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1987 …2019
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Research Output 1987 2019

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Article
2019

Alcoholic Hepatitis: A Review

Hosseini, N., Shor, J. & Szabó, G., júl. 1 2019, In : Alcohol and alcoholism (Oxford, Oxfordshire). 54, 4, p. 408-416 9 p.

Research output: Article

Alcoholic Hepatitis
Liver
Fibrosis
Alcoholic Liver Diseases
Alcohols
2 Citations (Scopus)

Alcohol-induced IL-17A production in Paneth cells amplifies endoplasmic reticulum stress, apoptosis, and inflammasome-IL-18 activation in the proximal small intestine in mice

Gyongyosi, B., Cho, Y., Lowe, P., Calenda, C. D., Iracheta-Vellve, A., Satishchandran, A., Ambade, A. & Szabó, G., jan. 1 2019, In : Mucosal Immunology.

Research output: Article

Paneth Cells
Inflammasomes
Interleukin-18
Endoplasmic Reticulum Stress
Interleukin-17
5 Citations (Scopus)

Alcohol-Related Liver Disease: Areas of Consensus, Unmet Needs and Opportunities for Further Study

Szabó, G., Kamath, P. S., Shah, V. H., Thursz, M. & Mathurin, P., jan. 1 2019, (Accepted/In press) In : Hepatology.

Research output: Article

Liver Diseases
Consensus
Alcohols
Alcoholic Liver Diseases
Alcohol Drinking
3 Citations (Scopus)

Biomarkers of Macrophage Activation and Immune Danger Signals Predict Clinical Outcomes in Alcoholic Hepatitis

Saha, B., Tornai, D., Kodys, K., Adejumo, A., Lowe, P., McClain, C., Mitchell, M., McCullough, A., Dasarathy, S., Kroll-Desrosiers, A., Barton, B., Radaeva, S. & Szabó, G., okt. 1 2019, In : Hepatology. 70, 4, p. 1134-1149 16 p.

Research output: Article

Alcoholic Hepatitis
Macrophage Activation
Biomarkers
Osteopontin
End Stage Liver Disease

Dysregulated Autophagy and Lysosome Function Are Linked to Exosome Production by Micro-RNA 155 in Alcoholic Liver Disease

Babuta, M., Furi, I., Bala, S., Bukong, T. N., Lowe, P., Catalano, D., Calenda, C., Kodys, K. & Szabó, G., jan. 1 2019, In : Hepatology.

Research output: Article

Exosomes
Alcoholic Liver Diseases
Autophagy
Lysosomes
MicroRNAs
3 Citations (Scopus)

Macrophage-Specific Hypoxia-Inducible Factor-1α Contributes to Impaired Autophagic Flux in Nonalcoholic Steatohepatitis

Wang, X., de Carvalho Ribeiro, M., Iracheta-Vellve, A., Lowe, P., Ambade, A., Satishchandran, A., Bukong, T., Catalano, D., Kodys, K. & Szabó, G., jan. 1 2019, (Accepted/In press) In : Hepatology.

Research output: Article

Hypoxia-Inducible Factor 1
Macrophages
Autophagy
Choline
Methionine
10 Citations (Scopus)

Pharmacological Inhibition of CCR2/5 Signaling Prevents and Reverses Alcohol-Induced Liver Damage, Steatosis, and Inflammation in Mice

Ambade, A., Lowe, P., Kodys, K., Catalano, D., Gyongyosi, B., Cho, Y., Iracheta-Vellve, A., Adejumo, A., Saha, B., Calenda, C., Mehta, J., Lefebvre, E., Vig, P. & Szabó, G., márc. 1 2019, In : Hepatology. 69, 3, p. 1105-1121 17 p.

Research output: Article

Fatty Liver
CC Chemokines
Alcohols
Pharmacology
Alcoholic Liver Diseases
1 Citation (Scopus)

Proton pump inhibitors increase the severity of hepatic encephalopathy in cirrhotic patients

Fasullo, M., Rau, P., Liu, D. Q., Holzwanger, E., Mathew, J. P., Guilarte-Walker, Y. & Szabó, G., jan. 1 2019, In : World Journal of Hepatology. 11, 6, p. 522-530 9 p.

Research output: Article

Open Access
Hepatic Encephalopathy
Proton Pump Inhibitors
Length of Stay
Ammonia
Liver Cirrhosis
2018
11 Citations (Scopus)

Abnormal neutrophil traps and impaired efferocytosis contribute to liver injury and sepsis severity after binge alcohol use

Bukong, T. N., Cho, Y., Iracheta-Vellve, A., Saha, B., Lowe, P., Adejumo, A., Furi, I., Ambade, A., Gyongyosi, B., Catalano, D., Kodys, K. & Szabó, G., jan. 1 2018, (Accepted/In press) In : Journal of Hepatology.

Research output: Article

Sepsis
Neutrophils
Alcohols
Liver
Wounds and Injuries
17 Citations (Scopus)

Acute-on-Chronic Liver Failure: Getting Ready for Prime Time?

Bajaj, J. S., Moreau, R., Kamath, P. S., Vargas, H. E., Arroyo, V., Reddy, K. R., Szabó, G., Tandon, P., Olson, J., Karvellas, C., Gustot, T., Lai, J. C. & Wong, F., jan. 1 2018, (Accepted/In press) In : Hepatology.

Research output: Article

Northern Asia
Transplants
Precipitating Factors
Mortality
Liver
21 Citations (Scopus)

Extracellular vesicles from mice with alcoholic liver disease carry a distinct protein cargo and induce macrophage activation through heat shock protein 90

Saha, B., Momen-Heravi, F., Furi, I., Kodys, K., Catalano, D., Gangopadhyay, A., Haraszti, R., Satishchandran, A., Iracheta-Vellve, A., Adejumo, A., Shaffer, S. A. & Szabó, G., máj. 1 2018, In : Hepatology. 67, 5, p. 1986-2000 15 p.

Research output: Article

HSP90 Heat-Shock Proteins
Alcoholic Liver Diseases
Macrophage Activation
Proteins
Extracellular Vesicles
3 Citations (Scopus)
Alcoholic Liver Diseases
Liver
Mycobiome
27 Citations (Scopus)

MicroRNA 122, Regulated by GRLH2, Protects Livers of Mice and Patients From Ethanol-Induced Liver Disease

Satishchandran, A., Ambade, A., Rao, S., Hsueh, Y. C., Iracheta-Vellve, A., Tornai, D., Lowe, P., Gyongyosi, B., Li, J., Catalano, D., Zhong, L., Kodys, K., Xie, J., Bala, S., Gao, G. & Szabó, G., jan. 1 2018, In : Gastroenterology. 154, 1, p. 238-252.e7

Research output: Article

MicroRNAs
Liver Diseases
Ethanol
Alcoholic Liver Diseases
Liver
9 Citations (Scopus)

Reduced gut microbiome protects from alcohol-induced neuroinflammation and alters intestinal and brain inflammasome expression

Lowe, P. P., Gyongyosi, B., Satishchandran, A., Iracheta-Vellve, A., Cho, Y., Ambade, A. & Szabó, G., okt. 27 2018, In : Journal of Neuroinflammation. 15, 1, 298.

Research output: Article

Inflammasomes
Alcohols
Brain
Anti-Bacterial Agents
Small Intestine
2017
13 Citations (Scopus)

Alcohol-induced miR-155 and HDAC11 inhibit negative regulators of the TLR4 pathway and lead to increased LPS responsiveness of Kupffer cells in alcoholic liver disease

Bala, S., Csak, T., Kodys, K., Catalano, D., Ambade, A., Furi, I., Lowe, P., Cho, Y., Iracheta-Vellve, A. & Szabó, G., aug. 1 2017, In : Journal of Leukocyte Biology. 102, 2, p. 487-498 12 p.

Research output: Article

Alcoholic Liver Diseases
Kupffer Cells
Alcohols
Interleukin-10
Cytokines
27 Citations (Scopus)

Alcohol-related changes in the intestinal icrobiome influence neutrophil infiltration, inflammation and steatosis in early alcoholic hepatitis in mice

Lowe, P. P., Gyongyosi, B., Satishchandran, A., Iracheta-Vellve, A., Ambade, A., Kodys, K., Catalano, D., Ward, D. V. & Szabó, G., márc. 1 2017, In : PLoS One. 12, 3, e0174544.

Research output: Article

alcoholic hepatitis
Alcoholic Hepatitis
Neutrophil Infiltration
Infiltration
neutrophils
12 Citations (Scopus)
Exosomes
Hepacivirus
Hepatitis
Monocytes
Macrophages
2 Citations (Scopus)

Clinical Trial Design for Alcoholic Hepatitis

Szabó, G., nov. 1 2017, In : Seminars in Liver Disease. 37, 4, p. 332-342 11 p.

Research output: Article

Alcoholic Hepatitis
Clinical Trials
Vulnerable Populations
Alcoholic Liver Diseases
Industry
9 Citations (Scopus)

Interleukin-1 inhibition facilitates recovery from liver injury and promotes regeneration of hepatocytes in alcoholic hepatitis in mice

Iracheta-Vellve, A., Petrasek, J., Gyogyosi, B., Bala, S., Csak, T., Kodys, K. & Szabó, G., júl. 1 2017, In : Liver International. 37, 7, p. 968-973 6 p.

Research output: Article

Alcoholic Hepatitis
Interleukin-1
Regeneration
Hepatocytes
Liver
70 Citations (Scopus)

Recovery of ethanol-induced Akkermansia muciniphila depletion ameliorates alcoholic liver disease

Grander, C., Adolph, T. E., Wieser, V., Lowe, P., Wrzosek, L., Gyongyosi, B., Ward, D. V., Grabherr, F., Gerner, R. R., Pfister, A., Enrich, B., Ciocan, D., Macheiner, S., Mayr, L., Drach, M., Moser, P., Moschen, A. R., Perlemuter, G., Szabó, G., Cassard, A. M. & 1 others, Tilg, H., máj. 26 2017, (Accepted/In press) In : Gut.

Research output: Article

Alcoholic Liver Diseases
Ethanol
Alcoholic Fatty Liver
Neutrophil Infiltration
Mucus
2016
12 Citations (Scopus)

Adult mouse model of early hepatocellular carcinoma promoted by alcoholic liver disease

Ambade, A., Satishchandran, A., Gyongyosi, B., Lowe, P. & Szabó, G., ápr. 28 2016, In : World Journal of Gastroenterology. 22, 16, p. 4091-4108 18 p.

Research output: Article

Alcoholic Liver Diseases
Nitrosamines
Hepatocellular Carcinoma
Alcohols
Liver
32 Citations (Scopus)
Alcoholic Hepatitis
Nitrosamines
Alcohols
Alcoholic Fatty Liver
Liver
121 Citations (Scopus)
Ribavirin
Hepacivirus
Genotype
Infection
Therapeutics
303 Citations (Scopus)

Elafibranor, an Agonist of the Peroxisome Proliferator-Activated Receptor-α and -δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening

Ratziu, V., Harrison, S. A., Francque, S., Bedossa, P., Lehert, P., Serfaty, L., Romero-Gomez, M., Boursier, J., Abdelmalek, M., Caldwell, S., Drenth, J., Anstee, Q. M., Hum, D., Hanf, R., Roudot, A., Megnien, S., Staels, B., Sanyal, A., Mathurin, P., Gournay, J. & 49 others, Nguyen-Khac, E., De Ledinghen, V., Larrey, D., Tran, A., Bourliere, M., Maynard-Muet, M., Asselah, T., Henrion, J., Nevens, F., Cassiman, D., Geerts, A., Moreno, C., Beuers, U. H., Galle, P. R., Spengler, U., Bugianesi, E., Craxi, A., Angelico, M., Fargion, S., Voiculescu, M., Gheorghe, L., Preotescu, L., Caballeria, J., Andrade, R. J., Crespo, J., Callera, J. L., Ala, A., Aithal, G., Abouda, G., Luketic, V., Huang, M. A., Gordon, S., Pockros, P., Poordad, F., Shores, N., Moehlen, M. W., Bambha, K., Clark, V., Satapathy, S., Parekh, S., Reddy, R. K., Sheikh, M. Y., Szabó, G., Vierling, J., Foster, T., Umpierrez, G., Chang, C., Box, T. & Gallegos-Orozco, J., máj. 1 2016, In : Gastroenterology. 150, 5, p. 1147-1159e5

Research output: Article

Peroxisome Proliferator-Activated Receptors
Fibrosis
Placebos
Intention to Treat Analysis
Odds Ratio
33 Citations (Scopus)

Endoplasmic reticulum stress-induced hepatocellular death pathways mediate liver injury and fibrosis via stimulator of interferon genes

Iracheta-Vellve, A., Petrasek, J., Gyongyosi, B., Satishchandran, A., Lowe, P., Kodys, K., Catalano, D., Calenda, C. D., Kurt-Jones, E. A., Fitzgerald, K. A. & Szabó, G., dec. 23 2016, In : Journal of Biological Chemistry. 291, 52, p. 26794-26805 12 p.

Research output: Article

Interferon Regulatory Factor-3
Endoplasmic Reticulum Stress
Liver Cirrhosis
Liver
Interferons
17 Citations (Scopus)
Transforming Growth Factors
Hepacivirus
Monocytes
Macrophages
Chronic Hepatitis C
23 Citations (Scopus)

Hepatocellular carcinoma is accelerated by NASH involving M2 macrophage polarization mediated by hif-1αinduced IL-10

Ambade, A., Satishchandran, A., Saha, B., Gyongyosi, B., Lowe, P., Kodys, K., Catalano, D. & Szabó, G., okt. 2 2016, In : OncoImmunology. 5, 10

Research output: Article

Interleukin-10
Hepatocellular Carcinoma
Macrophages
Nitrosamines
Hepatocytes
18 Citations (Scopus)

Inhibition of spleen tyrosine kinase activation ameliorates inflammation, cell death, and steatosis in alcoholic liver disease

Bukong, T. N., Iracheta-Vellve, A., Saha, B., Ambade, A., Satishchandran, A., Gyongyosi, B., Lowe, P., Catalano, D., Kodys, K. & Szabó, G., okt. 1 2016, In : Hepatology. 64, 4, p. 1057-1071 15 p.

Research output: Article

Alcoholic Liver Diseases
Cell Death
Inflammation
Liver
Alcohols
54 Citations (Scopus)
Macrophages
MicroRNAs
Monocytes
Alcohols
Exosomes
68 Citations (Scopus)

The pro-inflammatory effects of miR-155 promote liver fibrosis and alcohol-induced steatohepatitis

Bala, S., Csak, T., Saha, B., Zatsiorsky, J., Kodys, K., Catalano, D., Satishchandran, A. & Szabó, G., jún. 1 2016, In : Journal of Hepatology. 64, 6, p. 1378-1387 10 p.

Research output: Article

Fatty Liver
Knockout Mice
Liver Cirrhosis
Alcohols
Peroxisome Proliferator-Activated Receptors
10 Citations (Scopus)

Therapeutic Benefits of Spleen Tyrosine Kinase Inhibitor Administration on Binge Drinking-Induced Alcoholic Liver Injury, Steatosis, and Inflammation in Mice

Bukong, T. N., Iracheta-Vellve, A., Gyongyosi, B., Ambade, A., Catalano, D., Kodys, K. & Szabó, G., júl. 1 2016, In : Alcoholism: Clinical and Experimental Research. 40, 7, p. 1524-1530 7 p.

Research output: Article

Binge Drinking
Fatty Liver
Liver
Protein-Tyrosine Kinases
Inflammation
2015
15 Citations (Scopus)

Alcohol and HCV: Implications for liver cancer

Szabó, G., Saha, B. & Bukong, T. N., 2015, In : Advances in Experimental Medicine and Biology. 815, p. 197-216 20 p.

Research output: Article

Liver Neoplasms
Liver
Alcohols
Medical problems
Viruses
35 Citations (Scopus)

Alcohol-induced miR-27a regulates differentiation and M2 macrophage polarization of normal human monocytes

Saha, B., Bruneau, J. C., Kodys, K. & Szabó, G., ápr. 1 2015, In : Journal of Immunology. 194, 7, p. 3079-3087 9 p.

Research output: Article

MicroRNAs
Monocytes
Macrophages
Alcohols
Hepacivirus
55 Citations (Scopus)

Biodistribution and function of extracellular miRNA-155 in mice

Bala, S., Csak, T., Momen-Heravi, F., Lippai, D., Kodys, K., Catalano, D., Satishchandran, A., Ambros, V. & Szabó, G., máj. 29 2015, In : Scientific Reports. 5, 10721.

Research output: Article

MicroRNAs
Exosomes
Adipose Tissue
Liver
Kupffer Cells
114 Citations (Scopus)
Exosomes
MicroRNAs
Monocytes
Hepatocytes
Alcohols
11 Citations (Scopus)

Gaps in Knowledge and Research Priorities for Alcoholic Hepatitis

Sanyal, A. J., Gao, B. & Szabó, G., júl. 1 2015, In : Gastroenterology. 149, 1, p. 4-9 6 p., 59786.

Research output: Article

110 Citations (Scopus)

Increased number of circulating exosomes and their microRNA cargos are potential novel biomarkers in alcoholic hepatitis

Momen-Heravi, F., Saha, B., Kodys, K., Catalano, D., Satishchandran, A. & Szabó, G., aug. 12 2015, In : Journal of Translational Medicine. 13, 1, 261.

Research output: Article

Exosomes
Alcoholic Hepatitis
Biomarkers
MicroRNAs
Alcohols
40 Citations (Scopus)

Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice

Iracheta-Vellve, A., Petrasek, J., Satishchandran, A., Gyongyosi, B., Saha, B., Kodys, K., Fitzgerald, K. A., Kurt-Jones, E. A. & Szabó, G., nov. 1 2015, In : Journal of Hepatology. 63, 5, p. 1147-1155 9 p.

Research output: Article

Alcoholic Fatty Liver
Inflammasomes
Uric Acid
Adenosine Triphosphate
Interleukin-1
21 Citations (Scopus)

Krüppel-like factor 4 is a transcriptional regulator of M1/M2 macrophage polarization in alcoholic liver disease

Saha, B., Bala, S., Hosseini, N., Kodys, K. & Szabó, G., máj. 1 2015, In : Journal of Leukocyte Biology. 97, 5, p. 963-973 11 p.

Research output: Article

Alcoholic Liver Diseases
Macrophages
Alcohols
Acetaldehyde
Liver
48 Citations (Scopus)

Metabolic danger signals, uric acid and ATP, mediate inflammatory cross-talk between hepatocytes and immune cells in alcoholic liver disease

Petrasek, J., Iracheta-Vellve, A., Saha, B., Satishchandran, A., Kodys, K., Fitzgerald, K. A., Kurt-Jones, E. A. & Szabó, G., aug. 1 2015, In : Journal of Leukocyte Biology. 98, 2, p. 249-256 8 p.

Research output: Article

Alcoholic Liver Diseases
Uric Acid
Hepatocytes
Adenosine Triphosphate
Inflammation
61 Citations (Scopus)

microRNA-122 regulates hypoxia-inducible factor-1 and vimentin in hepatocytes and correlates with fibrosis in diet-induced steatohepatitis

Csak, T., Bala, S., Lippai, D., Satishchandran, A., Catalano, D., Kodys, K. & Szabó, G., febr. 1 2015, In : Liver International. 35, 2, p. 532-541 10 p.

Research output: Article

Hypoxia-Inducible Factor 1
Vimentin
Fatty Liver
Choline
MicroRNAs
40 Citations (Scopus)

MicroRNA-155 deficiency attenuates liver steatosis and fibrosis without reducing inflammation in a mouse model of steatohepatitis

Csak, T., Bala, S., Lippai, D., Kodys, K., Catalano, D., Iracheta-Vellve, A. & Szabó, G., jún. 4 2015, In : PLoS One. 10, 6, e0129251.

Research output: Article

liver cirrhosis
fatty liver
Fatty Liver
Choline
MicroRNAs
27 Citations (Scopus)

MicroRNAs in alcoholic liver disease

Szabó, G. & Satishchandran, A., febr. 1 2015, In : Seminars in Liver Disease. 35, 1, p. 36-42 7 p.

Research output: Article

Alcoholic Liver Diseases
MicroRNAs
Alcohols
Liver Circulation
Alcoholic Hepatitis
49 Citations (Scopus)
Fatty Liver
Nutrition
Sugars
Liver
Tumors
2014
141 Citations (Scopus)

Acute binge drinking increases serum endotoxin and bacterial DNA levels in healthy individuals

Bala, S., Marcos, M., Gattu, A., Catalano, D. & Szabó, G., máj. 14 2014, In : PLoS One. 9, 5, e96864.

Research output: Article

Binge Drinking
Bacterial DNA
binging
endotoxins
blood serum
3 Citations (Scopus)
Virus Diseases
Viruses
Hepacivirus
Peptides
Hinges
29 Citations (Scopus)

Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88- dependent manner in dietary steatohepatitis

Csak, T., Pillai, A., Ganz, M., Lippai, D., Petrasek, J., Park, J. K., Kodys, K., Dolganiuc, A., Kurt-Jones, E. A. & Szabó, G., 2014, In : Liver International. 34, 9, p. 1402-1413 12 p.

Research output: Article

Inflammasomes
Fatty Liver
Melanoma
Bone Marrow
Interleukin-1
42 Citations (Scopus)
Alcohols
Liver
Brain
Alcohol Drinking
Encephalitis
105 Citations (Scopus)

Exosome-mediated delivery of functionally active miRNA-155 inhibitor to macrophages

Momen-Heravi, F., Bala, S., Bukong, T. & Szabó, G., okt. 1 2014, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 10, 7, p. 1517-1527 11 p.

Research output: Article

Exosomes
Macrophages
MicroRNAs
Cells
Biomolecules
161 Citations (Scopus)
Exosomes
Viral RNA
Hepatitis C
Infection
Proton Pumps