• 1721 Citations
  • 25 h-Index
20012020

Research output per year

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Research Output

2020

2-oxo-1,2-dihydroquinoline-4-carboxylic acid derivatives as potent modulators of ABCB1-related drug resistance of mouse T-lymphoma cells

Baba, Y. F., Misbahi, H., Rodi, Y. K., Ouzidan, Y., Essassi, E. M., Vincze, K., Nové, M., Gajdács, M., Molnár, J., Spengler, G. & Mazzah, A., okt. 2020, In : Chemical Data Collections. 29, 100501.

Research output: Article

Open Access

Biofilm eradication by symmetrical selenoesters for food-borne pathogens

Nové, M., Kincses, A., Szalontai, B., Rácz, B., Blair, J. M. A., González-Prádena, A., Benito-Lama, M., Domínguez-Álvarez, E. & Spengler, G., ápr. 2020, In : Microorganisms. 8, 4, 566.

Research output: Article

Open Access

Core-shell nanoparticles suppress metastasis and modify the tumour-supportive activity of cancer-associated fibroblasts

Kovács, D., Igaz, N., Marton, A., Rónavári, A., Bélteky, P., Bodai, L., Spengler, G., Tiszlavicz, L., Rázga, Z., Hegyi, P., Vizler, C., Boros, I. M., Kónya, Z. & Kiricsi, M., jan. 21 2020, In : Journal of Nanobiotechnology. 18, 1, 18.

Research output: Article

Open Access
1 Citation (Scopus)

Discovery of phenylselenoether-hydantoin hybrids as ABCB1 efflux pump modulating agents with cytotoxic and antiproliferative actions in resistant T-lymphoma

Ali, W., Spengler, G., Kincses, A., Nové, M., Battistelli, C., Latacz, G., Starek, M., Dąbrowska, M., Honkisz-Orzechowska, E., Romanelli, A., Rasile, M. M., Szymańska, E., Jacob, C., Zwergel, C. & Handzlik, J., aug. 15 2020, In : European Journal of Medicinal Chemistry. 200, 112435.

Research output: Article

Insight into the anticancer activity of copper(Ii) 5-methylenetrimethylammonium-thiosemicarbazonates and their interaction with organic cation transporters

Milunović, M. N. M., Palamarciuc, O., Sirbu, A., Shova, S., Dumitrescu, D., Dvoranová, D., Rapta, P., Petrasheuskaya, T. V., Enyedy, E., Spengler, G., Ilic, M., Sitte, H. H., Lubec, G. & Arion, V. B., szept. 2020, In : Biomolecules. 10, 9, p. 1-30 30 p., 1213.

Research output: Article

Open Access

Repurposing old drugs to fight multidrug resistant cancers

Dinić, J., Efferth, T., García-Sosa, A. T., Grahovac, J., Padrón, J. M., Pajeva, I., Rizzolio, F., Saponara, S., Spengler, G. & Tsakovska, I., szept. 2020, In : Drug Resistance Updates. 52, 100713.

Research output: Review article

Open Access

Salicylaldehyde thiosemicarbazone copper complexes: Impact of hybridization with estrone on cytotoxicity, solution stability and redox activity

Petrasheuskaya, T. V., Kiss, M. A., Dömötör, O., Holczbauer, T., May, N. V., Spengler, G., Kincses, A., Čipak Gašparović, A., Frank, É. & Enyedy, É. A., júl. 28 2020, In : New Journal of Chemistry. 44, 28, p. 12154-12168 15 p.

Research output: Article

Open Access

Search for ABCB1 modulators among 2-amine-5-arylideneimidazolones as a new perspective to overcome cancer multidrug resistance

Kaczor, A., Nové, M., Kincses, A., Spengler, G., Szymánska, E., Latacz, G. & Handzlik, J., máj. 1 2020, In : Molecules. 25, 9, 2258.

Research output: Article

Open Access

Solution equilibrium, structural and cytotoxicity studies on Ru(η6-p-cymene) and copper complexes of pyrazolyl thiosemicarbazones

Dömötör, O., Kiss, M. A., Gál, G. T., May, N. V., Spengler, G., Nové, M., Gašparović, A. Č., Frank, E. & Enyedy, É. A., jan. 2020, In : Journal of Inorganic Biochemistry. 202, 110883.

Research output: Article

Open Access
3 Citations (Scopus)

The role of efflux pumps and environmental pH in bacterial multidrug resistance

Nové, M., Kincses, A., Molnár, J., Amaral, L. & Spengler, G., 2020, In : In Vivo. 34, 1, p. 65-71 7 p.

Research output: Article

Open Access
1 Citation (Scopus)
2019

Antifibrotic effect of mitomycin-C on human vocal cord fibroblasts

Szabó, D., Kovács, D., Endrész, V., Igaz, N., Jenovai, K., Spengler, G., Tiszlavicz, L., Molnár, J., Burián, K., Kiricsi, M. & Rovó, L., júl. 2019, In : Laryngoscope. 129, 7, p. E255-E262

Research output: Article

2 Citations (Scopus)

Antiviral, antimicrobial and antibiofilm activity of selenoesters and selenoanhydrides

Spengler, G., Kincses, A., Mosolygó, T., Maræ, M. A., Nové, M., Gajdács, M., Sanmartín, C., McNeil, H. E., Blair, J. M. A. & Domínguez-Álvarez, E., nov. 22 2019, In : Molecules. 24, 23, 4264.

Research output: Article

Open Access
1 Citation (Scopus)

Bioactive compounds of Nigella sativa essential oil as antibacterial agents against Chlamydia trachomatis D

Mosolygó, T., Mouwakeh, A., Ali, M. H., Kincses, A., Mohácsi-Farkas, C., Kiskó, G. & Spengler, G., szept. 2019, In : Microorganisms. 7, 9, 370.

Research output: Article

Open Access

Comparative solution and structural studies of half-sandwich rhodium and ruthenium complexes bearing curcumin and acetylacetone

Mészáros, J. P., Poljarevic, J. M., Gál, G. T., May, N. V., Spengler, G. & Enyedy, É. A., jún. 2019, In : Journal of Inorganic Biochemistry. 195, p. 91-100 10 p.

Research output: Article

5 Citations (Scopus)

Comparative solution studies and cytotoxicity of gallium(III) and iron(III) complexes of 3-hydroxy-2(1H)-pyridinones

Enyedy, É. A., Mészáros, J. P., Spengler, G., Hanif, M. & Hartinger, C. G., nov. 1 2019, In : Polyhedron. 172, p. 141-147 7 p.

Research output: Article

1 Citation (Scopus)

Cucurbalsaminones A-C, Rearranged Triterpenoids with a 5/6/3/6/5-Fused Pentacyclic Carbon Skeleton from Momordica balsamina, as Multidrug Resistance Reversers

Mónico, A., Ramalhete, C., André, V., Spengler, G., Mulhovo, S., Duarte, M. T. & Ferreira, M. J. U., aug. 23 2019, In : Journal of Natural Products. 82, 8, p. 2138-2143 6 p.

Research output: Article

Dually acting nonclassical 1,4-dihydropyridines promote the anti-tuberculosis (Tb) activities of clofazimine

Lentz, F., Reiling, N., Spengler, G., Kincses, A., Csonka, A., Molnár, J. & Hilgeroth, A., aug. 8 2019, In : Molecules. 24, 16, 2873.

Research output: Article

Open Access

New Chalcone derivative inhibits ABCB1 in multidrug resistant T-cell lymphoma and colon adenocarcinoma cells

Čižmáriková, M., Takáč, P., Spengler, G., Kincses, A., Nové, M., Vilková, M. & Mojžiš, J., jan. 1 2019, In : Anticancer research. 39, 12, p. 6499-6505 7 p.

Research output: Article

Open Access
1 Citation (Scopus)

Nigella sativa essential oil and its bioactive compounds as resistance modifiers against Staphylococcus aureus

Mouwakeh, A., Kincses, A., Nové, M., Mosolygó, T., Mohácsi-Farkas, C., Kiskó, G. & Spengler, G., ápr. 2019, In : Phytotherapy Research. 33, 4, p. 1010-1018 9 p.

Research output: Article

5 Citations (Scopus)

Novel latonduine derived proligands and their copper(ii) complexes show cytotoxicity in the nanomolar range in human colon adenocarcinoma cells and: In vitro cancer selectivity

Bacher, F., Wittmann, C., Nové, M., Spengler, G., Marć, M. A., Enyedy, E. A., Darvasiová, D., Rapta, P., Reiner, T. & Arion, V. B., 2019, In : Dalton Transactions. 48, 28, p. 10464-10478 15 p.

Research output: Article

Open Access

Organoselenium compounds as novel adjuvants of chemotherapy drugs—a promising approach to fight cancer drug resistance

Spengler, G., Gajdács, M., Marć, M. A., Domínguez-Álvarez, E. & Sanmartín, C., jan. 18 2019, In : Molecules. 24, 2, 336.

Research output: Article

17 Citations (Scopus)
1 Citation (Scopus)

Pronounced activity of aromatic selenocyanates against multidrug resistant ESKAPE bacteria

Nasim, M. J., Witek, K., Kincses, A., Abdin, A. Y., Żesławska, E., Marć, M. A., Gajdács, M., Spengler, G., Nitek, W., Latacz, G., Karczewska, E., Kieć-Kononowicz, K., Handzlik, J. & Jacob, C., 2019, In : New Journal of Chemistry. 43, 15, p. 6021-6031 11 p.

Research output: Article

5 Citations (Scopus)

Selenocompounds as novel antibacterial agents and bacterial efflux pump inhibitors

Mosolygó, T., Kincses, A., Csonka, A., Tönki, Á. S., Witek, K., Sanmartín, C., Marć, M. A., Handzlik, J., Kieć-Kononowicz, K., Domínguez-Álvarez, E. & Spengler, G., ápr. 16 2019, In : Molecules. 24, 8, 1487.

Research output: Article

Open Access
5 Citations (Scopus)

Selenoesters and selenoanhydrides as novel agents against resistant breast cancer

Csonka, A., Kincses, A., Nové, M., Vadas, Z., Sanmartín, C., Domínguez-Álvarez, E. & Spengler, G., jan. 1 2019, In : Anticancer research. 39, 7, p. 3777-3783 7 p.

Research output: Article

2 Citations (Scopus)
Open Access
5 Citations (Scopus)

The Search for Histamine H4 Receptor Ligands with Anticancer Activity among Novel (Thio)urea Derivatives

Domínguez-Álvarez, E., Łażewska, D., Szabó, Z., Hagenow, S., Reiner, D., Gajdács, M., Spengler, G., Stark, H., Handzlik, J. & Kieć-Kononowicz, K., szept. 30 2019, In : ChemistrySelect. 4, 36, p. 10943-10952 10 p.

Research output: Article

1 Citation (Scopus)
2018

Antibacterial and resistance modifying activities of nigella sativa essential oil and its active compounds against listeria monocytogenes

Mouwakeh, A., Telbisz, Á., Spengler, G., Mohácsi-Farkas, C. & Kiskó, G., júl. 1 2018, In : In Vivo. 32, 4, p. 737-743 7 p.

Research output: Article

7 Citations (Scopus)

Antiproliferative and cytotoxic activities of furocoumarins of Ducrosia anethifolia

Mottaghipisheh, J., Nové, M., Spengler, G., Kúsz, N., Hohmann, J. & Csupora, D., jan. 1 2018, In : Pharmaceutical Biology. 56, 1, p. 658-664 7 p.

Research output: Article

6 Citations (Scopus)

Benzoxazole-based Zn(II) and Cu(II) complexes overcome multidrug-resistance in cancer

Spengler, G., Kincses, A., Rácz, B., Varga, B., Watanabe, G., Saijo, R., Sekiya, H., Tamai, E., Maki, J., Molnár, J. & Kawase, M., nov. 2018, In : Anticancer research. 38, 11, p. 6181-6187 7 p.

Research output: Article

1 Citation (Scopus)

Bioactive compounds from the African medicinal plant Cleistochlamys kirkii as resistance modifiers in bacteria

Kincses, A., Varga, B., Csonka, Á., Sancha, S., Mulhovo, S., Madureira, A. M., Ferreira, M. J. U. & Spengler, G., jún. 2018, In : Phytotherapy Research. 32, 6, p. 1039-1046 8 p.

Research output: Article

6 Citations (Scopus)

Bioactive Segetane, Ingenane, and Jatrophane Diterpenes from Euphorbia taurinensis

Rédei, D., Kúsz, N., Sátori, G., Kincses, A., Spengler, G., Burián, K., Barina, Z. & Hohmann, J., júl. 1 2018, In : Planta Medica. 84, 9-10, p. 729-735 7 p.

Research output: Article

4 Citations (Scopus)

Comparative solution equilibrium and structural studies of half-sandwich ruthenium(II)(η6-toluene) complexes of picolinate derivatives

Poljarević, J. M., Tamás Gál, G., May, N. V., Spengler, G., Dömötör, O., Savić, A. R., Grgurić-Šipka, S. & Enyedy, É. A., ápr. 2018, In : Journal of Inorganic Biochemistry. 181, p. 74-85 12 p.

Research output: Article

9 Citations (Scopus)

Exocyclic sulfur and selenoorganic compounds towards their anticancer effects: Crystallographic and biological studies

Zesławska, E., Kincses, A., Unger, V., Toth, V., Spengler, G., Nitek, W. & Tejchman, W., aug. 1 2018, In : Anticancer Research. 38, 8, p. 4577-4584 8 p.

Research output: Article

5 Citations (Scopus)

Interactions of Schiff base compounds and their coordination complexes with the drug cisplatin

Magyari, J., Barta Holló, B., Vojinović-Ješić, L. S., Radanović, M. M., Armaković, S., Armaković, S. J., Molnár, J., Kincses, A., Gajdács, M., Spengler, G. & Meszaros Szecsenyi, K., jan. 1 2018, In : New Journal of Chemistry. 42, 8, p. 5834-5843 10 p.

Research output: Article

7 Citations (Scopus)

In vitro evaluation of the multidrug resistance reversing activity of novel imidazo[4,5-b]pyridine derivatives

Bourichi, S., Misbahi, H., Rodi, Y. K., Chahdi, F. O., Essassi, E. M., Szabo, S., Szalontai, B., Gajdács, M., Molnár, J. & Spengler, G., júl. 2018, In : Anticancer research. 38, 7, p. 3999-4003 5 p.

Research output: Article

2 Citations (Scopus)

Synthesis, structural elucidation and biological evaluations of new guanidine-containing terpenoids as anticancer agents

Duca, G., Aricu, A., Kuchkova, K., Secara, E., Barba, A., Dragalin, I., Ungur, N. & Spengler, G., jan. 1 2018, (Accepted/In press) In : Natural Product Research.

Research output: Article

1 Citation (Scopus)

Synthesis and characterization of Sr and Mg-doped hydroxyapatite by a simple precipitation method

Nagyné-Kovács, T., Studnicka, L., Kincses, A., Spengler, G., Molnár, M., Tolner, M., Lukács, I. E., Szilágyi, I. M. & Pokol, G., dec. 15 2018, In : Ceramics International. 44, 18, p. 22976-22982 7 p.

Research output: Article

7 Citations (Scopus)

Terpenoids from Euphorbia pedroi as Multidrug-Resistance Reversers

Ferreira, R. J., Kincses, A., Gajdács, M., Spengler, G., Dos Santos, D. J. V. A., Molnár, J. & Ferreira, M. J. U., jan. 1 2018, (Accepted/In press) In : Journal of Natural Products.

Research output: Article

8 Citations (Scopus)
2017

Exploring Jolkinol D Derivatives to Overcome Multidrug Resistance in Cancer

Reis, M. A., Ahmed, O. B., Spengler, G., Molnár, J., Lage, H. & Ferreira, M. J. U., máj. 26 2017, In : Journal of Natural Products. 80, 5, p. 1411-1420 10 p.

Research output: Article

14 Citations (Scopus)
37 Citations (Scopus)

New roads leading to old destinations: Efflux pumps as targets to reverse multidrug resistance in bacteria

Spengler, G., Kincses, A., Gajdács, M. & Amaral, L., márc. 2017, In : Molecules. 22, 3, 468.

Research output: Review article

59 Citations (Scopus)

Possible biological and clinical applications of phenothiazines

Varga, B., Csonka, Á., Csonka, A., Molnár, J., Amaral, L. & Spengler, G., nov. 1 2017, In : Anticancer Research. 37, 11, p. 5983-5993 11 p.

Research output: Review article

26 Citations (Scopus)

Selenoesters and selenoanhydrides as novel multidrug resistance reversing agents: A confirmation study in a colon cancer MDR cell line

Gajdács, M., Spengler, G., Sanmartín, C., Marć, M. A., Handzlik, J. & Domínguez-Álvarez, E., jan. 1 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 4, p. 797-802 6 p.

Research output: Article

25 Citations (Scopus)
2016

Coordination compounds of a hydrazone derivative with Co(III), Ni(II), Cu(II) and Zn(II): Synthesis, characterization, reactivity assessment and biological evaluation

Barta Holló, B., Magyari, J., Armaković, S., Bogdanović, G. A., Rodić, M. V., Armaković, S. J., Molnár, J., Spengler, G., Leovac, V. M. & Meszaros Szecsenyi, K., jan. 1 2016, In : New Journal of Chemistry. 40, 7, p. 5885-5895 11 p.

Research output: Article

9 Citations (Scopus)

Fluorimetric methods for analysis of permeability, drug transport kinetics, and inhibition of the ABCB1 membrane transporter

Armada, A., Martins, C., Spengler, G., Molnár, J., Amaral, L., Rodrigues, A. S. & Viveiros, M., máj. 1 2016, Methods in Molecular Biology. Humana Press Inc., Vol. 1395. p. 87-103 17 p. (Methods in Molecular Biology; vol. 1395).

Research output: Chapter

5 Citations (Scopus)

Fluorinated beta-diketo phosphorus ylides are novel efflux pump inhibitors in bacteria

Kincses, A., Szabó, Á. M., Saijo, R., Watanabe, G., Kawase, M., Molnár, J. & Spengler, G., nov. 1 2016, In : In Vivo. 30, 6, p. 813-817 5 p.

Research output: Article

4 Citations (Scopus)

Identification of selenocompounds with promising properties to reverse cancer multidrug resistance

Domínguez-Álvarez, E., Gajdács, M., Spengler, G., Palop, J. A., Marć, M. A., Kieć-Kononowicz, K., Amaral, L., Molnár, J., Jacob, C., Handzlik, J. & Sanmartín, C., márc. 15 2016, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters.

Research output: Article

30 Citations (Scopus)