• 6132 Citations
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1978 …2019
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Research Output 1978 2019

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Article
2019

Acute physiological changes caused by complement activators and amphotericin b-containing liposomes in mice

Őrfi, E., Mészáros, T., Hennies, M., Fülöp, T., Dézsi, L., Nardocci, A., Rosivall, L., Hamar, P., Neun, B. W., Dobrovolskaia, M. A., Szebeni, J. & Szénási, G., jan. 1 2019, In : International journal of nanomedicine. 14, p. 1563-1573 11 p.

Research output: Article

Open Access
Liposomes
Amphotericin B
Chemical activation
Cholesterol
Phospholipids

Doxebo (doxorubicin-free Doxil-like liposomes) is safe to use as a pre-treatment to prevent infusion reactions to PEGylated nanodrugs

Bavli, Y., Winkler, I., Chen, B. M., Roffler, S., Cohen, R., Szebeni, J. & Barenholz, Y., júl. 28 2019, In : Journal of Controlled Release. 306, p. 138-148 11 p.

Research output: Article

Liposomes
Doxorubicin
Therapeutics
liposomal doxorubicin
Hypersensitivity

Pseudo-anaphylaxis to Polyethylene Glycol (PEG)-Coated Liposomes: Roles of Anti-PEG IgM and Complement Activation in a Porcine Model of Human Infusion Reactions

Kozma, G., Mészáros, T., Vashegyi, I., Fülöp, T., Örfi, E., Dézsi, L., Rosivall, L., Bavli, Y., Urbanics, R., Mollnes, T. E., Barenholz, Y. & Szebeni, J., jan. 1 2019, (Accepted/In press) In : ACS Nano.

Research output: Article

anaphylaxis
Polyethylenes
Anaphylatoxins
Allergies
Immunization
2018
4 Citations (Scopus)

Animal models for analysis of immunological responses to nanomaterials: Challenges and considerations

Zamboni, W. C., Szebeni, J., Kozlov, S. V., Lucas, A. T., Piscitelli, J. A. & Dobrovolskaia, M. A., jan. 1 2018, (Accepted/In press) In : Advanced Drug Delivery Reviews.

Research output: Article

Nanotechnology
Nanostructures
Animal Models
Nanoparticles
Immune System
3 Citations (Scopus)

Anticoagulants influence the performance of in vitro assays intended for characterization of nanotechnology-based formulations

Cedrone, E., Neun, B. W., Rodriguez, J., Vermilya, A., Clogston, J. D., McNeil, S. E., Barenholz, Y., Szebeni, J. & Dobrovolskaia, M. A., jan. 1 2018, In : Molecules. 23, 1, 12.

Research output: Article

anticoagulants
Nanotechnology
nanotechnology
Anticoagulants
Assays
7 Citations (Scopus)
Complement Activation
Nanoparticles
Swine
Molecular Weight
ferumoxides
12 Citations (Scopus)

Dextran-coated superparamagnetic iron oxide nanoparticles for magnetic resonance imaging: Evaluation of size-dependent imaging properties, storage stability and safety

Unterweger, H., Dézsi, L., Matuszak, J., Janko, C., Poettler, M., Jordan, J., Bäuerle, T., Szebeni, J., Fey, T., Boccaccini, A. R., Alexiou, C. & Cicha, I., márc. 28 2018, In : International Journal of Nanomedicine. 13, p. 1899-1915 17 p.

Research output: Article

Dextran
Magnetic resonance
Iron oxides
Nanoparticles
Contrast Media
4 Citations (Scopus)

From design to the clinic: practical guidelines for translating cardiovascular nanomedicine

Cicha, I., Chauvierre, C., Texier, I., Cabella, C., Metselaar, J. M., Szebeni, J., Dézsi, L., Alexiou, C., Rouzet, F., Storm, G., Stroes, E., Bruce, D., MacRitchie, N., Maffia, P. & Letourneur, D., nov. 1 2018, In : Cardiovascular Research. 114, 13, p. 1714-1727 14 p.

Research output: Article

Nanomedicine
Cardiovascular Diseases
Guidelines
Nanoparticles
Obesity
2 Citations (Scopus)
Surface Properties
Complement Activation
Polystyrenes
Nanoparticles
Surface properties
11 Citations (Scopus)

Roadmap and strategy for overcoming infusion reactions to nanomedicines

Szebeni, J., Simberg, D., González-Fernández, Á., Barenholz, Y. & Dobrovolskaia, M. A., jan. 1 2018, (Accepted/In press) In : Nature Nanotechnology.

Research output: Article

Medical nanotechnology
Drug products
Nanotechnology
products
nanotechnology
5 Citations (Scopus)

Theranostic Imaging May Vaccinate against the Therapeutic Benefit of Long Circulating PEGylated Liposomes and Change Cargo Pharmacokinetics

Børresen, B., Henriksen, J. R., Clergeaud, G., Jørgensen, J. S., Melander, F., Elema, D. R., Szebeni, J., Engelholm, S. A., Kristensen, A. T., Kjær, A., Andresen, T. L. & Hansen, A. E., nov. 27 2018, In : ACS Nano. 12, 11, p. 11386-11398 13 p.

Research output: Article

cargo
Pharmacokinetics
Liposomes
clearances
blood
5 Citations (Scopus)

Understanding the Role of Anti-PEG Antibodies in the Complement Activation by Doxil in Vitro

Neun, B. W., Barenholz, Y., Szebeni, J. & Dobrovolskaia, M. A., júl. 12 2018, In : Molecules (Basel, Switzerland). 23, 7

Research output: Article

Complement Activation
antibodies
complement
glycols
polyethylenes
2017
46 Citations (Scopus)

Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes

Wibroe, P. P., Anselmo, A. C., Nilsson, P. H., Sarode, A., Gupta, V., Urbanics, R., Szebeni, J., Hunter, A. C., Mitragotri, S., Mollnes, T. E. & Moghimi, S. M., jún. 6 2017, In : Nature Nanotechnology. 12, 6, p. 589-594 6 p.

Research output: Article

macrophages
Macrophages
erythrocytes
attachment
swine
4 Citations (Scopus)

Immunological response to nitroglycerin-loaded shear-responsive liposomes in vitro and in vivo

Buscema, M., Matviykiv, S., Mészáros, T., Gerganova, G., Weinberger, A., Mettal, U., Mueller, D., Neuhaus, F., Stalder, E., Ishikawa, T., Urbanics, R., Saxer, T., Pfohl, T., Szebeni, J., Zumbuehl, A. & Müller, B., okt. 28 2017, In : Journal of Controlled Release. 264, p. 14-23 10 p.

Research output: Article

Complement Activation
Nitroglycerin
Liposomes
Swine
Vasodilator Agents
23 Citations (Scopus)

Non-immunogenic dextran-coated superparamagnetic iron oxide nanoparticles: A biocompatible, size-tunable contrast agent for magnetic resonance imaging

Unterweger, H., Janko, C., Schwarz, M., Dézsi, L., Urbanics, R., Matuszak, J., Őrfi, E., Fülöp, T., Bäuerle, T., Szebeni, J., Journé, C., Boccaccini, A. R., Alexiou, C., Lyer, S. & Cicha, I., júl. 24 2017, In : International Journal of Nanomedicine. 12, p. 5223-5238 16 p.

Research output: Article

Dextran
Magnetic resonance
Iron oxides
Nanoparticles
Contrast Media
2016
2 Citations (Scopus)
ammonium sulfates
Liposomes
Ammonium Sulfate
Agglomeration
glycols
23 Citations (Scopus)
Sus scrofa
Complement Activation
Toxicity
Chemical activation
Swine
11 Citations (Scopus)

Factor H inhibits complement activation induced by liposomal and micellar drugs and the therapeutic antibody rituximab in vitro

Mészáros, T., Csincsi, Á. I., Uzonyi, B., Hebecker, M., Fülöp, T. G., Erdei, A., Szebeni, J. & Józsi, M., máj. 1 2016, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 12, 4, p. 1023-1031 9 p.

Research output: Article

Complement Factor H
Complement Activation
Antibodies
Chemical activation
Pharmaceutical Preparations
5 Citations (Scopus)

Liposomal doxorubicin: the good, the bad and the not-so-ugly

Szebeni, J., Fülöp, T., Dézsi, L., Metselaar, B. & Storm, G., ápr. 26 2016, (Accepted/In press) In : Journal of Drug Targeting. p. 1-3 3 p.

Research output: Article

Hypersensitivity
Nanomedicine
Pharmaceutical Preparations
Pharmacology
Drug Therapy
25 Citations (Scopus)

Nanoparticles for intravascular applications: Pcharacterization and cytotoxicity testing

Matuszak, J., Baumgartner, J., Zaloga, J., Juenet, M., Da Silva, A. E., Franke, D., Almer, G., Texier, I., Faivre, D., Metselaar, J. M., Navarro, F. P., Chauvierre, C., Prassl, R., Dézsi, L., Urbanics, R., Alexiou, C., Mangge, H., Szebeni, J., Letourneur, D. & Cicha, I., márc. 1 2016, In : Nanomedicine. 11, 6, p. 597-616 20 p.

Research output: Article

Cytotoxicity
Nanoparticles
Nanosystems
Testing
Endothelial cells
2015
5 Citations (Scopus)

Blood cell changes in complement activation-related pseudoallergy

Patkó, Z. & Szebeni, J., jún. 1 2015, In : European Journal of Nanomedicine. 7, 3, p. 233-244 12 p.

Research output: Article

Anaphylatoxins
blood cells
Complement Activation
Leukocytosis
Platelet Activation
36 Citations (Scopus)
Therapeutic Equivalency
Complement Activation
Liposomes
Chemical activation
Pharmaceutical Preparations
Medical nanotechnology
Blood
Chemical activation
Medical nanotechnology
Viruses
Chemical activation
2 Citations (Scopus)

Exosomes: Potential model for complement-stealth delivery systems

Milosevits, G., Szebeni, J. & Krol, S., jún. 1 2015, In : European Journal of Nanomedicine. 7, 3, p. 207-218 12 p.

Research output: Article

Exosomes
immune systems
Immune system
complement
delivery
40 Citations (Scopus)

Hypersensitivity to intravenous iron: Classification, terminology, mechanisms and management

Szebeni, J., Fishbane, S., Hedenus, M., Howaldt, S., Locatelli, F., Patni, S., Rampton, D., Weiss, G. & Folkersen, J., nov. 1 2015, In : British Journal of Pharmacology. 172, 21, p. 5025-5036 12 p.

Research output: Article

Terminology
Hypersensitivity
Iron
Complement Activation
Iron-Deficiency Anemias
15 Citations (Scopus)
Nanomedicine
Medical nanotechnology
lessons learned
hypertension
hemodynamics
7 Citations (Scopus)

Membrane attack complex formation on a supported lipid bilayer: Initial steps towards a CARPA predictor nanodevice

Yorulmaz, S., Tabaei, S. R., Kim, M., Seo, J., Hunziker, W., Szebeni, J. & Cho, N. J., jún. 1 2015, In : European Journal of Nanomedicine. 7, 3, p. 245-255 11 p.

Research output: Article

Complement Membrane Attack Complex
Lipid bilayers
Lipid Bilayers
attack
lipids
4 Citations (Scopus)
Zymosan
Liposomes
complement
blood
mice
10 Citations (Scopus)
macrophages
Alveolar Macrophages
Swine
Chemical activation
activation
4 Citations (Scopus)
rodents
Complement Activation
complement
inhibitors
Liposomes
11 Citations (Scopus)

Surprising lack of liposome-induced complement activation by artificial 1,3-diamidophospholipids in vitro

Bugna, S., Buscema, M., Matviykiv, S., Urbanics, R., Weinberger, A., Mészáros, T., Szebeni, J., Zumbuehl, A., Saxer, T. & Müller, B., jún. 11 2015, (Accepted/In press) In : Nanomedicine: Nanotechnology, Biology, and Medicine.

Research output: Article

Liposomes
Complement Activation
Chemical activation
Hemodynamics
Swine
3 Citations (Scopus)
Complement Factor H
Liposomes
Complement Activation
complement
Autoimmune Diseases
7 Citations (Scopus)
Complement Activation
Paclitaxel
complement
serums
Screening
2014
96 Citations (Scopus)
Nanomedicine
Complement Activation
Hypersensitivity
Anaphylatoxins
Mast Cells
36 Citations (Scopus)

Features of complement activation-related pseudoallergy to liposomes with different surface charge and PEGylation: Comparison of the porcine and rat responses

Dézsi, L., Fülöp, T., Mészáros, T., Szénási, G., Urbanics, R., Vázsonyi, C., Orfi, E., Rosivall, L., Nemes, R., Kok, R. J., Metselaar, J. M., Storm, G. & Szebeni, J., dec. 10 2014, In : Journal of Controlled Release. 195, p. 2-10 9 p.

Research output: Article

Complement Activation
Liposomes
Swine
Tachyphylaxis
Hypotension
105 Citations (Scopus)

Hypersensitivity reactions to intravenous iron: Guidance for risk minimization and management

Rampton, D., Folkersen, J., Fishbane, S., Hedenus, M., Howaldt, S., Locatelli, F., Patni, S., Szebeni, J. & Weiss, G., nov. 1 2014, In : Haematologica. 99, 11, p. 1671-1676 6 p.

Research output: Article

Risk Management
Hypersensitivity
Iron
Drug Hypersensitivity
Iron-Deficiency Anemias
13 Citations (Scopus)

Hypersensitivity reactions to intravenous lipid emulsion in Swine: Relevance for lipid resuscitation studies

Bedocs, P., Capacchione, J., Potts, L., Chugani, R., Weiszhar, Z., Szebeni, J. & Buckenmaier, C. C., nov. 4 2014, In : Anesthesia and Analgesia. 119, 5, p. 1094-1101 8 p.

Research output: Article

Intravenous Fat Emulsions
Emulsions
Resuscitation
Hypersensitivity
Swine
2013
29 Citations (Scopus)

Complement activation by PEGylated liposomes containing prednisolone

Van Den Hoven, J. M., Nemes, R., Metselaar, J. M., Nuijen, B., Beijnen, J. H., Storm, G. & Szebeni, J., máj. 13 2013, In : European Journal of Pharmaceutical Sciences. 49, 2, p. 265-271 7 p.

Research output: Article

Complement Activation
Prednisolone
Liposomes
Hypersensitivity
Cholesterol
4 Citations (Scopus)

Surfactant-mediated complement activation in beagle dogs

Moein Moghimi, S., Wibroe, P. P., Szebeni, J. & Christy Hunter, A., 2013, In : International Immunopharmacology. 17, 1, p. 33-34 2 p.

Research output: Article

Complement Activation
Surface-Active Agents
Dogs
2012
63 Citations (Scopus)

A porcine model of complement-mediated infusion reactions to drug carrier nanosystems and other medicines

Szebeni, J., Bedocs, P., Csukás, D., Rosivall, L., Bünger, R. & Urbanics, R., dec. 2012, In : Advanced Drug Delivery Reviews. 64, 15, p. 1706-1716 11 p.

Research output: Article

Drug Carriers
Swine
Pharmaceutical Preparations
Hypersensitivity
Anaphylatoxins
104 Citations (Scopus)

Complement activation by polyethoxylated pharmaceutical surfactants: Cremophor-EL, tween-80 and tween-20

Weiszhár, Z., Czúcz, J., Révész, C., Rosivall, L., Szebeni, J. & Rozsnyay, Z., márc. 12 2012, In : European Journal of Pharmaceutical Sciences. 45, 4, p. 492-498 7 p.

Research output: Article

Polysorbates
Complement Activation
Surface-Active Agents
docetaxel
Pharmaceutical Preparations
Inbred MRL lpr Mouse
Intravenous Immunoglobulins
Glycine
Kidney
Skin
10 Citations (Scopus)

Flow cytometric analysis of supravesicular structures in doxorubicin-containing pegylated liposomes

Milosevits, G., Rozsnyay, Z., Kozma, G., Milosevits, J., Tömöry, G., Robotka, H., Rosivall, L. & Szebeni, J., máj. 2012, In : Chemistry and Physics of Lipids. 165, 4, p. 482-487 6 p.

Research output: Article

Liposomes
Doxorubicin
Assays
Lipids
liposomal doxorubicin
69 Citations (Scopus)

Hemocompatibility of liposomes loaded with lipophilic prodrugs of methotrexate and melphalan in the lipid bilayer

Kuznetsova, N. R., Sevrin, C., Lespineux, D., Bovin, N. V., Vodovozova, E. L., Mészáros, T., Szebeni, J. & Grandfils, C., jún. 10 2012, In : Journal of Controlled Release. 160, 2, p. 394-400 7 p.

Research output: Article

Melphalan
Prodrugs
Lipid Bilayers
Methotrexate
Liposomes
51 Citations (Scopus)
Nanomedicine
Medical nanotechnology
Materials Testing
Biological Assay
complement
111 Citations (Scopus)

Liposome-induced complement activation and related cardiopulmonary distress in pigs: Factors promoting reactogenicity of Doxil and AmBisome

Szebeni, J., Bedocs, P., Rozsnyay, Z., Weiszhár, Z., Urbanics, R., Rosivall, L., Cohen, R., Garbuzenko, O., Báthori, G., Tóth, M., Bünger, R. & Barenholz, Y., febr. 2012, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 8, 2, p. 176-184 9 p.

Research output: Article

Liposomes
Complement Activation
Swine
Chemical activation
Doxorubicin
49 Citations (Scopus)

Prevention of infusion reactions to PEGylated liposomal doxorubicin via tachyphylaxis induction by placebo vesicles: A porcine model

Szebeni, J., Bedocs, P., Urbanics, R., Bünger, R., Rosivall, L., Tóth, M. & Barenholz, Y., jún. 10 2012, In : Journal of Controlled Release. 160, 2, p. 382-387 6 p.

Research output: Article

Tachyphylaxis
Swine
Placebos
Liposomes
liposomal doxorubicin
21 Citations (Scopus)

Structure and biological activity of pathogen-like synthetic nanomedicines

Lorincz, O., Toke, E. R., Somogyi, E., Horkay, F., Chandran, P. L., Douglas, J. F., Szebeni, J. & Lisziewicz, J., máj. 2012, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 8, 4, p. 497-506 10 p.

Research output: Article

Nanomedicine
Medical nanotechnology
Pathogens
Bioactivity
Nanoparticles
1 Citation (Scopus)

Új perspektíva a krónikus mieloid leukémia kezelésében? Géncsendesítéses terápia

Éva, K. T., Adrienn, J. S., Péter, K., Szebeni, J., Emöke, K. T., László, B. & Bertalan, F., 2012, In : Magyar Onkologia. 56, 1, p. 16-22 7 p.

Research output: Article

Gene Silencing
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Genetic Therapy
Protein-Tyrosine Kinases
RNA Interference