• 14834 Citations
  • 70 h-Index
1987 …2019
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Research Output 1987 2019

2019

Alcoholic Hepatitis: A Review

Hosseini, N., Shor, J. & Szabó, G., júl. 1 2019, In : Alcohol and alcoholism (Oxford, Oxfordshire). 54, 4, p. 408-416 9 p.

Research output: Article

Alcoholic Hepatitis
Liver
Fibrosis
Alcoholic Liver Diseases
Alcohols
1 Citation (Scopus)

Alcohol-induced IL-17A production in Paneth cells amplifies endoplasmic reticulum stress, apoptosis, and inflammasome-IL-18 activation in the proximal small intestine in mice

Gyongyosi, B., Cho, Y., Lowe, P., Calenda, C. D., Iracheta-Vellve, A., Satishchandran, A., Ambade, A. & Szabó, G., jan. 1 2019, In : Mucosal Immunology.

Research output: Article

Paneth Cells
Inflammasomes
Interleukin-18
Endoplasmic Reticulum Stress
Interleukin-17
6 Citations (Scopus)

Alcohol-related liver disease: Areas of consensus, unmet needs and opportunities for further study

Thursz, M., Kamath, P. S., Mathurin, P., Szabó, G. & Shah, V. H., márc. 1 2019, In : Journal of Hepatology. 70, 3, p. 521-530 10 p.

Research output: Review article

Alcoholic Liver Diseases
Alcohol Drinking
Liver Diseases
Consensus
Alcohols
1 Citation (Scopus)

Alcohol-Related Liver Disease: Areas of Consensus, Unmet Needs and Opportunities for Further Study

Szabó, G., Kamath, P. S., Shah, V. H., Thursz, M. & Mathurin, P., jan. 1 2019, (Accepted/In press) In : Hepatology.

Research output: Article

Liver Diseases
Consensus
Alcohols
Alcoholic Liver Diseases
Alcohol Drinking
1 Citation (Scopus)

Biomarkers of Macrophage Activation and Immune Danger Signals Predict Clinical Outcomes in Alcoholic Hepatitis

Saha, B., Tornai, D., Kodys, K., Adejumo, A., Lowe, P., McClain, C., Mitchell, M., McCullough, A., Dasarathy, S., Kroll-Desrosiers, A., Barton, B., Radaeva, S. & Szabó, G., okt. 1 2019, In : Hepatology. 70, 4, p. 1134-1149 16 p.

Research output: Article

Alcoholic Hepatitis
Macrophage Activation
Biomarkers
Osteopontin
End Stage Liver Disease

Dysregulated Autophagy and Lysosome Function Are Linked to Exosome Production by Micro-RNA 155 in Alcoholic Liver Disease

Babuta, M., Furi, I., Bala, S., Bukong, T. N., Lowe, P., Catalano, D., Calenda, C., Kodys, K. & Szabó, G., jan. 1 2019, In : Hepatology.

Research output: Article

Exosomes
Alcoholic Liver Diseases
Autophagy
Lysosomes
MicroRNAs

Introducing the 2019 American Association for the Study of Liver Diseases Guidance on Alcohol-Related Liver Disease

Lucey, M. R., Im, G. Y., Mellinger, J. L., Szabó, G. & Crabb, D. W., jan. 1 2019, (Accepted/In press) In : Liver Transplantation.

Research output: Editorial

Liver Diseases
Alcohols
2 Citations (Scopus)

Macrophage-Specific Hypoxia-Inducible Factor-1α Contributes to Impaired Autophagic Flux in Nonalcoholic Steatohepatitis

Wang, X., de Carvalho Ribeiro, M., Iracheta-Vellve, A., Lowe, P., Ambade, A., Satishchandran, A., Bukong, T., Catalano, D., Kodys, K. & Szabó, G., jan. 1 2019, (Accepted/In press) In : Hepatology.

Research output: Article

Hypoxia-Inducible Factor 1
Macrophages
Autophagy
Choline
Methionine

Pathogenesis of Acute-on-Chronic Liver Failure in Patients With Infection

Szabo, G., szept. 1 2019, In : Clinical Liver Disease. 14, 3, p. 103-106 4 p.

Research output: Review article

Infection
Acute-On-Chronic Liver Failure
6 Citations (Scopus)

Pharmacological Inhibition of CCR2/5 Signaling Prevents and Reverses Alcohol-Induced Liver Damage, Steatosis, and Inflammation in Mice

Ambade, A., Lowe, P., Kodys, K., Catalano, D., Gyongyosi, B., Cho, Y., Iracheta-Vellve, A., Adejumo, A., Saha, B., Calenda, C., Mehta, J., Lefebvre, E., Vig, P. & Szabó, G., márc. 1 2019, In : Hepatology. 69, 3, p. 1105-1121 17 p.

Research output: Article

Fatty Liver
CC Chemokines
Alcohols
Pharmacology
Alcoholic Liver Diseases
1 Citation (Scopus)

Proton pump inhibitors increase the severity of hepatic encephalopathy in cirrhotic patients

Fasullo, M., Rau, P., Liu, D. Q., Holzwanger, E., Mathew, J. P., Guilarte-Walker, Y. & Szabó, G., jan. 1 2019, In : World Journal of Hepatology. 11, 6, p. 522-530 9 p.

Research output: Article

Open Access
Hepatic Encephalopathy
Proton Pump Inhibitors
Length of Stay
Ammonia
Liver Cirrhosis
2018
7 Citations (Scopus)

Abnormal neutrophil traps and impaired efferocytosis contribute to liver injury and sepsis severity after binge alcohol use

Bukong, T. N., Cho, Y., Iracheta-Vellve, A., Saha, B., Lowe, P., Adejumo, A., Furi, I., Ambade, A., Gyongyosi, B., Catalano, D., Kodys, K. & Szabó, G., jan. 1 2018, (Accepted/In press) In : Journal of Hepatology.

Research output: Article

Sepsis
Neutrophils
Alcohols
Liver
Wounds and Injuries
14 Citations (Scopus)

Acute-on-Chronic Liver Failure: Getting Ready for Prime Time?

Bajaj, J. S., Moreau, R., Kamath, P. S., Vargas, H. E., Arroyo, V., Reddy, K. R., Szabó, G., Tandon, P., Olson, J., Karvellas, C., Gustot, T., Lai, J. C. & Wong, F., jan. 1 2018, (Accepted/In press) In : Hepatology.

Research output: Article

Northern Asia
Transplants
Precipitating Factors
Mortality
Liver
16 Citations (Scopus)

Alcoholic liver disease

Seitz, H. K., Bataller, R., Cortez-Pinto, H., Gao, B., Gual, A., Lackner, C., Mathurin, P., Mueller, S., Szabó, G. & Tsukamoto, H., dec. 1 2018, In : Nature Reviews Disease Primers. 4, 1, 16.

Research output: Review article

Alcoholic Fatty Liver
Alcoholic Liver Diseases
Fibrosis
Liver Neoplasms
Liver Diseases
1 Citation (Scopus)

Alcoholic liver disease accelerates early hepatocellular cancer in amouse model

Szabó, G., jan. 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 71-79 9 p. (Advances in Experimental Medicine and Biology; vol. 1032).

Research output: Chapter

Alcoholic Liver Diseases
Liver Neoplasms
Liver
Alcohols
Liver Diseases
1 Citation (Scopus)

Erratum to: Alcoholic liver disease (Nature Reviews Disease Primers, (2018), 4, 1, (16), 10.1038/s41572-018-0014-7)

Seitz, H. K., Bataller, R., Cortez-Pinto, H., Gao, B., Gual, A., Lackner, C., Mathurin, P., Mueller, S., Szabó, G. & Tsukamoto, H., dec. 1 2018, In : Nature Reviews Disease Primers. 4, 1, 18.

Research output: Comment/debate

Alcoholic Liver Diseases
Fibrosis
Esophageal and Gastric Varices
17 Citations (Scopus)

Extracellular vesicles from mice with alcoholic liver disease carry a distinct protein cargo and induce macrophage activation through heat shock protein 90

Saha, B., Momen-Heravi, F., Furi, I., Kodys, K., Catalano, D., Gangopadhyay, A., Haraszti, R., Satishchandran, A., Iracheta-Vellve, A., Adejumo, A., Shaffer, S. A. & Szabó, G., máj. 1 2018, In : Hepatology. 67, 5, p. 1986-2000 15 p.

Research output: Article

HSP90 Heat-Shock Proteins
Alcoholic Liver Diseases
Macrophage Activation
Proteins
Extracellular Vesicles
2 Citations (Scopus)
Alcoholic Liver Diseases
Liver
Mycobiome
4 Citations (Scopus)

Hypoxia downregulates protein S expression

Pilli, V. S., Datta, A., Afreen, S., Catalano, D., Szabó, G. & Majumder, R., júl. 26 2018, In : Blood. 132, 4, p. 452-455 4 p.

Research output: Letter

Alpha Subunit Hypoxia-Inducible Factor 1
Protein S
Hep G2 Cells
Knockout Mice
Thrombosis
1 Citation (Scopus)

IL-1α in acetaminophen toxicity: A sterile danger signal

Iracheta-Vellve, A. & Szabó, G., márc. 1 2018, In : Cellular and Molecular Immunology. 15, 3, p. 284-285 2 p.

Research output: Letter

Acetaminophen
23 Citations (Scopus)

MicroRNA 122, Regulated by GRLH2, Protects Livers of Mice and Patients From Ethanol-Induced Liver Disease

Satishchandran, A., Ambade, A., Rao, S., Hsueh, Y. C., Iracheta-Vellve, A., Tornai, D., Lowe, P., Gyongyosi, B., Li, J., Catalano, D., Zhong, L., Kodys, K., Xie, J., Bala, S., Gao, G. & Szabó, G., jan. 1 2018, In : Gastroenterology. 154, 1, p. 238-252.e7

Research output: Article

MicroRNAs
Liver Diseases
Ethanol
Alcoholic Liver Diseases
Liver
2 Citations (Scopus)
Alcoholic Hepatitis
Acute-On-Chronic Liver Failure
8 Citations (Scopus)

Reduced gut microbiome protects from alcohol-induced neuroinflammation and alters intestinal and brain inflammasome expression

Lowe, P. P., Gyongyosi, B., Satishchandran, A., Iracheta-Vellve, A., Cho, Y., Ambade, A. & Szabó, G., okt. 27 2018, In : Journal of Neuroinflammation. 15, 1, 298.

Research output: Article

Inflammasomes
Alcohols
Brain
Anti-Bacterial Agents
Small Intestine

Reply

Satishchandran, A. & Szabó, G., jún. 1 2018, In : Gastroenterology. 154, 8, p. 2277-2278 2 p.

Research output: Letter

4 Citations (Scopus)
Alcoholic Liver Diseases
2017
13 Citations (Scopus)

Alcohol-induced miR-155 and HDAC11 inhibit negative regulators of the TLR4 pathway and lead to increased LPS responsiveness of Kupffer cells in alcoholic liver disease

Bala, S., Csak, T., Kodys, K., Catalano, D., Ambade, A., Furi, I., Lowe, P., Cho, Y., Iracheta-Vellve, A. & Szabó, G., aug. 1 2017, In : Journal of Leukocyte Biology. 102, 2, p. 487-498 12 p.

Research output: Article

Alcoholic Liver Diseases
Kupffer Cells
Alcohols
Interleukin-10
Cytokines
25 Citations (Scopus)

Alcohol-related changes in the intestinal icrobiome influence neutrophil infiltration, inflammation and steatosis in early alcoholic hepatitis in mice

Lowe, P. P., Gyongyosi, B., Satishchandran, A., Iracheta-Vellve, A., Ambade, A., Kodys, K., Catalano, D., Ward, D. V. & Szabó, G., márc. 1 2017, In : PLoS One. 12, 3, e0174544.

Research output: Article

alcoholic hepatitis
Alcoholic Hepatitis
Neutrophil Infiltration
Infiltration
neutrophils
11 Citations (Scopus)
Exosomes
Hepacivirus
Hepatitis
Monocytes
Macrophages
2 Citations (Scopus)

Clinical Trial Design for Alcoholic Hepatitis

Szabó, G., nov. 1 2017, In : Seminars in Liver Disease. 37, 4, p. 332-342 11 p.

Research output: Article

Alcoholic Hepatitis
Clinical Trials
Vulnerable Populations
Alcoholic Liver Diseases
Industry
10 Citations (Scopus)

Extracellular vesicle isolation: Present and future

Furi, I., Momen-Heravi, F. & Szabó, G., jan. 1 2017, In : Annals of Translational Medicine. 5, 12, 263.

Research output: Editorial

Extracellular Vesicles
45 Citations (Scopus)
Liver Diseases
Biomarkers
Therapeutics
Alcoholic Liver Diseases
Liver
17 Citations (Scopus)

Gut-liver axis and sterile signals in the development of alcoholic liver disease

Szabó, G. & Petrasek, J., júl. 1 2017, In : Alcohol and Alcoholism. 52, 4, p. 414-424 11 p.

Research output: Review article

Alcoholic Liver Diseases
Liver
Inflammation
Alcoholic Hepatitis
Alcohols
8 Citations (Scopus)

Interleukin-1 inhibition facilitates recovery from liver injury and promotes regeneration of hepatocytes in alcoholic hepatitis in mice

Iracheta-Vellve, A., Petrasek, J., Gyogyosi, B., Bala, S., Csak, T., Kodys, K. & Szabó, G., júl. 1 2017, In : Liver International. 37, 7, p. 968-973 6 p.

Research output: Article

Alcoholic Hepatitis
Interleukin-1
Regeneration
Hepatocytes
Liver
62 Citations (Scopus)

Recovery of ethanol-induced Akkermansia muciniphila depletion ameliorates alcoholic liver disease

Grander, C., Adolph, T. E., Wieser, V., Lowe, P., Wrzosek, L., Gyongyosi, B., Ward, D. V., Grabherr, F., Gerner, R. R., Pfister, A., Enrich, B., Ciocan, D., Macheiner, S., Mayr, L., Drach, M., Moser, P., Moschen, A. R., Perlemuter, G., Szabó, G., Cassard, A. M. & 1 others, Tilg, H., máj. 26 2017, (Accepted/In press) In : Gut.

Research output: Article

Alcoholic Liver Diseases
Ethanol
Alcoholic Fatty Liver
Neutrophil Infiltration
Mucus
2016
12 Citations (Scopus)

Adult mouse model of early hepatocellular carcinoma promoted by alcoholic liver disease

Ambade, A., Satishchandran, A., Gyongyosi, B., Lowe, P. & Szabó, G., ápr. 28 2016, In : World Journal of Gastroenterology. 22, 16, p. 4091-4108 18 p.

Research output: Article

Alcoholic Liver Diseases
Nitrosamines
Hepatocellular Carcinoma
Alcohols
Liver
31 Citations (Scopus)
Alcoholic Hepatitis
Nitrosamines
Alcohols
Alcoholic Fatty Liver
Liver
120 Citations (Scopus)
Ribavirin
Hepacivirus
Genotype
Infection
Therapeutics
287 Citations (Scopus)

Elafibranor, an Agonist of the Peroxisome Proliferator-Activated Receptor-α and -δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening

Ratziu, V., Harrison, S. A., Francque, S., Bedossa, P., Lehert, P., Serfaty, L., Romero-Gomez, M., Boursier, J., Abdelmalek, M., Caldwell, S., Drenth, J., Anstee, Q. M., Hum, D., Hanf, R., Roudot, A., Megnien, S., Staels, B., Sanyal, A., Mathurin, P., Gournay, J. & 49 others, Nguyen-Khac, E., De Ledinghen, V., Larrey, D., Tran, A., Bourliere, M., Maynard-Muet, M., Asselah, T., Henrion, J., Nevens, F., Cassiman, D., Geerts, A., Moreno, C., Beuers, U. H., Galle, P. R., Spengler, U., Bugianesi, E., Craxi, A., Angelico, M., Fargion, S., Voiculescu, M., Gheorghe, L., Preotescu, L., Caballeria, J., Andrade, R. J., Crespo, J., Callera, J. L., Ala, A., Aithal, G., Abouda, G., Luketic, V., Huang, M. A., Gordon, S., Pockros, P., Poordad, F., Shores, N., Moehlen, M. W., Bambha, K., Clark, V., Satapathy, S., Parekh, S., Reddy, R. K., Sheikh, M. Y., Szabó, G., Vierling, J., Foster, T., Umpierrez, G., Chang, C., Box, T. & Gallegos-Orozco, J., máj. 1 2016, In : Gastroenterology. 150, 5, p. 1147-1159e5

Research output: Article

Peroxisome Proliferator-Activated Receptors
Fibrosis
Placebos
Intention to Treat Analysis
Odds Ratio
27 Citations (Scopus)

Endoplasmic reticulum stress-induced hepatocellular death pathways mediate liver injury and fibrosis via stimulator of interferon genes

Iracheta-Vellve, A., Petrasek, J., Gyongyosi, B., Satishchandran, A., Lowe, P., Kodys, K., Catalano, D., Calenda, C. D., Kurt-Jones, E. A., Fitzgerald, K. A. & Szabó, G., dec. 23 2016, In : Journal of Biological Chemistry. 291, 52, p. 26794-26805 12 p.

Research output: Article

Interferon Regulatory Factor-3
Endoplasmic Reticulum Stress
Liver Cirrhosis
Liver
Interferons

HCV, alcohol, and the liver

Bukong, T. N., Saha, B. & Szabó, G., jan. 1 2016, Hepatitis C Virus II: Infection and Disease. Springer Japan, p. 137-163 27 p.

Research output: Chapter

Hepacivirus
Alcohols
Liver
Liver Diseases
Virus Diseases
17 Citations (Scopus)
Transforming Growth Factors
Hepacivirus
Monocytes
Macrophages
Chronic Hepatitis C
22 Citations (Scopus)

Hepatocellular carcinoma is accelerated by NASH involving M2 macrophage polarization mediated by hif-1αinduced IL-10

Ambade, A., Satishchandran, A., Saha, B., Gyongyosi, B., Lowe, P., Kodys, K., Catalano, D. & Szabó, G., okt. 2 2016, In : OncoImmunology. 5, 10

Research output: Article

Interleukin-10
Hepatocellular Carcinoma
Macrophages
Nitrosamines
Hepatocytes
15 Citations (Scopus)

Inhibition of spleen tyrosine kinase activation ameliorates inflammation, cell death, and steatosis in alcoholic liver disease

Bukong, T. N., Iracheta-Vellve, A., Saha, B., Ambade, A., Satishchandran, A., Gyongyosi, B., Lowe, P., Catalano, D., Kodys, K. & Szabó, G., okt. 1 2016, In : Hepatology. 64, 4, p. 1057-1071 15 p.

Research output: Article

Alcoholic Liver Diseases
Cell Death
Inflammation
Liver
Alcohols
83 Citations (Scopus)
Alcoholic Fatty Liver
Inflammasomes
Alcoholic Hepatitis
Alcoholic Liver Diseases
Interleukin-1
53 Citations (Scopus)
Macrophages
MicroRNAs
Monocytes
Alcohols
Exosomes

Prevention of Alcohol-Induced Inflammation of Murine Small Intestine by MicroRNA-155 Deficiency

Lippai, D. & Szabó, G., jan. 26 2016, Insights to Neuroimmune Biology: Second Edition. Elsevier Inc., p. 243-256 14 p.

Research output: Chapter

MicroRNAs
Small Intestine
Alcohols
Inflammation
Endotoxins
27 Citations (Scopus)

Role of MicroRNAs in NAFLD/NASH

Szabó, G. & Csak, T., máj. 1 2016, In : Digestive Diseases and Sciences. 61, 5, p. 1314-1324 11 p.

Research output: Review article

MicroRNAs
Biological Phenomena
Untranslated RNA
Genes
Non-alcoholic Fatty Liver Disease
83 Citations (Scopus)

Standard Definitions and Common Data Elements for Clinical Trials in Patients with Alcoholic Hepatitis: Recommendation from the NIAAA Alcoholic Hepatitis Consortia

Crabb, D. W., Bataller, R., Chalasani, N. P., Kamath, P. S., Lucey, M., Mathurin, P., McClain, C., McCullough, A., Mitchell, M. C., Morgan, T. R., Nagy, L., Radaeva, S., Sanyal, A., Shah, V. & Szabó, G., ápr. 1 2016, In : Gastroenterology. 150, 4, p. 785-790 6 p.

Research output: Comment/debate

Severity of Illness Index
National Institute on Alcohol Abuse and Alcoholism (U.S.)
Endpoint Determination
Alcoholic Hepatitis
Research Design
67 Citations (Scopus)

The pro-inflammatory effects of miR-155 promote liver fibrosis and alcohol-induced steatohepatitis

Bala, S., Csak, T., Saha, B., Zatsiorsky, J., Kodys, K., Catalano, D., Satishchandran, A. & Szabó, G., jún. 1 2016, In : Journal of Hepatology. 64, 6, p. 1378-1387 10 p.

Research output: Article

Fatty Liver
Knockout Mice
Liver Cirrhosis
Alcohols
Peroxisome Proliferator-Activated Receptors
9 Citations (Scopus)

Therapeutic Benefits of Spleen Tyrosine Kinase Inhibitor Administration on Binge Drinking-Induced Alcoholic Liver Injury, Steatosis, and Inflammation in Mice

Bukong, T. N., Iracheta-Vellve, A., Gyongyosi, B., Ambade, A., Catalano, D., Kodys, K. & Szabó, G., júl. 1 2016, In : Alcoholism: Clinical and Experimental Research. 40, 7, p. 1524-1530 7 p.

Research output: Article

Binge Drinking
Fatty Liver
Liver
Protein-Tyrosine Kinases
Inflammation