• 13515 Citations
  • 62 h-Index
1971 …2019
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Research Output 1971 2019

  • 13515 Citations
  • 62 h-Index
  • 232 Article
  • 5 Chapter
  • 1 Review article
2019
Pluripotent Stem Cells
Stem cells
Drug-Related Side Effects and Adverse Reactions
Toxicity
Screening

Cellular expression and function of naturally occurring variants of the human ABCG2 multidrug transporter

Zámbó, B., Mózner, O., Bartos, Z., Török, G., Várady, G., Telbisz, Á., Homolya, L., Orbán, T. I. & Sarkadi, B., jan. 1 2019, In : Cellular and Molecular Life Sciences.

Research output: Article

Open Access
Hyperuricemia
Gout
Protein Folding
Xenobiotics
Drug-Related Side Effects and Adverse Reactions
Open Access
Multiple Endocrine Neoplasia Type 2a
Germ-Line Mutation
Codon
Mutation
Genetic Testing
Transgenic Rats
Hemodynamics
Calcium
Cardiovascular Models
Proteins
2018
1 Citation (Scopus)

A new fluorescent dye accumulation assay for parallel measurements of the ABCG2, ABCB1 and ABCC1 multidrug transporter functions

Szabó, E., Türk, D., Telbisz, Á., Kucsma, N., Horváth, T., Szakács, G., Homolya, L., Sarkadi, B. & Várady, G., jan. 1 2018, In : PLoS One. 13, 1, e0190629.

Research output: Article

fluorescent dyes
Fluorescent Dyes
transporters
Assays
Fluorescence
2 Citations (Scopus)
Induced Pluripotent Stem Cells
Dentate Gyrus
Calcium
Neurons
Proteins
1 Citation (Scopus)

Characterization of new, efficient Mycobacterium tuberculosis topoisomerase-I inhibitors and their interaction with human ABC multidrug transporters

Temesszentandrási-Ambrus, C., Tóth, S., Verma, R., Bánhegyi, P., Szabadkai, I., Baska, F., Szántai-Kis, C., Hartkoorn, R. C., Lingerfelt, M. A., Sarkadi, B., Szakács, G., Őrfi, L., Nagaraja, V., Ekins, S. & Telbisz, Á., szept. 1 2018, In : PLoS One. 13, 9, e0202749.

Research output: Article

Topoisomerase I Inhibitors
DNA topoisomerase
Type I DNA Topoisomerase
ATP-Binding Cassette Transporters
Mycobacterium tuberculosis
3 Citations (Scopus)

Clinically relevant mutations in the ABCG2 transporter uncovered by genetic analysis linked to erythrocyte membrane protein expression

Zámbó, B., Bartos, Z., Mózner, O., Szabó, E., Várady, G., Poór, G., Pálinkás, M., Andrikovics, H., Hegedűs, T., Homolya, L. & Sarkadi, B., dec. 1 2018, In : Scientific Reports. 8, 1, 7487.

Research output: Article

Erythrocyte Membrane
Membrane Proteins
Gout
Mutation
Precision Medicine
1 Citation (Scopus)

Generation of multidrug resistant human tissues by overexpression of the ABCG2 multidrug transporter in embryonic stem cells

Erdei, Z., Schamberger, A., Török, G., Szebényi, K., Várady, G., Orbán, T. I., Homolya, L., Sarkadi, B. & Apáti, A., ápr. 1 2018, In : PLoS One. 13, 4, e0194925.

Research output: Article

embryonic stem cells
Embryonic Stem Cells
Stem cells
transporters
stem cells
2017
1 Citation (Scopus)

ABCMdb reloaded: Updates on mutations in ATP binding cassette proteins

Tordai, H., Jakab, K., Gyimesi, G., András, K., Brózik, A., Sarkadi, B. & Hegedűs, T., jan. 1 2017, In : Database. 2017, 1, bax023.

Research output: Article

Adenosinetriphosphate
Carrier Proteins
Adenosine Triphosphate
Proteins
mutation
8 Citations (Scopus)

Extensive astrocyte synchronization advances neuronal coupling in slow wave activity in vivo

Szabó, Z., Héja, L., Szalay, G., Kékesi, O., Füredi, A., Szebényi, K., Dobolyi, A., Orbán, T. I., Kolacsek, O., Tompa, T., Miskolczy, Z., Biczók, L., Rózsa, B., Sarkadi, B. & Kardos, J., dec. 1 2017, In : Scientific Reports. 7, 1, 6018.

Research output: Article

Astrocytes
Neurons
Transgenic Rats
Calcium
Wakefulness
2016
9 Citations (Scopus)

Application of fluorescent dye substrates for functional characterization of ABC multidrug transporters at a single cell level

Nerada, Z., Hegyi, Z., Szepesi, Á., Tóth, S., Hegedüs, C., Várady, G., Matula, Z., Homolya, L., Sarkadi, B. & Telbisz, Á., szept. 1 2016, In : Cytometry Part A. 89, 9, p. 826-834 9 p.

Research output: Article

ATP-Binding Cassette Transporters
Fluorescent Dyes
Coloring Agents
Poisons
Multiple Drug Resistance
4 Citations (Scopus)

Exogenous Nitric Oxide Protects Human Embryonic Stem Cell-Derived Cardiomyocytes against Ischemia/Reperfusion Injury

Pálóczi, J., Varga, Z. V., Apáti, A., Szebényi, K., Sarkadi, B., Madonna, R., De Caterina, R., Csont, T., Eschenhagen, T., Ferdinándy, P. & Görbe, A., 2016, In : Oxidative Medicine and Cellular Longevity. 2016, 4298945.

Research output: Article

S-Nitroso-N-Acetylpenicillamine
Brain Natriuretic Peptide
Stem cells
Reperfusion Injury
Cardiac Myocytes
3 Citations (Scopus)

Functional characterization of the ABCG2 5′ non-coding exon variants: Stem cell specificity, translation efficiency and the influence of drug selection

Sándor, S., Jordanidisz, T., Schamberger, A., Várady, G., Erdei, Z., Apáti, A., Sarkadi, B. & Orbán, T. I., júl. 1 2016, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1859, 7, p. 943-951 9 p.

Research output: Article

Stem cells
Exons
Stem Cells
RNA Isoforms
Messenger RNA
19 Citations (Scopus)

Jump into a new fold-A homology based model for the ABCG2/BCRP multidrug transporter

Lászloá, L., Sarkadi, B. & Hegedüs, T., okt. 1 2016, In : PLoS One. 11, 10, e0164426.

Research output: Article

Computer Simulation
gout
transporters
ABC transporters
ATP-Binding Cassette Transporters
57 Citations (Scopus)

Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells

Klawitter, S., Fuchs, N. V., Upton, K. R., Muñoz-Lopez, M., Shukla, R., Wang, J., Garcia-Cañadas, M., Lopez-Ruiz, C., Gerhardt, D. J., Sebe, A., Grabundzija, I., Merkert, S., Gerdes, P., Pulgarin, J. A., Bock, A., Held, U., Witthuhn, A., Haase, A., Sarkadi, B., Löwer, J. & 7 others, Wolvetang, E. J., Martin, U., Ivics, Z., Izsvák, Z., Garcia-Perez, J. L., Faulkner, G. J. & Schumann, G. G., jan. 8 2016, In : Nature Communications. 7, 10286.

Research output: Article

Induced Pluripotent Stem Cells
stem cells
Stem cells
actuators
Pluripotent Stem Cells
3 Citations (Scopus)

The importance of drug transporters in human pluripotent stem cells and in early tissue differentiation

Apáti, A., Szebényi, K., Erdei, Z., Várady, G., Orbán, T. I. & Sarkadi, B., jan. 2 2016, In : Expert Opinion on Drug Metabolism and Toxicology. 12, 1, p. 77-92 16 p.

Research output: Article

Pluripotent Stem Cells
Stem cells
Tissue
Stem Cells
Pharmaceutical Preparations
2015
7 Citations (Scopus)

ABCG2 is a selectable marker for enhanced multilineage differentiation potential in periodontal ligament stem cells

Szepesi, Á., Matula, Z., Szigeti, A., Várady, G., Szabó, G., Uher, F., Sarkadi, B. & Német, K., jan. 15 2015, In : Stem Cells and Development. 24, 2, p. 244-252 9 p.

Research output: Article

Periodontal Ligament
Stem Cells
Adenosine Triphosphate
Tooth
Regeneration
5 Citations (Scopus)

Alterations of membrane protein expression in red blood cells of Alzheimer's disease patients

Várady, G., Szabó, E., Fehér, Á., Németh, A., Zámbó, B., Pákáski, M., Janka, Z. & Sarkadi, B., szept. 1 2015, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 1, 3, p. 334-338 5 p.

Research output: Article

Alzheimer Disease
Membrane Proteins
Erythrocytes
Biomarkers
Insulin Receptor
2 Citations (Scopus)
drug toxicity
Xenobiotics
Drug-Related Side Effects and Adverse Reactions
Metabolism
pharmacokinetics
12 Citations (Scopus)

Calcium signaling in human pluripotent stem cells

Apáti, A., Berecz, T. & Sarkadi, B., okt. 8 2015, (Accepted/In press) In : Cell Calcium.

Research output: Article

Pluripotent Stem Cells
Calcium Signaling
Calcium
Stem Cells
Homeostasis
3 Citations (Scopus)
Stem cells
Stem Cells
Fluorescence
Tissue
Proteins
2 Citations (Scopus)
Tight Junctions
Hepatocytes
MARVEL Domain Containing 2 Protein
Claudin-4
Agrin
8 Citations (Scopus)

Generation of a Homozygous Transgenic Rat Strain Stably Expressing a Calcium Sensor Protein for Direct Examination of Calcium Signaling

Szebenyi, K., Füredi, A., Kolacsek, O., Pergel, E., Bösze, Z., Bender, B., Vajdovich, P., Tóvári, J., Homolya, L., Szakács, G., Heja, L., Enyedi, A., Sarkadi, B., Apáti, A. & Orban, T. I., aug. 3 2015, In : Scientific Reports. 5, 12645.

Research output: Article

Transgenic Rats
Calcium Signaling
Calcium
Pharmacology
Proteins
ATP-Binding Cassette Transporters
Databases
Mutation
Hematologic Diseases
Gout
15 Citations (Scopus)

Inconsistencies in the red blood cell membrane proteome analysis: Generation of a database for research and diagnostic applications

Hegedűs, T., Chaubey, P. M., Várady, G., Szabó, E., Sarankó, H., Hofstetter, L., Roschitzki, B., Stieger, B. & Sarkadi, B., 2015, In : Database : the journal of biological databases and curation. 2015, bav056.

Research output: Article

Proteome
Cell membranes
proteome
cell membranes
Blood
17 Citations (Scopus)

Lipid Regulation of the ABCB1 and ABCG2 Multidrug Transporters

Hegedüs, C., Telbisz, Á., Hegedűs, T., Sarkadi, B. & Özvegy-Laczka, C., 2015, In : Advances in Cancer Research. 125, p. 97-137 41 p.

Research output: Article

Lipids
ATP-Binding Cassette Transporters
Cholesterol
ATP Binding Cassette Transporter, Sub-Family G, Member 2
Xenobiotics
2 Citations (Scopus)
Mesenchymal Stromal Cells
Dendritic Cells
Monocytes
Bone Marrow
Tretinoin
13 Citations (Scopus)
Consensus Sequence
Sterols
Tyrosine
Amino Acid Sequence
Cholesterol
15 Citations (Scopus)

Visualization of calcium dynamics in kidney proximal tubules

Szebényi, K., Füredi, A., Kolacsek, O., Csohány, R., Prókai, Á., Kis-Petik, K., Szabó, A., Bösze, Z., Bender, B., Tóvári, J., Enyedi, A., Orbán, T. I., Apáti, A. & Sarkadi, B., nov. 1 2015, In : Journal of the American Society of Nephrology. 26, 11, p. 2731-2740 10 p.

Research output: Article

Proximal Kidney Tubule
Calcium
Transgenic Rats
Renal Circulation
Angiotensin Receptor Antagonists
2014
8 Citations (Scopus)

Excision efficiency is not strongly coupled to transgenic rate: Cell type-dependent transposition efficiency of sleeping beauty and piggy bac DNA transposons

Kolacsek, O., Erdei, Z., Apáti, A., Sándor, S., Izsvák, Z., Ivics, Z., Sarkadi, B. & Orbán, T. I., aug. 1 2014, In : Human gene therapy methods. 25, 4, p. 241-252 12 p.

Research output: Article

Beauty
DNA Transposable Elements
Transposases
Efficiency
Genetic Therapy
11 Citations (Scopus)

Expression pattern of the human ABC transporters in pluripotent embryonic stem cells and in their derivatives

Erdei, Z., Lorincz, R., Szebényi, K., Péntek, A., Varga, N., Likó, I., Várady, G., Szakács, G., Orbán, T. I., Sarkadi, B. & Apáti, A., 2014, In : Cytometry Part B - Clinical Cytometry. 86, 5, p. 299-310 12 p.

Research output: Article

Pluripotent Stem Cells
ATP-Binding Cassette Transporters
Embryonic Stem Cells
Carrier Proteins
Adenosine Triphosphate

Human Stem-Cell-Derived Cardiomyocytes in Drug Discovery and Toxicity Testing

Szebényi, K., Péntek, A., Varga, N., Erdei, Z., Vofély, G., Orbán, T. I., Sarkadi, B. & Apáti, A., jún. 3 2014, Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology. Wiley Blackwell, p. 267-298 32 p.

Research output: Chapter

Drug Discovery
Stem cells
Drug-Related Side Effects and Adverse Reactions
Cardiac Myocytes
Toxicity
20 Citations (Scopus)
Adenosine Triphosphate
Steroids
Binding Sites
Cholesterol
Mutation
14 Citations (Scopus)

Screening the expression of ABCB6 in erythrocytes reveals an unexpectedly high frequency of Lan mutations in healthy Individuals

Koszarska, M., Kucsma, N., Kiss, K., Varady, G., Gera, M., Antalffy, G., Andrikovics, H., Tordai, A., Studzian, M., Strapagiel, D., Pulaski, L., Tani, Y., Sarkadi, B. & Szakács, G., okt. 31 2014, In : PLoS One. 9, 10, e111590.

Research output: Article

Mutation Rate
Screening
Blood
erythrocytes
Erythrocytes
2013
32 Citations (Scopus)

ABCC6 is a basolateral plasma membrane protein

Pomozi, V., Le Saux, O., Brampton, C., Apana, A., Iliás, A., Szeri, F., Martin, L., Monostory, K., Paku, S., Sarkadi, B., Szakács, G. & Váradi, A., máj. 24 2013, In : Circulation Research. 112, 11

Research output: Article

Blood Proteins
Membrane Proteins
Cell Membrane
Hepatocytes
Mitochondria
9 Citations (Scopus)
Glutathione
ATP-Binding Cassette Transporters
Adenosine Triphosphatases
Sf9 Cells
Active Biological Transport
16 Citations (Scopus)

Cell surface membrane proteins as personalized biomarkers: Where we stand and where we are headed

Várady, G., Cserepes, J., Németh, A., Szabó, E. & Sarkadi, B., okt. 2013, In : Biomarkers in Medicine. 7, 5, p. 803-819 17 p.

Research output: Article

Biomarkers
Membrane Proteins
Blood
Membranes
Erythrocytes
19 Citations (Scopus)

Characterization of calcium signals in human embryonic stem cells and in their differentiated offspring by a stably integrated calcium indicator protein

Apáti, A., Pászty, K., Hegedus, L., Kolacsek, O., Orbán, T. I., Erdei, Z., Szebényi, K., Péntek, A., Enyedi, A. & Sarkadi, B., ápr. 2013, In : Cellular Signalling. 25, 4, p. 752-759 8 p.

Research output: Article

Calcium
Proteins
Calcium Signaling
Ligands
Cardiac Myocytes
17 Citations (Scopus)

Dynamic ABCG2 expression in human embryonic stem cells provides the basis for stress response

Erdei, Z., Sarkadi, B., Brózik, A., Szebényi, K., Várady, G., Makó, V., Péntek, A., Orbán, T. I. & Apáti, A., márc. 2013, In : European Biophysics Journal. 42, 2-3, p. 169-179 11 p.

Research output: Article

Cell Membrane
Pluripotent Stem Cells
Membrane Transport Proteins
Cell Separation
Poisons
17 Citations (Scopus)
Gout
Polymorphism
Mutation
Cell membranes
Processing
26 Citations (Scopus)
Bile Acids and Salts
Cholesterol
Lipids
Detergents
Adenosine Triphosphatases
2 Citations (Scopus)

Erratum: Reliable transgene-independent method for determining sleeping beauty transposon copy numbers (Mobile DNA 4 (11))

Kolacsek, O., Krízsik, V., Schamberger, A., Erdei, Z., Apáti, A., Várady, G., Mátés, L., Izsvák, Z., Ivics, Z., Sarkadi, B. & Orbán, T. I., 2013, In : Mobile DNA. 4, 1, 11.

Research output: Article

Beauty
Transgenes
DNA
56 Citations (Scopus)

Sleeping Beauty transposon-based system for cellular reprogramming and targeted gene insertion in induced pluripotent stem cells

Grabundzija, I., Wang, J., Sebe, A., Erdei, Z., Kajdi, R., Devaraj, A., Steinemann, D., Szuhai, K., Stein, U., Cantz, T., Schambach, A., Baum, C., Izsvák, Z., Sarkadi, B. & Ivics, Z., febr. 2013, In : Nucleic Acids Research. 41, 3, p. 1829-1847 19 p.

Research output: Article

Beauty
Induced Pluripotent Stem Cells
Insertional Mutagenesis
Fibroblasts
Embryoid Bodies
22 Citations (Scopus)

Structure-activity relationships of chromone derivatives toward the mechanism of interaction with and inhibition of breast cancer resistance protein ABCG2

Winter, E., Lecerf-Schmidt, F., Gozzi, G., Peres, B., Lightbody, M., Gauthier, C., Özvegy-Laczka, C., Szakács, G., Sarkadi, B., Creczynski-Pasa, T. B., Boumendjel, A. & Di Pietro, A., dec. 27 2013, In : Journal of Medicinal Chemistry. 56, 24, p. 9849-9860 12 p.

Research output: Article

Chromones
Structure-Activity Relationship
Adenosine Triphosphatases
Mitoxantrone
Breast Neoplasms
2012
17 Citations (Scopus)

ABCMdb: A database for the comparative analysis of protein mutations in ABC transporters, and a potential framework for a general application

Gyimesi, G., Borsodi, D., Sarankó, H., Tordai, H., Sarkadi, B. & Hegedu double acutes, T., nov. 2012, In : Human Mutation. 33, 11, p. 1547-1556 10 p.

Research output: Article

ATP-Binding Cassette Transporters
Databases
Mutation
Carrier Proteins
Proteins
13 Citations (Scopus)

Antibody binding shift assay for rapid screening of drug interactions with the human ABCG2 multidrug transporter

Telbisz, Á., Hegedüs, C., Özvegy-Laczka, C., Goda, K., Várady, G., Takáts, Z., Szabó, E., Sorrentino, B. P., Váradi, A. & Sarkadi, B., jan. 23 2012, In : European Journal of Pharmaceutical Sciences. 45, 1-2, p. 101-109 9 p.

Research output: Article

Xenobiotics
Drug Interactions
Antibodies
Heme
Drug Resistance
23 Citations (Scopus)

Calcium signaling in pluripotent stem cells

Apáti, A., Pászty, K., Erdei, Z., Szebényi, K., Homolya, L. & Sarkadi, B., ápr. 28 2012, In : Molecular and Cellular Endocrinology. 353, 1-2, p. 57-67 11 p.

Research output: Article

Pluripotent Stem Cells
Calcium Signaling
Stem cells
Calcium
Mesenchymal Stromal Cells
1 Citation (Scopus)
ATP-Binding Cassette Transporters
Hydrolysis
Adenosine Triphosphate
18 Citations (Scopus)

Expression Levels of the ABCG2 Multidrug Transporter in Human Erythrocytes Correspond to Pharmacologically Relevant Genetic Variations

Kasza, I., Várady, G., Andrikovics, H., Koszarska, M., Tordai, A., Scheffer, G. L., Németh, A., Szakács, G. & Sarkadi, B., nov. 15 2012, In : PLoS One. 7, 11, e48423.

Research output: Article

membrane proteins
transporters
Membrane Proteins
erythrocytes
Erythrocytes