• 2602 Citations
  • 28 h-Index
1984 …2019
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Research Output 1984 2019

  • 2602 Citations
  • 28 h-Index
  • 66 Article
  • 2 Review article
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Article
2019
2 Citations (Scopus)

Angiogenin mutations in Hungarian patients with amyotrophic lateral sclerosis: Clinical, genetic, computational, and functional analyses

Tripolszki, K., Danis, J., Padhi, A. K., Gomes, J., Bozó, R., Nagy, Z. F., Nagy, D., Klivényi, P., Engelhardt, J. & Széll, M., jan. 1 2019, In : Brain and Behavior. e01293.

Research output: Article

Open Access
Amyotrophic Lateral Sclerosis
Mutation
Molecular Dynamics Simulation
Proteins
angiogenin

Comprehensive genetic analysis of a Hungarian amyotrophic lateral sclerosis cohort

Tripolszki, K., Gampawar, P., Schmidt, H., Nagy, Z. F., Nagy, D., Klivényi, P., Engelhardt, J. & Széll, M., jan. 1 2019, In : Frontiers in Genetics. 10, JUL, 732.

Research output: Article

Open Access
Amyotrophic Lateral Sclerosis
Genes
Neurodegenerative Diseases
Penetrance
Motor Neurons

Experimental motor neuron disease induced in mice with long-term repeated intraperitoneal injections of serum from ALS patients

Obál, I., Nógrádi, B., Meszlényi, V., Patai, R., Ricken, G., Kovacs, G. G., Tripolszki, K., Széll, M., Siklós, L. & Engelhardt, J., máj. 2 2019, In : International journal of molecular sciences. 20, 10, 2573.

Research output: Article

Open Access
Motor Neuron Disease
Amyotrophic Lateral Sclerosis
Motor Neurons
Intraperitoneal Injections
neurons
2018
4 Citations (Scopus)

The rs13388259 intergenic polymorphism in the genomic context of the BCYRN1 gene is associated with Parkinson's disease in the hungarian population

Márki, S., Göblös, A., Szlávicz, E., Török, N., Balicza, P., Bereznai, B., Takáts, A., Engelhardt, J., Klivényi, P., Vécsei, L., Molnár, M. J., Nagy, N. & Széll, M., jan. 1 2018, In : Parkinson's Disease. 2018, 9351598.

Research output: Article

Parkinson Disease
Long Noncoding RNA
Population
Genes
Penetrance
2017
1 Citation (Scopus)
Axotomy
Parvalbumins
Motor Neurons
Calcium
Chemokines
9 Citations (Scopus)

Genetic analysis of the SOD1 and C9ORF72 genes in Hungarian patients with amyotrophic lateral sclerosis

Tripolszki, K., Csányi, B., Nagy, D., Ratti, A., Tiloca, C., Silani, V., Kereszty, É., Török, N., Vécsei, L., Engelhardt, J., Klivényi, P., Nagy, N. & Széll, M., máj. 1 2017, In : Neurobiology of Aging. 53, p. 195.e1-195.e5

Research output: Article

Chromosomes, Human, Pair 9
Amyotrophic Lateral Sclerosis
Open Reading Frames
Genes
Mutation
6 Citations (Scopus)

High-throughput sequencing revealed a novel SETX mutation in a Hungarian patient with amyotrophic lateral sclerosis

Tripolszki, K., Török, D., Goudenège, D., Farkas, K., Sulák, A., Török, N., Engelhardt, J., Klivényi, P., Procaccio, V., Nagy, N. & Széll, M., 2017, (Accepted/In press) In : Brain and Behavior.

Research output: Article

Amyotrophic Lateral Sclerosis
Mutation
Motor Neuron Disease
Genes
Motor Neurons
17 Citations (Scopus)

Novel AARS2 gene mutation producing leukodystrophy: A case report

Szpisjak, L., Zsindely, N., Engelhardt, J., Vécsei, L., Kovacs, G. G. & Klivenyi, P., febr. 1 2017, In : Journal of Human Genetics. 62, 2, p. 329-333 5 p.

Research output: Article

Leukoencephalopathies
Mutation
Genes
Genetic Testing
Mitochondrial Diseases
3 Citations (Scopus)
AMPA Receptors
Presynaptic Terminals
Amyotrophic Lateral Sclerosis
Calcium
GYKI 53405
2016
1 Citation (Scopus)

A novel SETX gene mutation producing ataxia with oculomotor apraxia type 2

Szpisjak, L., Obal, I., Engelhardt, J., Vécsei, L. & Klivényi, P., jan. 25 2016, (Accepted/In press) In : Acta Neurologica Belgica. p. 1-3 3 p.

Research output: Article

RNA Helicases
Spinocerebellar Ataxias
Multiplex Polymerase Chain Reaction
Missense Mutation
Mutation
2015
3 Citations (Scopus)
Calcitriol Receptors
Amyotrophic Lateral Sclerosis
Alleles
Vitamin D
Single Nucleotide Polymorphism
2014
19 Citations (Scopus)

Highly immunoreactive IgG antibodies directed against a set of twenty human proteins in the sera of patients with amyotrophic lateral sclerosis identified by protein array

May, C., Nordhoff, E., Casjens, S., Turewicz, M., Eisenacher, M., Gold, R., Brüning, T., Pesch, B., Stephan, C., Woitalla, D., Penke, B., Janáky, T., Virók, D., Siklós, L., Engelhardt, J. & Meyer, H. E., febr. 26 2014, In : PLoS One. 9, 2, e89596.

Research output: Article

Protein Array Analysis
Amyotrophic Lateral Sclerosis
Neurons
blood proteins
Blood Proteins
1 Citation (Scopus)

The role of cognitive training in the neurorehabilitation of a patient who survived a lightning strike. A case study

Tánczos, T., Zádori, D., Jakab, K., Hnyilicza, Z., Klivényi, P., Keresztes, L., Engelhardt, J., Németh, D. & Vécsei, L., 2014, In : NeuroRehabilitation. 35, 1, p. 137-146 10 p.

Research output: Article

Lightning
Lightning Injuries
Short-Term Memory
Semantics
Intelligence Tests
2013
1 Citation (Scopus)

Hashimoto-encephalopathia

Pocsay, G., Gazdag, A., Engelhardt, J., Szaniszló, I., Szolnoki, Z., Forczek, G. & Mikló, L., aug. 1 2013, In : Orvosi Hetilap. 154, 33, p. 1312-1316 5 p.

Research output: Article

Iodide Peroxidase
Thyroid Diseases
Brain Diseases
Immunosuppressive Agents
Serum
2011
24 Citations (Scopus)
GYKI 53405
Motor Neurons
Calcium
Transgenic Mice
Electrons
2010
9 Citations (Scopus)
Axotomy
Parvalbumins
Motor Neurons
Calcium
Neurons
2009
12 Citations (Scopus)
Microscopy
Staining and Labeling
Light
Sciatic Neuropathy
Dissection
2008
101 Citations (Scopus)

Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis

Appel, S. H., Engelhardt, J., Henkel, J. S., Siklós, L., Beers, D. R., Yen, A. A., Simpson, E. P., Luo, Y., Carrum, G., Heslop, H. E., Brenner, M. K. & Popat, U., okt. 21 2008, In : Neurology. 71, 17, p. 1326-1334 9 p.

Research output: Article

Hematopoietic Stem Cell Transplantation
Tissue Donors
Motor Neurons
DNA
Amyotrophic Lateral Sclerosis
2007
22 Citations (Scopus)

CIDP cured by allogeneic hematopoietic stem cell transplantation [1]

Reményi, P., Masszi, T., Borbényi, Z., Soós, J., Siklós, L. & Engelhardt, J., aug. 2007, In : European Journal of Neurology. 14, 8

Research output: Article

Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Aplastic Anemia
Hematopoietic Stem Cell Transplantation
Alopecia
Homologous Transplantation
2006
28 Citations (Scopus)
Axotomy
Calcium-Binding Proteins
Parvalbumins
Motor Neurons
Calcium
2005
30 Citations (Scopus)

Subcellular localization of IgG from the sera of ALS patients in the nervous system

Engelhardt, J., Soós, J., Obál, I., Vigh, L. & Siklós, L., aug. 2005, In : Acta Neurologica Scandinavica. 112, 2, p. 126-133 8 p.

Research output: Article

Amyotrophic Lateral Sclerosis
Nervous System
Immunoglobulin G
Motor Neurons
Serum
10 Citations (Scopus)

Sublethal dose of 4-hydroxynonenal reduces intracellular calcium in surviving motor neurons in vivo

Vigh, L., Smith, R. G., Soós, J., Engelhardt, J., Appel, S. H. & Siklós, L., jún. 2005, In : Acta Neuropathologica. 109, 6, p. 567-575 9 p.

Research output: Article

Motor Neurons
Amyotrophic Lateral Sclerosis
Calcium
Cerebrospinal Fluid
Lipid Peroxidation
2004
349 Citations (Scopus)

Presence of Dendritic Cells, MCP-1, and Activated Microglia/Macrophages in Amyotrophic Lateral Sclerosis Spinal Cord Tissue

Henkel, J. S., Engelhardt, J., Siklós, L., Simpson, E. P., Kim, S. H., Pan, T., Goodman, J. C., Siddique, T., Beers, D. R. & Appel, S. H., febr. 2004, In : Annals of Neurology. 55, 2, p. 221-235 15 p.

Research output: Article

Amyotrophic Lateral Sclerosis
Microglia
Dendritic Cells
Spinal Cord
Macrophages
57 Citations (Scopus)

The expression of PARP, NF-κB and parvalbumin is increased in Parkinson disease

Soós, J., Engelhardt, J., Siklós, L., Havas, L. & Majtényi, K., aug. 6 2004, In : NeuroReport. 15, 11, p. 1715-1718 4 p.

Research output: Article

Parvalbumins
Poly(ADP-ribose) Polymerases
Substantia Nigra
Parkinson Disease
Lewy Body Disease
36 Citations (Scopus)

Widespread increased expression of the DNA repair enzyme PARP in brain in ALS

Kim, S. H., Engelhardt, J., Henkel, J. S., Siklós, L., Soós, J., Goodman, C. & Appel, S. H., jan. 27 2004, In : Neurology. 62, 2, p. 319-322 4 p.

Research output: Article

DNA Repair Enzymes
Poly(ADP-ribose) Polymerases
Parietal Lobe
Motor Cortex
Brain
2003
43 Citations (Scopus)

PARP expression is increased in astrocytes but decreased in motor neurons in the spinal cord of sporadic ALS patients

Kim, S. H., Henkel, J. S., Beers, D. R., Sengun, I. S., Simpson, E. P., Goodman, J. C., Engelhardt, J., Siklós, L. & Appel, S. H., jan. 1 2003, In : Journal of Neuropathology and Experimental Neurology. 62, 1, p. 88-103 16 p.

Research output: Article

Poly(ADP-ribose) Polymerases
Motor Neurons
Astrocytes
Spinal Cord
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
2002
8 Citations (Scopus)

Altered calcium in motoneurons by IgG from human motoneuron diseases

Obal, I., Siklós, L. & Engelhardt, J., nov. 1 2002, In : Acta Neurologica Scandinavica. 106, 5, p. 282-291 10 p.

Research output: Article

Motor Neurons
Immunoglobulin G
Calcium
Presynaptic Terminals
Neuromuscular Junction
28 Citations (Scopus)
Motor Neurons
Homeostasis
Calcium
Amyotrophic Lateral Sclerosis
Autoimmunity
67 Citations (Scopus)

Immunoglobulin Fcγ receptor promotes immunoglobulin uptake, immunoglobulin-mediated Calcium increase, and neurotransmitter release in motor neurons

Mohamed, H. A., Mosier, D. R., Zou, L. L., Siklós, L., Alexianu, M. E., Engelhardt, J., Beers, D. R., Le, W. D. & Appel, S. H., júl. 1 2002, In : Journal of Neuroscience Research. 69, 1, p. 110-116 7 p.

Research output: Article

Fc Receptors
Motor Neurons
Neurotransmitter Agents
Immunoglobulins
Immunoglobulin G
2001
50 Citations (Scopus)

Calcium: The Darth Vader of ALS

Appel, S. H., Beers, D., Siklós, L., Engelhardt, J. & Mosier, D. R., márc. 2001, In : Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 2, SUPPL. 1

Research output: Article

Amyotrophic Lateral Sclerosis
Motor Neurons
Calcium
Calbindin 1
Parvalbumins
33 Citations (Scopus)

Recruitment of activated microglia cells in the spinal cord of mice by ALS IgG

Obál, I., Jakab, J. S. K., Siklós, L. & Engelhardt, J., aug. 8 2001, In : NeuroReport. 12, 11, p. 2449-2452 4 p.

Research output: Article

Amyotrophic Lateral Sclerosis
Microglia
Spinal Cord
Immunoglobulin G
Motor Neurons
6 Citations (Scopus)
Huntington Disease
Lymphocytes
Apoptosis
Neurodegenerative Diseases
Cell Death
2000
15 Citations (Scopus)

Altered calcium homeostasis in spinal motoneurons but not in oculomotor neurons of SOD-1 knockout mice

Siklós, L., Engelhardt, J., Reaume, A. G., Scott, R. W., Adalbert, R., Obál, I. & Appel, S. H., máj. 2000, In : Acta Neuropathologica. 99, 5, p. 517-524 8 p.

Research output: Article

Motor Neurons
Knockout Mice
Homeostasis
Calcium
Neurons
16 Citations (Scopus)
Cholinergic Neurons
Alzheimer Disease
Immunoglobulin G
Injections
Wounds and Injuries
5 Citations (Scopus)

Ultrastructural evidence of calcium involvement in experimental autoimmune gray matter disease

Alexianu, M. E., Manole, E., Engelhardt, J. & Appel, S. H., 2000, In : Journal of Neuroscience Research. 60, 1, p. 98-105 8 p.

Research output: Article

Motor Neurons
Calcium
Gray Matter
Oxalates
Wounds and Injuries
1999
10 Citations (Scopus)

Calcium-containing endosomes at oculomotor terminals in animal models of ALS

Siklós, L., Engelhardt, J., Adalbert, R. & Appel, S. H., aug. 20 1999, In : NeuroReport. 10, 12, p. 2539-2545 7 p.

Research output: Article

Endosomes
Animal Models
Calcium
Neurons
Vacuoles
1998
82 Citations (Scopus)

Experimental destruction of substantia nigra initiated by Parkinson disease immunoglobulins

Chen, S., Le, W. D., Xie, W. J., Alexianu, M. E., Engelhardt, J., Siklós, L. & Appel, S. H., aug. 1998, In : Archives of Neurology. 55, 8, p. 1075-1080 6 p.

Research output: Article

Substantia Nigra
Parkinson Disease
Immunoglobulins
Immunoglobulin G
Injections
110 Citations (Scopus)

Intracellular calcium parallels motoneuron degeneration in SOD-1 mutant mice

Siklós, L., Engelhardt, J., Alexianu, M. E., Gurney, M. E., Siddique, T. & Appel, S. H., jún. 1998, In : Journal of Neuropathology and Experimental Neurology. 57, 6, p. 571-587 17 p.

Research output: Article

Motor Neurons
Calcium
Parvalbumins
Calbindin 1
Homeostasis
18 Citations (Scopus)
Polyneuropathies
Antigen-Antibody Complex
Systemic Lupus Erythematosus
Basement Membrane
Schwann Cells
1997
39 Citations (Scopus)
Presynaptic Terminals
Motor Neurons
Homeostasis
Amyotrophic Lateral Sclerosis
Calcium
24 Citations (Scopus)

Experimental immune-mediated damage of septal cholinergic neurons

Kálmán, J., Engelhardt, J., Le, W. D., Xie, W., Kovacs, I., Kása, P. & Appel, S. H., júl. 1997, In : Journal of Neuroimmunology. 77, 1, p. 63-74 12 p.

Research output: Article

Cholinergic Neurons
Choline O-Acetyltransferase
Hippocampus
Guinea Pigs
Diagonal Band of Broca
10 Citations (Scopus)
Choline O-Acetyltransferase
Motor Neurons
Immunization
Guinea Pigs
Immunoglobulin G
1996
44 Citations (Scopus)

Autoimmunity and ALS

Smith, R. G., Siklós, L., Alexianu, M. E., Engelhardt, J., Mosier, D. R., Colom, L., Mohamed, A. H. & Appel, S. H., okt. 1996, In : Neurology. 47, 4 SUPPL.

Research output: Article

Motor Neurons
Autoimmunity
Immunoglobulins
Apoptosis
Calcium-Binding Proteins
235 Citations (Scopus)

Ultrastructural evidence for altered calcium in motor nerve terminals in amyotrophic lateral sclerosis

Siklós, L., Engelhardt, J., Harati, Y., Smith, R. G., Joó, F. & Appel, S. H., 1996, In : Annals of Neurology. 39, 2, p. 203-216 14 p.

Research output: Article

Amyotrophic Lateral Sclerosis
Calcium
Immunoglobulin G
Mitochondrial Size
Oxalates
1995
80 Citations (Scopus)
Motor Neurons
Calcium Channels
Calcium
Immunoglobulin G
Antibodies
30 Citations (Scopus)

Autoimmunity as an etiological factor in sporadic amyotrophic lateral sclerosis.

Appel, S. H., Smith, R. G., Alexianu, M. F., Engelhardt, J. I. & Stefani, E., 1995, In : Advances in neurology. 68, p. 47-57 11 p.

Research output: Article

31 Citations (Scopus)

Experimental autoimmune nigral damage in guinea pigs

Le, W. D., Engelhardt, J., Xie, W. J., Schneider, L., Smith, R. G. & Appel, S. H., 1995, In : Journal of Neuroimmunology. 57, 1-2, p. 45-53 9 p.

Research output: Article

Substantia Nigra
Guinea Pigs
Neurons
Hypokinesia
Hybrid Cells
1994
45 Citations (Scopus)

Evidence for autoimmunity in amyotrophic lateral sclerosis

Appel, S. H., Smith, R. G., Engelhardt, J. & Stefani, E., 1994, In : Journal of the Neurological Sciences. 124, SUPPL., p. 14-19 6 p.

Research output: Article

Amyotrophic Lateral Sclerosis
Autoimmunity
Motor Neurons
Immunoglobulin G
Spinal Cord
10 Citations (Scopus)

Neurodegenerative disease: Autoimmunity involving calcium channels

Appel, S. H., Glenn Smith, R., Alexilnu, M., Engelhardt, J., Mosier, D., Colom, L. & Stefani, E., 1994, In : Annals of the New York Academy of Sciences. 747, p. 183-194 12 p.

Research output: Article

Calcium
Autoimmunity