• 8440 Citations
  • 45 h-Index
1975 …2020

Research output per year

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Research Output

2020

Imaging Sigma-1 Receptor (S1R) Expression Using Iodine-124-Labeled 1-(4-Iodophenyl)-3-(2-adamantyl)guanidine ([124I]IPAG)

Gangangari, K. K., Váradi, A., Majumdar, S., Larson, S. M., Pasternak, G. W. & Pillarsetty, N. V. K., ápr. 1 2020, In : Molecular Imaging and Biology. 22, 2, p. 358-366 9 p.

Research output: Article

1 Citation (Scopus)
2019

Dietary Pyrophosphate Modulates Calcification in a Mouse Model of Pseudoxanthoma Elasticum: Implication for Treatment of Patients

Pomozi, V., Julian, C. B., Zoll, J., Pham, K., Kuo, S., Tőkési, N., Martin, L., Váradi, A. & Le Saux, O., máj. 2019, In : Journal of Investigative Dermatology. 139, 5, p. 1082-1088 7 p.

Research output: Article

2 Citations (Scopus)

PXE, a Mysterious Inborn Error Clarified

Borst, P., Váradi, A. & van de Wetering, K., febr. 2019, In : Trends in Biochemical Sciences. 44, 2, p. 125-140 16 p.

Research output: Review article

2 Citations (Scopus)

Synthesis of spiro-2,6-dioxopiperazine and spiro-2,6-dioxopyrazine scaffolds using amino acids in a three-component reaction to generate potential Sigma-1 (σ1) receptor selective ligands

Uprety, R., Váradi, A., Allaoa, A., Redel-Traub, G. N., Palmer, T. C., Feinberg, E. N., Ferris, A. C., Pande, V. S., Pasternak, G. W. & Majumdar, S., febr. 15 2019, In : European Journal of Medicinal Chemistry. 164, p. 241-251 11 p.

Research output: Article

2018
3 Citations (Scopus)

In vitro transport of methotrexate by Drosophila Multidrug Resistance-associated Protein

Karasik, A., Váradi, A. & Szeri, F., okt. 2018, In : PloS one. 13, 10, e0205657.

Research output: Article

2017

14-O-Methylmorphine: A Novel Selective Mu-Opioid Receptor Agonist with High Efficacy and Affinity

Zádor, F., Balogh, M., Váradi, A., Zádori, Z. S., Király, K., Szűcs, E., Varga, B., Lázár, B., Hosztafi, S., Riba, P., Benyhe, S., Fürst, S. & Al-Khrasani, M., nov. 5 2017, In : European Journal of Pharmacology. 814, p. 264-273 10 p.

Research output: Article

2 Citations (Scopus)

Functional Rescue of ABCC6 Deficiency by 4-Phenylbutyrate Therapy Reduces Dystrophic Calcification in Abcc6–/– Mice

Pomozi, V., Brampton, C., Szeri, F., Dedinszki, D., Kozák, E., van de Wetering, K., Hopkins, H., Martin, L., Váradi, A. & Le Saux, O., márc. 1 2017, In : Journal of Investigative Dermatology. 137, 3, p. 595-602 8 p.

Research output: Article

13 Citations (Scopus)

Genetic dissociation of morphine analgesia from hyperalgesia in mice

Marrone, G. F., Le Rouzic, V., Varadi, A., Xu, J., Rajadhyaksha, A. M., Majumdar, S., Pan, Y. X. & Pasternak, G. W., jún. 1 2017, In : Psychopharmacology. 234, 12, p. 1891-1900 10 p.

Research output: Article

6 Citations (Scopus)
13 Citations (Scopus)

Isocyanide-based multicomponent reactions based upon intramolecular nitrilium trapping

Majumdar, S., Váradi, A. & Palmer, T. C., jan. 1 2017, Multicomponent Reactions: Synthesis of Bioactive Heterocycles. CRC Press, p. 33-56 24 p.

Research output: Chapter

New opioid receptor antagonist: Naltrexone-14-O-sulfate synthesis and pharmacology

Zádor, F., Király, K., Váradi, A., Balogh, M., Fehér, Á., Kocsis, D., Erdei, A., Lackó, E., Zádori, Z., Hosztafi, S., Noszál, B., Riba, P., Benyhe, S., Fürst, S. & Al-Khrasani, M., jan. 1 2017, In : European Journal of Pharmacology. 809, p. 111-121 11 p.

Research output: Article

3 Citations (Scopus)

Oral administration of pyrophosphate inhibits connective tissue calcification

Dedinszki, D., Szeri, F., Kozák, E., Pomozi, V., Tőkési, N., Mezei, T. R., Merczel, K., Letavernier, E., Tang, E., Le Saux, O., Arányi, T., van de Wetering, K. & Váradi, A., nov. 1 2017, In : EMBO Molecular Medicine. 9, 11, p. 1463-1470 8 p.

Research output: Article

22 Citations (Scopus)

Pyrophosphate Supplementation Prevents Chronic and Acute Calcification in ABCC6-Deficient Mice

Pomozi, V., Brampton, C., van de Wetering, K., Zoll, J., Calio, B., Pham, K., Owens, J. B., Marh, J., Moisyadi, S., Váradi, A., Martin, L., Bauer, C., Erdmann, J., Aherrahrou, Z. & Le Saux, O., jún. 2017, In : American Journal of Pathology. 187, 6, p. 1258-1272 15 p.

Research output: Article

18 Citations (Scopus)

Synthesis and pharmacological evaluation of novel selective MOR agonist 6β-pyridinyl amidomorphines exhibiting long-lasting antinociception

Urai, Á., Váradi, A., Szőcs, L., Komjáti, B., Le Rouzic, V., Hunkele, A., Pasternak, G. W., Majumdar, S. & Hosztafi, S., 2017, In : MedChemComm. 8, 1, p. 152-157 6 p.

Research output: Article

2 Citations (Scopus)
1 Citation (Scopus)
2016

Isocyanide-based multicomponent reactions for the synthesis of heterocycles

Váradi, A., Palmer, T. C., Dardashti, R. N. & Majumdar, S., jan. 1 2016, In : Molecules. 21, 1, 19.

Research output: Review article

34 Citations (Scopus)

Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2

Váradi, A., Marrone, G. F., Palmer, T. C., Narayan, A., Szabó, M. R., Le Rouzic, V., Grinnell, S. G., Subrath, J. J., Warner, E., Kalra, S., Hunkele, A., Pagirsky, J., Eans, S. O., Medina, J. M., Xu, J., Pan, Y. X., Borics, A., Pasternak, G. W., McLaughlin, J. P. & Majumdar, S., szept. 22 2016, In : Journal of Medicinal Chemistry. 59, 18, p. 8381-8397 17 p.

Research output: Article

75 Citations (Scopus)

New morphine analogs produce peripheral antinociception within a certain dose range of their systemic administration

Lackó, E., Riba, P., Giricz, Z., Váradi, A., Cornic, L., Balogh, M., Király, K., Cseko, K., Mousa, S. A., Hosztafi, S., Schäfer, M., Zádori, Z., Helyes, Z., Ferdinandy, P., Fürst, S. & Al-Khrasani, M., okt. 1 2016, In : Journal of Pharmacology and Experimental Therapeutics. 359, 1, p. 171-181 11 p.

Research output: Article

7 Citations (Scopus)

New perspectives on rare connective tissue calcifying diseases

Rashdan, N. A., Rutsch, F., Kempf, H., Váradi, A., Lefthériotis, G. & Macrae, V. E., jún. 1 2016, In : Current Opinion in Pharmacology. 28, p. 14-23 10 p.

Research output: Review article

11 Citations (Scopus)

Research Progress in Pseudoxanthoma Elasticum and Related Ectopic Mineralization Disorders

Li, Q., Arányi, T., Váradi, A., Terry, S. F. & Uitto, J., jan. 1 2016, In : Journal of Investigative Dermatology. 136, p. 550-556 7 p.

Research output: Short survey

15 Citations (Scopus)

Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators

Kruegel, A. C., Gassaway, M. M., Kapoor, A., Váradi, A., Majumdar, S., Filizola, M., Javitch, J. A. & Sames, D., jún. 1 2016, In : Journal of the American Chemical Society. 138, 21, p. 6754-6764 11 p.

Research output: Article

71 Citations (Scopus)
2015

Mild, Pd-catalyzed stannylation of radioiodination targets

Pickett, J. E., Váradi, A., Palmer, T. C., Grinnell, S. G., Schrock, J. M., Pasternak, G. W., Karimov, R. R. & Majumdar, S., ápr. 15 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 8, p. 1761-1764 4 p.

Research output: Article

10 Citations (Scopus)
13 Citations (Scopus)

Synthesis and Characterization of a Dual Kappa-Delta Opioid Receptor Agonist Analgesic Blocking Cocaine Reward Behavior

Váradi, A., Marrone, G. F., Eans, S. O., Ganno, M. L., Subrath, J. J., Le Rouzic, V., Hunkele, A., Pasternak, G. W., McLaughlin, J. P. & Majumdar, S., szept. 1 2015, In : ACS Chemical Neuroscience. 6, 11, p. 1813-1824 12 p.

Research output: Article

14 Citations (Scopus)

Synthesis of Carfentanil Amide Opioids Using the Ugi Multicomponent Reaction

Váradi, A., Palmer, T. C., Haselton, N., Afonin, D., Subrath, J. J., Le Rouzic, V., Hunkele, A., Pasternak, G. W., Marrone, G. F., Borics, A. & Majumdar, S., júl. 6 2015, In : ACS Chemical Neuroscience. 6, 9, p. 1570-1577 8 p.

Research output: Article

16 Citations (Scopus)
2014

ABCC6-mediated ATP secretion by the liver is the main source of the mineralization inhibitor inorganic pyrophosphate in the systemic circulation - Brief report

Jansen, R. S., Duijst, S., Mahakena, S., Sommer, D., Szeri, F., Váradi, A., Plomp, A., Bergen, A. A., Oude Elferink, R. P. J., Borst, P. & Van De Wetering, K., szept. 2014, In : Arteriosclerosis, thrombosis, and vascular biology. 34, 9, p. 1985-1989 5 p.

Research output: Article

118 Citations (Scopus)

Analysis of pseudoxanthoma elasticum-causing missense mutants of ABCC6 in vivo; Pharmacological correction of the mislocalized proteins

Pomozi, V., Brampton, C., Fülöp, K., Chen, L. H., Apana, A., Li, Q., Uitto, J., Le Saux, O. & Váradi, A., ápr. 2014, In : Journal of Investigative Dermatology. 134, 4, p. 946-953 8 p.

Research output: Article

25 Citations (Scopus)

Hungary: Research agency will lose autonomy

Váradi, A. & Kertész, J., dec. 18 2014, In : Nature. 516, 7531, 1 p.

Research output: Letter

It is all about calcification

Váradi, A., dec. 15 2014, In : Cell Cycle. 13, 24, 1 p.

Research output: Comment/debate

1 Citation (Scopus)

Pseudoxanthoma elasticum: Diagnostic features, classification and treatment options

Uitto, J., Jiang, Q., Váradi, A., Bercovitch, L. G. & Terry, S. F., jún. 2014, In : Expert Opinion on Orphan Drugs. 2, 6, p. 567-577 11 p.

Research output: Review article

31 Citations (Scopus)
23 Citations (Scopus)

The level of hepatic ABCC6 expression determines the severity of calcification after cardiac injury

Brampton, C., Aherrahrou, Z., Chen, L. H., Martin, L., Bergen, A. A. B., Gorgels, T. G. M. F., Erdfdi, J., Schunkert, H., Szabó, Z., Váradi, A. & Le Saux, O., jan. 1 2014, In : American Journal of Pathology. 184, 1, p. 159-170 12 p.

Research output: Article

16 Citations (Scopus)

Three-component coupling approach for the synthesis of diverse heterocycles utilizing reactive nitrilium trapping

Váradi, A., Palmer, T. C., Notis, P. R., Redel-Traub, G. N., Afonin, D., Subrath, J. J., Pasternak, G. W., Hu, C., Sharma, I. & Majumdar, S., márc. 21 2014, In : Organic Letters. 16, 6, p. 1668-1671 4 p.

Research output: Article

18 Citations (Scopus)
2013

ABCC6 is a basolateral plasma membrane protein

Pomozi, V., Le Saux, O., Brampton, C., Apana, A., Iliás, A., Szeri, F., Martin, L., Monostory, K., Paku, S., Sarkadi, B., Szakács, G. & Váradi, A., máj. 24 2013, In : Circulation research. 112, 11, p. e148-e151

Research output: Article

33 Citations (Scopus)
27 Citations (Scopus)

Glucosides of morphine derivatives: Synthesis and characterization

Váradi, A., Lévai, D., Tóth, G., Horváth, P., Noszál, B. & Hosztafi, S., jan. 1 2013, In : Monatshefte fur Chemie. 144, 2, p. 255-262 8 p.

Research output: Article

2 Citations (Scopus)

Novel 6β-acylaminomorphinans with analgesic activity

Váradi, A., Hosztafi, S., Le Rouzic, V., Tóth, G., Urai, Á., Noszál, B., Pasternak, G. W., Grinnell, S. G. & Majumdar, S., okt. 8 2013, In : European Journal of Medicinal Chemistry. 69, p. 786-789 4 p.

Research output: Article

9 Citations (Scopus)

Pseudoxanthoma elasticum: Progress in research toward treatment: Summary of the 2012 PXE international research meeting

Uitto, J., Váradi, A., Bercovitch, L., Terry, P. F. & Terry, S. F., jún. 2013, In : Journal of Investigative Dermatology. 133, 6, p. 1444-1449 6 p.

Research output: Article

33 Citations (Scopus)
1 Citation (Scopus)

Transcriptional regulation of the ABCC6 gene and the background of impaired function of missense disease-causing mutations

Arányi, T., Bacquet, C., de Boussac, H., Ratajewski, M., Pomozi, V., Fülöp, K., Brampton, C. N., Pulaski, L., Le Saux, O. & Váradi, A., ápr. 18 2013, In : Frontiers in Genetics. 4, MAR, Article 27.

Research output: Review article

5 Citations (Scopus)
2012

ABCC6 expression is regulated by CCAAT/enhancer-binding protein activating a primate-specific sequence located in the first intron of the gene

Ratajewski, M., De Boussac, H., Sachrajda, I., Bacquet, C., Kovács, T., Váradi, A., Pulaski, L. & Arányi, T., dec. 2012, In : Journal of Investigative Dermatology. 132, 12, p. 2709-2717 9 p.

Research output: Article

11 Citations (Scopus)

A novel μ-opioid receptor ligand with high in vitro and in vivo agonist efficacy

Lackó, E., Váradi, A., Rapavi, R., Zádor, F., Riba, P., Benyhe, S., Borsodi, A., Hosztafi, S., Timár, J., Noszál, B., Fürst, S. & Al-Khrasani, M., jan. 1 2012, In : Current medicinal chemistry. 19, 27, p. 4699-4707 9 p.

Research output: Article

11 Citations (Scopus)

Antibody binding shift assay for rapid screening of drug interactions with the human ABCG2 multidrug transporter

Telbisz, Á., Hegedüs, C., Özvegy-Laczka, C., Goda, K., Várady, G., Takáts, Z., Szabó, E., Sorrentino, B. P., Váradi, A. & Sarkadi, B., jan. 23 2012, In : European Journal of Pharmaceutical Sciences. 45, 1-2, p. 101-109 9 p.

Research output: Article

15 Citations (Scopus)

Detection and identification of the new potential synthetic cannabinoids 1-pentyl-3-(2-iodobenzoyl)indole and 1-pentyl-3-(1-adamantoyl)indole in seized bulk powders in Hungary

Jankovics, P., Váradi, A., Tölgyesi, L., Lohner, S., Németh-Palotás, J. & Balla, J., jan. 10 2012, In : Forensic Science International. 214, 1-3, p. 27-32 6 p.

Research output: Article

57 Citations (Scopus)
45 Citations (Scopus)

PI3-kinase and mTOR inhibitors differently modulate the function of the ABCG2 multidrug transporter

Hegedüs, C., Truta-Feles, K., Antalffy, G., Brózik, A., Kasza, I., Német, K., Orbán, T. I., Özvegy-Laczka, C., Váradi, A. & Sarkadi, B., ápr. 20 2012, In : Biochemical and biophysical research communications. 420, 4, p. 869-874 6 p.

Research output: Article

14 Citations (Scopus)

Stimulus-induced expression of the ABCG2 multidrug transporter in HepG2 hepatocarcinoma model cells involves the ERK1/2 cascade and alternative promoters

de Boussac, H., Orbán, T. I., Várady, G., Tihanyi, B., Bacquet, C., Brózik, A., Váradi, A., Sarkadi, B. & Arányi, T., szept. 21 2012, In : Biochemical and biophysical research communications. 426, 2, p. 172-176 5 p.

Research output: Article

9 Citations (Scopus)
11 Citations (Scopus)