• 2135 Citations
  • 15 h-Index
20012019
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Research Output 2001 2019

  • 2135 Citations
  • 15 h-Index
  • 34 Article
2001
27 Citations (Scopus)
Transglutaminases
Calcium
Binding Sites
varespladib methyl
EF Hand Motifs
7 Citations (Scopus)
Inclusion Bodies
Glutamine
Lysine
Nucleotides
Peptides
23 Citations (Scopus)
Calbindin 1
Calbindin 2
EF Hand Motifs
Calcium
Nuclear magnetic resonance
2003
112 Citations (Scopus)

A labile regulatory copper ion lies near the T1 copper site in the multicopper oxidase CueO

Roberts, S. A., Wildner, G. F., Grass, G., Weichsel, A., Ambrus, A., Rensing, C. & Montfort, W. R., aug. 22 2003, In : Journal of Biological Chemistry. 278, 34, p. 31958-31963 6 p.

Research output: Article

Copper
Oxidoreductases
Ions
Methionine
Atoms
2005
4 Citations (Scopus)
Ionization
Mass spectrometry
Desorption
Mass Spectrometry
DNA Polymerase I
355 Citations (Scopus)

Solution structure of the biologically relevant G-quadruplex element in the human c-MYC promoter. Implications for G-quadruplex stabilization

Ambrus, A., Chen, D., Dai, J., Jones, R. A. & Yang, D., febr. 15 2005, In : Biochemistry. 44, 6, p. 2048-2058 11 p.

Research output: Article

Transcriptional Silencer Elements
G-Quadruplexes
Guanine
Conformations
Nucleotides
15 Citations (Scopus)

Total and semisynthesis and in vitro studies of both enantiomers of 20-fluorocamptothecin

Tangirala, R. S., Dixon, R., Yang, D., Ambrus, A., Antony, S., Agama, K., Pommier, Y. & Curran, D. P., nov. 1 2005, In : Bioorganic and Medicinal Chemistry Letters. 15, 21, p. 4736-4740 5 p.

Research output: Article

Camptothecin
Enantiomers
Type I DNA Topoisomerase
Lactones
Assays
2006
297 Citations (Scopus)

An intramolecular G-quadruplex structure with mixed parallel/antiparallel G-strands formed in the human BCL-2 promoter region in solution

Dai, J., Dexheimer, T. S., Chen, D., Carver, M., Ambrus, A., Jones, R. A. & Yang, D., febr. 1 2006, In : Journal of the American Chemical Society. 128, 4, p. 1096-1098 3 p.

Research output: Article

G-Quadruplexes
Guanine
Nucleotides
Genetic Promoter Regions
GC Rich Sequence
767 Citations (Scopus)

Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution

Ambrus, A., Chen, D., Dai, J., Bialis, T., Jones, R. A. & Yang, D., 2006, In : Nucleic Acids Research. 34, 9, p. 2723-2735 13 p.

Research output: Article

G-Quadruplexes
Potassium
Tandem Repeat Sequences
Drug Design
Telomerase
16 Citations (Scopus)

Oligomerization of nitrophorins

Ambrus, A., Friedrich, K. & Somogyi, Á., máj. 15 2006, In : Analytical Biochemistry. 352, 2, p. 286-295 10 p.

Research output: Article

Oligomerization
Nitric Oxide
Insects
Saliva
Rhodnius
2007
23 Citations (Scopus)
Nuclear magnetic resonance spectroscopy
Magnetic Resonance Spectroscopy
G-Quadruplexes
DNA sequences
DNA
244 Citations (Scopus)

Structure of the intramolecular human telomeric G-quadruplex in potassium solution: A novel adenine triple formation

Dai, J., Punchihewa, C., Ambrus, A., Chen, D., Jones, R. A. & Yang, D., ápr. 2007, In : Nucleic Acids Research. 35, 7, p. 2440-2450 11 p.

Research output: Article

G-Quadruplexes
Adenine
Potassium
3' Flanking Region
5' Flanking Region
2009
32 Citations (Scopus)
Nucleotide Motifs
DNA sequences
DNA
Cytosine
Nuclear magnetic resonance
12 Citations (Scopus)

A re-evaluation of the role of matrix acidification in uncoupler-induced Ca2+ release from mitochondria

Vajda, S., Mándi, M., Konràd, C., Kiss, G., Ambrus, A., Ádám-Vizi, V. & Chinopoulos, C., máj. 2009, In : FEBS Journal. 276, 10, p. 2713-2724 12 p.

Research output: Article

Oligomycins
Mitochondria
Acidification
Phosphates
Depolarization
37 Citations (Scopus)
Ketoglutarate Dehydrogenase Complex
Thioctic Acid
Reactive Oxygen Species
NAD
Dihydrolipoamide Dehydrogenase
13 Citations (Scopus)
Dihydrolipoamide Dehydrogenase
Flavin-Adenine Dinucleotide
Oxidoreductases
Enzymes
Branched Chain Amino Acids
9 Citations (Scopus)
Dihydrolipoamide Dehydrogenase
Proteins
Purification
Inclusion Bodies
Affinity chromatography
2011
28 Citations (Scopus)
Dihydrolipoamide Dehydrogenase
Reactive Oxygen Species
Mutation
Circular Dichroism
Gel Chromatography
2013
16 Citations (Scopus)
Dihydrolipoamide Dehydrogenase
Molecular Dynamics Simulation
Conformations
Molecular dynamics
Reactive Oxygen Species
2014
25 Citations (Scopus)
Ketoglutarate Dehydrogenase Complex
Thiamine
Multienzyme Complexes
Thiamine Pyrophosphate
Superoxides
25 Citations (Scopus)

Human 2-oxoglutarate dehydrogenase complex E1 component forms a thiamin-derived radical by aerobic oxidation of the enamine intermediate

Nemeria, N. S., Ambrus, A., Patel, H., Gerfen, G., Ádám-Vizi, V., Tretter, L., Zhou, J., Wang, J. & Jordan, F., okt. 24 2014, In : Journal of Biological Chemistry. 289, 43, p. 29859-29873 15 p.

Research output: Article

Ketoglutarate Dehydrogenase Complex
Thiamine
Multienzyme Complexes
Thiamine Pyrophosphate
Superoxides
9 Citations (Scopus)
Mitochondria
Homeostasis
Aconitate Hydratase
Oxidative stress
Citric Acid Cycle
2015
25 Citations (Scopus)
Multienzyme Complexes
Ketoglutarate Dehydrogenase Complex
Pyruvic Acid
Reactive Oxygen Species
Escherichia coli
2016
9 Citations (Scopus)
Dihydrolipoamide Dehydrogenase
Deuterium
Hydrogen
Mass Spectrometry
Mutation
2017
8 Citations (Scopus)
Reactive Oxygen Species
Biochemical Phenomena
3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)
Dihydrolipoamide Dehydrogenase
Thioctic Acid
2018
4 Citations (Scopus)

A multipronged approach unravels unprecedented protein–protein interactions in the human 2-oxoglutarate dehydrogenase multienzyme complex

Zhou, J., Yang, L., Ozohanics, O., Zhang, X., Wang, J., Ambrus, A., Arjunan, P., Brukh, R., Nemeria, N. S., Furey, W. & Jordan, F., jan. 1 2018, In : Journal of Biological Chemistry. 293, 50, p. 19213-19227 15 p.

Research output: Article

Multienzyme Complexes
Ketoglutarate Dehydrogenase Complex
Oxidoreductases
Deuterium
Hydrogen
2 Citations (Scopus)

Crystal structures of the disease-causing D444V mutant and the relevant wild type human dihydrolipoamide dehydrogenase

Szabo, E., Mizsei, R., Wilk, P., Zambo, Z., Törőcsik, B., Weiss, M. S., Ádám-Vizi, V. & Ambrus, A., aug. 20 2018, In : Free Radical Biology and Medicine. 124, p. 214-220 7 p.

Research output: Article

Dihydrolipoamide Dehydrogenase
Crystal structure
Reactive Oxygen Species
Catalyst activity
Catalytic Domain
4 Citations (Scopus)
Circular Dichroism
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
DNA
Freezing
2 Citations (Scopus)
Heart Mitochondria
Proton-Motive Force
Electron Transport
Membrane Potentials
Hydrogen Peroxide
4 Citations (Scopus)
Electron Transport Complex I
Mitochondria
Oxidative stress
Glycols
Energy Metabolism
2019
Open Access
3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)
Dihydrolipoamide Dehydrogenase
Multienzyme Complexes
Jews
Inborn Genetic Diseases
vinpocetine
Mitochondria
Synaptosomes
Endothelial cells
Neuroprotective Agents

Underlying molecular alterations in human dihydrolipoamide dehydrogenase deficiency revealed by structural analyses of disease-causing enzyme variants

Szabo, E., Wilk, P., Nagy, B., Zambo, Z., Bui, D., Weichsel, A., Arjunan, P., Torocsik, B., Hubert, A., Furey, W., Montfort, W. R., Jordan, F., Weiss, M. S., Adam-Vizi, V. & Ambrus, A., okt. 15 2019, In : Human molecular genetics. 28, 20, p. 3339-3354 16 p.

Research output: Article

Multienzyme Complexes
Reactive Oxygen Species
Catalytic Domain
Dihydrolipoamide Dehydrogenase
Genetic Databases