• 6596 Citations
  • 41 h-Index
1978 …2019

Research output per year

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Research Output

  • 6596 Citations
  • 41 h-Index
  • 191 Article
  • 23 Review article
  • 5 Editorial
  • 2 Chapter
2019

Targeted drug combination therapy design based on driver genes

Zsákai, L., Sipos, A., Dobos, J., Eros, D., Szántai-Kis, C., Bánhegyi, P., Pató, J., Orfi, L., Matula, Z., Mikala, G., Kéri, G., Peták, I. & Vályi-Nagy, I., jan. 1 2019, In : Oncotarget. 10, 51, p. 5255-5266 12 p.

Research output: Article

2017

Machine learning and docking models for Mycobacterium tuberculosis topoisomerase I

Ekins, S., Godbole, A. A., Kéri, G., Orfi, L., Pato, J., Bhat, R. S., Verma, R., Bradley, E. K. & Nagaraja, V., márc. 1 2017, In : Tuberculosis. 103, p. 52-60 9 p.

Research output: Article

7 Citations (Scopus)

Molecular subtype specific efficacy of MEK inhibitors in pancreatic cancers

Brauswetter, D., Gurbi, B., Varga, A., Várkondi, E., Schwab, R., Bánhegyi, G., Fábián, O., Kéri, G., Vályi-Nagy, I. & Peták, I., jan. 1 2017, In : PLoS One. 12, 9, p. e0185687

Research output: Article

7 Citations (Scopus)
2016

Design and synthesis of new imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrazine derivatives with antiproliferative activity against melanoma cells

Garamvölgyi, R., Dobos, J., Sipos, A., Boros, S., Illyés, E., Baska, F., Kékesi, L., Szabadkai, I., Szántai-Kis, C., Kéri, G. & Őrfi, L., jan. 27 2016, In : European Journal of Medicinal Chemistry. 108, p. 623-643 21 p.

Research output: Article

14 Citations (Scopus)

Novel compounds reducing IRS-1 serine phosphorylation for treatment of diabetes

Simon-Szabó, L., Kokas, M., Greff, Z., Boros, S., Bánhegyi, P., Zsákai, L., Szántai-Kis, C., Vántus, T., Mandl, J., Bánhegyi, G., Vályi-Nagy, I., Őrfi, L., Ullrich, A., Csala, M. & Kéri, G., jan. 15 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 2, p. 424-428 5 p.

Research output: Article

7 Citations (Scopus)

Synthesis, characterization and systematic comparison of FITC-labelled GnRH-I, -II and -III analogues on various tumour cells

Murányi, J., Gyulavári, P., Varga, A., Bökönyi, G., Tanai, H., Vántus, T., Pap, D., Ludányi, K., Mező, G. & Kéri, G., aug. 1 2016, In : Journal of Peptide Science. p. 552-560 9 p.

Research output: Article

6 Citations (Scopus)
2015

Decreased functional activity of multidrug resistance protein in primary colorectal cancer

Micsik, T., Lõrincz, A., Mersich, T., Baranyai, Z., Besznyák, I., Dede, K., Zaránd, A., Jakab, F., Szöllösi, L. K., Kéri, G., Schwab, R. & Peták, I., ápr. 16 2015, In : Diagnostic Pathology. 10, 1, 26.

Research output: Article

5 Citations (Scopus)

Erratum: Targeting vascular endothelial growth factor receptor 2 and protein kinase d1 related pathways by a multiple kinase inhibitor in angiogenesis and inflammation related processes in vitro (PLoS ONE)

Varga, A., Gyulavári, P., Greff, Z., Futosi, K., Nemeth, T., Simon-Szabó, L., Kerekes, K., Szántai-Kis, C., Brauswetter, D., Kokas, M., Borbely, G., Erdei, A., Mócsai, A., Kéri, G. & Vántus, T., dec. 1 2015, In : PLoS One. 10, 12, e0144792.

Research output: Article

Gremlin regulates renal inflammation via the vascular endothelial growth factor receptor 2 pathway

Lavoz, C., Alique, M., Rodrigues-Diez, R., Pato, J., Keri, G., Mezzano, S., Egido, J. & Ruiz-Ortega, M., aug. 1 2015, In : Journal of Pathology. 236, 4, p. 407-420 14 p.

Research output: Article

20 Citations (Scopus)

Lead selection and characterization of antitubercular compounds using the Nested Chemical Library

Sipos, A., Pató, J., Székely, R., Hartkoorn, R. C., Kékesi, L., Orfi, L., Szántai-Kis, C., Mikušová, K., Svetlíková, Z., Korduláková, J., Nagaraja, V., Godbole, A. A., Bush, N., Collin, F., Maxwell, A., Cole, S. T. & Kéri, G., jún. 1 2015, In : Tuberculosis. 95, S1, p. S200-S206

Research output: Article

20 Citations (Scopus)

Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes

Herrero, A., Pinto, A., Colón-Bolea, P., Casar, B., Jones, M., Agudo-Ibáñez, L., Vidal, R., Tenbaum, S. P., Nuciforo, P., Valdizán, E. M., Horvath, Z., Orfi, L., Pineda-Lucena, A., Bony, E., Keri, G., Rivas, G., Pazos, A., Gozalbes, R., Palmer, H. G., Hurlstone, A. & 1 others, Crespo, P., aug. 10 2015, In : Cancer Cell. 28, 2, p. 170-182 13 p.

Research output: Article

61 Citations (Scopus)

Targeting vascular endothelial growth factor receptor 2 and protein kinase D1 related pathways by a multiple kinase inhibitor in angiogenesis and inflammation related processes in vitro

Varga, A., Gyulavári, P., Greff, Z., Futosi, K., Németh, T., Simon-Szabó, L., Kerekes, K., Szántai-Kis, C., Brauswetter, D., Kokas, M., Borbély, G., Erdei, A., Mócsai, A., Kéri, G. & Vántus, T., ápr. 14 2015, In : PloS one. 10, 4, e0124234.

Research output: Article

7 Citations (Scopus)
2014

Activation of HER3 interferes with antitumor effects of axl receptor tyrosine kinase inhibitors: Suggestion of combination therapy

Torka, R., Pénzes, K., Gusenbauer, S., Baumann, C., Szabadkai, I., Orfi, L., Kéri, G. & Ullrich, A., 2014, In : Neoplasia (United States). 16, 4, p. 301-318 18 p.

Research output: Article

17 Citations (Scopus)

Anticytolytic screen identifies inhibitors of mycobacterial virulence protein secretion

Rybniker, J., Chen, J. M., Sala, C., Hartkoorn, R. C., Vocat, A., Benjak, A., Boy-Röttger, S., Zhang, M., Székely, R., Greff, Z., Orfi, L., Szabadkai, I., Pató, J., Kéri, G. & Cole, S. T., okt. 8 2014, In : Cell Host and Microbe. 16, 4, p. 538-548 11 p.

Research output: Article

40 Citations (Scopus)

Combined inhibition of AXL, Lyn and p130Cas kinases block migration of triple negative breast cancer cells

Pénzes, K., Baumann, C., Szabadkai, I., Orfi, L., Kéri, G., Ullrich, A. & Torka, R., nov. 1 2014, In : Cancer Biology and Therapy. 15, 11, p. 1571-1582 12 p.

Research output: Article

12 Citations (Scopus)

Discovery and biological evaluation of novel dual EGFR/c-Met inhibitors

Szokol, B., Gyulavári, P., Kurkó, I., Baska, F., Szántai-Kis, C., Greff, Z., Orfi, Z., Peták, I., Pénzes, K., Torka, R., Ullrich, A., Orfi, L., Vántus, T. & Kéri, G., ápr. 10 2014, In : ACS Medicinal Chemistry Letters. 5, 4, p. 298-303 6 p.

Research output: Article

8 Citations (Scopus)

Erlotinib-érzékeny és erlotinib-rezisztens sejtvonalakat gátló pirido[2,3-b] pirazinok, és eloállítasuk régiószelektív kondenzációs reakcióval

László, K., Anna, S., Gábor, N., András, D., Eszter, I., Sándor, B., Nóra, B., Zoltán, N., Bálint, H. B., János, P., Zoltán, G., György, K. & László, O., jan. 1 2014, In : Acta pharmaceutica Hungarica. 84, 3, p. 91-104 14 p.

Research output: Article

1 Citation (Scopus)

Identification of protein kinase inhibitors with a selective negative effect on the viability of Epstein-Barr virus infected B cell lines

Mavromatidis, V., Varga, Z., Waczek, F., Orfi, Z., Orfi, L., Kéri, G. & Mosialos, G., ápr. 23 2014, In : PloS one. 9, 4, e95688.

Research output: Article

1 Citation (Scopus)
50 Citations (Scopus)

NADPH oxidase 4 is expressed in pulmonary artery adventitia and contributes to hypertensive vascular remodeling

Barman, S. A., Chen, F., Su, Y., Dimitropoulou, C., Wang, Y., Catravas, J. D., Han, W., Orfi, L., Szantai-Kis, C., Keri, G., Szabadkai, I., Barabutis, N., Rafikova, O., Rafikov, R., Black, S. M., Jonigk, D., Giannis, A., Asmis, R., Stepp, D. W., Ramesh, G. & 1 others, Fulton, D. J. R., aug. 2014, In : Arteriosclerosis, thrombosis, and vascular biology. 34, 8, p. 1704-1715 12 p.

Research output: Article

67 Citations (Scopus)

Pharmacophore and binding analysis of known and novel b-raf kinase inhibitors

Baska, F., Szabadkai, I., Sipos, A., Breza, N., Szántai-Kis, C., Kékesi, L., Garamvölgyi, R., Nemes, Z., Baska, F., Neumann, L., Torka, R., Ullrich, A., Kéri, G. & Orfi, L., jún. 2014, In : Current medicinal chemistry. 21, 17, p. 1938-1955 18 p.

Research output: Article

6 Citations (Scopus)

Preparation of pyrido [2,3-b] pyrazine ring system via regioselective condensation reaction

Kékesi, L., Dancsó, A., Illyés, E., Boros, S., Patób, J., Greff, Z., Németh, G., Garamvölgyi, R., Baska, F., Orfi, L. & Kéri, G., nov. 2014, In : Letters in Organic Chemistry. 11, 9, p. 651-656 6 p.

Research output: Article

2 Citations (Scopus)

Screening for MAPK modulators using an in-cell western assay

Schnaiter, S., Fürst, B., Neu, J., Wáczek, F., Orfi, L., Kéri, G., Huber, L. A. & Wunderlich, W., 2014, Ras Signaling: Methods and Protocols. Humana Press Inc., p. 121-129 9 p. (Methods in Molecular Biology; vol. 1120).

Research output: Chapter

3 Citations (Scopus)

Synthesis and evaluation of phosphorus containing, specific CDK9/CycT1 inhibitors

Németh, G., Greff, Z., Sipos, A., Varga, Z., Székely, R., Sebestyén, M., Jászay, Z., Béni, S., Nemes, Z., Pirat, J. L., Volle, J. N., Virieux, D., Gyuris, Á., Kelemenics, K., Áy, É., Minarovits, J., Szathmary, S., Kéri, G. & Orfi, L., máj. 22 2014, In : Journal of Medicinal Chemistry. 57, 10, p. 3939-3965 27 p.

Research output: Article

44 Citations (Scopus)

TP53 mutation-correlated genes predict the risk of tumor relapse and identify MPS1 as a potential therapeutic kinase in TP53-mutated breast cancers

Gyorffy, B., Bottai, G., Lehmann-Che, J., Kéri, G., Orfi, L., Iwamoto, T., Desmedt, C., Bianchini, G., Turner, N. C., de Thè, H., André, F., Sotiriou, C., Hortobagyi, G. N., Di Leo, A., Pusztai, L. & Santarpia, L., máj. 2014, In : Molecular Oncology. 8, 3, p. 508-519 12 p.

Research output: Article

35 Citations (Scopus)
2013

Connective tissue growth factor is a new ligand of epidermal growth factor receptor

Rayego-Mateos, S., Rodrigues-Díez, R., Morgado-Pascual, J. L., Rodrigues Díez, R. R., Mas, S., Lavoz, C., Alique, M., Pato, J., Keri, G., Ortiz, A., Egido, J. & Ruiz-Ortega, M., okt. 1 2013, In : Journal of Molecular Cell Biology. 5, 5, p. 323-335 13 p.

Research output: Article

33 Citations (Scopus)

Developing FGFR4 inhibitors as potential anti-cancer agents via in silico design, supported by in vitro and cell-based testing

Ho, H. K., Németh, G., Ng, Y. R., Pang, E., Szántai-Kis, C., Zsákai, L., Breza, N., Greff, Z., Horváth, Z., Pató, J., Szabadkai, I., Szokol, B., Baska, F., Orfi, L., Ullrich, A., Kéri, G. & Chua, B. T., ápr. 1 2013, In : Current medicinal chemistry. 20, 10, p. 1203-1217 15 p.

Research output: Article

9 Citations (Scopus)

EGFR/c-Met ketto{combining double acute accent}sgátlók fejlesztése és biokémiai vizsgálata

Bálint, S., Ṕal, G., Ferenc, B., Kurkó, I., Zoltán, G., Kis-Csaba, S., Orfi, Z., István, P., Ullrich, A., Tibor, V., Gÿorgy, K. & Laśzló, O., dec. 1 2013, In : Acta pharmaceutica Hungarica. 83, 4, p. 121-133 13 p.

Research output: Review article

1 Citation (Scopus)

Mycobacterium tuberculosis ellenes hatóanyagok fejlesztése és szerkezet-hatâs összefüggéseinek vizsgâlata

Ferenc, B., Rita, S. E., Csaba, S. K., Pêter, B., Bâlint, H. B., Gabor, N., Nóra, B., Lilian, Z., Zoltän, G., Jänos, P., György, K. & Laszló, Ö., dec. 2 2013, In : Acta pharmaceutica Hungarica. 83, 3, p. 88-95 8 p.

Research output: Article

Potenciális antitumor hatású FGFR inhibitorok fejlesztése.

Zsákai, L., Németh, G., Szántai-Kis, C., Greff, Z., Horváth, Z., Szokol, B., Baska, F., Boon, T. C., Orfi, L. & Kéri, G., 2013, In : Unknown Journal. 83, 2, p. 47-56 10 p.

Research output: Article

2 Citations (Scopus)

Preface

Keri, G. & Ullrich, A., ápr. 1 2013, In : Current Signal Transduction Therapy. 8, 1, 1 p.

Research output: Editorial

Synthesis and biological evaluation of novel pyrido[2,3-b]pyrazines inhibiting both erlotinib-sensitive and erlotinib-resistant cell lines

Kékesi, L., Sipos, A., Németh, G., Pató, J., Breza, N., Baska, F., Örfi, L. & Kéri, G., nov. 15 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 22, p. 6152-6155 4 p.

Research output: Article

4 Citations (Scopus)

The Inflammatory Kinase MAP4K4 Promotes Reactivation of Kaposi's Sarcoma Herpesvirus and Enhances the Invasiveness of Infected Endothelial Cells

Haas, D. A., Bala, K., Büsche, G., Weidner-Glunde, M., Santag, S., Kati, S., Gramolelli, S., Damas, M., Dittrich-Breiholz, O., Kracht, M., Rückert, J., Varga, Z., Keri, G. & Schulz, T. F., nov. 1 2013, In : PLoS Pathogens. 9, 11, e1003737.

Research output: Article

29 Citations (Scopus)

TWEAK transactivation of the epidermal growth factor receptor mediates renal inflammation

Rayego-Mateos, S., Morgado-Pascual, J. L., Sanz, A. B., Ramos, A. M., Eguchi, S., Batlle, D., Pato, J., Keri, G., Egido, J., Ortiz, A. & Ruiz-Ortega, M., dec. 1 2013, In : Journal of Pathology. 231, 4, p. 480-494 15 p.

Research output: Article

35 Citations (Scopus)
2012
7 Citations (Scopus)

Dendrimer-based macromolecular conjugate for the kidney-directed delivery of a multitargeted sunitinib analogue

Dolman, M. E. E. M., van Dorenmalen, K. M. A., Pieters, E. H. E., Sparidans, R. W., Lacombe, M., Szokol, B., Orfi, L., Kéri, G., Bovenschen, N., Storm, G., Hennink, W. E. & Kok, R. J., jan. 1 2012, In : Macromolecular Bioscience. 12, 1, p. 93-103 11 p.

Research output: Article

12 Citations (Scopus)

Inibitori delle chinasi riducono l'espressione genica dell'onco-soppressore indotto da 7,12- dimethylbenz[a]anthracene in esperimenti a breve termine

Gergely, P., Budán, F., Szabó, I., Mezey, G., Németh, Á., Huszár, A., Iványi, J., Gombos, K., Knapp, Á., Orfi, L., Kéri, G. & Ember, I., dec. 1 2012, In : European Journal of Oncology. 17, 1, p. 11-21 11 p.

Research output: Article

1 Citation (Scopus)
45 Citations (Scopus)

Optimization of important early ADME(T) parameters of NADPH oxidase-4 inhibitor molecules

Borbély, G., Huszár, M., Varga, A., Futosi, K., Mócsai, A., Orfi, L., Idei, M., Mandl, J., Kéri, G. & Vántus, T., márc. 2012, In : Medicinal Chemistry. 8, 2, p. 174-181 8 p.

Research output: Article

3 Citations (Scopus)

Preface

Kéri, G. & Ullrich, A., jan. 1 2012, In : Current Signal Transduction Therapy. 7, 1, 1 p.

Research output: Editorial

Targeting of a platinum-bound sunitinib analog to renal proximal tubular cells

Dolman, M., Harmsen, S., Pieters, E. H. E., Sparidans, R. W., Lacombe, M., Szokol, B., Orfi, L., Kéri, G., Storm, G., Hennink, W. E. & Kok, R. J., febr. 10 2012, In : International journal of nanomedicine. 7, p. 417-433 17 p.

Research output: Article

20 Citations (Scopus)
2011

Current Signal Transduction Therapy: Preface

Kéri, G. & Ullrich, A., jan. 1 2011, In : Current Signal Transduction Therapy. 6, 1, 1 p.

Research output: Editorial

Development of a cell-selective and intrinsically active multikinase inhibitor bioconjugate

Harmsen, S., Dolman, M. E. M., Nemes, Z., Lacombe, M., Szokol, B., Pató, J., Kéri, G., Öfi, L., Storm, G., Hennink, W. E. & Kok, R. J., ápr. 20 2011, In : Bioconjugate Chemistry. 22, 4, p. 540-545 6 p.

Research output: Article

14 Citations (Scopus)

How Förster resonance energy transfer imaging improves the understanding of protein interaction networks in cancer biology

Fruhwirth, G. O., Fernandes, L. P., Weitsman, G., Patel, G., Kelleher, M., Lawler, K., Brock, A., Poland, S. P., Matthews, D. R., Keri, G., Barber, P. R., Vojnovic, B., Ameer-Beg, S. M., Coolen, A. C. C., Fraternali, F. & Ng, T., febr. 25 2011, In : ChemPhysChem. 12, 3, p. 442-461 20 p.

Research output: Review article

39 Citations (Scopus)

N-methylated sst 2 selective somatostatin cyclic peptide analogue as a potent candidate for treating neurogenic inflammation

Chatterjee, J., Laufer, B., Beck, J. G., Helyes, Z., Pintér, E., Szolcsányi, J., Horvath, A., Mandl, J., Reubi, J. C., Kéri, G. & Kessler, H., júl. 14 2011, In : ACS Medicinal Chemistry Letters. 2, 7, p. 509-514 6 p.

Research output: Article

15 Citations (Scopus)

Novel, selective CDK9 inhibitors for the treatment of HIV infection

Németh, G., Varga, Z., Greff, Z., Bencze, G., Sipos, A., Szántai-Kis, C., Baska, F., Gyuris, Á., Kelemenics, K., Szathmáry, Z., Minárovits, J., Kéri, G. & Orfi, L., jan. 2011, In : Current medicinal chemistry. 18, 3, p. 342-358 17 p.

Research output: Article

26 Citations (Scopus)

Protein kinase inhibitor as a potential candidate for epilepsy treatment

Gajda, Z., Török, R., Horváth, Z., Szántai-Kis, C., Orfi, L., Kéri, G. & Szente, M., márc. 1 2011, In : Epilepsia. 52, 3, p. 579-588 10 p.

Research output: Article

6 Citations (Scopus)

The challenges of integrating molecular imaging into the optimization of cancer therapy

Patel, G. S., Kiuchi, T., Lawler, K., Ofo, E., Fruhwirth, G. O., Kelleher, M., Shamil, E., Zhang, R., Selvin, P. R., Santis, G., Spicer, J., Woodman, N., Gillett, C. E., Barber, P. R., Vojnovic, B., Kéri, G., Schaeffter, T., Goh, V., O'Doherty, M. J., Ellis, P. A. & 1 others, Ng, T., jún. 1 2011, In : Integrative Biology. 3, 6, p. 603-631 29 p.

Research output: Review article

12 Citations (Scopus)