• 9181 Citations
  • 43 h-Index
1962 …2020

Research output per year

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Research Output

2020

Organosilicon compounds, SILA-409 and SILA-421, as doxorubicin resistance-reversing agents in human colon cancer cells

Wesołowska, O., Michalak, K., Błaszczyk, M., Molnár, J. & Sroda-Pomianek, K., jan. 1 2020, In : Molecules. 25, 7, 1654.

Research output: Article

Open Access

The role of efflux pumps and environmental pH in bacterial multidrug resistance

Nové, M., Kincses, A., Molnár, J., Amaral, L. & Spengler, G., jan. 1 2020, In : In Vivo. 34, 1, p. 65-71 7 p.

Research output: Article

Open Access
1 Citation (Scopus)
2019

Dually acting nonclassical 1,4-dihydropyridines promote the anti-tuberculosis (Tb) activities of clofazimine

Lentz, F., Reiling, N., Spengler, G., Kincses, A., Csonka, A., Molnár, J. & Hilgeroth, A., aug. 8 2019, In : Molecules. 24, 16, 2873.

Research output: Article

Open Access

Effective MDR reversers through phytochemical study of Euphorbia boetica

Neto, S., Duarte, N., Pedro, C., Spengler, G., Molnár, J. & Ferreira, M. J. U., jan. 1 2019, In : Phytochemical Analysis. 30, 5, p. 498-511 14 p.

Research output: Article

1 Citation (Scopus)
2018

Amyloid-beta interactions with ABC transporters and resistance modifiers

Molnar, J., Ocsovszki, I. & Pusztai, R., jún. 2018, In : Anticancer research. 38, 6, p. 3407-3410 4 p.

Research output: Article

2 Citations (Scopus)

Benzoxazole-based Zn(II) and Cu(II) complexes overcome multidrug-resistance in cancer

Spengler, G., Kincses, A., Rácz, B., Varga, B., Watanabe, G., Saijo, R., Sekiya, H., Tamai, E., Maki, J., Molnár, J. & Kawase, M., nov. 2018, In : Anticancer research. 38, 11, p. 6181-6187 7 p.

Research output: Article

1 Citation (Scopus)

Discovery of novel enhancers of isoniazid toxicity in mycobacterium tuberculosis

Lentz, F., Reiling, N., Martins, A., Molnár, J. & Hilgeroth, A., 2018, In : Molecules. 23, 4, 825.

Research output: Article

1 Citation (Scopus)

Interactions of Schiff base compounds and their coordination complexes with the drug cisplatin

Magyari, J., Barta Holló, B., Vojinović-Ješić, L. S., Radanović, M. M., Armaković, S., Armaković, S. J., Molnár, J., Kincses, A., Gajdács, M., Spengler, G. & Meszaros Szecsenyi, K., jan. 1 2018, In : New Journal of Chemistry. 42, 8, p. 5834-5843 10 p.

Research output: Article

7 Citations (Scopus)

In vitro evaluation of the multidrug resistance reversing activity of novel imidazo[4,5-b]pyridine derivatives

Bourichi, S., Misbahi, H., Rodi, Y. K., Chahdi, F. O., Essassi, E. M., Szabo, S., Szalontai, B., Gajdács, M., Molnár, J. & Spengler, G., júl. 2018, In : Anticancer research. 38, 7, p. 3999-4003 5 p.

Research output: Article

2 Citations (Scopus)

In Vitro Studies of Anti-Hemolytic and Cytotoxic Activity of Procyanidin-Rich Extract from the Leaves of Actinidia arguta

Cyboran-Mikołajczyk, S., Csonka, Á., Molnar, J., Szabó, D., Oszmiański, J. & Kleszczyńska, H., jún. 1 2018, In : Polish Journal of Food and Nutrition Sciences. 68, 2, p. 171-177 7 p.

Research output: Article

2 Citations (Scopus)

Multidrug resistance reversal activity of extract and a rare dimeric naphthoquinone from Diospyros lotus

Rauf, A., Shaheen, U., Raza, M., Uddin, G., Ben Hadda, T., Mabkhot, Y. N., Jehan, N., Ahmad, B., Raza, S., Molnar, J., Csonka, Á. & Szabó, D., máj. 2018, In : Pakistan Journal of Pharmaceutical Sciences. 31, 3, p. 821-825 5 p.

Research output: Article

Terpenoids from Euphorbia pedroi as Multidrug-Resistance Reversers

Ferreira, R. J., Kincses, A., Gajdács, M., Spengler, G., Dos Santos, D. J. V. A., Molnár, J. & Ferreira, M. J. U., jan. 1 2018, (Accepted/In press) In : Journal of Natural Products.

Research output: Article

7 Citations (Scopus)
2017

Backstabbing P-gp: Side-chain cleaved ecdysteroid 2,3-dioxolanes hyper-sensitize MDR cancer cells to doxorubicin without efflux inhibition

Hunyadi, A., Csábi, J., Martins, A., Molnár, J., Balázs, A. & Tóth, G., febr. 2017, In : Molecules. 22, 2, 199.

Research output: Article

11 Citations (Scopus)

Dregamine and tabernaemontanine derivatives as ABCB1 modulators on resistant cancer cells

Paterna, A., Kincses, A., Spengler, G., Mulhovo, S., Molnár, J. & Ferreira, M. J. U., márc. 10 2017, In : European Journal of Medicinal Chemistry. 128, p. 247-257 11 p.

Research output: Article

12 Citations (Scopus)

Exploring Jolkinol D Derivatives to Overcome Multidrug Resistance in Cancer

Reis, M. A., Ahmed, O. B., Spengler, G., Molnár, J., Lage, H. & Ferreira, M. J. U., máj. 26 2017, In : Journal of Natural Products. 80, 5, p. 1411-1420 10 p.

Research output: Article

14 Citations (Scopus)

Isolation of chlorogenic acid from soil borne fungi Screlotium rolfsii, their reversal of multidrug resistance and anti-proliferative in mouse lymphoma cells

Ahmad, B., Rizwan, M., Rauf, A., Raza, M., Bashir, S., Molnár, J., Csonka, Á., Szabó, D., Mubarak, M. S., Noor, M. & Siddiqui, B. S., dec. 1 2017, In : Medicinal Chemistry. 13, 8, p. 721-726 6 p.

Research output: Article

3 Citations (Scopus)

Possible biological and clinical applications of phenothiazines

Varga, B., Csonka, Á., Csonka, A., Molnár, J., Amaral, L. & Spengler, G., nov. 1 2017, In : Anticancer Research. 37, 11, p. 5983-5993 11 p.

Research output: Review article

25 Citations (Scopus)

Synthesis and SAR Study of Anticancer Protoflavone Derivatives: Investigation of Cytotoxicity and Interaction with ABCB1 and ABCG2 Multidrug Efflux Transporters

Dankó, B., Tóth, S., Martins, A., Vágvölgyi, M., Kúsz, N., Molnár, J., Chang, F. R., Wu, Y. C., Szakács, G. & Hunyadi, A., jan. 1 2017, In : ChemMedChem. 12, 11, p. 850-859 10 p.

Research output: Article

7 Citations (Scopus)
2016
3 Citations (Scopus)

Anomalous products in the halogenation reactions of Vinca alkaloids

Keglevich, A., Hegedûs, L., Péter, L., Gyenese, J., Szántay, C., Dubrovay, Z., Dékány, M., Szigetvári, Á., Martins, A., Molnár, J., Hunyadi, A., Keglevich, P. & Hazai, L., okt. 1 2016, In : Current Organic Chemistry. 20, 24, p. 2639-2646 8 p.

Research output: Article

Coordination compounds of a hydrazone derivative with Co(III), Ni(II), Cu(II) and Zn(II): Synthesis, characterization, reactivity assessment and biological evaluation

Barta Holló, B., Magyari, J., Armaković, S., Bogdanović, G. A., Rodić, M. V., Armaković, S. J., Molnár, J., Spengler, G., Leovac, V. M. & Meszaros Szecsenyi, K., jan. 1 2016, In : New Journal of Chemistry. 40, 7, p. 5885-5895 11 p.

Research output: Article

9 Citations (Scopus)

Fluorimetric methods for analysis of permeability, drug transport kinetics, and inhibition of the ABCB1 membrane transporter

Armada, A., Martins, C., Spengler, G., Molnár, J., Amaral, L., Rodrigues, A. S. & Viveiros, M., máj. 1 2016, Methods in Molecular Biology. Humana Press Inc., Vol. 1395. p. 87-103 17 p. (Methods in Molecular Biology; vol. 1395).

Research output: Chapter

5 Citations (Scopus)

Fluorinated beta-diketo phosphorus ylides are novel efflux pump inhibitors in bacteria

Kincses, A., Szabó, Á. M., Saijo, R., Watanabe, G., Kawase, M., Molnár, J. & Spengler, G., nov. 1 2016, In : In Vivo. 30, 6, p. 813-817 5 p.

Research output: Article

4 Citations (Scopus)

Identification of selenocompounds with promising properties to reverse cancer multidrug resistance

Domínguez-Álvarez, E., Gajdács, M., Spengler, G., Palop, J. A., Marć, M. A., Kieć-Kononowicz, K., Amaral, L., Molnár, J., Jacob, C., Handzlik, J. & Sanmartín, C., márc. 15 2016, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters.

Research output: Article

29 Citations (Scopus)
4 Citations (Scopus)

Jatrophane diterpenes and cancer multidrug resistance - ABCB1 efflux modulation and selective cell death induction

Reis, M. A., Ahmed, O. B., Spengler, G., Molnár, J., Lage, H. & Ferreira, M. J. U., aug. 15 2016, In : Phytomedicine. 23, 9, p. 968-978 11 p.

Research output: Article

26 Citations (Scopus)

Reversal of multidrug resistance and computational studies of pistagremic acid isolated from Pistacia integerrima

Rauf, A., Uddin, G., Raza, M., Ahmad, A., Jehan, N., Ahmad, B., Nisar, M., Molnar, J., Csonka, A., Szabo, D., Khan, A., Farooq, U. & Noor, M., jan. 1 2016, In : Asian Pacific Journal of Cancer Prevention. 17, 4, p. 2311-2314 4 p.

Research output: Article

3 Citations (Scopus)

Reversal of multidrug resistance in mouse lymphoma cells by extracts and flavonoids from Pistacia integerrima

Rauf, A., Uddin, G., Raza, M., Ahmad, B., Jehan, N., Siddiqui, B. S., Molnar, J., Csonka, A. & Szabo, D., 2016, In : Asian Pacific Journal of Cancer Prevention. 17, 1, p. 51-55 5 p.

Research output: Article

6 Citations (Scopus)

Silver nanoparticles modulate ABC transporter activity and enhance chemotherapy in multidrug resistant cancer

Kovács, D., Szoke, K., Igaz, N., Spengler, G., Molnár, J., Tóth, T., Madarász, D., Rázga, Z., Kónya, Z., Boros, I. & Kiricsi, M., ápr. 1 2016, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 12, 3, p. 601-610 10 p.

Research output: Article

23 Citations (Scopus)

Synthesis and in vitro evaluation of the antitumor potential and chemo-sensitizing activity of fluorinated ecdysteroid derivatives

Csábi, J., Martins, A., Sinka, I., Csorba, A., Molnár, J., Zupkó, I., Tóth, G., Tillekeratne, L. M. V. & Hunyadi, A., jan. 1 2016, In : MedChemComm. 7, 12, p. 2282-2289 8 p.

Research output: Article

6 Citations (Scopus)

The anticancer activity of the old neuroleptic phenothiazine-type drug thioridazine

Spengler, G., Csonka, Á., Molnár, J. & Amaral, L., nov. 2016, In : Anticancer research. 36, 11, p. 5701-5706 6 p.

Research output: Review article

11 Citations (Scopus)

Triterpenoids from Momordica balsamina: Reversal of ABCB1-mediated multidrug resistance

Ramalhete, C., Mulhovo, S., Molnár, J. & Ferreira, M. J. U., 2016, In : Bioorganic and Medicinal Chemistry. 24, 21, p. 5061-5067 7 p.

Research output: Article

8 Citations (Scopus)
2015

Design, synthesis and biological profile of new inhibitors of multidrug resistance associated proteins carrying a polycyclic scaffold

Bisi, A., Gobbi, S., Merolle, L., Farruggia, G., Belluti, F., Rampa, A., Molnar, J., Malucelli, E. & Cappadone, C., márc. 6 2015, In : European Journal of Medicinal Chemistry. 92, p. 471-480 10 p.

Research output: Article

14 Citations (Scopus)

Discovery of 9,10-dihydroacridines as novel class of ABCB1 inhibitors

Hilgeroth, A., Hemmer, M., Neuber, S., Molnár, J. & Lage, H., jan. 1 2015, In : Medicinal Chemistry. 11, 4, p. 329-335 7 p.

Research output: Article

6 Citations (Scopus)
10 Citations (Scopus)

Epoxylathyrol Derivatives: Modulation of ABCB1-Mediated Multidrug Resistance in Human Colon Adenocarcinoma and Mouse T-Lymphoma Cells

Matos, A. M., Reis, M., Duarte, N., Spengler, G., Molnár, J. & Ferreira, M. J. U., szept. 25 2015, In : Journal of Natural Products. 78, 9, p. 2215-2228 14 p.

Research output: Article

20 Citations (Scopus)

Fluorinated diketo phosphorus ylides are novel inhibitors of the abcb1 efflux pump of cancer cells

Spengler, G., Ocsovszki, I., Tonki, Á. S., Saijo, R., Watanabe, G., Kawase, M. & Molnár, J., nov. 2015, In : Anticancer research. 35, 11, p. 5915-5919 5 p.

Research output: Article

6 Citations (Scopus)

Imidazolidine-4-one derivatives in the search for novel chemosensitizers of Staphylococcus aureus MRSA: Synthesis, biological evaluation and molecular modeling studies

Matys, A., Podlewska, S., Witek, K., Witek, J., Bojarski, A. J., Schabikowski, J., Otrębska-Machaj, E., Latacz, G., Szymańska, E., Kieć-Kononowicz, K., Molnar, J., Amaral, L. & Handzlik, J., júl. 7 2015, In : European Journal of Medicinal Chemistry. 101, p. 313-325 13 p., 7940.

Research output: Article

13 Citations (Scopus)

Molecular docking analysis of steroid-based copper transporter 1 inhibitors

Kadioglu, O., Serly, J., Seo, E. J., Vincze, I., Somlai, C., Saeed, M. E. M., Molnár, J. & Efferth, T., dec. 2015, In : Anticancer research. 35, 12, p. 6505-6508 4 p.

Research output: Article

Novel non-substrate modulators of the transmembrane efflux pump P-glycoprotein (ABCB1)

Krawczyk, S., Baumert, C., Molnár, J., Ritter, C., Höpner, J., Kloft, C. & Hilgeroth, A., máj. 1 2015, In : MedChemComm. 6, 5, p. 860-866 7 p.

Research output: Article

Reversal of ABCB1-related multidrug resistance of colonic adenocarcinoma cells by phenothiazines

Takács, D., Csonka, Á., Horváth, Á., Windt, T., Gajdács, M., Riedl, Z., Hajós, G., Amaral, L., Molnár, J. & Spengler, G., jún. 1 2015, In : Anticancer research. 35, 6, p. 3245-3251 7 p.

Research output: Article

20 Citations (Scopus)
3 Citations (Scopus)
2014
16 Citations (Scopus)

Diterpenes from Euphorbia piscatoria: Synergistic interaction of lathyranes with doxorubicin on resistant cancer cells

Reis, M. A., Paterna, A., Mónico, A., Molnar, J., Lage, H. & Ferreira, M. J. U., dec. 2014, In : Planta Medica. 80, 18, p. 1739-1745 7 p.

Research output: Article

23 Citations (Scopus)
2 Citations (Scopus)
58 Citations (Scopus)

Euphorbia and Momordica metabolites for overcoming multidrug resistance

Ferreira, M. J. U., Duarte, N., Reis, M., Madureira, A. M. & Molnár, J., nov. 9 2014, In : Phytochemistry Reviews. 13, 4, p. 915-935 21 p.

Research output: Review article

24 Citations (Scopus)

Improving the MDR reversal activity of 6,17-epoxylathyrane diterpenes

Vieira, C., Duarte, N., Reis, M. A., Spengler, G., Madureira, A. M., Molnár, J. & Ferreira, M. J. U., nov. 15 2014, In : Bioorganic and Medicinal Chemistry. 22, 22, p. 6392-6400 9 p.

Research output: Article

25 Citations (Scopus)