ZNF804A may be associated with executive control of attention

Z. Balog, I. Kiss, S. Kéri

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

ZNF804A, encoding the transcription factor zinc-finger protein 804A, is a genome-wide supported psychosis gene associated with schizophrenia and bipolar disorder. However, only little information is available on the role of ZNF804A regarding the cognitive phenotype of psychosis. In this study, we investigated the relationship between the single-nucleotide polymorphism rs1344706 (A/C, A = risk allele) in ZNF804A and attention in 200 healthy volunteers. We used the attention network test, which was designed to separate the three main components of attention (alerting, orienting and executive control). Results showed a significant association with the executive control network: the A/A genotype and the A-allele were associated with increased reaction time when conflicting information was present. In contrast, rs1344706 was not related to alerting and orienting. These results suggest that the genome-wide supported psychosis risk variant of ZNF804A is associated with altered executive control (larger conflict effect), which is a potential endophenotype of psychotic disorders.

Original languageEnglish
Pages (from-to)223-227
Number of pages5
JournalGenes, Brain and Behavior
Volume10
Issue number2
DOIs
Publication statusPublished - Mar 2011

Fingerprint

Executive Function
Psychotic Disorders
Alleles
Genome
Endophenotypes
Zinc Fingers
Bipolar Disorder
Reaction Time
Single Nucleotide Polymorphism
Schizophrenia
Healthy Volunteers
Transcription Factors
Genotype
Phenotype
Genes
Proteins

Keywords

  • Attention
  • Executive control
  • Psychosis
  • Schizophrenia
  • ZNF804A

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Genetics
  • Neurology

Cite this

ZNF804A may be associated with executive control of attention. / Balog, Z.; Kiss, I.; Kéri, S.

In: Genes, Brain and Behavior, Vol. 10, No. 2, 03.2011, p. 223-227.

Research output: Contribution to journalArticle

Balog, Z. ; Kiss, I. ; Kéri, S. / ZNF804A may be associated with executive control of attention. In: Genes, Brain and Behavior. 2011 ; Vol. 10, No. 2. pp. 223-227.
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