & Cicha, I., márc. 2016, In : Nanomedicine. 11, 6, p. 597-616 20 p.

Research output: Article

30 Citations (Scopus)

Surprising lack of liposome-induced complement activation by artificial 1,3-diamidophospholipids in vitro

Bugna, S., Buscema, M., Matviykiv, S., Urbanics, R., Weinberger, A., Meszaros, T., Szebeni, J., Zumbuehl, A., Saxer, T. & Müller, B., ápr. 1 2016, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 12, 3, p. 845-849 5 p.

Research output: Article

12 Citations (Scopus)
2015

Membrane attack complex formation on a supported lipid bilayer: Initial steps towards a CARPA predictor nanodevice

Yorulmaz, S., Tabaei, S. R., Kim, M., Seo, J., Hunziker, W., Szebeni, J. & Cho, N. J., jún. 1 2015, In : European Journal of Nanomedicine. 7, 3, p. 245-255 11 p.

Research output: Article

7 Citations (Scopus)
4 Citations (Scopus)
2014

Features of complement activation-related pseudoallergy to liposomes with different surface charge and PEGylation: Comparison of the porcine and rat responses

Dézsi, L., Fülöp, T., Mészáros, T., Szénási, G., Urbanics, R., Vázsonyi, C., Orfi, E., Rosivall, L., Nemes, R., Kok, R. J., Metselaar, J. M., Storm, G. & Szebeni, J., dec. 10 2014, In : Journal of Controlled Release. 195, p. 2-10 9 p.

Research output: Article

39 Citations (Scopus)

Hypersensitivity reactions to intravenous iron: Guidance for risk minimization and management

Rampton, D., Folkersen, J., Fishbane, S., Hedenus, M., Howaldt, S., Locatelli, F., Patni, S., Szebeni, J. & Weiss, G., nov. 1 2014, In : Haematologica. 99, 11, p. 1671-1676 6 p.

Research output: Article

115 Citations (Scopus)

Hypersensitivity reactions to intravenous lipid emulsion in Swine: Relevance for lipid resuscitation studies

Bedocs, P., Capacchione, J., Potts, L., Chugani, R., Weiszhar, Z., Szebeni, J. & Buckenmaier, C. C., nov. 4 2014, In : Anesthesia and analgesia. 119, 5, p. 1094-1101 8 p.

Research output: Article

17 Citations (Scopus)
2013

Complement activation by PEGylated liposomes containing prednisolone

Van Den Hoven, J. M., Nemes, R., Metselaar, J. M., Nuijen, B., Beijnen, J. H., Storm, G. & Szebeni, J., máj. 13 2013, In : European Journal of Pharmaceutical Sciences. 49, 2, p. 265-271 7 p.

Research output: Article

36 Citations (Scopus)
2012

Complement activation by polyethoxylated pharmaceutical surfactants: Cremophor-EL, tween-80 and tween-20

Weiszhár, Z., Czúcz, J., Révész, C., Rosivall, L., Szebeni, J. & Rozsnyay, Z., márc. 12 2012, In : European Journal of Pharmaceutical Sciences. 45, 4, p. 492-498 7 p.

Research output: Article

115 Citations (Scopus)

Flow cytometric analysis of supravesicular structures in doxorubicin-containing pegylated liposomes

Milosevits, G., Rozsnyay, Z., Kozma, G. T., Milosevits, J., Tömöry, G., Robotka, H., Rosivall, L. & Szebeni, J., máj. 1 2012, In : Chemistry and Physics of Lipids. 165, 4, p. 482-487 6 p.

Research output: Article

10 Citations (Scopus)

Hemocompatibility of liposomes loaded with lipophilic prodrugs of methotrexate and melphalan in the lipid bilayer

Kuznetsova, N. R., Sevrin, C., Lespineux, D., Bovin, N. V., Vodovozova, E. L., Mészáros, T., Szebeni, J. & Grandfils, C., jún. 10 2012, In : Journal of Controlled Release. 160, 2, p. 394-400 7 p.

Research output: Article

71 Citations (Scopus)
52 Citations (Scopus)

Liposome-induced complement activation and related cardiopulmonary distress in pigs: Factors promoting reactogenicity of Doxil and AmBisome

Szebeni, J., Bedocs, P., Rozsnyay, Z., Weiszhár, Z., Urbanics, R., Rosivall, L., Cohen, R., Garbuzenko, O., Báthori, G., Tóth, M., Bünger, R. & Barenholz, Y., febr. 1 2012, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 8, 2, p. 176-184 9 p.

Research output: Article

120 Citations (Scopus)

Prevention of infusion reactions to PEGylated liposomal doxorubicin via tachyphylaxis induction by placebo vesicles: A porcine model

Szebeni, J., Bedocs, P., Urbanics, R., Bünger, R., Rosivall, L., Tóth, M. & Barenholz, Y., jún. 10 2012, In : Journal of Controlled Release. 160, 2, p. 382-387 6 p.

Research output: Article

51 Citations (Scopus)

Structure and biological activity of pathogen-like synthetic nanomedicines

Lorincz, O., Toke, E. R., Somogyi, E., Horkay, F., Chandran, P. L., Douglas, J. F., Szebeni, J. & Lisziewicz, J., máj. 1 2012, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 8, 4, p. 497-506 10 p.

Research output: Article

21 Citations (Scopus)

Új perspektíva a krónikus mieloid leukémia kezelésében? Géncsendesítéses terápia

Éva, K. T., Adrienn, J. S., Péter, K., János, S., Emöke, K. T., László, B. & Bertalan, F., 2012, In : Magyar onkologia. 56, 1, p. 16-22 7 p.

Research output: Article

1 Citation (Scopus)
2011

In vitro and in vivo complement activation and related anaphylactic effects associated with polyethylenimine and polyethylenimine-graft-poly(ethylene glycol) block copolymers

Merkel, O. M., Urbanics, R., Bedocs, P., Rozsnyay, Z., Rosivall, L., Toth, M., Kissel, T. & Szebeni, J., júl. 1 2011, In : Biomaterials. 32, 21, p. 4936-4942 7 p.

Research output: Article

78 Citations (Scopus)
2010

Complement activation cascade triggered by PEG-PL engineered nanomedicines and carbon nanotubes: The challenges ahead

Moghimi, S. M., Andersen, A. J., Hashemi, S. H., Lettiero, B., Ahmadvand, D., Hunter, A. C., Andresen, T. L., Hamad, I. & Szebeni, J., szept. 1 2010, In : Journal of Controlled Release. 146, 2, p. 175-181 7 p.

Research output: Article

133 Citations (Scopus)

Physicochemical parameters affecting liposomal bisphosphonates bioactivity for restenosis therapy: Internalization, cell inhibition, activation of cytokines and complement, and mechanism of cell death

Epstein-Barash, H., Gutman, D., Markovsky, E., Mishan-Eisenberg, G., Koroukhov, N., Szebeni, J. & Golomb, G., szept. 1 2010, In : Journal of Controlled Release. 146, 2, p. 182-195 14 p.

Research output: Article

54 Citations (Scopus)
4 Citations (Scopus)
2008
165 Citations (Scopus)
2007

Poly(amino acid)s: Promising enzymatically degradable stealth coatings for liposomes

Romberg, B., Metselaar, J. M., Baranyi, L., Snel, C. J., Bünger, R., Hennink, W. E., Szebeni, J. & Storm, G., márc. 1 2007, In : International Journal of Pharmaceutics. 331, 2, p. 186-189 4 p.

Research output: Article

56 Citations (Scopus)
2006

Activation of the human complement system by cholesterol-rich and PEGylated liposomes - Modulation of cholesterol-rich liposome-mediated complement activation by elevated serum LDL and HDL levels

Moghimi, S. M., Hamad, I., Bünger, R., Andresen, T. L., Jørgensen, K., Hunter, A. C., Baranji, L., Rosivall, L. & Szebeni, J., szept. 1 2006, In : Journal of Liposome Research. 16, 3, p. 167-174 8 p.

Research output: Article

40 Citations (Scopus)
74 Citations (Scopus)
136 Citations (Scopus)
2005

Cerebrovascular involvement in liposome-induced cardiopulmonary distress in pigs

Bodo, M., Szebeni, J., Baranyi, L., Savay, S., Pearce, F. J., Alving, C. R. & Bünger, R., júl. 25 2005, In : Journal of Liposome Research. 15, 1-2, p. 3-14 12 p.

Research output: Article

9 Citations (Scopus)

Comparative in vitro properties and clinical pharmacokinetics of paclitaxel following the administration of taxol® and paxene®

Scripture, C. D., Szebeni, J., Loos, W. J., Figg, W. D. & Sparreboom, A., máj. 2005, In : Cancer Biology and Therapy. 4, 5, p. 555-560 6 p.

Research output: Article

Open Access
9 Citations (Scopus)
2004
85 Citations (Scopus)
2003

Complement activation during hemorrhagic shock and resuscitation in swine.

Szebeni, J., Baranyi, L., Savay, S., Götze, O., Alving, C. R., Bünger, R. & Mongan, P. D., okt. 2003, In : Shock (Augusta, Ga.). 20, 4, p. 347-355 9 p.

Research output: Article

46 Citations (Scopus)

Complement activation following first exposure to pegylated liposomal doxorubicin (Doxil®): Possible role in hypersensitivity reactions

Chanan-Khan, A., Szebeni, J., Savay, S., Liebes, L., Rafique, N. M., Alving, C. R. & Muggia, F. M., szept. 1 2003, In : Annals of Oncology. 14, 9, p. 1430-1437 8 p.

Research output: Article

273 Citations (Scopus)

Complement-Dependent Shock and Tissue Damage Induced by Intravenous Injection of Cholesterol-Enriched Liposomes in Rats

Baranyi, L., Szebeni, J., Sávay, S., Bodo, M., Basta, M., Bentley, T. B., Bunger, R. & Alving, C. R., jún. 1 2003, In : Journal of Applied Research. 3, 3, p. 221-231 11 p.

Research output: Article

11 Citations (Scopus)

F(ab)'2-mediated neutralization of C3a and C5a anaphylatoxins: A novel effector function of immunoglobulins

Basta, M., Van Goor, F., Luccioli, S., Billings, E. M., Vortmeyer, A. O., Baranyi, L., Szebeni, J., Alving, C. R., Carroll, M. C., Berkower, I., Stojilkovic, S. S. & Metcalfe, D. D., ápr. 1 2003, In : Nature medicine. 9, 4, p. 431-438 8 p.

Research output: Article

175 Citations (Scopus)