Zonula occludens-1, occludin, and E-cadherin protein expression in biliary tract cancers

Zsuzsanna Németh, Attila Marcell Szász, Áron Somorácz, Péter Tátrai, Júlia Németh, Hajnalka Győrffy, Attila Szíjártó, Péter Kupcsulik, András Kiss, Zsuzsa Schaff

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The incidence of cholangiocarcinomas originating from intrahepatic and extrahepatic bile ducts, as well as of gallbladder carcinoma is increasing worldwide. The malignant transformation of biliary epithelia involves profound alterations of proteins in the intercellular junctions, among others zonula occludens-1 (ZO-1), occludin, and E-cadherin. Each plays important role in the maintenance of epithelial cell polarity and regulation of cell growth and differentiation. Our aim was to investigate ZO-1, occludin, and E-cadherin immunohistochemical reactions in tissue microarray blocks containing 57 normal and 62 neoplastic biliary tract samples. We demonstrated that the tight junction components ZO-1, occludin, and E-cadherin are downregulated in carcinomas arising from various compartments of the biliary tract (normal intrahepatic and extrahepatic bile ducts, gallbladder) as compared with their normal sites of origin. These results were confirmed by discriminant analysis yielding clear separation of the three normal sample groups from carcinomas in the corresponding locations.

Original languageEnglish
Pages (from-to)533-539
Number of pages7
JournalPathology and Oncology Research
Volume15
Issue number3
DOIs
Publication statusPublished - Sep 2009

Keywords

  • Adherens junction
  • Biliary tract cancer
  • Tight junction

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

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