• 1332 Citations
  • 21 h-Index
20012019
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Research Output 2001 2019

  • 1332 Citations
  • 21 h-Index
  • 84 Article
  • 5 Review article
  • 4 Chapter
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Article
2019

Antifibrotic effect of mitomycin-C on human vocal cord fibroblasts

Szabó, D., Kovács, D., Endrész, V., Igaz, N., Jenovai, K., Spengler, G., Tiszlavicz, L., Molnár, J., Burián, K., Kiricsi, M. & Rovó, L., jan. 1 2019, (Accepted/In press) In : Laryngoscope.

Research output: Article

Vocal Cords
Mitomycin
Fibroblasts
Transforming Growth Factors
Pathologic Constriction

Comparative solution and structural studies of half-sandwich rhodium and ruthenium complexes bearing curcumin and acetylacetone

Mészáros, J. P., Poljarevic, J. M., Gál, G. T., May, N. V., Spengler, G. & Enyedy, E., jún. 1 2019, In : Journal of Inorganic Biochemistry. 195, p. 91-100 10 p.

Research output: Article

Bearings (structural)
Rhodium
Curcumin
Ruthenium
Toluene
Pyridones
Gallium
Cytotoxicity
gallium
Iron

Nigella sativa essential oil and its bioactive compounds as resistance modifiers against Staphylococcus aureus

Mouwakeh, A., Kincses, A., Nové, M., Mosolygó, T., Mohácsi-Farkas, C., Kiskó, G. & Spengler, G., jan. 1 2019, (Accepted/In press) In : Phytotherapy Research.

Research output: Article

Volatile Oils
Staphylococcus aureus
Methicillin Resistance
Ethidium
Membranes
1 Citation (Scopus)

Organoselenium compounds as novel adjuvants of chemotherapy drugs—a promising approach to fight cancer drug resistance

Spengler, G., Gajdács, M., Marć, M. A., Domínguez-Álvarez, E. & Sanmartín, C., jan. 18 2019, In : Molecules. 24, 2, 336.

Research output: Article

Organoselenium Compounds
Selenium Compounds
Chemotherapy
chemotherapy
Adjuvant Chemotherapy
Rhodanine
X ray analysis
Acetic Acid
Salts
X-Rays

Pronounced activity of aromatic selenocyanates against multidrug resistant ESKAPE bacteria

Nasim, M. J., Witek, K., Kincses, A., Abdin, A. Y., Żesławska, E., Marć, M. A., Gajdács, M., Spengler, G., Nitek, W., Latacz, G., Karczewska, E., Kieć-Kononowicz, K., Handzlik, J. & Jacob, C., jan. 1 2019, In : New Journal of Chemistry. 43, 15, p. 6021-6031 11 p.

Research output: Article

Cytotoxicity
Bacteria
Selenium compounds
Cells
Antimicrobial agents

Selenocompounds as novel antibacterial agents and bacterial efflux pump inhibitors

Mosolygó, T., Kincses, A., Csonka, A., Tönki, Á. S., Witek, K., Sanmartín, C., Marć, M. A., Handzlik, J., Kieć-Kononowicz, K., Domínguez-Álvarez, E. & Spengler, G., ápr. 16 2019, In : Molecules. 1487.

Research output: Article

Open Access
efflux
Multiple Drug Resistance
Methicillin-Resistant Staphylococcus aureus
inhibitors
Methicillin
2018
1 Citation (Scopus)

Antibacterial and resistance modifying activities of nigella sativa essential oil and its active compounds against listeria monocytogenes

Mouwakeh, A., Telbisz, Á., Spengler, G., Mohácsi-Farkas, C. & Kiskó, G., júl. 1 2018, In : In Vivo. 32, 4, p. 737-743 7 p.

Research output: Article

Nigella sativa
Listeria
Listeria monocytogenes
Volatile Oils
Reserpine

Antiproliferative and cytotoxic activities of furocoumarins of Ducrosia anethifolia

Mottaghipisheh, J., Nové, M., Spengler, G., Kúsz, N., Hohmann, J. & Csupora, D., jan. 1 2018, In : Pharmaceutical Biology. 56, 1, p. 658-664 7 p.

Research output: Article

Inhibitory Concentration 50
Harmine
Fibroblasts
Aerial Plant Components
Norisoprenoids

Benzoxazole-based Zn(II) and Cu(II) complexes overcome multidrug-resistance in cancer

Spengler, G., Kincses, A., Rácz, B., Varga, B., Watanabe, G., Saijo, R., Sekiya, H., Tamai, E., Maki, J., Molnár, J. & Kawase, M., nov. 1 2018, In : Anticancer Research. 38, 11, p. 6181-6187 7 p.

Research output: Article

Benzoxazoles
Multiple Drug Resistance
Neoplasms
T-Cell Lymphoma
P-Glycoprotein
2 Citations (Scopus)

Bioactive compounds from the African medicinal plant Cleistochlamys kirkii as resistance modifiers in bacteria

Kincses, A., Varga, B., Csonka, Á., Sancha, S., Mulhovo, S., Madureira, A. M., Ferreira, M. J. U. & Spengler, G., jan. 1 2018, (Accepted/In press) In : Phytotherapy Research.

Research output: Article

Medicinal Plants
Methicillin
Multiple Drug Resistance
Anti-Bacterial Agents
Bacteria
1 Citation (Scopus)

Bioactive Segetane, Ingenane, and Jatrophane Diterpenes from Euphorbia taurinensis

Rédei, D., Kúsz, N., Sátori, G., Kincses, A., Spengler, G., Burián, K., Barina, Z. & Hohmann, J., márc. 19 2018, (Accepted/In press) In : Planta Medica.

Research output: Article

Euphorbia
Diterpenes
Multiple Drug Resistance
Cells
Leukemia L5178
5 Citations (Scopus)

Comparative solution equilibrium and structural studies of half-sandwich ruthenium(II)(η6-toluene) complexes of picolinate derivatives

Poljarević, J. M., Tamás Gál, G., May, N. V., Spengler, G., Dömötör, O., Savić, A. R., Grgurić-Šipka, S. & Enyedy, E., ápr. 1 2018, In : Journal of Inorganic Biochemistry. 181, p. 74-85 12 p.

Research output: Article

Ruthenium
Toluene
Chlorides
Derivatives
Cells
1 Citation (Scopus)

Exocyclic sulfur and selenoorganic compounds towards their anticancer effects: Crystallographic and biological studies

Zesławska, E., Kincses, A., Unger, V., Toth, V., Spengler, G., Nitek, W. & Tejchman, W., aug. 1 2018, In : Anticancer Research. 38, 8, p. 4577-4584 8 p.

Research output: Article

Sulfur Compounds
Selenium
Sulfur
T-Cell Lymphoma
Multiple Drug Resistance
4 Citations (Scopus)

Interactions of Schiff base compounds and their coordination complexes with the drug cisplatin

Magyari, J., Barta Holló, B., Vojinović-Ješić, L. S., Radanović, M. M., Armaković, S., Armaković, S. J., Molnár, J., Kincses, A., Gajdács, M., Spengler, G. & Meszaros Szecsenyi, K., jan. 1 2018, In : New Journal of Chemistry. 42, 8, p. 5834-5843 10 p.

Research output: Article

Schiff Bases
Coordination Complexes
Cisplatin
Ligands
Hydrazones
1 Citation (Scopus)

In vitro evaluation of the multidrug resistance reversing activity of novel imidazo[4,5-b]pyridine derivatives

Bourichi, S., Misbahi, H., Rodi, Y. K., Chahdi, F. O., Essassi, E. M., Szabo, S., Szalontai, B., Gajdács, M., Molnár, J. & Spengler, G., júl. 1 2018, In : Anticancer Research. 38, 7, p. 3999-4003 5 p.

Research output: Article

Multiple Drug Resistance
Rhodamine 123
Cell Line
T-Cell Lymphoma
P-Glycoprotein

Synthesis, structural elucidation and biological evaluations of new guanidine-containing terpenoids as anticancer agents

Duca, G., Aricu, A., Kuchkova, K., Secara, E., Barba, A., Dragalin, I., Ungur, N. & Spengler, G., jan. 1 2018, (Accepted/In press) In : Natural Product Research.

Research output: Article

guanidines
antineoplastic agents
Guanidine
Terpenes
terpenoids
1 Citation (Scopus)

Synthesis and characterization of Sr and Mg-doped hydroxyapatite by a simple precipitation method

Nagyné-Kovács, T., Studnicka, L., Kincses, A., Spengler, G., Molnár, M., Tolner, M., Lukács, I. E., Szilágyi, I. M. & Pokol, G., jan. 1 2018, (Accepted/In press) In : Ceramics International.

Research output: Article

Durapatite
Hydroxyapatite
Crystallite size
Lattice constants
Energy dispersive spectroscopy

Terpenoids from Euphorbia pedroi as Multidrug-Resistance Reversers

Ferreira, R. J., Kincses, A., Gajdács, M., Spengler, G., Dos Santos, D. J. V. A., Molnár, J. & Ferreira, M. J. U., jan. 1 2018, (Accepted/In press) In : Journal of Natural Products.

Research output: Article

Euphorbia
Terpenes
Multiple Drug Resistance
Cytotoxicity
Assays
2017
7 Citations (Scopus)

Exploring Jolkinol D Derivatives to Overcome Multidrug Resistance in Cancer

Reis, M. A., Ahmed, O. B., Spengler, G., Molnár, J., Lage, H. & Ferreira, M. J. U., máj. 26 2017, In : Journal of Natural Products. 80, 5, p. 1411-1420 10 p.

Research output: Article

Multiple Drug Resistance
Modulators
Assays
Bearings (structural)
Cells
14 Citations (Scopus)

Selenoesters and selenoanhydrides as novel multidrug resistance reversing agents: A confirmation study in a colon cancer MDR cell line

Gajdács, M., Spengler, G., Sanmartín, C., Marć, M. A., Handzlik, J. & Domínguez-Álvarez, E., febr. 15 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 4, p. 797-802 6 p.

Research output: Article

Multiple Drug Resistance
Colonic Neoplasms
Cells
Verapamil
Derivatives
2016
6 Citations (Scopus)

Coordination compounds of a hydrazone derivative with Co(III), Ni(II), Cu(II) and Zn(II): Synthesis, characterization, reactivity assessment and biological evaluation

Barta Holló, B., Magyari, J., Armaković, S., Bogdanović, G. A., Rodić, M. V., Armaković, S. J., Molnár, J., Spengler, G., Leovac, V. M. & Meszaros Szecsenyi, K., 2016, In : New Journal of Chemistry. 40, 7, p. 5885-5895 11 p.

Research output: Article

Hydrazones
Ligands
Derivatives
Cobalt compounds
Ionization potential
3 Citations (Scopus)

Fluorinated beta-diketo phosphorus ylides are novel efflux pump inhibitors in bacteria

Kincses, A., Szabó, Á. M., Saijo, R., Watanabe, G., Kawase, M., Molnár, J. & Spengler, G., nov. 1 2016, In : In Vivo. 30, 6, p. 813-817 5 p.

Research output: Article

Quorum Sensing
Phosphorus
Bacteria
Pumps
Escherichia coli
17 Citations (Scopus)

Identification of selenocompounds with promising properties to reverse cancer multidrug resistance

Domínguez-Álvarez, E., Gajdács, M., Spengler, G., Palop, J. A., Marć, M. A., Kieć-Kononowicz, K., Amaral, L., Molnár, J., Jacob, C., Handzlik, J. & Sanmartín, C., márc. 15 2016, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters.

Research output: Article

Multiple Drug Resistance
Pumps
Verapamil
Ketones
Assays
20 Citations (Scopus)

Jatrophane diterpenes and cancer multidrug resistance - ABCB1 efflux modulation and selective cell death induction

Reis, M. A., Ahmed, O. B., Spengler, G., Molnár, J., Lage, H. & Ferreira, M. J. U., aug. 15 2016, In : Phytomedicine. 23, 9, p. 968-978 11 p.

Research output: Article

Diterpenes
Multiple Drug Resistance
Cell Death
Neoplasms
Caspase 3
18 Citations (Scopus)

Silver nanoparticles modulate ABC transporter activity and enhance chemotherapy in multidrug resistant cancer

Kovács, D., Szoke, K., Igaz, N., Spengler, G., Molnár, J., Tóth, T., Madarász, D., Rázga, Z., Kónya, Z., Boros, I. & Kiricsi, M., ápr. 1 2016, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 12, 3, p. 601-610 10 p.

Research output: Article

ATP-Binding Cassette Transporters
Chemotherapy
Silver
Nanoparticles
Cells
20 Citations (Scopus)

Structure-antiproliferative activity studies on l-proline- and homoproline-4-: N -pyrrolidine-3-thiosemicarbazone hybrids and their nickel(II), palladium(II) and copper(II) complexes

Dobrova, A., Platzer, S., Bacher, F., Milunovic, M. N. M., Dobrov, A., Spengler, G., Enyedy, E., Novitchi, G. & Arion, V. B., 2016, In : Dalton Transactions. 45, 34, p. 13427-13439 13 p.

Research output: Article

Thiosemicarbazones
Coordination Complexes
Palladium
Nickel
Proline
10 Citations (Scopus)

The 5-aromatic hydantoin-3-acetate derivatives as inhibitors of the tumour multidrug resistance efflux pump P-glycoprotein (ABCB1): Synthesis, crystallographic and biological studies

Zesławska, E., Kincses, A., Spengler, G., Nitek, W., Wyrzuc, K., Kieć-Kononowicz, K. & Handzlik, J., febr. 5 2016, (Accepted/In press) In : Bioorganic and Medicinal Chemistry.

Research output: Article

Hydantoins
Phenytoin
Multiple Drug Resistance
P-Glycoprotein
Tumors
2015
17 Citations (Scopus)

Epoxylathyrol Derivatives: Modulation of ABCB1-Mediated Multidrug Resistance in Human Colon Adenocarcinoma and Mouse T-Lymphoma Cells

Matos, A. M., Reis, M., Duarte, N., Spengler, G., Molnár, J. & Ferreira, M. J. U., szept. 25 2015, In : Journal of Natural Products. 78, 9, p. 2215-2228 14 p.

Research output: Article

T-Cell Lymphoma
Aromatic compounds
Diterpenes
Multiple Drug Resistance
Doxorubicin
4 Citations (Scopus)

Fluorinated diketo phosphorus ylides are novel inhibitors of the abcb1 efflux pump of cancer cells

Spengler, G., Ocsovszki, I., Tonki, Á. S., Saijo, R., Watanabe, G., Kawase, M. & Molnár, J., nov. 1 2015, In : Anticancer Research. 35, 11, p. 5915-5919 5 p.

Research output: Article

Multiple Drug Resistance
Phosphorus
T-Cell Lymphoma
P-Glycoprotein
Verapamil
15 Citations (Scopus)

Reversal of ABCB1-related multidrug resistance of colonic adenocarcinoma cells by phenothiazines

Takács, D., Csonka, Á., Horváth, Á., Windt, T., Gajdács, M., Riedl, Z., Hajós, G., Amaral, L., Molnár, J. & Spengler, G., jún. 1 2015, In : Anticancer Research. 35, 6, p. 3245-3251 7 p.

Research output: Article

Phenothiazines
Multiple Drug Resistance
Adenocarcinoma
Rhodamine 123
ATP-Binding Cassette Transporters
3 Citations (Scopus)
Multiple Drug Resistance
Lymphoma
Prostatic Neoplasms
P-Glycoprotein
Steroids
2014
2 Citations (Scopus)
Enantiomers
Pumps
Bacterial Drug Resistance
Derivatives
Ethidium
34 Citations (Scopus)
Gram-Negative Bacteria
Anti-Bacterial Agents
Phenothiazines
Bacteria
Regulon
20 Citations (Scopus)

Improving the MDR reversal activity of 6,17-epoxylathyrane diterpenes

Vieira, C., Duarte, N., Reis, M. A., Spengler, G., Madureira, A. M., Molnár, J. & Ferreira, M. J. U., nov. 15 2014, In : Bioorganic and Medicinal Chemistry. 22, 22, p. 6392-6400 9 p.

Research output: Article

Diterpenes
Modulators
Assays
Euphorbia
Anhydrides
10 Citations (Scopus)
Phenothiazines
T-Cell Lymphoma
Multiple Drug Resistance
P-Glycoprotein
Thioridazine
2013
9 Citations (Scopus)

Effect of thioridazine stereoisomers on the drug accumulation of mouse lymphoma and human prostate cancer cell lines in vitro

Csonka, Á., Spengler, G., Martins, A., Ocsovszki, I., Christensen, J. B., Hendricks, O., Kristiansen, J. E., Amaral, L. & Molnár, J., nov. 2013, In : In Vivo. 27, 6, p. 815-820 6 p.

Research output: Article

Thioridazine
Stereoisomerism
Multiple Drug Resistance
Lymphoma
Prostatic Neoplasms
2 Citations (Scopus)
Chlamydia muridarum
Chlamydia Infections
Interleukin-17
Lung
Infection
2 Citations (Scopus)
Thioridazine
Multidrug-Resistant Tuberculosis
Patents
Pulmonary Tuberculosis
Antitubercular Agents
2012
12 Citations (Scopus)

5-Arylidene(thio)hydantoin derivatives as modulators of cancer efflux pump

Handzlik, J., Spengler, G., Mastek, B., Dela, A., Molnár, J., Amaral, L. & Kieć-Kononowicz, K., 2012, In : Acta Poloniae Pharmaceutica - Drug Research. 69, 1, p. 149-156 8 p.

Research output: Article

Neoplasm Drug Resistance
Thiohydantoins
Hydantoins
Rhodamine 123
T-Cell Lymphoma
4 Citations (Scopus)

Activity of fourteen new hydantoin compounds on the human ABCB1 efflux pump

Martins, A., Dymek, A., Handzlik, J., Spengler, G., Armada, A., Molnár, J., Kiéc-Kononowicz, K. & Amaral, L., márc. 2012, In : In Vivo. 26, 2, p. 293-297 5 p.

Research output: Article

Hydantoins
Pumps
Ethidium
Multiple Drug Resistance
Neoplasms
19 Citations (Scopus)

Genetic response of Salmonella enterica serotype Enteritidis to thioridazine rendering the organism resistant to the agent

Spengler, G., Rodrigues, L., Martins, A., Martins, M., McCusker, M., Cerca, P., MacHado, L., Costa, S. S., Ntokou, E., Couto, I., Viveiros, M., Fanning, S., Molnár, J. & Amaral, L., jan. 2012, In : International Journal of Antimicrobial Agents. 39, 1, p. 16-21 6 p.

Research output: Article

Thioridazine
Salmonella enterica
Regulon
Proton Ionophores
Genes
15 Citations (Scopus)

Inhibitors of bacterial efflux pumps that also inhibit efflux pumps of cancer cells

Amaral, L., Spengler, G., Martins, A., Armada, A., Handzlik, J., Kiec-Kononowicz, K. & Molnar, J., júl. 2012, In : Anticancer Research. 32, 7, p. 2947-2958 12 p.

Research output: Article

Bacteria
Neoplasms
Multiple Drug Resistance
Drug Therapy
Therapeutics
9 Citations (Scopus)

The activity of 16 new hydantoin compounds on the intrinsic and overexpressed efflux pump system of Staphylococcus aureus

Dymek, A., Armada, A., Handzlik, J., Viveiros, M., Spengler, G., Molnár, J., Kieć-Kononowicz, K. & Amaral, L., márc. 2012, In : In Vivo. 26, 2, p. 223-229 7 p.

Research output: Article

Hydantoins
Staphylococcus aureus
Pumps
Oxacillin
Ethidium
2011
21 Citations (Scopus)

Biological activity of twenty-three hydantoin derivatives on intrinsic efflux pump system of Salmonella enterica serovar enteritidis NCTC 13349

Machado, L., Spengler, G., Evaristo, M., Handzlik, J., Molnár, J., Viveiros, M., Kiec-Kononowicz, K. & Amaral, L., szept. 2011, In : In Vivo. 25, 5, p. 769-772 4 p.

Research output: Article

Hydantoins
Salmonella enteritidis
Salmonella
Bioactivity
Pumps
15 Citations (Scopus)

Ethidium bromide efflux by Salmonella: Modulation by metabolic energy, pH, ions and phenothiazines

Amaral, L., Cerca, P., Spengler, G., MacHado, L., Martins, A., Couto, I., Viveiros, M., Fanning, S. & Pags, J. M., aug. 2011, In : International Journal of Antimicrobial Agents. 38, 2, p. 140-145 6 p.

Research output: Article

Phenothiazines
Ethidium
Salmonella
Ions
Maintenance
31 Citations (Scopus)

Inhibition of efflux pumps in meticillin-resistant Staphylococcus aureus and Enterococcus faecalis resistant strains by triterpenoids from Momordica balsamina

Ramalhete, C., Spengler, G., Martins, A., Martins, M., Viveiros, M., Mulhovo, S., Ferreira, M. J. U. & Amaral, L., jan. 2011, In : International Journal of Antimicrobial Agents. 37, 1, p. 70-74 5 p.

Research output: Article

Momordica
Methicillin
Enterococcus faecalis
Staphylococcus aureus
Ethidium
16 Citations (Scopus)

Modulation of multidrug efflux pump activity by new hydantoin derivatives on colon adenocarcinoma cells without inducing apoptosis

Spengler, G., Handzlik, J., Ocsovszki, I., Viveiros, M., Kieć-Kononowicz, K., Molnár, J. & Amaral, L., okt. 2011, In : Anticancer Research. 31, 10, p. 3285-3288 4 p.

Research output: Article

Hydantoins
Colon
Adenocarcinoma
Apoptosis
Carcinoma
1 Citation (Scopus)

Prevention of VP-16 resistance by a disiloxane, SILA409: Effects of SILA409 on the expression of GRP78 in NCI-H446 human small cell lung cancer cells

Li, E., Zhang, J., Wang, J., Gao, F., Yang, Z., Meng, Q., Zhang, Q., Li, N., Huang, M., Spengler, G., Molnár, J. & Wang, Q., okt. 2011, In : Letters in Drug Design and Discovery. 8, 8, p. 691-697 7 p.

Research output: Article

Ionophores
Small Cell Lung Carcinoma
Calcimycin
Etoposide
Cell Line