Zur Wirkung von Phenylquecksilberacetat und Nitrat bei kombinierter Verabreichung an Ratten: Schilddrüse, Enzyme der Leber, morphologische Befunde an Gehirn und Nieren

H. Höring, Ch Ellinger, M. Nagel, A. Páldy, I. Dési

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Rats were exposed to nitrate (NO3) in drinking water. to phenylmercuryacetate (PMA) by gavage and to NO3 and PMA together during 4 different experiments. PMA impaired kidneys, NO3 thyroid gland, and NO3 and PMA together both organs. In the last case a synergistic effect on the thyroid gland was shown. The lowest effective concentration of NO3 was 40 mg/l. It resulted in histomorphological changes of the thyroid epithel cells. That low effective dose of NO3 and possible synergistic effects should give a further impulse to take into consideration not only a low iodide intake but also goitrogenic environmental chemicals when evaluating the endemic goitre prevalence.

Original languageGerman
Pages (from-to)713-721
Number of pages9
JournalDie Nahrung
Issue number7
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Food Science

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