Zn overdose may cause disturbance in iron metabolism in inactive inflammatory bowel diseases

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The antioxidant defense system is partly related to the element status via enzyme activity. Therefore, we wanted to examine whether or not the element content of blood shows alteration in inactive inflammatory bowel diseases, compared to the control. Element analysis of blood with ICP-OES and spectrophotometric as well as chemiluminometric methods were applied for redox reactions of plasma and erythrocytes in 8 Caucasian volunteers, and 12 randomly chosen Caucasian patients with inactive IBD. Elevated Zn concentration was observed for some IBD patients, consequently nutritional supplementation, and the Zn vs. Fe amount showed significant negative correlation in total blood. Negative correlation coefficients were calculated between Zn-MCHC, Zn-K, Zn-S, Zn-Na, Zn-Cu, however, a positive correlation was found between Zn-PLT and Cu-Fe in IBD patients. We could not find any significant difference between redox parameters and element states in inactive IBD vs. controls. The erythrocyte scavenger capacity was insufficient in IBD in spite of adequate therapy and nutritional supplementation, therefore we concluded, that the redox state of erythrocyte indicates previous active stages. Zn, Cu and Fe are essential elements and their deficiencies cause severe metabolic disorders, therefore, it is very important to know that simultaneous supplementation involves health risks, especially in IBD.

Original languageEnglish
Pages (from-to)240-247
Number of pages8
JournalTrace Elements and Electrolytes
Volume21
Issue number4
Publication statusPublished - 2004

Fingerprint

Inflammatory Bowel Diseases
Metabolism
Oxidation-Reduction
Blood
Iron
Erythrocytes
Redox reactions
Health risks
Enzyme activity
Volunteers
Antioxidants
Plasmas
Health
Enzymes
Therapeutics

Keywords

  • Inflammatory bowel diseases
  • Redox reactions
  • Trace elements

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

@article{6b5614e7875d4e06819c7153d3cfe0c9,
title = "Zn overdose may cause disturbance in iron metabolism in inactive inflammatory bowel diseases",
abstract = "The antioxidant defense system is partly related to the element status via enzyme activity. Therefore, we wanted to examine whether or not the element content of blood shows alteration in inactive inflammatory bowel diseases, compared to the control. Element analysis of blood with ICP-OES and spectrophotometric as well as chemiluminometric methods were applied for redox reactions of plasma and erythrocytes in 8 Caucasian volunteers, and 12 randomly chosen Caucasian patients with inactive IBD. Elevated Zn concentration was observed for some IBD patients, consequently nutritional supplementation, and the Zn vs. Fe amount showed significant negative correlation in total blood. Negative correlation coefficients were calculated between Zn-MCHC, Zn-K, Zn-S, Zn-Na, Zn-Cu, however, a positive correlation was found between Zn-PLT and Cu-Fe in IBD patients. We could not find any significant difference between redox parameters and element states in inactive IBD vs. controls. The erythrocyte scavenger capacity was insufficient in IBD in spite of adequate therapy and nutritional supplementation, therefore we concluded, that the redox state of erythrocyte indicates previous active stages. Zn, Cu and Fe are essential elements and their deficiencies cause severe metabolic disorders, therefore, it is very important to know that simultaneous supplementation involves health risks, especially in IBD.",
keywords = "Inflammatory bowel diseases, Redox reactions, Trace elements",
author = "A. Bl{\'a}zovics and K. Szentmih{\'a}lyi and P. Vinkler and A. Kov{\'a}cs",
year = "2004",
language = "English",
volume = "21",
pages = "240--247",
journal = "Trace Elements in Medicine",
issn = "0946-2104",
publisher = "Dustri-Verlag Dr. Karl Feistle",
number = "4",

}

TY - JOUR

T1 - Zn overdose may cause disturbance in iron metabolism in inactive inflammatory bowel diseases

AU - Blázovics, A.

AU - Szentmihályi, K.

AU - Vinkler, P.

AU - Kovács, A.

PY - 2004

Y1 - 2004

N2 - The antioxidant defense system is partly related to the element status via enzyme activity. Therefore, we wanted to examine whether or not the element content of blood shows alteration in inactive inflammatory bowel diseases, compared to the control. Element analysis of blood with ICP-OES and spectrophotometric as well as chemiluminometric methods were applied for redox reactions of plasma and erythrocytes in 8 Caucasian volunteers, and 12 randomly chosen Caucasian patients with inactive IBD. Elevated Zn concentration was observed for some IBD patients, consequently nutritional supplementation, and the Zn vs. Fe amount showed significant negative correlation in total blood. Negative correlation coefficients were calculated between Zn-MCHC, Zn-K, Zn-S, Zn-Na, Zn-Cu, however, a positive correlation was found between Zn-PLT and Cu-Fe in IBD patients. We could not find any significant difference between redox parameters and element states in inactive IBD vs. controls. The erythrocyte scavenger capacity was insufficient in IBD in spite of adequate therapy and nutritional supplementation, therefore we concluded, that the redox state of erythrocyte indicates previous active stages. Zn, Cu and Fe are essential elements and their deficiencies cause severe metabolic disorders, therefore, it is very important to know that simultaneous supplementation involves health risks, especially in IBD.

AB - The antioxidant defense system is partly related to the element status via enzyme activity. Therefore, we wanted to examine whether or not the element content of blood shows alteration in inactive inflammatory bowel diseases, compared to the control. Element analysis of blood with ICP-OES and spectrophotometric as well as chemiluminometric methods were applied for redox reactions of plasma and erythrocytes in 8 Caucasian volunteers, and 12 randomly chosen Caucasian patients with inactive IBD. Elevated Zn concentration was observed for some IBD patients, consequently nutritional supplementation, and the Zn vs. Fe amount showed significant negative correlation in total blood. Negative correlation coefficients were calculated between Zn-MCHC, Zn-K, Zn-S, Zn-Na, Zn-Cu, however, a positive correlation was found between Zn-PLT and Cu-Fe in IBD patients. We could not find any significant difference between redox parameters and element states in inactive IBD vs. controls. The erythrocyte scavenger capacity was insufficient in IBD in spite of adequate therapy and nutritional supplementation, therefore we concluded, that the redox state of erythrocyte indicates previous active stages. Zn, Cu and Fe are essential elements and their deficiencies cause severe metabolic disorders, therefore, it is very important to know that simultaneous supplementation involves health risks, especially in IBD.

KW - Inflammatory bowel diseases

KW - Redox reactions

KW - Trace elements

UR - http://www.scopus.com/inward/record.url?scp=7444251698&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=7444251698&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:7444251698

VL - 21

SP - 240

EP - 247

JO - Trace Elements in Medicine

JF - Trace Elements in Medicine

SN - 0946-2104

IS - 4

ER -