• 507 Citations
  • 14 h-Index
1992 …2019
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Research Output 1992 2019

  • 507 Citations
  • 14 h-Index
  • 35 Article
  • 1 Conference contribution
2019

Biochemical and pharmacological investigation of novel nociceptin/OFQ analogues and N/OFQ-RYYRIK hybrid peptides

Erdei, A., Borbély, A., Magyar, A., Szűcs, E., Ötvös, F., Gombos, D., Al-Khrasani, M., Stefanucci, A., Dimmito, M. P., Luisi, G., Mollica, A. & Benyhe, S., febr. 1 2019, In : Peptides. 112, p. 106-113 8 p.

Research output: Article

Pharmacology
Peptides
Vas Deferens
Bioassay
Biological Assay
2 Citations (Scopus)
Open Access
Cell-Penetrating Peptides
Tight Junctions
Permeability
Cell Membrane
Claudin-4
1 Citation (Scopus)
Peptaibols
Molecular Dynamics Simulation
folding
peptides
Molecular dynamics
2017
2 Citations (Scopus)

Chaperone co-inducer BGP-15 inhibits histone deacetylases and enhances the heat shock response through increased chromatin accessibility

Budzyński, M. A., Crul, T., Himanen, S. V., Toth, N., Ötvös, F., Sistonen, L. & Vígh, L., szept. 1 2017, In : Cell Stress and Chaperones. 22, 5, p. 717-728 12 p.

Research output: Article

Heat-Shock Response
Histone Deacetylases
Chromatin
Homeostasis
Chemical activation
2016
27 Citations (Scopus)

Reversible Opening of Intercellular Junctions of Intestinal Epithelial and Brain Endothelial Cells with Tight Junction Modulator Peptides

Bocsik, A., Walter, F. R., Gyebrovszki, A., Fülöp, L., Blasig, I., Dabrowski, S., Ötvös, F., Tóth, A., Rákhely, G., Veszelka, S., Vastag, M., Szabó-Révész, P. & Deli, M., febr. 1 2016, In : Journal of Pharmaceutical Sciences. 105, 2, p. 754-765 12 p.

Research output: Article

Intercellular Junctions
Tight Junctions
Claudin-5
Endothelial Cells
Occludin
2015
6 Citations (Scopus)
Biochemistry
Molecular modeling
morphine
mu Opioid Receptor
narcotics
2014
2 Citations (Scopus)
Grid
Molecular Dynamics
Molecular dynamics
Infrastructure
Computational chemistry
2013
6 Citations (Scopus)

Divalent heavy metal cations block the TRPV1 Ca2+ channel

Pecze, L., Winter, Z., Jósvay, K., Ötvös, F., Kolozsi, C., Vízler, C., Budai, D., Letoha, T., Dombi, G., Szakonyi, G. & Oláh, Z., 2013, In : Biological Trace Element Research. 151, 3, p. 451-461 11 p.

Research output: Article

Heavy Metals
Cations
Inhibitory Concentration 50
Cells
Transient Receptor Potential Channels
38 Citations (Scopus)
Ion Channels
Amino Acids
Neurogenic Inflammation
Mutation
Calmodulin
2012
1 Citation (Scopus)

Homology modeling and phylogenetic relationships of catalases of an opportunistic pathogen Rhizopus oryzae

Linka, B., Szakonyi, G., Petkovits, T., Nagy, L. G., Papp, T., Vágvölgyi, C., Benyhe, S. & Ötvös, F., aug. 21 2012, In : Life Sciences. 91, 3-4, p. 115-126 12 p.

Research output: Article

Rhizopus
Pathogens
Catalase
Proteins
Structural Models
16 Citations (Scopus)
rimonabant
Cannabinoid Receptors
Opioid Receptors
Prosencephalon
Ala(2)-MePhe(4)-Gly(5)-enkephalin
4 Citations (Scopus)
molecular conformation
Molecular Conformation
Potassium Channels
potassium channels
Genes
2011
1 Citation (Scopus)

Gridifying the TINKER conformer generator application for gLite grid

Kertész, A., Ötvös, F. & Kacsuk, P., 2011, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 6586 LNCS. p. 185-192 8 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 6586 LNCS).

Research output: Conference contribution

Generator
Grid
Molecular Dynamics
Molecular dynamics
Grid Portal
2007
21 Citations (Scopus)

Anti-calmodulins and tricyclic adjuvants in pain therapy block the TRPV1 channel

Oláh, Z., Jósvay, K., Pecze, L., Letoha, T., Babai, N., Budai, D., Ötvös, F., Szalma, S. & Vízler, C., jún. 20 2007, In : PLoS One. 2, 6, e545.

Research output: Article

calmodulin
Calmodulin
adjuvants
pain
calcium
4 Citations (Scopus)
Neurokinin-2 Receptors
Lactams
Tics
Structure-Activity Relationship
Amino acids
2006
20 Citations (Scopus)
Chirality
Conformations
flexibility
Opiate Alkaloids
Dinoprost
2005
24 Citations (Scopus)
Quantitative Structure-Activity Relationship
Conformations
Ligands
Free energy
Opiate Alkaloids
2003
23 Citations (Scopus)

Conformational analysis of endomorphin-2 by molecular dynamics methods

Leitgeb, B., Ötvös, F. & Tóth, G., ápr. 2003, In : Biopolymers - Peptide Science Section. 68, 4, p. 497-511 15 p.

Research output: Article

Molecular Dynamics Simulation
Simulated annealing
Peptides
Molecular dynamics
Atoms
5 Citations (Scopus)
Molecular Dynamics Simulation
Structure-Activity Relationship
Peptides
peptides
Molecular dynamics
2002
1 Citation (Scopus)

A specific binding site for a fragment of the B-loop of epidermal growth factor and related peptides

Gembitsky, D. S., Bozsó, Z., O'Flaharty, M., Ötvös, F., Murphy, R. F. & Lovas, S., 2002, In : Peptides. 23, 1, p. 97-102 6 p.

Research output: Article

Epidermal Growth Factor
Binding Sites
Peptides
Epidermal Growth Factor Receptor
Squamous Cell Carcinoma
2001
45 Citations (Scopus)

Pancreatic cancer cells require an EGF receptor-mediated autocrine pathway for proliferation in serum-free conditions

Murphy, L. O., Cluck, M. W., Lovas, S., Ötvös, F., Murphy, R. F., Schally, A. V., Permert, J., Larsson, J., Knezetic, J. A. & Adrian, T. E., ápr. 6 2001, In : British Journal of Cancer. 84, 7, p. 926-935 10 p.

Research output: Article

Pancreatic Neoplasms
Epidermal Growth Factor Receptor
Mitogen-Activated Protein Kinase Kinases
Serum
Epidermal Growth Factor
1999
6 Citations (Scopus)
Epidermal Growth Factor
Anhydrides
Conformations
Esters
Peptides
12 Citations (Scopus)

Importance of the aromatic residue at position 6 of [Nle10]neurokinin A(4-10) for binding to the NK-2 receptor and receptor activation

Gembitsky, D. S., Murnin, M., Ötvös, F., Allen, J., Murphy, R. F. & Lovas, S., júl. 29 1999, In : Journal of Medicinal Chemistry. 42, 15, p. 3004-3007 4 p.

Research output: Article

Neurokinin-2 Receptors
Chemical activation
Bioactivity
neurokinin A(4-10)
Molecular recognition
10 Citations (Scopus)
kappa Opioid Receptor
Tissue
Radioligand Assay
Tritium
Radioactivity
2 Citations (Scopus)

Tritium labeling of 7-isopropoxyisoflavone

Ötvös, F., Tóth, G., Szatmári, I. & Lévai, F., 1999, In : Journal of Labelled Compounds and Radiopharmaceuticals. 42, 5, p. 497-503 7 p.

Research output: Article

Tritium
Labeling
Bromine
Halogenation
ipriflavone
32 Citations (Scopus)

μ-Opioid receptor specific antagonist cyprodime: Characterization by in vitro radioligand and [35S]GTPγS binding assays

Márki, A., Monory, K., Ötvös, F., Tóth, G., Krassnig, R., Schmidhammer, H., Traynor, J. R., Roques, B. P., Maldonado, R. & Borsodi, A., okt. 27 1999, In : European Journal of Pharmacology. 383, 2, p. 209-214 6 p.

Research output: Article

Narcotic Antagonists
Opioid Receptors
Biological Assay
Morphine
Morphinans
1998

Erratum: Synthesis of gonadotropin-releasing hormone III analogs. Structure-antitumor activity relationships (Journal of Medical Chemistry (1997) 40)

Mezo, I., Lovas, S., Palyi, I., Vincze, B., Kalnay, A., Turi, G., Vadasz, Z., Seprődi, J., Idei, M., Toth, G., Hunyadi-Gulyás, E., Ötvös, F., Mak, M., Horváth, J., Teplan, I. & Murphy, R. F., máj. 21 1998, In : Journal of Medicinal Chemistry. 41, 11, p. 1996 1 p.

Research output: Article

gonadotropin-releasing hormone-III
16 Citations (Scopus)

Interaction of agonist peptide [3H]Tyr-D-Ala-Phe-Phe-NH2 with μ- opioid receptor in rat brain and CHO-μ/1 cell line

Spetea, M., Ötvös, F., Tóth, G., Nguyen, T. M. D., Schiller, P. W., Vogel, Z. & Borsodi, A., jún. 1998, In : Peptides. 19, 6, p. 1091-1098 8 p.

Research output: Article

Opioid Receptors
Cricetulus
Rats
Ovary
Brain

NKA, analogs with conformational constraint

Ötvös, F., Gembitsky, D. S., Murphy, R. F. & Lovas, S., 1998, In : Biochemical Society Transactions. 26, 1

Research output: Article

1997
29 Citations (Scopus)

Tritium labeling of neuropeptides.

Tóth, G., Lovas, S. & Ötvös, F., 1997, In : Methods in molecular biology (Clifton, N.J.). 73, p. 219-230 12 p.

Research output: Article

Neuropeptide Receptors
Isotope Labeling
Protein Precursors
Tritium
Molecular Structure
1996
3 Citations (Scopus)
Tritium
tritium
Labeling
Opioid Analgesics
marking
1995
5 Citations (Scopus)

Synthesis of high specific activity [15,16-3H2]buprenorphine

Ötvös, F., Hosztafi, S., Simon, C. & Toth, G., 1995, In : Journal of Labelled Compounds and Radiopharmaceuticals. 36, 1, p. 79-83 5 p.

Research output: Article

Buprenorphine
Tritium
Skeleton
Labeling
Morphine
1994
65 Citations (Scopus)

Binding characteristics of the novel highly selective delta agonist, [3H]Ile5,6deltorphin II

Nevin, S. T., Kabasakal, L., Ötvös, F., Töth, G. & Borsodi, A., 1994, In : Neuropeptides. 26, 4, p. 261-265 5 p.

Research output: Article

Opioid Receptors
Dehalogenation
Rats
Brain
Substitution reactions
1993
10 Citations (Scopus)
naltrindole
delta Opioid Receptor
hydrazine
Narcotic Antagonists
Tritium
1992
53 Citations (Scopus)

Characterization of [3H]naltrindole binding to delta opioid receptors in rat brain

Yamamura, M. S., Horvath, R., Toth, G., Ötvös, F., Malatynska, E., Knapp, R. J., Porreca, F., Hruby, V. J. & Yamamura, H. I., 1992, In : Life Sciences. 50, 16

Research output: Article

naltrindole
delta Opioid Receptor
Rats
Brain
D-Penicillamine (2,5)-Enkephalin
14 Citations (Scopus)
bromination
Narcotic Antagonists
Tritium
mu Opioid Receptor
tritium